AR026183A1 - Dispositivo y metodo de administracion de medicamentos oftalmicos - Google Patents

Dispositivo y metodo de administracion de medicamentos oftalmicos

Info

Publication number
AR026183A1
AR026183A1 ARP000105517A ARP000105517A AR026183A1 AR 026183 A1 AR026183 A1 AR 026183A1 AR P000105517 A ARP000105517 A AR P000105517A AR P000105517 A ARP000105517 A AR P000105517A AR 026183 A1 AR026183 A1 AR 026183A1
Authority
AR
Argentina
Prior art keywords
active agent
human eye
pharmaceutically active
administration
sclera
Prior art date
Application number
ARP000105517A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR026183A1 publication Critical patent/AR026183A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00885Methods or devices for eye surgery using laser for treating a particular disease
    • A61F2009/00891Glaucoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente se refiere a un dispositivo de administracion de medicamentos para un ojo humano. El ojo humano tiene una esclerotica, un musculo oblicuoinferior, y una mácula. El dispositivo del presente invento incluye un agente activo farmacéuticament e, y una geometría que facilita la implantacion deldispositivo sobre una superficie externa de la esclerotica, debajo del musculo oblicuo inferior, y con el agente activo farmacéuticamente dispuesto sobre lamácula. También se revelan métodos de admin istracion de un agente activo farmacéuticamente al segmento posterior del ojo humano.
ARP000105517A 1999-10-21 2000-10-19 Dispositivo y metodo de administracion de medicamentos oftalmicos AR026183A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16067399P 1999-10-21 1999-10-21
US09/664,790 US6416777B1 (en) 1999-10-21 2000-09-19 Ophthalmic drug delivery device

Publications (1)

Publication Number Publication Date
AR026183A1 true AR026183A1 (es) 2003-01-29

Family

ID=26857116

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP000105517A AR026183A1 (es) 1999-10-21 2000-10-19 Dispositivo y metodo de administracion de medicamentos oftalmicos
ARP030101033A AR039130A2 (es) 1999-10-21 2003-03-25 Metodo de administracion de un agente farmaceuticamente activo a un ojo humano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP030101033A AR039130A2 (es) 1999-10-21 2003-03-25 Metodo de administracion de un agente farmaceuticamente activo a un ojo humano

Country Status (19)

Country Link
US (4) US6416777B1 (es)
EP (1) EP1221919B1 (es)
JP (1) JP4685311B2 (es)
KR (1) KR100752821B1 (es)
CN (1) CN100341470C (es)
AR (2) AR026183A1 (es)
AT (1) ATE289500T1 (es)
AU (2) AU764226B2 (es)
BR (1) BR0014928B1 (es)
CA (1) CA2384255C (es)
DE (1) DE60018298T2 (es)
DK (1) DK1221919T3 (es)
ES (1) ES2237463T3 (es)
HK (1) HK1048428B (es)
PL (1) PL196539B1 (es)
PT (1) PT1221919E (es)
TR (1) TR200201046T2 (es)
TW (1) TW539560B (es)
WO (1) WO2001028474A1 (es)

