AR070584A1 - Derivados de benzoxazol carboxamida como inhibidores de poli (adp- ribosa) polimerasa (parp) - Google Patents
Derivados de benzoxazol carboxamida como inhibidores de poli (adp- ribosa) polimerasa (parp)Info
- Publication number
- AR070584A1 AR070584A1 ARP090100416A ARP090100416A AR070584A1 AR 070584 A1 AR070584 A1 AR 070584A1 AR P090100416 A ARP090100416 A AR P090100416A AR P090100416 A ARP090100416 A AR P090100416A AR 070584 A1 AR070584 A1 AR 070584A1
- Authority
- AR
- Argentina
- Prior art keywords
- nrarb
- group
- alkyl
- heterocycloalkylthio
- heterocycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
También descritas en la presente, están composiciones farmacéuticas que incluyen al menos, un compuesto descrito en la presente y el uso de un compuesto o composicion farmacéutica descrita en la presente, para tratar enfermedades, trastornos, y condiciones que son aliviadas por la inhibicion de actividad PARP. Reivindicacion 1: Un compuesto de la formula (1) o formula (2) caracterizado porque: Y se selecciona del grupo que consiste de a) un grupo arilo opcionalmente sustituido con 1, 2, o 3 R5; en donde cada R5 se selecciona independientemente del grupo que consiste de alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquinilo, arilo, arilalquilo, cicloalquilo, cicloalquilalquilo, ciano, haloalcoxi, haloalquilo, halogeno, hidroxilo, hidroxialquilo, nitro, oxo, heteroarilo, heteroarilalcoxi, heteroariloxi, heteroariltio, heteroarilalquiltio, heterociclo, heterocicloalcoxi, heterocicloalquiltio, heterociclooxi, heterociclotio, NRARB, (NRARB)alquilo, (NRARB)carbonilo, (NRARB)carbonilalquilo, y (NRARB)sulfonilo, en donde cuando arilo es fenilo, el fenilo es sustituido con al menos un sustituyente seleccionado independientemente del grupo que consiste de alcoxialquilo, heteroarilo, heteroarilalcoxi, heteroariloxi, heteroariltio, heteroarilalquiltio, heterociclo, heterocicloalcoxi, heterocicloalquiltio, heterociclooxi, heterociclotio, (NRARB)alquilo; b) un grupo heteroarilo opcionalmente sustituido con 1, 2, o 3 R5; en donde cada R5 es como se define previamente; c) un grupo L-T en donde L se selecciona del grupo que consiste de alquenileno, alquileno, alquinileno, cicloalquileno y espiroheterociclo y T se selecciona del grupo que consiste de heteroarilo, heteroarilalcoxi, heteroariloxi, heteroariltio, heteroarilalquiltio, heterociclo, heterocicloalcoxi, heterocicloalquiltio, heterociclooxi, heterociclotio, NRARB; d) un anillo heterociclo monocíclico o bicíclico de 4, 5, 6, 7, 8, 9, 10, 11 o 12 elementos no aromático, que tiene 1 o 2 átomos de nitrogeno y, opcionalmente, un átomo de azufre u oxígeno, en donde el heterociclo es opcionalmente sustituido con 1, 2, o 3 R6; en donde cada R6 se selecciona independientemente del grupo que consiste de alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquinilo, arilo, arilalquilo, cicloalquilo, cicloalquilalquilo, ciano, haloalcoxi, haloalquilo, halogeno, hidroxilo, hidroxialquilo, nitro, oxo, heteroarilo, heteroarilalcoxi, heteroariloxi, heteroariltio, heteroarilalquiltio, heterociclo, heterocicloalcoxi, heterocicloalquiltio, heterociclooxi, heterociclotio, NRARB, (NRARB)alquilo, (NRARB)carbonilo, (NRARB)carbonilalquilo, y (NRARB)sulfonilo y en donde cuando el heterociclo es bicíclico, el(los) sustituyente(s) opcional(es) están