AR062680A1 - Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas - Google Patents
Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onasInfo
- Publication number
- AR062680A1 AR062680A1 ARP070103937A ARP070103937A AR062680A1 AR 062680 A1 AR062680 A1 AR 062680A1 AR P070103937 A ARP070103937 A AR P070103937A AR P070103937 A ARP070103937 A AR P070103937A AR 062680 A1 AR062680 A1 AR 062680A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- cr7r8
- alkyl
- formula
- cycloalkyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940045996 isethionic acid Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84305106P | 2006-09-08 | 2006-09-08 | |
| US94210407P | 2007-06-05 | 2007-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062680A1 true AR062680A1 (es) | 2008-11-26 |
Family
ID=38988315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103937A AR062680A1 (es) | 2006-09-08 | 2007-09-06 | Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7781583B2 (enExample) |
| EP (1) | EP2069344A2 (enExample) |
| JP (1) | JP2008094834A (enExample) |
| KR (1) | KR20090052385A (enExample) |
| CN (1) | CN101511829A (enExample) |
| AR (1) | AR062680A1 (enExample) |
| AU (1) | AU2007297286A1 (enExample) |
| BR (1) | BRPI0716880A2 (enExample) |
| CA (1) | CA2662768A1 (enExample) |
| IL (1) | IL197242A0 (enExample) |
| MX (1) | MX2009002069A (enExample) |
| RU (1) | RU2009108006A (enExample) |
| TW (1) | TW200821309A (enExample) |
| WO (1) | WO2008032157A2 (enExample) |
| ZA (1) | ZA200901270B (enExample) |
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| CN101001857B (zh) | 2002-01-22 | 2011-06-22 | 沃尼尔·朗伯有限责任公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮 |
| BRPI0821209A2 (pt) | 2007-12-19 | 2019-09-24 | Amgen Inc | composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor. |
| US8389533B2 (en) * | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
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| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| PH12013501940A1 (en) | 2011-03-23 | 2015-12-04 | Amgen Inc | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
| AU2013323360B2 (en) | 2012-09-28 | 2017-09-07 | Cancer Research Technology Limited | Azaquinazoline inhibitors of atypical protein kinase C |
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| CN104610254B (zh) * | 2015-01-26 | 2017-02-01 | 新发药业有限公司 | 一种帕博赛布的低成本制备方法 |
| HUE047626T2 (hu) * | 2015-02-03 | 2020-05-28 | Jiangsu Hengrui Medicine Co | Ciklin-függõ, fehérje kináz inhibitor hidroxietil-szulfonátja, annak kristályos formája és elõállítására szolgáló eljárás |
| CZ201589A3 (cs) * | 2015-02-11 | 2016-08-24 | Zentiva, K.S. | Pevné formy soli Palbociclibu |
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| CN104887641B (zh) * | 2015-04-08 | 2017-12-01 | 上海鲁源医药科技有限公司 | 帕布昔利布胃漂浮片及其制备方法 |
| CN104910149A (zh) * | 2015-04-28 | 2015-09-16 | 上海百奇医药科技有限公司 | 一种Palbociclib制备方法 |
| CN106117199A (zh) * | 2015-05-04 | 2016-11-16 | 江苏恒瑞医药股份有限公司 | 一种细胞周期蛋白依赖性激酶抑制剂的二羟乙基磺酸盐、其结晶形式及其制备方法 |
| CN113616606A (zh) | 2015-06-04 | 2021-11-09 | 辉瑞公司 | 帕博西尼的固体剂型 |
| CN106317053A (zh) * | 2015-06-29 | 2017-01-11 | 北大方正集团有限公司 | 一种帕博昔布晶型a的制备方法 |
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| CN106474129A (zh) * | 2015-09-01 | 2017-03-08 | 上海方楠生物科技有限公司 | 一种帕博西林或其药学上可接受的盐与药用辅料的组合物及其制备方法 |
| WO2017036390A1 (zh) * | 2015-09-01 | 2017-03-09 | 上海方楠生物科技有限公司 | 帕博西林或其药学上可接受的盐与药用辅料的组合物及其制备方法 |
| CN106632311B (zh) | 2015-11-02 | 2021-05-18 | 上海科胜药物研发有限公司 | 一种帕博西尼晶型a和晶型b的制备方法 |
| CN105418603A (zh) * | 2015-11-17 | 2016-03-23 | 重庆莱美药业股份有限公司 | 一种高纯度帕布昔利布及其反应中间体的制备方法 |
| CN106749259B (zh) * | 2015-11-19 | 2019-02-01 | 华东师范大学 | 一种环戊基嘧啶并吡咯类化合物的合成方法 |
| CN106831759A (zh) * | 2015-12-03 | 2017-06-13 | 上海星泰医药科技有限公司 | 帕布昔利布及其中间体的制备方法 |
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| CN106967061A (zh) * | 2016-01-13 | 2017-07-21 | 常州方楠医药技术有限公司 | 帕博西林的盐、晶型及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101001857B (zh) * | 2002-01-22 | 2011-06-22 | 沃尼尔·朗伯有限责任公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮 |
| DK1648889T3 (da) * | 2003-07-11 | 2009-01-05 | Warner Lambert Co | Isethionatsalt af en selektiv CDK4-inhibitor |
-
2007
- 2007-08-27 EP EP07804871A patent/EP2069344A2/en not_active Withdrawn
- 2007-08-27 BR BRPI0716880-2A2A patent/BRPI0716880A2/pt not_active IP Right Cessation
- 2007-08-27 CN CNA2007800334161A patent/CN101511829A/zh active Pending
- 2007-08-27 RU RU2009108006/04A patent/RU2009108006A/ru not_active Application Discontinuation
- 2007-08-27 AU AU2007297286A patent/AU2007297286A1/en not_active Abandoned
- 2007-08-27 CA CA002662768A patent/CA2662768A1/en not_active Abandoned
- 2007-08-27 WO PCT/IB2007/002524 patent/WO2008032157A2/en not_active Ceased
- 2007-08-27 MX MX2009002069A patent/MX2009002069A/es not_active Application Discontinuation
- 2007-08-27 KR KR1020097007146A patent/KR20090052385A/ko not_active Ceased
- 2007-09-06 AR ARP070103937A patent/AR062680A1/es not_active Application Discontinuation
- 2007-09-07 TW TW096133457A patent/TW200821309A/zh unknown
- 2007-09-07 JP JP2007232730A patent/JP2008094834A/ja not_active Withdrawn
- 2007-09-10 US US11/852,873 patent/US7781583B2/en not_active Expired - Fee Related
-
2009
- 2009-02-23 ZA ZA200901270A patent/ZA200901270B/xx unknown
- 2009-02-25 IL IL197242A patent/IL197242A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7781583B2 (en) | 2010-08-24 |
| US20080125588A1 (en) | 2008-05-29 |
| AU2007297286A1 (en) | 2008-03-20 |
| EP2069344A2 (en) | 2009-06-17 |
| CN101511829A (zh) | 2009-08-19 |
| RU2009108006A (ru) | 2010-10-20 |
| CA2662768A1 (en) | 2008-03-20 |
| ZA200901270B (en) | 2010-05-26 |
| BRPI0716880A2 (pt) | 2013-10-15 |
| WO2008032157A3 (en) | 2008-10-23 |
| IL197242A0 (en) | 2009-12-24 |
| MX2009002069A (es) | 2009-03-06 |
| TW200821309A (en) | 2008-05-16 |
| JP2008094834A (ja) | 2008-04-24 |
| WO2008032157A2 (en) | 2008-03-20 |
| KR20090052385A (ko) | 2009-05-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |