AR065728A1 - Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergico - Google Patents
Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergicoInfo
- Publication number
- AR065728A1 AR065728A1 ARP080101040A ARP080101040A AR065728A1 AR 065728 A1 AR065728 A1 AR 065728A1 AR P080101040 A ARP080101040 A AR P080101040A AR P080101040 A ARP080101040 A AR P080101040A AR 065728 A1 AR065728 A1 AR 065728A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- disorder
- pain
- deuterium
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/64—Quaternary ammonium compounds having quaternised nitrogen atoms bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe la síntesis química y usos médicos de inhibidores novedosos de absorcion de neurotransmisores de monoamina y sus sales y prodrogas farmacéuticamente aceptables, para el tratamiento y/o manejo de trastornos psicotropicos, trastornos deansiedad, trastornos generalizados de ansiedad, depresion, trastornos post-traumáticos de estrés, trastorno obsesivo-compulsivo, trastornos por pánico, despedir calor, demencia senil, migrana, síndrome hepatopulmonar, dolor cronico, dolornociceptivo, dolor neuropático, retinopatía diabética dolorosa, depresion bipolar, apnea obstructiva del sueno, trastornos psiquiátricos, trastorno disforica premenstrual, fobia social, trastorno de ansiedad social, incontinencia urinaria, anorexia,bulimia nervosa, obesidad, isquemia, herida en la cabeza, sobrecarga de calcio en células cerebrales, dependencia de la droga, trastorno hiperactivo de déficit de atencion, fibromialgia, síndrome de colon irritable, y/o eyaculacion precoz. Reivindicacion 1: Un compuesto con formula (1) estructural o su sal, solvato o prodroga farmacéuticamente aceptable, en donde: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26,y R27 se seleccionan independientemente del grupo que consiste en hidrogeno y deuterio; y al menos uno de R11, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, y R27 es deuterio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89504907P | 2007-03-15 | 2007-03-15 | |
US94439907P | 2007-06-15 | 2007-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065728A1 true AR065728A1 (es) | 2009-06-24 |
Family
ID=39595792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101040A AR065728A1 (es) | 2007-03-15 | 2008-03-13 | Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergico |
Country Status (16)
Country | Link |
---|---|
US (4) | US20080234257A1 (es) |
EP (5) | EP2514740B1 (es) |
AR (1) | AR065728A1 (es) |
AU (1) | AU2008251773A1 (es) |
CA (1) | CA2680912C (es) |
CY (1) | CY1118174T1 (es) |
DK (1) | DK2125698T3 (es) |
ES (3) | ES2605371T3 (es) |
HR (1) | HRP20161581T1 (es) |
HU (1) | HUE031070T2 (es) |
LT (1) | LT2125698T (es) |
PL (1) | PL2125698T3 (es) |
PT (1) | PT2125698T (es) |
SI (1) | SI2125698T1 (es) |
TW (1) | TW200846305A (es) |
WO (1) | WO2008140859A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100076087A1 (en) * | 2005-10-06 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Methods of reduction of interpatient variability |
SI1954669T1 (sl) * | 2005-12-01 | 2016-01-29 | Auspex Pharmaceuticals, Inc. | Substituirani fenetilamini s serotoninergično in / ali noradrenalinsko aktivnostjo |
DK2125698T3 (en) | 2007-03-15 | 2016-11-07 | Auspex Pharmaceuticals Inc | Deuterated d9-VENLAFAXINE |
WO2010028130A2 (en) * | 2008-09-03 | 2010-03-11 | Concert Pharmaceuticals, Inc. | Antidepressant compounds |
ES2343050B1 (es) * | 2008-12-16 | 2011-06-14 | Chemo Iberica, S.A. | Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables. |