unidos a cualquiera o ambos de los anillos cíclicos; R1, R2, y R3 son cada uno seleccionados independientemente a partir del grupo que consiste de hidrogeno, halogeno, alquenilo, alcoxi, alcoxicarbonilo, alquilo, cicloalquilo, alquinilo, ciano, haloalcoxi, haloalquilo, hidroxilo, hidroxialquilo, nitro, NRCRD, y (NRCRD)carbonilo; cada RA, RB, RC, y RD son seleccionados independientemente del grupo que consiste de hidrogeno, alquilo, cicloalquilo, y alquilcarbonilo; R4, se selecciona del grupo que consiste de hidrogeno, alquilo, cicloalquilo, alcoxialquilo, haloalquilo, hidroxialquilo, y (NRARB)alquilo; o isomeros, sales, solvatos, formas químicamente protegidas y profármacos de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2669008P | 2008-02-06 | 2008-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070584A1 true AR070584A1 (es) | 2010-04-21 |
Family
ID=40932306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100416A AR070584A1 (es) | 2008-02-06 | 2009-02-06 | Derivados de benzoxazol carboxamida como inhibidores de poli (adp- ribosa) polimerasa (parp) |
Country Status (7)
Country | Link |
---|---|
US (1) | US8088760B2 (es) |
EP (1) | EP2247600A4 (es) |
JP (1) | JP2011511078A (es) |
CN (1) | CN101998959B (es) |
AR (1) | AR070584A1 (es) |
TW (1) | TWI434847B (es) |
WO (1) | WO2009099736A2 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2805945T1 (sl) * | 2007-01-10 | 2019-09-30 | Msd Italia S.R.L. | Amid substituirani indazoli, kot inhibitorji poli(ADP-riboza)polimeraze(PARP) |
BRPI0917119B1 (pt) | 2008-08-06 | 2021-07-13 | Medivation Technologies, Inc. | Composto, composição farmacêutica, uso dos mesmos e seu processo de fabricação |
WO2010083220A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Benzoxazole inhibitors of poly(adp-ribose)polymerase |
US8519176B1 (en) * | 2009-10-05 | 2013-08-27 | Boehringer Ingelheim International Gmbh | Process for preparation of substituted P-aminophenol |
CA2787844C (en) | 2010-02-03 | 2019-08-27 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency |
CA2788114C (en) | 2010-02-08 | 2018-11-06 | Biomarin Pharmaceutical Inc. | Processes of synthesizing dihydropyridophthalazinone derivatives |
KR20210028747A (ko) | 2010-10-21 | 2021-03-12 | 메디베이션 테크놀로지즈 엘엘씨 | 결정질의 (8s,9r)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1h-1,2,4-트리아졸-5-일)-8,9-디하이드로-2h-피리도[4,3,2-de]프탈라진-3(7h)-온 토실레이트 염 |
EP2794565B1 (en) * | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
CN110711188A (zh) | 2012-01-20 | 2020-01-21 | 德玛公司 | 经取代的己糖醇类用于治疗恶性肿瘤的用途 |
CN103242273B (zh) * | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
BR112015004858A2 (pt) * | 2012-09-05 | 2017-07-04 | Bayer Cropscience Ag | uso de 2-amidobenzimidazóis, 2-amidobenzoxazóis e 2-amidobenzotiazóis substituídos ou sais dos mesmos como substâncias ativas contra estresse abiótico em plantas |
CN103923088B (zh) * | 2013-01-11 | 2016-09-07 | 上海汇伦生命科技有限公司 | 2,5-二氮杂双环[2.2.1]庚烷类化合物和制备方法、其药用组合物及其在医药上的应用 |
CN103059019B (zh) * | 2013-01-28 | 2015-11-04 | 合肥医工医药有限公司 | 咪唑[4,5-c]吡啶-7-甲酰胺衍生物、其制法及医药用途 |
ME03564B (me) | 2013-03-13 | 2020-07-20 | Forma Therapeutics Inc | DERIVATI 2-HIDROKSI-1-{4-[(4-FENILFENIL)KARBONIL]PIPERAZIN-1-IL}ETAN-1-ONA l SRODNA JEDINJENJA KAO INHIBITORI SINTAZE MASNIH KISELINA (FASN) ZA LEČENJE KANCERA |
CN105008329B (zh) | 2013-03-21 | 2018-01-05 | 默克专利股份公司 | 作为fasn抑制剂的哌嗪衍生物 |
KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
TWI652014B (zh) | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
WO2015042397A1 (en) * | 2013-09-20 | 2015-03-26 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
WO2015154064A2 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
CN105130973B (zh) * | 2014-05-26 | 2018-05-01 | 海南国瑞堂中药制药有限公司 | 5-吡啶基-2-氨基-苯并[d]噁唑衍生物及其制备方法和用途 |
US20180368404A1 (en) * | 2014-11-06 | 2018-12-27 | Basf Se | 3-pyridyl heterobicyclic compound for controlling invertebrate pests |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
JP6871169B2 (ja) | 2015-03-02 | 2021-05-12 | シナイ ヘルス システム | 相同組換え因子 |
CN104788398B (zh) * | 2015-03-24 | 2017-09-08 | 上海交通大学 | 苯并恶唑类化合物及其制备方法和用途 |
CN104788442A (zh) * | 2015-04-02 | 2015-07-22 | 湖南华腾制药有限公司 | 一种取代苯并恶唑衍生物的制备方法 |
CN105646452B (zh) * | 2015-12-24 | 2018-05-01 | 北京康立生医药技术开发有限公司 | 一种蛋白激酶抑制剂的合成方法 |
MX2018012016A (es) | 2016-04-01 | 2019-01-24 | Basf Se | Compuestos biciclicos. |
CN106008565B (zh) * | 2016-06-14 | 2018-05-15 | 华南师范大学 | 一种对有机小分子具有荧光识别功能的多孔金属有机框架的制备方法 |
CN106187865A (zh) * | 2016-07-08 | 2016-12-07 | 武汉工程大学 | (r)‑1‑叔丁氧羰基‑3‑苄基‑3‑甲酸哌啶的合成及手性拆分方法 |
CN108752353B (zh) * | 2018-04-28 | 2020-05-08 | 程春晓 | 抗卵巢癌药物Rucaparib关键中间体1408282‐26‐7的制备方法 |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
CN109824677B (zh) * | 2019-04-03 | 2021-09-03 | 江苏开元药业有限公司 | 治疗卵巢癌药物瑞卡帕布的制备方法 |
WO2021155841A1 (en) | 2020-02-07 | 2021-08-12 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4690926A (en) * | 1986-02-03 | 1987-09-01 | Bristol-Myers Company | Boxazomycin A and B, new antibiotics containing benzoxazole nucleus |
GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
JPH0827133A (ja) * | 1994-07-08 | 1996-01-30 | Sumitomo Chem Co Ltd | 双環式化合物、その用途およびその製造中間体 |
JP2002528531A (ja) * | 1998-11-03 | 2002-09-03 | ビーエーエスエフ アクチェンゲゼルシャフト | 置換2−フェニルベンズイミダゾール、その製造法および使用 |
USRE39608E1 (en) * | 1998-11-27 | 2007-05-01 | Abbott Gmbh & Co. Kg | Substituted benzimidazoles and their use as PARP inhibitors |
GB9914825D0 (en) | 1999-06-24 | 1999-08-25 | Smithkline Beecham Spa | Novel compounds |
GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
JP2004524289A (ja) * | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
EP1482931B1 (en) | 2002-03-05 | 2011-10-19 | TransTech Pharma, Inc. | Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage |
WO2004098494A2 (en) | 2003-04-30 | 2004-11-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
NZ560969A (en) * | 2005-02-17 | 2010-08-27 | Albany Molecular Res Inc | Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome |
TWI375673B (en) * | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
WO2006124780A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
ATE536349T1 (de) | 2005-09-29 | 2011-12-15 | Abbott Lab | In der 2-stellung durch phenyl substituierte 1h- benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren |
CA2647545C (en) * | 2006-04-03 | 2016-02-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors |
ATE523508T1 (de) * | 2007-10-25 | 2011-09-15 | Astrazeneca Ab | Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate |
-
2009
- 2009-01-15 EP EP09708325A patent/EP2247600A4/en not_active Withdrawn
- 2009-01-15 CN CN2009801122427A patent/CN101998959B/zh not_active Expired - Fee Related
- 2009-01-15 JP JP2010545920A patent/JP2011511078A/ja active Pending
