AR089862A1 - USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA - Google Patents
USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEAInfo
- Publication number
- AR089862A1 AR089862A1 ARP130100296A ARP130100296A AR089862A1 AR 089862 A1 AR089862 A1 AR 089862A1 AR P130100296 A ARP130100296 A AR P130100296A AR P130100296 A ARP130100296 A AR P130100296A AR 089862 A1 AR089862 A1 AR 089862A1
- Authority
- AR
- Argentina
- Prior art keywords
- laquinimod
- crohn
- disease
- thumor
- tnfa
- Prior art date
Links
- 208000011231 Crohn disease Diseases 0.000 title abstract 2
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004577 laquinimod Drugs 0.000 title abstract 2
- 230000017074 necrotic cell death Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261595006P | 2012-02-03 | 2012-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089862A1 true AR089862A1 (es) | 2014-09-24 |
Family
ID=48903432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100296A AR089862A1 (es) | 2012-02-03 | 2013-02-01 | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9161935B2 (https=) |
| EP (1) | EP2811832A4 (https=) |
| JP (2) | JP2015505564A (https=) |
| KR (1) | KR20140138694A (https=) |
| CN (2) | CN104093310A (https=) |
| AR (1) | AR089862A1 (https=) |
| AU (2) | AU2013214909A1 (https=) |
| BR (1) | BR112014018485A8 (https=) |
| CA (1) | CA2862865A1 (https=) |
| EA (1) | EA201491460A1 (https=) |
| HK (1) | HK1202776A1 (https=) |
| IL (1) | IL233557A0 (https=) |
| MX (1) | MX2014009373A (https=) |
| SG (1) | SG11201404214QA (https=) |
| TW (1) | TW201345527A (https=) |
| WO (1) | WO2013116657A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2234485B1 (en) | 2007-12-20 | 2013-11-13 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| CA2851525A1 (en) | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| JP6215238B2 (ja) | 2012-02-16 | 2017-10-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| EP2916915A4 (en) | 2012-11-07 | 2016-06-22 | Teva Pharma | LAQUINIMOD AMINE SALTS |
| US20160046582A1 (en) | 2013-03-14 | 2016-02-18 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| HK1225969A1 (zh) * | 2014-01-17 | 2017-09-22 | Teva Pharmaceutical Industries Ltd | 利用低剂量的拉喹莫德治疗克隆氏病 |
| WO2015168103A1 (en) | 2014-04-29 | 2015-11-05 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| CN108290058B (zh) * | 2015-09-17 | 2023-05-16 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
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| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| CN118649163A (zh) * | 2018-11-30 | 2024-09-17 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
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| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| US20130345257A1 (en) | 2012-06-26 | 2013-12-26 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
| AR091706A1 (es) | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
| UY34896A (es) | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
| TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| BR112015007782A2 (pt) | 2012-10-12 | 2017-07-04 | Teva Pharma | laquinimod para reduzir danos talâmicos na esclerose múltipla |
| EP2916915A4 (en) | 2012-11-07 | 2016-06-22 | Teva Pharma | LAQUINIMOD AMINE SALTS |
| BR112015019564A2 (pt) | 2013-02-15 | 2017-07-18 | Teva Pharma | tratamento de esclerose múltipla com laquinimod |
| US20160038435A1 (en) | 2013-03-14 | 2016-02-11 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
| US20160046582A1 (en) | 2013-03-14 | 2016-02-18 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| HK1225969A1 (zh) * | 2014-01-17 | 2017-09-22 | Teva Pharmaceutical Industries Ltd | 利用低剂量的拉喹莫德治疗克隆氏病 |
-
2013
- 2013-02-01 CN CN201380007766.6A patent/CN104093310A/zh active Pending
- 2013-02-01 EA EA201491460A patent/EA201491460A1/ru unknown
- 2013-02-01 BR BR112014018485A patent/BR112014018485A8/pt not_active IP Right Cessation
- 2013-02-01 MX MX2014009373A patent/MX2014009373A/es unknown
- 2013-02-01 CA CA2862865A patent/CA2862865A1/en not_active Abandoned
- 2013-02-01 AU AU2013214909A patent/AU2013214909A1/en not_active Abandoned
- 2013-02-01 HK HK15103524.2A patent/HK1202776A1/xx unknown
- 2013-02-01 KR KR1020147024856A patent/KR20140138694A/ko not_active Withdrawn
- 2013-02-01 AR ARP130100296A patent/AR089862A1/es unknown
- 2013-02-01 WO PCT/US2013/024356 patent/WO2013116657A1/en not_active Ceased
- 2013-02-01 TW TW102104087A patent/TW201345527A/zh unknown
- 2013-02-01 US US13/757,004 patent/US9161935B2/en active Active
- 2013-02-01 SG SG11201404214QA patent/SG11201404214QA/en unknown
- 2013-02-01 EP EP13744015.2A patent/EP2811832A4/en not_active Withdrawn
- 2013-02-01 JP JP2014555758A patent/JP2015505564A/ja not_active Withdrawn
- 2013-02-01 CN CN201610357641.1A patent/CN106063787A/zh active Pending
-
2014
- 2014-07-08 IL IL233557A patent/IL233557A0/en unknown
-
2015
- 2015-08-25 US US14/835,123 patent/US20150359788A1/en not_active Abandoned
-
2017
- 2017-01-24 AU AU2017200472A patent/AU2017200472A1/en not_active Abandoned
- 2017-05-26 JP JP2017104049A patent/JP2017200926A/ja not_active Withdrawn
- 2017-06-26 US US15/633,132 patent/US20170290822A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN106063787A (zh) | 2016-11-02 |
| CA2862865A1 (en) | 2013-08-08 |
| AU2017200472A1 (en) | 2017-02-09 |
| US20150359788A1 (en) | 2015-12-17 |
| HK1202776A1 (en) | 2015-10-09 |
| JP2017200926A (ja) | 2017-11-09 |
| EP2811832A1 (en) | 2014-12-17 |
| EP2811832A4 (en) | 2015-09-23 |
| BR112014018485A2 (https=) | 2017-06-20 |
| BR112014018485A8 (pt) | 2017-07-11 |
| CN104093310A (zh) | 2014-10-08 |
| TW201345527A (zh) | 2013-11-16 |
| US9161935B2 (en) | 2015-10-20 |
| SG11201404214QA (en) | 2014-08-28 |
| EA201491460A1 (ru) | 2015-01-30 |
| KR20140138694A (ko) | 2014-12-04 |
| MX2014009373A (es) | 2014-08-27 |
| JP2015505564A (ja) | 2015-02-23 |
| US20130203807A1 (en) | 2013-08-08 |
| AU2013214909A1 (en) | 2014-09-18 |
| WO2013116657A1 (en) | 2013-08-08 |
| IL233557A0 (en) | 2014-08-31 |
| US20170290822A1 (en) | 2017-10-12 |
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