CO5640106A2 - Derivados de 2-acilamino -4-feniltiazol, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 2-acilamino -4-feniltiazol, su preparacion y su aplicacion en terapeutica

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Publication number
CO5640106A2
CO5640106A2 CO05108740A CO05108740A CO5640106A2 CO 5640106 A2 CO5640106 A2 CO 5640106A2 CO 05108740 A CO05108740 A CO 05108740A CO 05108740 A CO05108740 A CO 05108740A CO 5640106 A2 CO5640106 A2 CO 5640106A2
Authority
CO
Colombia
Prior art keywords
alk
feniltiazol
acilamino
therapeutics
derivatives
Prior art date
Application number
CO05108740A
Other languages
English (en)
Inventor
Pierre Carayon
Casellas Pierre
Daniel Floutard
Pierre Fraisse
Samir Jegham
Bernard Labbeeuw
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO5640106A2 publication Critical patent/CO5640106A2/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
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Abstract

1.- Compuestos que responden a la fórmula (1):en la cual:R1 representa un átomo de hidrógeno o de halógeno [ un Grupo alquilo (C1-C4) [trifluoroetilo[hidroxilo[alcoxi (C1-C4) [trifluorometoxi[trifluoroetoxi[cicloalquiloxi(C3-Cs) [alquiltio(C1-C4); aliloxi[ciclopropilmetoxi,-R2 representa un átomo de hidrógeno o de halógeno [ un grupo alquilo (C1-Cs), trifluoroetilo [perfluoroalquilo ( C1-C4) [cicloalquilo (C3-C10) [fenilo[alcoxi (C1-Cs) [trifluorometoxi[trifluoroetoxi[aliloxi[cicloalquilmetoxi(C3-Cs), cicloalquilmetilo(C3-Cs); cicloalquiloxi (C3-Cs) [-R3 representa un grupo elegido entre:m) a1) -O-alk(Cz-C4)-A; a2) -O-alk (C1 -C4) -B;n) alk(Cz-C4)-A o) B p) d1) -alk(C1-C4)-NR4-alk(C2-C3)-A; d2) -alk(C1-C4)-NR4-alk(C1-C3)-B q) e1) -CONR4-alk (C2-C4) -A; e2) CONRcalk(C1-C4) -B; -13T B; e3) -CONRcE; f1) -CO-D-alk(C1-C2) -A; f2) -CO-G-A.
CO05108740A 2003-04-25 2005-10-25 Derivados de 2-acilamino -4-feniltiazol, su preparacion y su aplicacion en terapeutica CO5640106A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0305213A FR2854158B1 (fr) 2003-04-25 2003-04-25 Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO5640106A2 true CO5640106A2 (es) 2006-05-31

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CO05108740A CO5640106A2 (es) 2003-04-25 2005-10-25 Derivados de 2-acilamino -4-feniltiazol, su preparacion y su aplicacion en terapeutica

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US (2) US7504511B2 (es)
EP (1) EP1656373B1 (es)
JP (2) JP4839208B2 (es)
KR (1) KR20060006935A (es)
CN (1) CN1826339A (es)
AR (1) AR044070A1 (es)
AT (1) ATE541843T1 (es)
AU (1) AU2004234101A1 (es)
BR (1) BRPI0409716A (es)
CA (1) CA2521158A1 (es)
CO (1) CO5640106A2 (es)
CR (1) CR8037A (es)
EC (1) ECSP056111A (es)
FR (1) FR2854158B1 (es)
MA (1) MA27769A1 (es)
MX (1) MXPA05011522A (es)
NO (1) NO20054905L (es)
OA (1) OA13049A (es)
RS (1) RS20050769A (es)
RU (1) RU2348630C2 (es)
TN (1) TNSN05254A1 (es)
TW (1) TW200510325A (es)
WO (1) WO2004096798A2 (es)
ZA (1) ZA200508608B (es)

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JO2527B1 (en) * 2004-04-06 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
FR2876692B1 (fr) * 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
US20060160869A1 (en) * 2005-01-05 2006-07-20 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
JP5078869B2 (ja) 2005-03-08 2012-11-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ニューロキニン（ｎｋ１）拮抗物質としてのジアザ−スピロ−［４．４］−ノナン誘導体
KR20080019213A (ko) 2005-05-09 2008-03-03 아칠리온 파르마세우티칼스 인코포레이티드 티아졸 화합물 및 그 사용방법
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
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US7777041B2 (en) 2010-08-17
KR20060006935A (ko) 2006-01-20
EP1656373A2 (fr) 2006-05-17
AU2004234101A1 (en) 2004-11-11
EP1656373B1 (fr) 2012-01-18
FR2854158A1 (fr) 2004-10-29
CN1826339A (zh) 2006-08-30
FR2854158B1 (fr) 2006-11-17
TW200510325A (en) 2005-03-16
AR044070A1 (es) 2005-08-24
BRPI0409716A (pt) 2006-05-02
RU2005136663A (ru) 2006-03-20
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US20090156574A1 (en) 2009-06-18
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US7504511B2 (en) 2009-03-17
MA27769A1 (fr) 2006-02-01
TNSN05254A1 (en) 2007-07-10
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CR8037A (es) 2008-07-29
US20060135575A1 (en) 2006-06-22
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