- 2009-01-15 WO PCT/US2009/031163 patent/WO2009099736A2/en active Application Filing
- 2009-01-16 US US12/355,692 patent/US8088760B2/en not_active Expired - Fee Related
- 2009-02-06 TW TW098103898A patent/TWI434847B/zh not_active IP Right Cessation
- 2009-02-06 AR ARP090100416A patent/AR070584A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2247600A2 (en) | 2010-11-10 |
JP2011511078A (ja) | 2011-04-07 |
US20090197863A1 (en) | 2009-08-06 |
WO2009099736A2 (en) | 2009-08-13 |
TWI434847B (zh) | 2014-04-21 |
TW200946518A (en) | 2009-11-16 |
CN101998959B (zh) | 2013-08-28 |
WO2009099736A3 (en) | 2009-10-08 |
CN101998959A (zh) | 2011-03-30 |
US8088760B2 (en) | 2012-01-03 |
EP2247600A4 (en) | 2011-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR070584A1 (es) | Derivados de benzoxazol carboxamida como inhibidores de poli (adp- ribosa) polimerasa (parp) | |
AR079327A1 (es) | Derivados de 2-amino-5,5-difluor -5,6-dihidro-4h-(1,3) oxazin-4-il) fenil)-amida | |
PE20080841A1 (es) | Derivados de quinazolinona e isoquinolinona y su uso para el tratamiento o prevencion de trastornos relacionados con el estres o la depresion | |
AR056536A1 (es) | Compuestos de 2-amino-5- [4-(difluormetoxi)fenil]-5-fenilimidazolona como inhibidores de la beta secretasa (bace) | |
PE20191540A1 (es) | DERIVADOS DE PIRROLO [1,2-b] PIRIDAZINA | |
AR076550A1 (es) | Inhibidores de la janus tirosina kinasa (jak) | |
AR058885A1 (es) | Compuestos de piperidina 3,5-sustituidos | |
AR056195A1 (es) | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos | |
AR080785A1 (es) | Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros. | |
AR087591A1 (es) | Derivados de ciclohexil azetidina como inhibidores de jak | |
CA2603784A1 (en) | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors | |
AR062074A1 (es) | Derivados de alcoholes 1-fenil-2-piridinil alquilenicos como inhibidores de fosfodiesterasa | |
AR054799A1 (es) | Derivados de oxindol | |
AR069524A1 (es) | Derivados de isoxazolo - pirazina, un procedimiento para la preparacion del compuesto, medicamento en base al compuesto y uso del compuesto para preparar un medicamento | |
AR094646A1 (es) | Morfinanos sustituidos y su uso | |
AR066583A1 (es) | Derivados de 3,3-espiroindolinona | |
AR043416A1 (es) | Un compuesto que comprende derivados de pirazolopiridina, procedimiento para preparar dicho compuesto y sus usos en la manufactura de medicamentos y composiciones farmaceuticas | |
AR060807A1 (es) | Derivados de arilaminopiridina heteroaril - susutituidos como inhibidores de mek | |
AR063602A1 (es) | Derivados de espiroindolinona, formulaciones farmaceuticas que los contienen y su uso en la obtencion de un medicamento para el tratamiento de trastornos oncologicos. | |
AR065015A1 (es) | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer | |
AR082888A1 (es) | Compuestos de piridina para la inhibicion de nampt | |
ES2662397T3 (es) | Inhibidores de la quinasa reguladora de la señal de apoptosis | |
PE20060775A1 (es) | Derivados de pirrolidilo de compuestos heteroaromaticos como inhibidores de fosfodiesterasa | |
PE20120058A1 (es) | Derivados de imidazopirazina como inhibidores de syk | |
AR067845A1 (es) | Compuestos para tratar trastornos relacionados con la modulacion de receptores de rianodina y composicion farmaceutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |