AR062680A1 - Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas - Google Patents
Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onasInfo
- Publication number
- AR062680A1 AR062680A1 ARP070103937A ARP070103937A AR062680A1 AR 062680 A1 AR062680 A1 AR 062680A1 AR P070103937 A ARP070103937 A AR P070103937A AR P070103937 A ARP070103937 A AR P070103937A AR 062680 A1 AR062680 A1 AR 062680A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- cr7r8
- alkyl
- formula
- cycloalkyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940045996 isethionic acid Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84305106P | 2006-09-08 | 2006-09-08 | |
| US94210407P | 2007-06-05 | 2007-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062680A1 true AR062680A1 (es) | 2008-11-26 |
Family
ID=38988315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103937A AR062680A1 (es) | 2006-09-08 | 2007-09-06 | Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7781583B2 (enExample) |
| EP (1) | EP2069344A2 (enExample) |
| JP (1) | JP2008094834A (enExample) |
| KR (1) | KR20090052385A (enExample) |
| CN (1) | CN101511829A (enExample) |
| AR (1) | AR062680A1 (enExample) |
| AU (1) | AU2007297286A1 (enExample) |
| BR (1) | BRPI0716880A2 (enExample) |
| CA (1) | CA2662768A1 (enExample) |
| IL (1) | IL197242A0 (enExample) |
| MX (1) | MX2009002069A (enExample) |
| RU (1) | RU2009108006A (enExample) |
| TW (1) | TW200821309A (enExample) |
| WO (1) | WO2008032157A2 (enExample) |
| ZA (1) | ZA200901270B (enExample) |
Families Citing this family (95)
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| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
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| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| KR101606250B1 (ko) | 2011-03-23 | 2016-03-24 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| JP6535430B2 (ja) | 2012-09-28 | 2019-06-26 | イグニタ、インク． | 非定型プロテインキナーゼｃのアザキナゾリン阻害薬 |
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| CN104610254B (zh) * | 2015-01-26 | 2017-02-01 | 新发药业有限公司 | 一种帕博赛布的低成本制备方法 |
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| CN118834207A (zh) * | 2024-06-26 | 2024-10-25 | 安徽大学 | 一种2-氯-8-环戊基-5-甲基-8h-吡啶并[2,3-d]嘧啶基-7-酮的合成方法 |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
| WO2026133192A1 (en) | 2024-12-20 | 2026-06-25 | Pfizer Inc. | Combination therapies using cdk4 inhibitors with pd-1 axis binding antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ534069A (en) * | 2002-01-22 | 2007-03-30 | Warner Lambert Co | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones to be used to treat neurodegenerative disorders, viruses and cancer |
| DE602004017474D1 (de) * | 2003-07-11 | 2008-12-11 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
-
2007
- 2007-08-27 KR KR1020097007146A patent/KR20090052385A/ko not_active Ceased
- 2007-08-27 AU AU2007297286A patent/AU2007297286A1/en not_active Abandoned
- 2007-08-27 CN CNA2007800334161A patent/CN101511829A/zh active Pending
- 2007-08-27 WO PCT/IB2007/002524 patent/WO2008032157A2/en not_active Ceased
- 2007-08-27 EP EP07804871A patent/EP2069344A2/en not_active Withdrawn
- 2007-08-27 CA CA002662768A patent/CA2662768A1/en not_active Abandoned
- 2007-08-27 BR BRPI0716880-2A2A patent/BRPI0716880A2/pt not_active IP Right Cessation
- 2007-08-27 MX MX2009002069A patent/MX2009002069A/es not_active Application Discontinuation
- 2007-08-27 RU RU2009108006/04A patent/RU2009108006A/ru not_active Application Discontinuation
- 2007-09-06 AR ARP070103937A patent/AR062680A1/es not_active Application Discontinuation
- 2007-09-07 TW TW096133457A patent/TW200821309A/zh unknown
- 2007-09-07 JP JP2007232730A patent/JP2008094834A/ja not_active Withdrawn
- 2007-09-10 US US11/852,873 patent/US7781583B2/en not_active Expired - Fee Related
-
2009
- 2009-02-23 ZA ZA200901270A patent/ZA200901270B/xx unknown
- 2009-02-25 IL IL197242A patent/IL197242A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008032157A3 (en) | 2008-10-23 |
| CA2662768A1 (en) | 2008-03-20 |
| IL197242A0 (en) | 2009-12-24 |
| JP2008094834A (ja) | 2008-04-24 |
| KR20090052385A (ko) | 2009-05-25 |
| US7781583B2 (en) | 2010-08-24 |
| RU2009108006A (ru) | 2010-10-20 |
| US20080125588A1 (en) | 2008-05-29 |
| CN101511829A (zh) | 2009-08-19 |
| WO2008032157A2 (en) | 2008-03-20 |
| EP2069344A2 (en) | 2009-06-17 |
| MX2009002069A (es) | 2009-03-06 |
| AU2007297286A1 (en) | 2008-03-20 |
| BRPI0716880A2 (pt) | 2013-10-15 |
| TW200821309A (en) | 2008-05-16 |
| ZA200901270B (en) | 2010-05-26 |
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| FA | Abandonment or withdrawal |