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040837A3 (en) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Medicaments for the treatment of a choroidal neovascularization (CNV) related disorder
AU767526B2 (en) 1999-04-26 2003-11-13 Gmp Vision Solutions, Inc. Trabeculotomy device and method for treating glaucoma
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
AR030346A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
WO2002078681A2 (en) * 2001-04-02 2002-10-10 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP1977724A1 (en) 2001-04-07 2008-10-08 Glaukos Corporation System for treating ocular disorders
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
EP1404297B1 (en) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
JP4261343B2 (ja) 2001-07-23 2009-04-30 アルコン,インコーポレイティド 眼薬投与装置
WO2003009784A1 (en) * 2001-07-23 2003-02-06 Alcon, Inc. Ophthalmic drug delivery device
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7749528B2 (en) * 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
ES2393101T3 (es) * 2001-08-29 2012-12-18 Ricardo A. P. De Carvalho Sistema implantable y sellable para la administración unidireccional de agentes terapéuticos a tejidos diana
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
RU2322233C2 (ru) * 2002-03-11 2008-04-20 Алькон, Инк. Имплантируемая система для доставки лекарственных средств
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
BR0309747A (pt) * 2002-05-03 2005-04-26 Alcon Inc Método para o tratamento de distúrbios vasculares mediados pelo fator de crescimento vascular endotelial
AU2003281817A1 (en) * 2002-08-05 2004-02-23 Alcon, Inc. Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration
DE10238310A1 (de) * 2002-08-21 2004-03-04 Erich Jaeger Gmbh Elektrodenanordnung
JP2006507368A (ja) * 2002-09-29 2006-03-02 サーモディックス,インコーポレイティド ステロイド含有治療剤の網膜下投与方法;脈絡膜及び網膜に薬力学作用を局在化するための方法;並びに網膜疾患の治療及び/又は予防のための関連する方法
US20030187072A1 (en) * 2003-02-14 2003-10-02 Kapin Michael A. Method of treating angiogenesis-related disorders
RU2005129276A (ru) * 2003-02-20 2006-01-27 Алькон, Инк. (Ch) Применение стероидов для лечения субъектов, страдающих заболеванием глаз
JP2006518383A (ja) * 2003-02-20 2006-08-10 アルコン,インコーポレイテッド 病的な眼の新脈管形成を処置するための糖質コルチコイド処方物
US20040236343A1 (en) * 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
CA2527121A1 (en) * 2003-06-13 2004-12-29 Alcon, Inc. Formulations of non-steroidal anti-inflammatory agents to treat pathologic ocular angiogenesis
EP1635842A4 (en) * 2003-06-20 2007-04-04 Alcon Inc TREATMENT OF AMD WITH A COMBINATION OF INGREDIENTS
MXPA05011517A (es) * 2003-07-10 2005-12-12 Alcon Inc Dispositivo para el suministro de medicamentos oftalmicos.
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
CA2536454C (en) * 2003-08-26 2013-03-26 Vista Scientific Ocular drug delivery device
CA2539324A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050158365A1 (en) * 2003-12-22 2005-07-21 David Watson Drug delivery device with mechanical locking mechanism
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US9549895B2 (en) * 2004-04-23 2017-01-24 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
WO2006014484A2 (en) 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
US7722669B2 (en) * 2004-08-13 2010-05-25 Richard Foulkes Method and insert for modifying eye color
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
CN100428958C (zh) * 2004-09-06 2008-10-29 段亚东 一种治疗眼病的植入剂
US8637070B2 (en) 2005-02-09 2014-01-28 Santen Pharmaceutical Co., Ltd. Rapamycin formulations and methods of their use
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
WO2006102378A2 (en) * 2005-03-21 2006-09-28 Macusight, Inc. Drug delivery systems for treatment of diseases or conditions
EP1868661A1 (en) 2005-04-08 2007-12-26 SurModics, Inc. Sustained release implants for subretinal delivery
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
KR20080033463A (ko) 2005-07-27 2008-04-16 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. 단백질 미스폴딩을 보정하는 작은 화합물 및 그의 용도
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
WO2007047626A1 (en) * 2005-10-14 2007-04-26 Alcon, Inc. Combination treatment with anecortave acetate and bevacizumab or ranibizumab for pathologic ocular angiogenesis
PT1968594E (pt) 2005-11-29 2010-11-18 Glaxosmithkline Llc Tratamento de distúrbios neovasculares oculares tais como degeneração macular, estrias angióides, uveite e edema macular
EP2001438A2 (en) * 2006-02-09 2008-12-17 Macusight, Inc. Stable formulations, and methods of their preparation and use
DE602007012417D1 (de) 2006-03-14 2011-03-24 Univ Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
WO2007130663A2 (en) * 2006-05-04 2007-11-15 Herbert Kaufman Method, device, and system for delivery of therapeutic agents to the eye
US8506515B2 (en) 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
WO2008063639A2 (en) * 2006-11-21 2008-05-29 Massachusetts Eye And Ear Infirmary Compositions and methods for preserving cells of the eye
ZA200903649B (en) * 2006-12-18 2010-08-25 Alcon Res Ltd Devices and methods for ophthalmic drug delivery
DE102007024642A1 (de) 2007-05-24 2008-11-27 Eyesense Ag Hydrogel-Implantat für Sensorik von Metaboliten am Auge
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
EP2266643B1 (en) * 2008-01-03 2015-06-17 University Of Southern California Implantable drug-delivery devices, and apparatus and methods for refilling the devices
JP2011519695A (ja) * 2008-05-08 2011-07-14 リプレニッシュ パンプス, エルエルシー 植設可能な薬物送達デバイスおよびそのデバイスを充填する装置および方法
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2320989B1 (en) * 2008-05-08 2015-03-11 MiniPumps, LLC Implantable pumps and cannulas therefor
ES2534865T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas de administración de fármacos
CA2723588A1 (en) 2008-05-12 2009-11-19 University Of Utah Research Foundation Intraocular drug delivery device and associated uses
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8664182B2 (en) 2008-11-12 2014-03-04 Duke University Methods of inhibiting cancer cell growth with HDAC inhibitors and methods of screening for HDAC10 inhibitors
PL2391419T3 (pl) 2009-01-29 2019-12-31 Forsight Vision4, Inc. Dostarczanie leku do tylnego odcinka
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
IN2012DN00352A (es) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
JP5758388B2 (ja) * 2009-08-18 2015-08-05 ミニパンプス, エルエルシー 適応制御を有する電解質薬物送達ポンプ
