AR078417A1 - Composiciones de pelicula sublingual y bucal - Google Patents

Composiciones de pelicula sublingual y bucal

Info

Publication number
AR078417A1
AR078417A1 ARP100102898A ARP100102898A AR078417A1 AR 078417 A1 AR078417 A1 AR 078417A1 AR P100102898 A ARP100102898 A AR P100102898A AR P100102898 A ARP100102898 A AR P100102898A AR 078417 A1 AR078417 A1 AR 078417A1
Authority
AR
Argentina
Prior art keywords
buprenorphine
pharmaceutically acceptable
acceptable salt
treatment
therapeutically effective
Prior art date
Application number
ARP100102898A
Other languages
English (en)
Original Assignee
Reckitt Benckiser Healthcare
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43428649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078417(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reckitt Benckiser Healthcare filed Critical Reckitt Benckiser Healthcare
Publication of AR078417A1 publication Critical patent/AR078417A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Abstract

Productos y métodos para el tratamiento de dependencia de narcoticos en un usuario. Se revelan formas de dosificacion autoportantes que presentan un agente activo para el tratamiento de dependencia de narcoticos y a la vez producen una adhesion bucal suficiente de la forma de dosificacion. Reivindicacion 1: Una composicion de película dosificadora que comprende: a) una matriz portadora polimérica; b) una cantidad terapéuticamente efectiva de buprenorfina o una sal farmacéuticamente aceptable de la misma; c) una cantidad terapéuticamente efectiva de naloxona o una sal farmacéuticamente aceptable de la misma; y d) un buffer en una cantidad que produzca un pH local de dicha composicion de un valor suficiente para optimizar la absorcion de dicha buprenorfina.
ARP100102898A 2009-08-07 2010-08-06 Composiciones de pelicula sublingual y bucal AR078417A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/537,571 US8475832B2 (en) 2009-08-07 2009-08-07 Sublingual and buccal film compositions

Publications (1)

Publication Number Publication Date
AR078417A1 true AR078417A1 (es) 2011-11-09

Family

ID=43428649

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102898A AR078417A1 (es) 2009-08-07 2010-08-06 Composiciones de pelicula sublingual y bucal

Country Status (24)