WO2010085589A2 (en) | 2009-01-22 | 2010-07-29 | G&H Brands Llc | Desensitizing drug product |
CA2774999A1 (en) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products |
BR112015005894B1 (pt) | 2012-09-18 | 2022-03-29 | Auspex Pharmaceuticals, Inc | Composto, composição farmacêutica, método para tratar um distúrbio mediado por vmat2 e formulação farmacêutica de liberação prolongada |
US8987327B1 (en) * | 2013-10-11 | 2015-03-24 | Eugene Lipov | Kits and methods for treating post traumatic stress disorder (PTSD) and hot flashes |
EA201691582A1 (ru) | 2014-02-07 | 2017-01-30 | Оспекс Фармасьютикалз, Инк. | Новые фармацевтические препараты |
US9561233B2 (en) | 2014-03-13 | 2017-02-07 | Demerx, Inc. | Use of ibogaine for the treatment of pain |
WO2015175531A1 (en) * | 2014-05-12 | 2015-11-19 | Steerwasher, Llc | Compositions and methods for treating depressive disorders |
US9592239B2 (en) | 2014-09-12 | 2017-03-14 | Demerx, Inc. | Methods and compositions for ibogaine treatment of impulse control disorder, anxiety-related disorders, violence and/or anger, or regulating food intake |
CN114796209A (zh) | 2015-03-06 | 2022-07-29 | 奥斯拜客斯制药有限公司 | 氘代丁苯那嗪或包含氘代丁苯那嗪的组合物 |
US10493045B2 (en) * | 2016-12-14 | 2019-12-03 | Ru-Band Lu | Method for treating alcohol dependence or alcohol abuse |
CN110218157B (zh) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 一种r-氯胺酮及其可药用盐的制备方法 |
CN108440315A (zh) * | 2018-03-12 | 2018-08-24 | 钦州学院 | 氘代o-去甲基文拉法辛及其制备方法和用途 |
EP4153564A4 (en) | 2020-05-19 | 2024-06-19 | Cybin IRL Limited | DEUTERATED TRYPTAMINE DERIVATIVES AND METHODS OF USE |
CN116500172B (zh) * | 2023-06-29 | 2023-09-05 | 成都普康唯新生物科技有限公司 | 一种酸性底物中胺类溶剂的检测方法 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4069346A (en) | 1977-02-14 | 1978-01-17 | The Dow Chemical Company | Compositions and methods for anesthetizing an animal using deuterated analogues of halothane and chloroform |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
IE56324B1 (en) | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
KR890002631B1 (ko) | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
US5612059A (en) | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
SE9002043D0 (sv) | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
ES2174864T3 (es) * | 1993-06-28 | 2002-11-16 | Wyeth Corp | Nuevos tratamientos que utilizan derivados de fenetilo. |
US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
TW344661B (en) | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
DE69535592T2 (de) | 1994-03-25 | 2008-06-12 | Isotechnika, Inc., Edmonton | Verbesserung der effektivität von arzneimitteln duren deuterierung |
US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
US5798119A (en) | 1995-06-13 | 1998-08-25 | S. C. Johnson & Son, Inc. | Osmotic-delivery devices having vapor-permeable coatings |
CA2224381A1 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
US6274171B1 (en) * | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
US20030215507A1 (en) * | 1996-03-25 | 2003-11-20 | Wyeth | Extended release formulation |
TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
US6419961B1 (en) | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
IL129242A0 (en) | 1996-10-01 | 2000-02-17 | Cima Labs Inc | Taste-masked microcapsule compositions and methods of manufacture |
CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
CA2219698C (en) | 1996-10-31 | 2007-09-04 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
ATE233088T1 (de) | 1996-12-20 | 2003-03-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe |
US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
