AR045386A1 - [1,8] naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia - Google Patents
[1,8] naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofreniaInfo
- Publication number
- AR045386A1 AR045386A1 ARP040103006A ARP040103006A AR045386A1 AR 045386 A1 AR045386 A1 AR 045386A1 AR P040103006 A ARP040103006 A AR P040103006A AR P040103006 A ARP040103006 A AR P040103006A AR 045386 A1 AR045386 A1 AR 045386A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- atoms
- hydroxy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente se refiere a [1,8]naftiridin-2-onas y su uso en el tratamiento de trastornos del sistema nervioso central y de otros trastornos. Reivindicación 1: Un compuesto de fórmula (1) en la que G es como se muestra en los grupos de fórmula (2) o (3); A es -(CH2)m-CH2-, -(CH2)mO- o -(CH2)mNH-, donde m es un número entero de 2 a 5 y donde 1 o 2 de los átomos de C o N de -(CH2)mCH2-, -(CH2)mO- y -(CH2)mNH- pueden estar sustituidos, opcional e independientemente, con 1 o 2 sustituyentes que se seleccionan, independientemente, entre F y metilo, o con 2 sustituyentes unidos al mismo átomo de C, formando junto con el C al que están unidos, un anillo de espirociclopropilo o espirociclobutilo; D es N, C o CH, con la condición de que cuando D es N, cada átomo de C unido covalentemente a D está unido mediante un enlace sencillo; Z y Q son independientemente N, C o CH, con la condición de que al menos uno de Z y Q sea N;-X-----Y- es -CH2-CH2, -CH=CH-, -CH2-NH-, -NH-CH2, -N=CH-, -CH=N-, -O-CH2- o -CH2-O-, donde -X-----Y- puede estar opcionalmente sustituido, en cualquier sitio de unión disponible, con uno a cuatro sustituyentes R2, R2´, R3 y R3´; V y W son independientemente N, C o CH; el anillo AA es un anillo carbocíclico de 5, 6 o 7 miembros saturado o insaturado en el que 1, 2 o 3 de los átomos de C de anillo AA no compartidos con el anillo benzo del grupo (3) pueden reemplazarse, opcional e independientemente, por un átomo de N, O, o S; R1 es H, -C(=O)CH3 o alquilo C1-3; R2, R2´, R3 y R3´ se seleccionan independientemente entre H, halo, ciano, oxo, hidroxi, -C(=O)CH3, alquilo C1-4 y alcoxi C1-4, donde los restos alquilo de los grupo alquilo C1-4, alcoxi C1-4 y -C(=O)CH3 pueden estar opcionalmente sustituidos con de 1 a 3 átomos de F y también pueden estar opcionalmente sustituidos con 1 sustituyentes amino o hidroxi; R4 y R5 se seleccionan independientemente entre H, halo, ciano, hidroxi, -C(=O)CH3, alquilo C1-4 y alcoxi C1-4, donde los restos alquilo de los grupos alquilo C1-4, alcoxi C1-4 y -C(=O)CH3 pueden estar opcionalmente sustituidos con de 1 a 3 átomos de F y también pueden estar opcionalmente sustituidos con un sustituyente amino o hidroxi; R6 y R7 se seleccionan, independientemente, entre H y metilo; R8, R9, R10, R11 y R12 se seleccionan independientemente entre H, halo, -C(=O)CH34, alquilo C1-4 y alcoxi C1-4, arilo y ariloxi, donde los restos alquilo de los grupos alquilo C1-4, alcoxi C1-4 y -C(=O)CH3 y los restos arilo y ariloxi pueden estar opcionalmente sustituidos con de 1 a 3 átomos de F y también pueden estar opcionalmente sustituidos con 1 sustituyente amino o hidroxi; R13 y R14 se seleccionan independientemente entre H, halo, ciano, oxo, hidroxi, -C(=O)CH3, alquilo C1-4 y alcoxi C1-4, donde los restos alquilo de los grupos alquilo C1-4, alcoxi C1-4 y -C(=O)CH3 pueden estar opcionalmente sustituidos con 1 a 3 átomos de F y también pueden estar opcionalmente sustituidos con un sustituyente amino o hidroxi; y las sales farmacéuticamente aceptables de tal compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49737003P | 2003-08-22 | 2003-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045386A1 true AR045386A1 (es) | 2005-10-26 |
Family
ID=34216117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103006A AR045386A1 (es) | 2003-08-22 | 2004-08-20 | [1,8] naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US7160888B2 (es) |
| EP (1) | EP1660497A1 (es) |
| JP (1) | JP4034811B2 (es) |
| KR (2) | KR100801794B1 (es) |
| CN (1) | CN100422181C (es) |
| AP (1) | AP2006003525A0 (es) |
| AR (1) | AR045386A1 (es) |
| AU (1) | AU2004266191B2 (es) |
| BR (1) | BRPI0413860A (es) |
| CA (1) | CA2538915C (es) |
| CR (2) | CR8254A (es) |
| CU (1) | CU23464B7 (es) |
| EA (1) | EA009645B1 (es) |
| EC (1) | ECSP066391A (es) |
| GE (1) | GEP20084447B (es) |
| GT (1) | GT200500007A (es) |
| HK (1) | HK1091815A1 (es) |
| HN (1) | HN2004000319A (es) |
| IL (1) | IL173439A0 (es) |
| IS (1) | IS8267A (es) |
| MA (1) | MA28003A1 (es) |
| ME (1) | MEP45308A (es) |
| MX (1) | MXPA06002070A (es) |
| MY (1) | MY140693A (es) |
| NL (1) | NL1026892C2 (es) |
| NO (1) | NO20060324L (es) |
| NZ (1) | NZ545078A (es) |
| OA (1) | OA13238A (es) |
| PA (1) | PA8609701A1 (es) |
| PE (1) | PE20051039A1 (es) |
| RS (1) | RS20060129A (es) |
| TN (1) | TNSN06063A1 (es) |
| TW (1) | TWI298327B (es) |
| UA (1) | UA82541C2 (es) |
| WO (1) | WO2005019215A1 (es) |
| ZA (1) | ZA200601526B (es) |
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| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
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| US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| AU2005251909A1 (en) * | 2004-06-08 | 2005-12-22 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | New disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| MXPA06013941A (es) | 2004-06-08 | 2007-12-10 | Neurosearch Sweden Ab | Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina. |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| HUE029790T2 (hu) | 2004-10-13 | 2017-04-28 | Teva Pharmaceuticals Int Gmbh | Eljárás 4-(3-metánszulfonil-fenil)-l-N-propil-piperidin elõállítására |
| FR2877005A1 (fr) * | 2004-10-22 | 2006-04-28 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
| WO2006081289A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2006090272A1 (en) * | 2005-02-22 | 2006-08-31 | Warner-Lambert Company Llc | Isoquinoline [1,8]naphthyridin-2-ones and related compounds for treatment of schizophrenia |
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| EP1869041A1 (en) * | 2005-04-01 | 2007-12-26 | Warner-Lambert Company LLC | Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia |
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| EA016388B1 (ru) * | 2006-09-15 | 2012-04-30 | Пфайзер Продактс Инк. | Соединения пиридо[2,3-d]пиримидинона и их применение в качестве pi3 ингибиторов |
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| US10004807B2 (en) | 2012-03-19 | 2018-06-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
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