US20120232102A1 (en) 2009-09-30 2012-09-13 Chun-Fang Xu Methods Of Administration And Treatment
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US20130137642A1 (en) 2010-04-23 2013-05-30 Demetrios Vavvas Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells
JP2013526572A (ja) 2010-05-17 2013-06-24 アエリエ・ファーマシューティカルズ・インコーポレーテッド 眼治療薬の送達のための薬物送達装置
US8939948B2 (en) 2010-06-01 2015-01-27 Forsight Vision5, Inc. Ocular insert apparatus and methods
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
SI2600812T1 (sl) 2010-08-05 2021-12-31 ForSight Vision4, Inc., Naprava za zdravljenje očesa
WO2012019136A2 (en) 2010-08-05 2012-02-09 Forsight Vision 4, Inc. Injector apparatus and method for drug delivery
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US20120109054A1 (en) * 2010-10-29 2012-05-03 Vista Scientific Llc Devices with an erodible surface for delivering at least one active agent to tissue over a prolonged period of time
US20140024598A1 (en) 2010-11-01 2014-01-23 Demetrios Vavvas Methods and compositions for preserving retinal ganglion cells
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EA032666B1 (ru) 2011-06-14 2019-06-28 Бикам Фармасьютикалз, Инк. Опсинсвязывающие лиганды и способы их применения
WO2013003467A2 (en) 2011-06-27 2013-01-03 Massachusetts Eye And Ear Infirmary Methods for treating ocular inflammatory disorders
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
WO2013025840A1 (en) 2011-08-15 2013-02-21 Massachusetts Eye And Ear Infirmary Methods for preserving photoreceptor cell viability following retinal detachment
WO2013040079A1 (en) 2011-09-13 2013-03-21 Dose Medical Corporation Intraocular physiological sensor
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
RS61758B1 (sr) 2011-09-16 2021-05-31 Forsight Vision4 Inc Aparati za razmenu tečnosti
CA2856703A1 (en) 2011-10-19 2013-04-25 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
EP2773341A2 (en) 2011-10-21 2014-09-10 Massachusetts Eye & Ear Infirmary Compositions comprising necrosis inhibitors, such as necrostatins, alone or in combination, for promoting axon regeneration and nerve function, thereby treating cns disorders
AU2012346214B2 (en) 2011-11-30 2017-09-14 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
WO2013081642A1 (en) 2011-12-01 2013-06-06 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CN104884006B (zh) 2012-10-26 2017-12-15 弗赛特影像5股份有限公司 用于持续释放药物到眼睛的眼科系统
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
CN105246438B (zh) 2013-03-28 2018-01-26 弗赛特影像4股份有限公司 用于输送治疗物质的眼科植入物
EP2991621B1 (en) * 2013-05-02 2020-12-09 Retina Foundation of the Southwest Two-layer ocular implant
CA2930015A1 (en) 2013-11-07 2015-05-14 Editas Medicine, Inc. Crispr-related methods and compositions with governing grnas
EP3089748A4 (en) 2014-01-02 2017-09-27 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
EP3114227B1 (en) 2014-03-05 2021-07-21 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
US11141493B2 (en) 2014-03-10 2021-10-12 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
WO2015138510A1 (en) 2014-03-10 2015-09-17 Editas Medicine., Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
EP3148491B1 (en) 2014-05-29 2020-07-01 Glaukos Corporation Implants with controlled drug delivery features and manufacturing method for said implants
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
CN107106551A (zh) 2014-08-08 2017-08-29 弗赛特影像4股份有限公司 受体酪氨酸激酶抑制剂的稳定且可溶的制剂和其制备方法
RU2708958C2 (ru) 2014-11-10 2019-12-12 Форсайт Вижн4, Инк. Расширяемые устройства доставки лекарственных средств и способы использования
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
WO2016187426A1 (en) 2015-05-19 2016-11-24 Amorphex Therapeutics Llc A device that delivers a sustained low-dose of a myopia-suppressing drug
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017075475A1 (en) 2015-10-30 2017-05-04 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
MX2018006234A (es) 2015-11-20 2018-08-14 Forsight Vision4 Inc Estructuras porosas para dispositivos de suministro de medicamentos de liberacion prolongada.
CN105997338B (zh) * 2016-03-09 2019-04-26 泰山医学院 经玻璃体纳米材料给药系统
MX2018012021A (es) 2016-04-05 2019-01-24 Forsight Vision4 Inc Dispositivos de administracion de farmacos oculares implantables.
EP3442479A1 (en) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
BR112019001887A2 (pt) 2016-08-02 2019-07-09 Editas Medicine Inc composições e métodos para o tratamento de doença associada a cep290
JP7100019B2 (ja) 2016-08-19 2022-07-12 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 選択的エストロゲン受容体モジュレーター(serm)は、光受容体の変性に対する保護を付与する
WO2018081504A1 (en) 2016-10-28 2018-05-03 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
WO2018204848A1 (en) 2017-05-05 2018-11-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (mbvs)
JP7221227B2 (ja) 2017-06-30 2023-02-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発毛を調節するための組成物及び方法
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
WO2019169291A1 (en) 2018-03-02 2019-09-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of il-34 to treat retinal inflammation and neurodegeneration
DE112019001996T5 (de) * 2018-04-18 2020-12-31 Nikon Corporation Bildverarbeitungsverfahren, Programm und Bildverarbeitungsvorrichtung
US20220079899A1 (en) * 2019-01-14 2022-03-17 The Regents Of The University Of California Compositions and methods for treating ocular conditions
KR20210133993A (ko) 2019-02-25 2021-11-08 에디타스 메디신, 인코포레이티드 Rho-연관 상염색체-우성 망막색소변성증(adrp)을 치료하기 위한 crispr/rna-가이드 뉴클레아제-관련 방법 및 조성물
EP4090381A1 (en) 2020-01-17 2022-11-23 The United States of America, as represented by the Secretary, Department of Health and Human Services <smallcaps/>? ? ?crx-? ? ? ? ?gene therapy for treatment ofautosomal dominant retinopathies
WO2022006439A2 (en) 2020-07-02 2022-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compound embodiments for treating retinal degeneration and method embodiments of making and using the same
US20240207448A1 (en) 2021-04-16 2024-06-27 Editas Medicine, Inc. Crispr/rna-guided nuclease-related methods and compositions for treating rho-associated autosomal-dominant retinitis pigmentosa (adrp)
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
WO2024196814A1 (en) 2023-03-17 2024-09-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for treatment of age-related macular degeneration

