AR065844A1 - Derivados de 8-(heteroarilmetoxi)quinolina, moduladores selectivos de receptores de bradiquinina (bk) b2, composiciones farmaceuticas que los contienen y usos en terapia. - Google Patents

Derivados de 8-(heteroarilmetoxi)quinolina, moduladores selectivos de receptores de bradiquinina (bk) b2, composiciones farmaceuticas que los contienen y usos en terapia.

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Publication number
AR065844A1
AR065844A1 ARP080101208A ARP080101208A AR065844A1 AR 065844 A1 AR065844 A1 AR 065844A1 AR P080101208 A ARP080101208 A AR P080101208A AR P080101208 A ARP080101208 A AR P080101208A AR 065844 A1 AR065844 A1 AR 065844A1
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AR
Argentina
Prior art keywords
diseases
independently selected
atom
heteroaryl
cycloalkyl
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ARP080101208A
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English (en)
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Jerini Ag
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Publication of AR065844A1 publication Critical patent/AR065844A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto caracterizado por la formula (1) o una sal, solvato o hidrato farmacologicamente aceptable de dicho compuesto, donde A es un heteroarilo de 6 miembros que tiene de 1 a 3 heteroátomos cada uno independientemente seleccionado de N o O,donde dicho heteroarilo de 6 miembros está sustituido con entre 2 y 4 sustituyentes cada uno independientemente seleccionado de un átomo de halogeno, un átomo de oxígeno, hidroxi, ciano, amino, nitro, mercapto, alquilo, alquenilo, alquinilo,heteroalquilo, cicloalquilo, heterocicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo; R5 es un átomo de halogeno, hidroxi, ciano, nitro, mercapto, alquilo, alquenilo, alquinilo oheteroalquilo; R6 es alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; heterocicloalquilo de 5 miembros que tiene de 1 a 3 heteroátomos cada uno independientemente seleccionado de N, O o S, o cicloalquilo, donde dichoheterocicloalquilo de 5 miembros o cicloalquilo está sustituido con entre 0 y 3 sustituyentes cada uno independientemente seleccionado de un átomo de halogeno, un átomo de oxígeno, hidroxi, ciano, amino, nitro, mercapto, alquilo, alquenilo,alquinilo, heteroalquilo, cicloalquilo, heterocicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo; heteroarilo de 5 miembros que tiene de 1 a 4 heteroátomos cada uno independientementeseleccionado de N, O o S, donde dicho heteroarilo de 5 miembros está sustituido con entre 0 y 3 sustituyentes cada uno independientemente seleccionado de un átomo de halogeno, un átomo de oxígeno, hidroxi, ciano, amino, nitro, mercapto, alquilo,alquenilo, alquinilo, heteroalquilo, arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; o -S-R10; R10 es heterocicloalquilo de 5 miembros que tiene de 1 a 3 heteroátomos cada uno independientemente seleccionado de N, O o S, ocicloalquilo, donde dicho heterocicloalquilo 5 miembros o cicloalquilo está sustituido con entre 0 y 4 sustituyentes cada uno independientemente seleccionado de un átomo de halogeno, un átomo de oxígeno, hidroxi, ciano, amino, nitro, mercapto,alquilo, alquenilo, alquinilo, heteroalquilo, cicloalquilo, heterocicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo; o heteroarilo de 5 miembros que tiene de 1 a 4 heteroátomos cada unoindependientemente seleccionado de N, O o S, donde dicho heteroarilo de 5 miembros está sustituido con entre 0 y 4 sustituyentes cada uno independientemente seleccionado de un átomo de halogeno, un átomo de oxígeno, hidroxi, ciano, amino, nitro,mercapto, alquilo, alquenilo, alquinilo, heteroalquilo, cicloalquilo, heterocicloalquilo, alquilcicloalquilo, heteroalquilcicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo; R7 es un átomo de hidrogeno, un átomo de halogeno, hidroxi,ciano, amino, nitro, alquilo o heteroalquilo; R8 es un átomo de hidrogeno o un átomo de halogeno; y R17 es un átomo de hidrogeno o un átomo de halogeno. Uso de los mismos en trastornos dérmicos; enfermedades oculares; enfermedades del oído;enfermedades de la boca, la garganta y las vías respiratorias; enfermedades gastrointestinales; enfermedades del hígado, la vesícula biliar y el páncreas; enfermedades del tracto urinario y los rinones; enfermedades de los organos genitalesmasculinos y los organos genitales femeninos; enfermedades del sistema hormonal; enfermedades metabolicas; enfermedades cardiovasculares; enfermedades de la sangre; enfermedades linfáticas; trastornos del sistema nervioso central; trastornoscerebrales; enfermedades del sistema musculoesquelético; trastornos alérgicos; dolor; enfermedades infecciosas; trastornos inflamatorios; heridas; trastornos inmunologicos; cáncer; enfermedades hereditarias; o edema,
ARP080101208A 2007-03-23 2008-03-25 Derivados de 8-(heteroarilmetoxi)quinolina, moduladores selectivos de receptores de bradiquinina (bk) b2, composiciones farmaceuticas que los contienen y usos en terapia. AR065844A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07006089 2007-03-23

Publications (1)

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AR065844A1 true AR065844A1 (es) 2009-07-08

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Country Status (19)

Country Link
US (1) US8410134B2 (es)
EP (2) EP2305668A1 (es)
KR (1) KR20090125779A (es)
CN (1) CN101679375A (es)
AR (1) AR065844A1 (es)
AT (1) ATE485289T1 (es)
AU (1) AU2008232021B2 (es)
BR (1) BRPI0809231A2 (es)
CA (1) CA2681206C (es)
DE (1) DE602008003116D1 (es)
DK (1) DK2144897T3 (es)
ES (1) ES2356197T3 (es)
IL (1) IL200922A0 (es)
MX (1) MX2009010246A (es)
PL (1) PL2144897T3 (es)
RU (1) RU2512541C2 (es)
TW (1) TWI407960B (es)
WO (1) WO2008116620A1 (es)
ZA (1) ZA200906307B (es)

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RU2512541C2 (ru) 2014-04-10
DE602008003116D1 (de) 2010-12-02
AU2008232021B2 (en) 2012-05-24
WO2008116620A1 (en) 2008-10-02
KR20090125779A (ko) 2009-12-07
BRPI0809231A2 (pt) 2014-09-02
AU2008232021A1 (en) 2008-10-02
ES2356197T3 (es) 2011-04-05
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TW200843767A (en) 2008-11-16
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CN101679375A (zh) 2010-03-24
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