CN104093310A - 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 - Google Patents

拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 Download PDF

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Publication number
CN104093310A
CN104093310A CN201380007766.6A CN201380007766A CN104093310A CN 104093310 A CN104093310 A CN 104093310A CN 201380007766 A CN201380007766 A CN 201380007766A CN 104093310 A CN104093310 A CN 104093310A
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CN
China
Prior art keywords
disease
laquinimod
crohn
patient
amount
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Pending
Application number
CN201380007766.6A
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English (en)
Chinese (zh)
Inventor
诺拉·塔克斯克
阿瑟·哈维夫
埃朗·布拉歌
乔尔·凯耶
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Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Priority to CN201610357641.1A priority Critical patent/CN106063787A/zh
Publication of CN104093310A publication Critical patent/CN104093310A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380007766.6A 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 Pending CN104093310A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610357641.1A CN106063787A (zh) 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595006P 2012-02-03 2012-02-03
US61/595,006 2012-02-03
PCT/US2013/024356 WO2013116657A1 (en) 2012-02-03 2013-02-01 USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610357641.1A Division CN106063787A (zh) 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途

Publications (1)

Publication Number Publication Date
CN104093310A true CN104093310A (zh) 2014-10-08

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380007766.6A Pending CN104093310A (zh) 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
CN201610357641.1A Pending CN106063787A (zh) 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途

Family Applications After (1)

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CN201610357641.1A Pending CN106063787A (zh) 2012-02-03 2013-02-01 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途

Country Status (16)

Country Link
US (3) US9161935B2 (https=)
EP (1) EP2811832A4 (https=)
JP (2) JP2015505564A (https=)
KR (1) KR20140138694A (https=)
CN (2) CN104093310A (https=)
AR (1) AR089862A1 (https=)
AU (2) AU2013214909A1 (https=)
BR (1) BR112014018485A8 (https=)
CA (1) CA2862865A1 (https=)
EA (1) EA201491460A1 (https=)
HK (1) HK1202776A1 (https=)
IL (1) IL233557A0 (https=)
MX (1) MX2014009373A (https=)
SG (1) SG11201404214QA (https=)
TW (1) TW201345527A (https=)
WO (1) WO2013116657A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN113226307A (zh) * 2018-11-30 2021-08-06 艾尼纳制药公司 治疗与s1p1受体有关的病况的方法

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TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
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