AR044070A1 - Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica

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Publication number
AR044070A1
AR044070A1 ARP040101382A ARP040101382A AR044070A1 AR 044070 A1 AR044070 A1 AR 044070A1 AR P040101382 A ARP040101382 A AR P040101382A AR P040101382 A ARP040101382 A AR P040101382A AR 044070 A1 AR044070 A1 AR 044070A1
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Argentina
Prior art keywords
alk
group
alkyl
conr4
formula
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ARP040101382A
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English (en)
Inventor
Daniel Floutard
Pierre Fraisse
Samir Jegham
Bernard Labeeuw
Pierre Carayon
Pierre Casellas
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Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR044070A1 publication Critical patent/AR044070A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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Abstract

Procedimiento de preparación intermediarios, composiciones farmacéuticas y usos del presente. Reivindicación 1: Compuestos que responden a la fórmula (1), en la cual: R1 representa un átomo de hidrógeno o de halógeno, un grupo alquilo (C1-4), trifluoroetilo, hidroxilo, alcoxi (C1-4), trifluorometoxi, trifluoroetoxi, cicloalquiloxi (C3-8), aliloxi, ciclopropilmetoxi, alquiltio (C1-4); R2 representa un átomo de hidrógeno o de halógeno, un grupo alquilo (C1-8), trifluoroetilo, perfluoroalquilo (C1-4), cicloalquilo (C3-10), fenilo, alcoxi (C1-8), trifluorometoxi, trifluoroetoxi, aliloxi, cicloalquilmetoxi (C3-8), cicloalquiloxi (C3-8), cicloalquilmetilo (C3-8); R3 representa un grupo elegido entre: a) -O-alk(C2-4)-A; -O- alk(C1-4)-B; -O-E; b) -alk(C1-4)-A; c) -B; d) -alk(C1-4)-NR4-alk(C2-3)-A; -alk(C1-4)-NR4-alk(C1-3)-B; e) -CONR4-alk(C2-4)-A; -CONR4-alk(C1-4)-B; -CONR4-E; f) -CO-D-alk(C1-2)-A; -CO-G-A; o un resto seleccionado del grupo de fórmulas (2); R4 representa un átomo de hidrógeno o un grupo alquilo (C1-4); A representa un grupo NR5R6; B representa un grupo de fórmula (3); D representa un grupo de fórmula (4); E representa un grupo de fórmula (5); G representa un grupo de fórmula (6); R5 y R6 representan cada uno, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo (C1-6), alilo, alk (C2-4), -O-alquilo (C1-4), alk(2-4)-OH, alk(C1-3)-CON(R4)2, alk(C2-3)-NHCO-alquilo (C1-4), cicloalquilo (C3-7), cicloalquilmetilo (C3-7), - CO-alquilo (C1-4), pirrolidinilo eventualmente sustituido por un grupo -CO-alquilo (C1-4), bencilo, tetrahidropiranilo, tetrahidropiranilmetilo, dimetiltetrahidropiranilo, tetrahidrofurilo, tetrahidrofurilmetilo; o R5 y R6 junto con el átomo de nitrógeno al cual están unidos constituyen un radical heterocíclico elegido entre: aziridinilo, azetidinilo, pirrolidinilo, piperidinilo, perhidroazepinilo, morfolinilo, piperazinilo, tropanilo, quinuclidinilo, 2-azabiciclo[2,2,1]heptanilo, 2- azabiciclo[2,2,2]octanilo, dichos radicales heterocíclicos están no sustituidos o sustituidos por un grupo fenilo, halogenofenilo, trifluorometilfenilo, trifluorometilo, hidroxi, metoxi, hidroximetilo, metoximetilo, formamido, trifluoroacetilamino, un grupo -NR4R7, tetrahidropiran-4-ilamino, -CON(R4)2, -CONR4R'4, -CH2CON(R4)2, alquilo(C1-4)-CONR4-, cicloalquilo(C3-8)-CONR4-, alquilo(C1-4)-OCONR4-, cicloalquilo(C3-8)-OCONR4-, (alquilo(C1-4)-OCO-)2N-, alquilo(C1-4)-COO-; o sustituidos por uno o varios grupos metilo; R'4 representa un grupo (CH2)s unido al átomo de carbono portador de -CONR4R'4; R7 representa un átomo de hidrógeno, un alquilo (C1-4), un grupo -SO2CH3 o R4 y R7 junto con el átomo de nitrógeno al cual están unidos constituyen un radical pirrolidinilo o piperidinilo; p representa 1, 2, 3, 4 ó 5; q representa 0, 1 ó 2; r representa 1 ó 2; s representa 2 ó 3; p + q es inferior o igual a 5; p + r es inferior o igual a 5; alk representa un alquileno; a condición de que R1 y R2 no sean simultáneamente un átomo de hidrógeno, en estado de base o de sal de adición con un ácido, así como también en estado de hidrato o de solvato.
ARP040101382A 2003-04-25 2004-04-23 Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica AR044070A1 (es)

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FR0305213A FR2854158B1 (fr) 2003-04-25 2003-04-25 Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique

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AR044070A1 true AR044070A1 (es) 2005-08-24

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US (2) US7504511B2 (es)
EP (1) EP1656373B1 (es)
JP (2) JP4839208B2 (es)
KR (1) KR20060006935A (es)
CN (1) CN1826339A (es)
AR (1) AR044070A1 (es)
AT (1) ATE541843T1 (es)
AU (1) AU2004234101A1 (es)
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BRPI0409716A (pt) 2006-05-02
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FR2854158B1 (fr) 2006-11-17
CN1826339A (zh) 2006-08-30
US20060135575A1 (en) 2006-06-22
WO2004096798A2 (fr) 2004-11-11
US7504511B2 (en) 2009-03-17
ZA200508608B (en) 2007-01-31
TNSN05254A1 (en) 2007-07-10
EP1656373A2 (fr) 2006-05-17
JP2006524669A (ja) 2006-11-02
NO20054905L (no) 2006-01-25
ATE541843T1 (de) 2012-02-15
MA27769A1 (fr) 2006-02-01
CO5640106A2 (es) 2006-05-31
US7777041B2 (en) 2010-08-17
NO20054905D0 (no) 2005-10-24
RU2348630C2 (ru) 2009-03-10
MXPA05011522A (es) 2006-01-23
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US20090156574A1 (en) 2009-06-18
RS20050769A (en) 2007-11-15
JP4839208B2 (ja) 2011-12-21
JP2011126891A (ja) 2011-06-30
FR2854158A1 (fr) 2004-10-29
CA2521158A1 (fr) 2004-11-11
AU2004234101A1 (en) 2004-11-11
WO2004096798A3 (fr) 2006-01-26
EP1656373B1 (fr) 2012-01-18
KR20060006935A (ko) 2006-01-20
CR8037A (es) 2008-07-29
ECSP056111A (es) 2006-03-01

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