HRP20121034T1 - Lijeäśenje upalnih bolesti - Google Patents
Lijeäśenje upalnih bolesti Download PDFInfo
- Publication number
- HRP20121034T1 HRP20121034T1 HRP20121034TT HRP20121034T HRP20121034T1 HR P20121034 T1 HRP20121034 T1 HR P20121034T1 HR P20121034T T HRP20121034T T HR P20121034TT HR P20121034 T HRP20121034 T HR P20121034T HR P20121034 T1 HRP20121034 T1 HR P20121034T1
- Authority
- HR
- Croatia
- Prior art keywords
- composition
- fty720
- chronic inflammatory
- subject
- treatment
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 7
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- DCQFFOLNJVGHLW-DSOBHZJASA-N 3,6-anhydro-alpha-L-galactopyranose Chemical compound O[C@H]1[C@@]2([H])OC[C@]1([H])O[C@@H](O)[C@H]2O DCQFFOLNJVGHLW-DSOBHZJASA-N 0.000 claims 3
- NMRLBSIYIBOLLJ-GOSISDBHSA-N [(2r)-2-amino-4-(4-heptoxyphenyl)-2-methylbutyl] dihydrogen phosphate Chemical compound CCCCCCCOC1=CC=C(CC[C@@](C)(N)COP(O)(O)=O)C=C1 NMRLBSIYIBOLLJ-GOSISDBHSA-N 0.000 claims 3
- LRFKWQGGENFBFO-IBGZPJMESA-N [(2s)-2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate Chemical compound CCCCCCCCC1=CC=C(CC[C@](N)(CO)COP(O)(O)=O)C=C1 LRFKWQGGENFBFO-IBGZPJMESA-N 0.000 claims 3
- 229960000556 fingolimod Drugs 0.000 claims 3
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (6)
1. Farmaceutski sastav, naznačen time, da sadrži FTY720, FTY720-P, AAL(R) ili AFD(R) za uporabu u liječenju kronične upalne demijelinacijske polineuropatije (CIDP) kod subjekta.
2. Sastav za uporabu prema zahtjevu 1, naznačen time, da se sastav daje subjektu prije ili poslije nastanka simptoma kronične upalne demijelinacijske polineuropatije. (CIPD).
3. Sastav za uporabu prema zahtjevu 1 ili 2, naznačen time, da je sastav prilagođen za oralno davanje.
4. Sastav za uporabu prema jednom od zahtjeva 1 do 3, naznačen time, da se sastav primjenjuje u kombinaciji s učinkovitom količinom imunosupresanta, kortikosteroida ili imunoglobulina.
5. Farmaceutski sastav koji sadrži FTY720, FTY720-P, AAL(R) ili AFD(R), naznačen time, da se upotrebljava za umanjivanje simptoma kronične upalne demijelinacijske polineuropatije (CIDP) kod subjekta.
6. Farmaceutski sastav koji sadrži FTY720, FTY720-P, AAL(R) ili AFD(R), naznačen time, da se upotrebljava za produljivanje vremena za povratak kronične upalne demijelinacijske polineuropatije (CIDP) kod subjekta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83822206P | 2006-08-17 | 2006-08-17 | |
PCT/US2007/018331 WO2008021532A2 (en) | 2006-08-17 | 2007-08-17 | Treatment of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20121034T1 true HRP20121034T1 (hr) | 2013-01-31 |
Family
ID=38941849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20121034TT HRP20121034T1 (hr) | 2006-08-17 | 2012-12-14 | Lijeäśenje upalnih bolesti |
Country Status (17)
Country | Link |
---|---|
US (3) | US8258150B2 (hr) |
EP (2) | EP2392320A1 (hr) |
JP (3) | JP5216769B2 (hr) |
CN (2) | CN101553216B (hr) |
AU (1) | AU2007284337B2 (hr) |
BR (1) | BRPI0715950A2 (hr) |
CA (1) | CA2660880C (hr) |
DK (1) | DK2056807T3 (hr) |
ES (1) | ES2393631T3 (hr) |
HK (1) | HK1131047A1 (hr) |
HR (1) | HRP20121034T1 (hr) |
MX (1) | MX2009001788A (hr) |
PL (1) | PL2056807T3 (hr) |
PT (1) | PT2056807E (hr) |
RU (1) | RU2440110C2 (hr) |
SI (1) | SI2056807T1 (hr) |
WO (1) | WO2008021532A2 (hr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2046315B1 (en) | 2006-06-02 | 2013-04-10 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of mantle cell lymphoma |
JP5216769B2 (ja) * | 2006-08-17 | 2013-06-19 | ザ・ユニバーシティ・オブ・シカゴ | 炎症性疾患の処置 |
SI2307007T1 (sl) | 2008-07-23 | 2014-11-28 | Novartis Ag | Modulatorji sfingozin 1 fosfatnega receptorja in njihova uporaba za zdravljenje mišičnega vnetja |
CN102186473B (zh) * | 2008-08-18 | 2014-07-02 | 诺华股份有限公司 | 用于治疗周围神经病的化合物 |
WO2010020609A1 (en) * | 2008-08-18 | 2010-02-25 | Novartis Ag | Amino alcohol derivatives for the treatment of demyelinating peripheral neuropathies |
EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
CN102186845B (zh) | 2008-10-17 | 2016-09-07 | 阿卡制药有限公司 | S1p受体调节剂以及它们的用途 |
WO2010042998A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
US8461362B2 (en) | 2009-04-13 | 2013-06-11 | The Ohio State University Research Foundation | Protein phosphatase 2A-activating agents |
CA2759011A1 (en) | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
PL3064206T3 (pl) | 2009-08-10 | 2020-02-28 | Active Biotech Ab | Leczenie choroby Huntingtona z zastosowaniem lakwinimodu |
EP2305660A1 (en) | 2009-09-25 | 2011-04-06 | Almirall, S.A. | New thiadiazole derivatives |
EP2343287A1 (en) | 2009-12-10 | 2011-07-13 | Almirall, S.A. | New 2-aminothiadiazole derivatives |
ES2558556T3 (es) * | 2010-03-03 | 2016-02-05 | Teva Pharmaceutical Industries Ltd. | Tratamiento de nefritis lúpica usando laquinimod |
EP2366702A1 (en) | 2010-03-18 | 2011-09-21 | Almirall, S.A. | New oxadiazole derivatives |
EP2390252A1 (en) | 2010-05-19 | 2011-11-30 | Almirall, S.A. | New pyrazole derivatives |
US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
CN106344576A (zh) * | 2011-10-12 | 2017-01-25 | 泰华制药工业有限公司 | 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症 |
CN104093310A (zh) | 2012-02-03 | 2014-10-08 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
RU2482842C1 (ru) * | 2012-04-26 | 2013-05-27 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения |
EP2708898A1 (de) * | 2012-09-14 | 2014-03-19 | Sterna Biologicals GmbH & Co. Kg | Verfahren zur Diagnose eines molekularen Phänotyps eines an einer mit chronischen Entzündungen einhergehenden Erkrankung leidenden Patienten |
EP2916915A4 (en) | 2012-11-07 | 2016-06-22 | Teva Pharma | LAQUINIMOD AMINE SALTS |
MX2015011627A (es) | 2013-03-14 | 2016-05-16 | Teva Pharma | Cristales de laquinimod sodico y proceso mejorado para la elaboracion de los mismos. |
CN103992985A (zh) * | 2014-05-09 | 2014-08-20 | 上海大学 | 神经鞘氨醇在中枢神经系统中的作用 |
CN112237575A (zh) * | 2020-11-09 | 2021-01-19 | 杭州端丽生物技术有限公司 | 芬戈莫德在防治鞘脂紊乱引起的神经退行性疾病中的医药用途 |
CN112924432A (zh) * | 2021-04-08 | 2021-06-08 | 济宁市第一人民医院 | 一种血液真菌感染检测试剂盒及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
US6479504B1 (en) * | 1999-06-16 | 2002-11-12 | The University Of Iowa Research Foundation | Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases |
RU2478378C2 (ru) * | 2002-09-24 | 2013-04-10 | Новартис Аг | Органические соединения |