US6884429B2 (en) | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
ATE423130T1 (de) | 1997-10-08 | 2009-03-15 | Isotechnika Inc | Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien |
US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
US6613358B2 (en) | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
US6579899B1 (en) * | 1998-07-16 | 2003-06-17 | Massachusetts Institute Of Technology | Composition for treatment of stress |
US6333342B1 (en) | 1998-11-04 | 2001-12-25 | Isotechnika, Inc | Methods of pharmacological treatment using S(−) amlodipine |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
US6071918A (en) * | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
ES2245944T3 (es) * | 1999-08-13 | 2006-02-01 | Vela Pharmaceuticals Inc | Uso de composiciones para tratar o prevenir alteraciones del sueño utilizando dosis muy bajas de ciclobenzaprina. |
US20050233459A1 (en) * | 2003-11-26 | 2005-10-20 | Melker Richard J | Marker detection method and apparatus to monitor drug compliance |
ES2193921T3 (es) * | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
WO2002017918A2 (en) | 2000-08-30 | 2002-03-07 | Pfizer Products Inc. | Sustained release formulations for growth hormone secretagogues |
US20020183553A1 (en) * | 2000-10-19 | 2002-12-05 | Ben-Zion Dolitzky | Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof |
US20050054942A1 (en) * | 2002-01-22 | 2005-03-10 | Melker Richard J. | System and method for therapeutic drug monitoring |
JP4220243B2 (ja) | 2001-02-12 | 2009-02-04 | ワイス | O−デスメチル−ベンラファキシンの新規コハク酸塩 |
WO2002085297A2 (en) | 2001-04-24 | 2002-10-31 | East Carolina University | Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease |
IL146462A (en) * | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
CA2548304A1 (en) | 2003-12-12 | 2005-07-07 | Eli Lilly And Company | Selective norepinephrine reuptake inhibitors for the treatment of hot flashes, impulse control disorders and personality change due to a general medical condition |
DE10359154A1 (de) | 2003-12-16 | 2005-07-28 | Krka Tovarna Zdravil, D.D. | Verfahren zur Herstellung von Venlafaxin und Venlafaxinhydrochlorid der Form I |
US20050181071A1 (en) * | 2004-02-18 | 2005-08-18 | Binder Michael R. | Method for the treatment of clinical depression |
US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
JP2008514612A (ja) | 2004-09-23 | 2008-05-08 | ミシャロウ、アレクサンダー | 対抗適応を誘発することにより神経伝達物質系を調節する方法 |
WO2006044916A2 (en) | 2004-10-18 | 2006-04-27 | Bionaut Pharmaceuticals, Inc. | Use of na+/ k+-atpase inhibitors and antagonists thereof |
EP1906935A4 (en) | 2005-07-28 | 2010-10-20 | Reddys Lab Ltd Dr | VENLAFAXIN COMPOSITIONS WITH EXTENDED RELEASE |
US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
US9191396B2 (en) * | 2005-09-08 | 2015-11-17 | International Business Machines Corporation | Identifying source of malicious network messages |
US20100076087A1 (en) | 2005-10-06 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Methods of reduction of interpatient variability |
AU2006310100B2 (en) * | 2005-11-06 | 2012-12-06 | Brain Watch Ltd. | Magnetic resonance imaging and spectroscopy means and methods thereof |
SI1954669T1 (sl) | 2005-12-01 | 2016-01-29 | Auspex Pharmaceuticals, Inc. | Substituirani fenetilamini s serotoninergično in / ali noradrenalinsko aktivnostjo |
US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
US20090312435A1 (en) * | 2006-08-30 | 2009-12-17 | Auspex Pharmaceuticals, Inc | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity |
DK2125698T3 (en) | 2007-03-15 | 2016-11-07 | Auspex Pharmaceuticals Inc | Deuterated d9-VENLAFAXINE |