Country Link
US (8) US8475832B2 (es)
EP (2) EP2461795B2 (es)
JP (1) JP5819827B2 (es)
KR (1) KR101699321B1 (es)
CN (1) CN102548535B (es)
AR (1) AR078417A1 (es)
AU (1) AU2010279440B2 (es)
BR (1) BR112012002817B8 (es)
CA (1) CA2770180C (es)
CL (1) CL2012000313A1 (es)
CO (1) CO6511219A2 (es)
DK (2) DK3031445T3 (es)
ES (2) ES2562634T5 (es)
HK (1) HK1171960A1 (es)
HR (1) HRP20160368T1 (es)
IL (2) IL217964A (es)
MX (1) MX2012001573A (es)
MY (1) MY156006A (es)
NZ (1) NZ598537A (es)
PE (1) PE20121136A1 (es)
RU (2) RU2012108632A (es)
SG (2) SG10201601214VA (es)
WO (1) WO2011017483A2 (es)
ZA (1) ZA201201647B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271788A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
KR101230804B1 (ko) 2006-07-21 2013-02-08 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 향상된 흡수를 갖는 경점막 전달 장치
EP1897543A1 (en) 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
US8475832B2 (en) * 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US8529914B2 (en) * 2010-06-28 2013-09-10 Richard C. Fuisz Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive
KR20140043303A (ko) 2010-11-23 2014-04-09 팬더릭스 인코포레이티드 광범위한, 미확인 또는 혼합된 임상적 적용에서 치료용 조성물들 및 방법들
JP6158810B2 (ja) 2011-08-18 2017-07-05 バイオデリバリー サイエンシズ インターナショナル，インコーポレーテッド ブプレノルフィンの乱用抵抗性粘膜付着性送達デバイス
PE20141198A1 (es) 2011-09-19 2014-10-05 Orexo Ab Nueva composicion farmaceutica resistente al abuso para el tratamiento de la dependencia de opioides
CN110123792A (zh) 2011-12-21 2019-08-16 拜欧帝力威瑞科学有限公司 用于慢性疼痛缓解的跨粘膜药物传递装置
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9687445B2 (en) 2012-04-12 2017-06-27 Lts Lohmann Therapie-Systeme Ag Oral film containing opiate enteric-release beads
WO2013171146A1 (en) 2012-05-15 2013-11-21 Lts Lohmann Therapie-Systeme Ag Oral film containing enteric release opiate resinate
US9822257B2 (en) 2012-07-23 2017-11-21 Crayola Llc Dissolvable films and methods of using the same
EP2732813A1 (en) * 2012-11-14 2014-05-21 Hexal AG Orodispersible film compositions
WO2014144366A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc. Steroid hormone delivery systems and methods of preparing the same
US20140297028A1 (en) * 2013-03-29 2014-10-02 Edward J. Bilotti Device for dispensing medication used for office-based opiate dependence treatment
US9867818B2 (en) 2013-09-10 2018-01-16 Insys Development Company, Inc. Sublingual buprenorphine spray
US9918981B2 (en) 2013-09-10 2018-03-20 Insys Development Company, Inc. Liquid buprenorphine formulations
ES2802976T3 (es) 2013-09-10 2021-01-22 Fresh Cut Dev Llc Pulverizador de buprenorfina sublingual
US9839611B2 (en) 2013-09-10 2017-12-12 Insys Development Company, Inc. Sublingual buprenorphine spray
EP2886103A1 (en) * 2013-12-23 2015-06-24 Hexal AG Pharmaceutical orodispersible film comprising buprenorphine particles with a particular size
US10722510B2 (en) 2014-07-08 2020-07-28 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
JP2017519803A (ja) 2014-07-08 2017-07-20 インシス・ファーマ・インコーポレーテッド 舌下ナロキソンスプレー
US10617686B2 (en) 2014-07-08 2020-04-14 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
WO2016022816A1 (en) * 2014-08-07 2016-02-11 Mucodel Pharma Llc Chemically stable and oromucosally absorbable gel compositions of a pharmaceutical active agent in a multi-chambered delivery system
US10493027B2 (en) 2014-08-07 2019-12-03 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi- chambered delivery system for mucosal delivery
WO2016071767A1 (en) 2014-11-07 2016-05-12 Indivior Uk Limited Buprenorphine dosing regimens
ES2761776T3 (es) 2014-12-22 2020-05-21 Suda Pharmaceuticals Ltd Prevención y tratamiento de la enfermedad metastásica en pacientes con cáncer trombocitótico
US20180311146A1 (en) * 2015-10-14 2018-11-01 Pharcon Inc Composition for intraoral delivery of biologically active peptides and proteins
US11007144B2 (en) 2016-11-15 2021-05-18 Klaria Pharma Holding Ab Pharmaceutical formulation
US11839604B2 (en) 2016-12-31 2023-12-12 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
US20180228728A1 (en) * 2017-02-13 2018-08-16 Kirti H. Valia Dosage form for administration of opioid antagonists
US9901545B1 (en) 2017-04-13 2018-02-27 Richard C. Fuisz Method and composition for making an oral soluble film, containing at least one active agent
US10238600B2 (en) 2017-04-13 2019-03-26 Richard C. Fuisz Package, system and methods for custody and control of drugs, and method and composition for making an oral soluble film, containing at least one active agent
GB201709141D0 (en) * 2017-06-08 2017-07-26 Klaria Pharma Holding Ab Pharmaceutical formulation
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
WO2019049142A1 (en) 2017-09-08 2019-03-14 Scicann Therapeutics Inc. COMPOSITIONS COMPRISING CANNABINOID AND SPILANTHOL
EP3473246A1 (en) 2017-10-19 2019-04-24 Capsugel Belgium NV Immediate release abuse deterrent formulations
MX2020003697A (es) 2017-10-20 2020-08-13 Chiesi Farm Spa Formulaciones farmaceuticas que comprenden un agonista del receptor opioide como ingredientes activos, metodos de fabricacion y usos terapeuticos de las mismas.
DE102018109981A1 (de) 2018-04-25 2019-10-31 Lts Lohmann Therapie-Systeme Ag U-förmiger oraler Dünnfilm
BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
JP7365409B2 (ja) 2018-06-28 2023-10-19 エイアールエックス エルエルシー 溶解性単位用量膜構造物を製造するための分配方法
MA55719A (fr) 2019-04-18 2022-02-23 Chiesi Farm Spa Procédé de traitement du syndrome de sevrage des opioïdes néonatal
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
WO2021163529A2 (en) 2020-02-13 2021-08-19 Biodelivery Sciences International, Inc. Methods of treatment with buprenorphine
WO2021168696A1 (en) * 2020-02-26 2021-09-02 The Procter & Gamble Company Oral care compositions for gum health
US11179331B1 (en) 2020-04-21 2021-11-23 Cure Pharmaceutcai Holding Corp Oral soluble film containing sildenafil citrate
US11173114B1 (en) 2020-07-10 2021-11-16 Nova Thin Film Pharmaceuticals Llc Method and system for manufacturing and oral soluble films and oral soluble films made by thereby
EP4119123A1 (en) * 2021-07-14 2023-01-18 G.L. Pharma GmbH Orally disintegrating film composition comprising buprenorphine
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US307537A (en) 1884-11-04 Dental capsicum-bag
US298054A (en) * 1884-05-06 Grain-harvesting machine
US688446A (en) 1901-05-20 1901-12-10 Herman F Stempel Jr Gum-plaster.
US3007848A (en) 1958-03-12 1961-11-07 Vol Pak Inc Method of forming an edible medicinal wafer strip package
NL247796A (es) 1959-01-27 1900-01-01
US3249109A (en) * 1963-11-01 1966-05-03 Maeth Harry Topical dressing
GB1142325A (en) * 1965-05-14 1969-02-05 Higham Stanley Russell Means for administering drugs
ES335314A1 (es) 1966-01-06 1967-12-01 Ceskoslovenska Akademie Ved Mejoras introducidas en la preparacion de vehiculos insolubles de sustancias al menos parcialmente solubles, biologicamente activas.
US3632740A (en) * 1968-06-13 1972-01-04 Johnson & Johnson Topical device for the therapeutic management of dermatological lesions with steroids
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3892905A (en) * 1970-08-12 1975-07-01 Du Pont Cold water soluble plastic films
US3641237A (en) * 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US3753732A (en) * 1971-04-19 1973-08-21 Merck & Co Inc Rapidly disintegrating bakery enrichment wafer
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3996934A (en) 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US4251400A (en) * 1971-11-03 1981-02-17 Borden, Inc. Hot and cold water redispersible polyvinyl acetate adhesives
US3814095A (en) * 1972-03-24 1974-06-04 H Lubens Occlusively applied anesthetic patch
US3980766A (en) 1973-08-13 1976-09-14 West Laboratories, Inc. Orally administered drug composition for therapy in the treatment of narcotic drug addiction
US3911099A (en) * 1974-01-23 1975-10-07 Defoney Brenman Mayes & Baron Long-acting articles for oral delivery and process
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
DE2432925C3 (de) 1974-07-05 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen Folienförmige Arzneimittel
DE2449865B2 (de) 1974-10-17 1981-06-19 Schering Ag Berlin Und Bergkamen, 1000 Berlin Folienförmiges Arzneimittel
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
GB1491272A (en) * 1975-09-10 1977-11-09 Lingner & Fischer Gmbh Polymer adhesive compositions containing gelling agents
DE2530563C2 (de) 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgetische Arzneimittel mit vermindertem Mißbrauchspotential
US4029758A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Preparation of pharmaceutical unit dosage forms
AU514195B2 (en) 1975-12-15 1981-01-29 F. Hoffmann-La Roche & Co. Dosage form
US4029757A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4031200A (en) * 1975-12-15 1977-06-21 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4123592A (en) 1976-04-07 1978-10-31 Philip Morris Incorporated Process for incorporating flavorant into cellulosic substrates and products produced thereby
JPS5453240A (en) 1977-10-03 1979-04-26 Toshiba Corp Reverse voltage generating circuit
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
US4675009A (en) * 1977-11-07 1987-06-23 Lec Tec Corporation Drug dispensing device for transdermal delivery of medicaments
SE7713618L (sv) * 1977-12-01 1979-06-02 Astra Laekemedel Ab Lokalanestetisk blandning
SE424955B (sv) * 1978-06-16 1982-08-23 Hesselgren Sven Gunnar Retentionspreparat for tandproteser
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
GB2042888B (en) 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4713239A (en) 1979-05-29 1987-12-15 Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr Antianginal film and method of treating ischemic heart disease
SE431092B (sv) 1979-07-10 1984-01-16 Thuresson Af Ekenstam Bo Terapeutiskt aktiva, substituerade piperidinkarboxianilider
US4291015A (en) 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4307075A (en) 1979-09-13 1981-12-22 American Home Products Corporation Topical treatment of aphthous stomatitis
JPS5933361Y2 (ja) * 1980-03-14 1984-09-18 日東電工株式会社 電極パッド
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
US4503070A (en) * 1981-07-31 1985-03-05 Eby Iii George A Method for reducing the duration of the common cold
US4432975A (en) * 1981-04-13 1984-02-21 Icn Pharmaceuticals, Inc. Process for introducing vitamin B-12 into the bloodstream
GB2108517B (en) * 1981-06-12 1985-06-12 Nat Res Dev Hydrogels
AU8533582A (en) 1981-07-10 1984-01-12 Reckitt & Colman Products Limited Stable solutions of buprenorphine
US4373036A (en) * 1981-12-21 1983-02-08 Block Drug Company, Inc. Denture fixative composition
US4460562A (en) * 1982-01-06 1984-07-17 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing propranolol
US4529748A (en) * 1982-08-16 1985-07-16 Richardson Gmbh Dental prosthesis adhesive
US4608249A (en) * 1982-11-02 1986-08-26 Nitto Electric Industrial Co., Ltd. Hydrophilic therapeutic material
US4562020A (en) 1982-12-11 1985-12-31 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing self-supporting glucan film
US4466973A (en) * 1983-02-01 1984-08-21 Thomas Rennie Method of treating nasal and sinus congestion
US4704119A (en) 1983-02-03 1987-11-03 Alza Corporation Method comprising transdermal and buccal treatment of angina
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
US5024701A (en) * 1983-08-01 1991-06-18 Hercules Incorporated Denture adhesive composition
JPH0830004B2 (ja) 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド 生物接着性組成物およびそれにより治療する方法
GB8332556D0 (en) 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US4659714A (en) * 1984-03-27 1987-04-21 Dentsply, Ltd. Anesthetic methods for mammals
CA1248450A (en) * 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
DE3580384D1 (de) * 1984-04-09 1990-12-13 Toyo Boseki Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle.
JPS60219238A (ja) 1984-04-14 1985-11-01 Hayashibara Biochem Lab Inc 徐崩性プルラン含有成形物とその製法
DE3581188D1 (de) * 1984-07-24 1991-02-07 Key Pharma Klebende schicht zur transdermalen freigabe.
JPS6160620A (ja) 1984-09-03 1986-03-28 Teijin Ltd ピログルタミン酸エステル類を含有する医薬品組成物
JPS6164570A (ja) * 1984-09-04 1986-04-02 Akebono Brake Ind Co Ltd アンチスキツド制御方法
JPS6185315A (ja) 1984-10-04 1986-04-30 Teikoku Seiyaku Kk シ−ト状製剤
GB8430346D0 (en) 1984-11-30 1985-01-09 Reckitt & Colmann Prod Ltd Analgesic compositions
US4593053A (en) * 1984-12-07 1986-06-03 Medtronic, Inc. Hydrophilic pressure sensitive biomedical adhesive composition
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4900556A (en) * 1985-04-26 1990-02-13 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
EP0200508B1 (en) 1985-04-27 1991-10-02 Nitto Denko Corporation Adhesive oral bandages and oral pharmaceutical preparations
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US4631837A (en) 1985-05-31 1986-12-30 Magoon Richard E Method and apparatus for drying fruit pulp and the like
JPS61280423A (ja) * 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
GB8514665D0 (en) * 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
AU6541786A (en) * 1985-10-09 1987-05-05 Desitin Arzneimittel Gmbh Process for producing an administration or dosage form of drugs, reagents or other active ingredients
JPS62126950A (ja) 1985-11-29 1987-06-09 Unie Koroido Kk グルコマンナンを含む可食性フイルム
US5229164A (en) * 1985-12-19 1993-07-20 Capsoid Pharma Gmbh Process for producing individually dosed administration forms
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
JPH0729915B2 (ja) 1986-02-01 1995-04-05 帝國製薬株式会社 シ−ト状口腔内貼付剤
JPH0759496B2 (ja) * 1986-03-25 1995-06-28 ロ−ト製薬株式会社 歯周病治療剤
JPS62223112A (ja) 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US4722761A (en) * 1986-03-28 1988-02-02 Baxter Travenol Laboratories, Inc. Method of making a medical electrode
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US4713243A (en) 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
USRE33093E (en) 1986-06-16 1989-10-17 Johnson & Johnson Consumer Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
DE3630603A1 (de) * 1986-09-09 1988-03-10 Desitin Arzneimittel Gmbh Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung
JPH0739508B2 (ja) * 1986-11-11 1995-05-01 株式会社林原生物化学研究所 プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途
JPH0744940B2 (ja) * 1986-12-24 1995-05-17 ライオン株式会社 口腔貼付用基材
US4851394A (en) 1986-12-30 1989-07-25 Uni Colloid Kabushiki Kaisha Glucomannan/polyhydric alcohol composition and film prepared therefrom
US4860754A (en) * 1987-04-01 1989-08-29 E. R. Squibb & Sons, Inc. Electrically conductive adhesive materials
US5028632A (en) * 1987-04-20 1991-07-02 Fuisz Pharmaceutical Ltd. Taste masked medicated pharmaceutical
DE3714074A1 (de) * 1987-04-28 1988-11-10 Hoechst Ag Grundlage fuer schleimhaut- und prothesenhaft-pasten, verfahren zu ihrer herstellung sowie pasten auf basis dieser grundlage
DE3726797A1 (de) * 1987-08-12 1989-02-23 Bayer Ag Arzneimittel fuer den bereich der mundhoehle
EP0303445A1 (en) 1987-08-13 1989-02-15 Walton S.A. Clebopride transdermal patch
GB8728294D0 (en) 1987-12-03 1988-01-06 Reckitt & Colmann Prod Ltd Treatment compositions
US4927634A (en) * 1987-12-16 1990-05-22 Richardson-Vicks Inc. Pharmaceutical compositions containing dyclonine HC1 and phenol
US4888354A (en) 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
SE8800080L (sv) 1988-01-13 1989-07-14 Kabivitrum Ab Laekemedelskomposition
JPH0710702Y2 (ja) * 1988-01-29 1995-03-15 ジューキ株式会社 ミシンの布送り装置
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US5047244A (en) * 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
US4876970A (en) 1988-07-29 1989-10-31 Wendy Bolduc Coin operated infant changing table
US4937078A (en) * 1988-08-26 1990-06-26 Mezei Associates Limited Liposomal local anesthetic and analgesic products
US5139790A (en) 1988-10-14 1992-08-18 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US4948580A (en) * 1988-12-08 1990-08-14 E. R. Squibb & Sons, Inc. Muco-bioadhesive composition
US5700479A (en) 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
JP2656338B2 (ja) 1989-01-31 1997-09-24 日東電工株式会社 口腔粘膜貼付製剤
JPH0645536B2 (ja) 1989-01-31 1994-06-15 日東電工株式会社 口腔粘膜貼付剤および口腔粘膜貼付製剤
US4910247A (en) * 1989-03-27 1990-03-20 Gaf Chemicals Corporation Adhesive composition
JPH02258718A (ja) * 1989-03-31 1990-10-19 Nippon Kayaku Co Ltd ペースト状基剤及び製剤
JP2708869B2 (ja) 1989-04-04 1998-02-04 不二製油株式会社 透明な可食性フィルムの製造方法
US5064717A (en) 1989-04-28 1991-11-12 Kanzaki Paper Manufacturing Co., Ltd. Adhesive sheet
US5089307A (en) * 1989-05-23 1992-02-18 Mitsubishi Rayon Co., Ltd. Edible film and method of making same
ATE94376T1 (de) 1989-07-13 1993-10-15 Oskar Altwirth Hafteinlage fuer zahnprothesen und verfahren zu deren herstellung.
US4992277A (en) 1989-08-25 1991-02-12 Schering Corporation Immediate release diltiazem formulation
US5271940A (en) 1989-09-14 1993-12-21 Cygnus Therapeutic Systems Transdermal delivery device having delayed onset
ES2062562T3 (es) 1989-10-14 1994-12-16 Desitin Arzneimittel Gmbh Medios para el cuidado de la boca y de los dientes.
US5009895A (en) 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
JPH03232817A (ja) 1990-02-07 1991-10-16 Showa Yakuhin Kako Kk 貼付剤
DE4018247A1 (de) * 1990-06-07 1991-12-12 Lohmann Therapie Syst Lts Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen
US5455043A (en) 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5045445A (en) * 1990-06-29 1991-09-03 E. I. Du Pont De Nemours And Company Continuous in-line preparation of photographic gelatin solutions
FR2673843B1 (fr) 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
US5273758A (en) 1991-03-18 1993-12-28 Sandoz Ltd. Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms
IT1249315B (it) 1991-05-23 1995-02-22 Euroresearch Srl Lamina di collageno non poroso per uso terapeutico, metodo ed apparecchiature per ottenerlo
IT1250421B (it) 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5272191A (en) 1991-08-21 1993-12-21 Fmc Corporation Cold water soluble films and film forming compositions
US5192802A (en) 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
JPH05147140A (ja) 1991-11-29 1993-06-15 Mitsubishi Rayon Co Ltd 包装用フイルム
US5354863A (en) 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
JP3232488B2 (ja) * 1992-08-20 2001-11-26 株式会社林原生物化学研究所 プルラン高含有物とその製造方法並びに用途
US5286502A (en) * 1992-04-21 1994-02-15 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5411945A (en) 1992-08-29 1995-05-02 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pullulan binder and its uses
AU679937B2 (en) 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US5346701A (en) * 1993-02-22 1994-09-13 Theratech, Inc. Transmucosal delivery of macromolecular drugs
US5700478A (en) 1993-08-19 1997-12-23 Cygnus, Inc. Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
WO1995018046A1 (en) 1993-12-28 1995-07-06 Frank Richard D Pakaging and dispensing device for sterile articles
JPH07322812A (ja) 1994-05-30 1995-12-12 Osaka Kagaku Gokin Kk 可食性ケーシングフィルムおよびこれを用いた加工食品の製造法
US5766839A (en) * 1994-06-17 1998-06-16 Ysi Incorporated Processes for preparing barrier layer films for use in enzyme electrodes and films made thereby
US5529787A (en) 1994-07-07 1996-06-25 Alza Corporation Hydromorphone therapy
DE69628415T3 (de) 1995-03-02 2008-06-26 R.P. Scherer Technologies, Inc., Paradise Valley Arzneimittel enthaltend monoaminooxidase-b-hemmer
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5891461A (en) 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5766620A (en) * 1995-10-23 1998-06-16 Theratech, Inc. Buccal delivery of glucagon-like insulinotropic peptides
US5766332A (en) * 1996-11-17 1998-06-16 Maybelline, Inc. Fast drying nail enamel composition and method
FR2742989B1 (fr) * 1995-12-29 1998-01-23 Adir Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs
US5773031A (en) 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
US5766623A (en) 1996-03-25 1998-06-16 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Compactable self-sealing drug delivery agents
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US20010006677A1 (en) * 1996-10-29 2001-07-05 Mcginity James W. Effervescence polymeric film drug delivery system
DE19646392A1 (de) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
DE19652188C2 (de) 1996-12-16 2002-02-14 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur Applikation und Freisetzung von Buprenorphin oder einer pharmakologisch vergleichbaren Substanz in der Mundhöhle und Verfahren zu ihrer Herstellung
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US5806284A (en) 1997-03-03 1998-09-15 Apothecus Pharmaceutical Corp. Method and system for producing sealed packages of a film which is dissolved in a body fluid
US6124282A (en) 1997-05-22 2000-09-26 Sellers; Edward M. Drug formulations
US6153210A (en) 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
BR9806303A (pt) 1997-10-07 2000-03-14 Fuisz Technologies Ltd Sistema de distrituição de droga termoformado, e, unidade de dosagem
US20050048102A1 (en) * 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
TR200001828T2 (tr) * 1997-12-22 2000-11-21 Euro-Celtique, S.A. Opioid dozaj şekillerinin kötüye kullanımını önlemeye yönelik bir yöntem.
US6072100A (en) 1998-01-28 2000-06-06 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
BR9908438A (pt) 1998-03-06 2000-10-31 Eurand Int Tabletes de desintegração rápida
US6103266A (en) 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
JP2002512950A (ja) 1998-04-29 2002-05-08 バイロテックス コーポレイション 粘膜表面への、薬剤化合物の送達に適する薬剤キャリアデバイス
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6800329B2 (en) 1999-02-12 2004-10-05 Lts Lohmann Therapie-Systeme Ag Method for producing film-type dosage
GB9904629D0 (en) 1999-03-02 1999-04-21 Danbiosyst Uk Oral drug delivery system
ATE313319T1 (de) 1999-03-31 2006-01-15 Janssen Pharmaceutica Nv Vorgelatinierte stärke in einer formulierung mit gesteuerter freigabe
US6231957B1 (en) * 1999-05-06 2001-05-15 Horst G. Zerbe Rapidly disintegrating flavor wafer for flavor enrichment
US6375963B1 (en) 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
US20020076440A1 (en) 1999-06-25 2002-06-20 Thomas Leon Veterinary delivery systems and methods of delivering effective agents to animals
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
AR031682A1 (es) 1999-11-19 2003-10-01 Reckitt Benckiser Helthcare Uk Composiciones farmaceuticas
US20030124176A1 (en) 1999-12-16 2003-07-03 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
CO5251456A1 (es) 1999-12-23 2003-02-28 Johnson & Johnson Consumer Metodo para preparar una pelicula soluble en agua
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
JP4461310B2 (ja) 2000-03-31 2010-05-12 小林製薬株式会社 ゼラチン固形物
US6375981B1 (en) 2000-06-01 2002-04-23 A. E. Staley Manufacturing Co. Modified starch as a replacement for gelatin in soft gel films and capsules
US6503532B1 (en) * 2001-04-13 2003-01-07 Murty Pharmaceuticals, Inc. Pharmaceutical composition containing tetrahydrocannabinol and a transdermal/transcutaneous delivery method thereof
US20020187192A1 (en) 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US20030118653A1 (en) 2001-07-06 2003-06-26 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
PT1416842E (pt) 2001-07-18 2009-03-31 Euro Celtique Sa Composições farmacêuticas de oxicodona e naloxona
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
WO2003030883A1 (en) 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7425292B2 (en) * 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
JP5701468B2 (ja) 2001-10-12 2015-04-15 モノソル・アールエックス・エルエルシー 自己凝集しない均一な異種性を有する薄膜、その生成方法、およびそれから製造した薬物送達系
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
DE10207394B4 (de) 2002-02-21 2007-03-29 Lts Lohmann Therapie-Systeme Ag Geschmacksmaskierte oblatenförmige Arzneizubereitung
US7666876B2 (en) 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US6824829B2 (en) 2002-08-23 2004-11-30 Acupac Packaging, Inc. Process for manufacturing thin film strips
US8999372B2 (en) 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
US20040191302A1 (en) 2003-03-28 2004-09-30 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US20040096569A1 (en) * 2002-11-15 2004-05-20 Barkalow David G. Edible film products and methods of making same
US20050042281A1 (en) 2003-08-21 2005-02-24 Singh Nikhilesh N. Compositions for delivering therapeutic agents across the oral mucosa
CA2543350C (en) 2003-10-24 2011-04-26 Adhesives Research, Inc. Disintegratable films for diagnostic devices
GB0403808D0 (en) 2004-02-20 2004-03-24 Bioprogress Technology Ltd Films for use as dosage forms
DE102004019916A1 (de) * 2004-04-21 2005-11-17 Grünenthal GmbH Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster
EP1695700A1 (en) 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
WO2006119286A1 (en) 2005-05-03 2006-11-09 Innozen, Inc. Edible film for transmucosal delivery of nutritional supplements
US20060281775A1 (en) 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
CA2629046C (en) * 2005-12-13 2014-04-08 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
US7520399B2 (en) 2006-06-28 2009-04-21 Amcor Limited Interlocking rectangular container
KR101230804B1 (ko) 2006-07-21 2013-02-08 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 향상된 흡수를 갖는 경점막 전달 장치
EP1897543A1 (en) * 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
DK2248519T3 (en) * 2006-10-02 2018-01-02 Applied Pharma Res Non-mucoadhesive film dosage forms
WO2008042508A1 (en) 2006-10-03 2008-04-10 University Of Southern California Grp78 as a predictor of responsiveness to therapeutic agents
CN1943575A (zh) * 2006-10-24 2007-04-11 岳振江 滥用潜力低的复方盐酸丁丙诺啡盐酸纳洛酮舌下片
WO2008068471A1 (en) 2006-12-04 2008-06-12 Orexo Ab New non-abusable pharmaceutical composition comprising opioids
AU2008216867B2 (en) * 2007-02-09 2014-01-30 Durect Corporation Transoral dosage forms comprising sufentanil and naloxone
GB2447016A (en) 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Buprenorphine/naloxone compositions
GB2447015A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition comprising a specific ratio of buprenorphine and naltrexone
CA2728912C (en) 2008-06-23 2018-04-10 Biodelivery Sciences International, Inc. Multidirectional mucosal delivery devices and methods of use
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions

Also Published As

Publication number Publication date
ES2562634T3 (es) 2016-03-07
HRP20160368T1 (hr) 2016-06-03
EP3031445B1 (en) 2019-11-06
ES2562634T5 (es) 2019-12-17
BR112012002817B8 (pt) 2021-05-25
EP2461795B2 (en) 2019-06-19
WO2011017483A8 (en) 2012-03-08
ZA201201647B (en) 2013-05-29
US20170209431A1 (en) 2017-07-27
KR20120059538A (ko) 2012-06-08
DK3031445T3 (da) 2019-11-25
US20130281481A1 (en) 2013-10-24
WO2011017483A2 (en) 2011-02-10
AU2010279440A1 (en) 2012-03-29
JP2013501717A (ja) 2013-01-17
EP3031445A1 (en) 2016-06-15
BR112012002817B1 (pt) 2020-12-01
WO2011017483A3 (en) 2011-06-03
JP5819827B2 (ja) 2015-11-24
DK2461795T4 (da) 2019-07-29
BR112012002817A8 (pt) 2017-10-24
US20140005218A1 (en) 2014-01-02
ES2757814T3 (es) 2020-04-30
CA2770180A1 (en) 2011-02-10
EP2461795A2 (en) 2012-06-13
CA2770180C (en) 2017-07-18
IL244974A0 (en) 2016-05-31
KR101699321B1 (ko) 2017-01-24
SG10201601214VA (en) 2016-03-30
MY156006A (en) 2015-12-31
HK1171960A1 (en) 2013-04-12
IL244974B (en) 2018-10-31
CO6511219A2 (es) 2012-08-31
SG178265A1 (en) 2012-03-29
US20110033541A1 (en) 2011-02-10
US20140378497A1 (en) 2014-12-25
DK2461795T3 (en) 2016-04-18
CL2012000313A1 (es) 2012-10-19
US20200030313A1 (en) 2020-01-30
US20150246005A1 (en) 2015-09-03
IL217964A (en) 2016-05-31
US11135216B2 (en) 2021-10-05
EP2461795B1 (en) 2016-01-27
US8475832B2 (en) 2013-07-02
CN102548535A (zh) 2012-07-04
AU2010279440B2 (en) 2015-04-09
IL217964A0 (en) 2012-03-29
PE20121136A1 (es) 2012-08-30
US9687454B2 (en) 2017-06-27
MX2012001573A (es) 2012-06-19
RU2012108632A (ru) 2013-09-20
NZ598537A (en) 2014-10-31
BR112012002817A2 (pt) 2017-07-11
CN102548535B (zh) 2014-12-10
US20160113885A1 (en) 2016-04-28
RU2018121855A (ru) 2019-03-06

Similar Documents

Publication Publication Date Title
AR078417A1 (es) Composiciones de pelicula sublingual y bucal
CL2013001136A1 (es) Un agente inhibitorio de la fosfodiesterasa 7 (pde7) para ser usado en el tratamiento o la reduccion de la posibilidad de una adiccion; y composicion farmaceutica, forma de dosificacion unitaria y kit farmaceutico que incluyen al inhibidor de fosfodiesterasa 7 (pde7) y un agente terapeutico adicional.
JP2013121983A5 (es)
CL2014002283A1 (es) Forma de dosificacion oral solida de liberacion inmediata que comprende particulas que comprenden un nucleo con un primer agente activo, un recubrimiento con un segundo agente activo sobre el y un material sensible al ph acido sobre dicho nucleo recubierto; proceso para prepararla; metodo de tratamiento; y uso para tratar dolor.
PE20140854A1 (es) Formas de dosificacion farmaceutica
RS52831B (en) THIN BUPRENORPHINE TILES FOR DRUG REPLACEMENT THERAPY
BRPI0906181A2 (pt) "método para tratamento de uma disfunção hiperproliferativa, composição farmacêutica, uso de uma combinação terapêutica na fabricação de um medicamento para o tratamento de câncer, artigo de fabricação para tratamento de uma disfunção hiperproliferativa, método para determinação de compostos a serem usados em combinação para o tratamento de câncer e método para determinação de uma combinação terapêutica a ser usada para o tratamento de câncer"
CL2011002858A1 (es) Uso de una composicion farmaceutica transmucosa oral que comprende dexmedetomidina y una sal farmaceuticamente aceptable y un excipiente farmaceuticamente aceptable para preparar un medicamento util para tratar o prevenir el dolor.
RS53391B (en) COPD COMBINED THERAPY (CHRONIC OBSTRUCTIVE LUNG DISEASES)
PE20230735A1 (es) Metodos de tratamiento de trastornos del desarrollo con gaboxadol
JP2012193216A5 (es)
MX2009012484A (es) Formulacion de nicotina oral recubierta regulada con aminoacido.
PE20142314A1 (es) Composiciones intranasales de dexmedetomidina y metodos de uso de ellas
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
AR090349A1 (es) Terapia de combinacion para trastornos proliferativos, kit y uso
DE602007010254D1 (de) Feste dosierungsform mit einem wirkstoff mit unterdrücktem geschmack
ES2572157T3 (es) Composiciones en forma de partículas para la administración de fármacos poco solubles
CL2013000677A1 (es) Composicion farmaceutica en forma de tabletas que comprenden microgranulos gastrointestinales que contienen 100 a 800 mg de rifaximina, hasta 30% p/p de excipientes extragranulares y un recubrimiento formador de pelicula; y uso para tratar una enfermedad infecciosa y/o inflamatoria del intestino, tal como la enfermedad de crohn.
PE20140255A1 (es) Tableta dispersable en forma oral
AR065581A1 (es) Mejoras en composiciones medicinales o relativas a las mismas
CL2012003012A1 (es) Composicion farmaceutica oral de liberacion prolongada que comprenden a) al menos un material de liberacion prolongada y b) hidromorfona o una sal y naloxona o una sal en una relacion 2:1 a 1:3; metodo de preparacion.
UA111599C2 (uk) Композиція каспофунгіну
CL2009001841A1 (es) Uso de una composición de liberación sostenida de 4-aminopiridina para preparar un medicamento útil para tratar esclerosis multiple en un sujeto.
TNSN08506A1 (en) Substituted carboxamides
PE20110943A1 (es) Formulacion oral solida de alisquireno

Legal Events

Date Code Title Description
FC Refusal