CA2539033C (en) * | 2003-09-12 | 2013-03-05 | Neuronova Ab | Treatment of disease or injury of the nervous system with fty720 |
JP5216769B2 (ja) * | 2006-08-17 | 2013-06-19 | ザ・ユニバーシティ・オブ・シカゴ | 炎症性疾患の処置 |
-
2007
- 2007-08-17 JP JP2009524698A patent/JP5216769B2/ja not_active Expired - Fee Related
- 2007-08-17 CA CA2660880A patent/CA2660880C/en not_active Expired - Fee Related
- 2007-08-17 AU AU2007284337A patent/AU2007284337B2/en not_active Ceased
- 2007-08-17 PT PT78370418T patent/PT2056807E/pt unknown
- 2007-08-17 DK DK07837041.8T patent/DK2056807T3/da active
- 2007-08-17 BR BRPI0715950-1A2A patent/BRPI0715950A2/pt not_active IP Right Cessation
- 2007-08-17 EP EP11170326A patent/EP2392320A1/en not_active Withdrawn
- 2007-08-17 EP EP07837041A patent/EP2056807B1/en active Active
- 2007-08-17 CN CN2007800344676A patent/CN101553216B/zh not_active Expired - Fee Related
- 2007-08-17 WO PCT/US2007/018331 patent/WO2008021532A2/en active Application Filing
- 2007-08-17 MX MX2009001788A patent/MX2009001788A/es active IP Right Grant
- 2007-08-17 ES ES07837041T patent/ES2393631T3/es active Active
- 2007-08-17 SI SI200731077T patent/SI2056807T1/sl unknown
- 2007-08-17 PL PL07837041T patent/PL2056807T3/pl unknown
- 2007-08-17 RU RU2009109418/15A patent/RU2440110C2/ru not_active IP Right Cessation
- 2007-08-17 CN CN201210024062.7A patent/CN102526736B/zh not_active Expired - Fee Related
- 2007-08-17 US US12/377,736 patent/US8258150B2/en not_active Expired - Fee Related
-
2009
- 2009-10-19 HK HK09109655.8A patent/HK1131047A1/xx not_active IP Right Cessation
-
2012
- 2012-08-06 US US13/567,590 patent/US9101576B2/en not_active Expired - Fee Related
- 2012-12-14 HR HRP20121034TT patent/HRP20121034T1/hr unknown
-
2013
- 2013-03-04 JP JP2013041387A patent/JP2013144694A/ja active Pending
-
2015
- 2015-08-05 US US14/818,534 patent/US9370497B2/en not_active Expired - Fee Related
- 2015-08-17 JP JP2015160277A patent/JP2015221824A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20130017190A1 (en) | 2013-01-17 |
US9101576B2 (en) | 2015-08-11 |
WO2008021532A2 (en) | 2008-02-21 |
PL2056807T3 (pl) | 2013-02-28 |
WO2008021532A3 (en) | 2008-05-29 |
CN102526736B (zh) | 2016-01-20 |
AU2007284337B2 (en) | 2012-07-19 |
CA2660880A1 (en) | 2008-02-21 |
JP2015221824A (ja) | 2015-12-10 |
EP2056807A2 (en) | 2009-05-13 |
RU2440110C2 (ru) | 2012-01-20 |
US20150335666A1 (en) | 2015-11-26 |
US20100310547A1 (en) | 2010-12-09 |
CN102526736A (zh) | 2012-07-04 |
HK1131047A1 (en) | 2010-01-15 |
JP2013144694A (ja) | 2013-07-25 |
PT2056807E (pt) | 2012-12-21 |
DK2056807T3 (da) | 2012-10-22 |
SI2056807T1 (sl) | 2012-12-31 |
EP2392320A1 (en) | 2011-12-07 |
US9370497B2 (en) | 2016-06-21 |
CN101553216B (zh) | 2012-03-21 |
CA2660880C (en) | 2015-10-13 |
JP5216769B2 (ja) | 2013-06-19 |
BRPI0715950A2 (pt) | 2013-07-30 |
MX2009001788A (es) | 2009-09-23 |
JP2010500995A (ja) | 2010-01-14 |
US8258150B2 (en) | 2012-09-04 |
EP2056807B1 (en) | 2012-09-26 |
RU2009109418A (ru) | 2010-09-27 |
AU2007284337A1 (en) | 2008-02-21 |
CN101553216A (zh) | 2009-10-07 |
ES2393631T3 (es) | 2012-12-26 |
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