US20080280991A1 (en) * | 2007-05-08 | 2008-11-13 | Auspex Pharmaceuticals, Inc. | Substituted naphthalenes |
WO2009018169A1 (en) | 2007-07-27 | 2009-02-05 | Auspex Pharmaceuticals, Inc. | Substituted cyclohexanols |
US20090069431A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched milnacipran |
US20090076162A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched desvenlafaxine |
US20100007087A1 (en) * | 2008-07-09 | 2010-01-14 | John Michael Pryke | Six fold game board and method of folding game board |
WO2010028130A2 (en) | 2008-09-03 | 2010-03-11 | Concert Pharmaceuticals, Inc. | Antidepressant compounds |
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2008
- 2008-03-13 DK DK08732084.2T patent/DK2125698T3/en active
- 2008-03-13 EP EP12176584.6A patent/EP2514740B1/en not_active Not-in-force
- 2008-03-13 ES ES08732084.2T patent/ES2605371T3/es active Active
- 2008-03-13 EP EP17169980.4A patent/EP3269706A1/en not_active Withdrawn
- 2008-03-13 AU AU2008251773A patent/AU2008251773A1/en not_active Abandoned
- 2008-03-13 HU HUE08732084A patent/HUE031070T2/en unknown
- 2008-03-13 PT PT87320842T patent/PT2125698T/pt unknown
- 2008-03-13 AR ARP080101040A patent/AR065728A1/es not_active Application Discontinuation
- 2008-03-13 EP EP16179352.6A patent/EP3103790B1/en not_active Not-in-force
- 2008-03-13 SI SI200831714A patent/SI2125698T1/sl unknown
- 2008-03-13 WO PCT/US2008/056780 patent/WO2008140859A1/en active Application Filing
- 2008-03-13 ES ES12176584T patent/ES2716048T3/es active Active
- 2008-03-13 EP EP08732084.2A patent/EP2125698B1/en not_active Not-in-force
- 2008-03-13 TW TW097108816A patent/TW200846305A/zh unknown
- 2008-03-13 LT LTEP08732084.2T patent/LT2125698T/lt unknown
- 2008-03-13 CA CA2680912A patent/CA2680912C/en active Active
- 2008-03-13 PL PL08732084T patent/PL2125698T3/pl unknown
- 2008-03-13 ES ES16179352.6T patent/ES2693948T3/es active Active
- 2008-03-13 US US12/048,012 patent/US20080234257A1/en not_active Abandoned
- 2008-03-13 EP EP16183223.3A patent/EP3130580A1/en not_active Withdrawn
-
2014
- 2014-12-03 US US14/559,520 patent/US10421710B2/en active Active
-
2016
- 2016-10-31 CY CY20161101104T patent/CY1118174T1/el unknown
- 2016-11-28 HR HRP20161581TT patent/HRP20161581T1/hr unknown
-
2019
- 2019-09-10 US US16/566,197 patent/US20200172469A1/en not_active Abandoned
-
2020
- 2020-08-21 US US16/999,367 patent/US20210101863A1/en not_active Abandoned
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Publication number | Publication date |
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US20150152042A1 (en) | 2015-06-04 |
US20200172469A1 (en) | 2020-06-04 |
EP2514740B1 (en) | 2018-12-19 |
HUE031070T2 (en) | 2017-06-28 |
US20080234257A1 (en) | 2008-09-25 |
CY1118174T1 (el) | 2017-06-28 |
PT2125698T (pt) | 2016-12-12 |
AU2008251773A1 (en) | 2008-11-20 |
SI2125698T1 (sl) | 2016-12-30 |
HRP20161581T1 (hr) | 2016-12-30 |
EP2125698A1 (en) | 2009-12-02 |
ES2693948T3 (es) | 2018-12-14 |
EP2125698B1 (en) | 2016-08-31 |
DK2125698T3 (en) | 2016-11-07 |
LT2125698T (lt) | 2016-10-10 |
ES2716048T3 (es) | 2019-06-07 |
PL2125698T3 (pl) | 2017-03-31 |
EP3130580A1 (en) | 2017-02-15 |
US10421710B2 (en) | 2019-09-24 |
EP2514740A1 (en) | 2012-10-24 |
TW200846305A (en) | 2008-12-01 |
US20210101863A1 (en) | 2021-04-08 |
CA2680912A1 (en) | 2008-11-20 |
EP3103790A1 (en) | 2016-12-14 |
WO2008140859A1 (en) | 2008-11-20 |
CA2680912C (en) | 2017-11-14 |
EP3269706A1 (en) | 2018-01-17 |
ES2605371T3 (es) | 2017-03-14 |
EP3103790B1 (en) | 2018-05-09 |
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