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3756478A (en) * 1971-02-03 1973-09-04 D Podell Eye drop dispenser with liquid metering device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
DE3905050A1 (de) 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii)
US4946450A (en) 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
ATE163531T1 (de) * 1989-08-14 1998-03-15 Photogenesis Inc Chirurgisches instrument und zellisolierung
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE4022553A1 (de) 1990-07-16 1992-01-23 Hund Helmut Gmbh Vorrichtung zur hochreproduzierbaren applikation definierter volumina von loesungen und suspensionen diagnostisch oder therapeutisch wirksamer substanzen auf der cornea-oberflaeche
US5290892A (en) 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5770592A (en) 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
US5679666A (en) * 1991-11-22 1997-10-21 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids
WO1993020785A1 (en) * 1992-04-20 1993-10-28 Basilice Vincent P Improvements in dispensing eye drops
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
FR2690846B1 (fr) 1992-05-05 1995-07-07 Aiache Jean Marc Forme galenique pour administration oculaire et procede de preparation.
US5387202A (en) * 1992-07-20 1995-02-07 Aaron Medical Industries Eye drop dispensing device
AU5092493A (en) 1992-09-08 1994-03-29 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
NZ256280A (en) * 1993-03-16 1997-05-26 Photogenesis Inc Eye graft; method and surgical instrument for forming a volute from donor eye tissue and inserting it into a host eye
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
NZ283658A (en) 1994-04-04 1999-09-29 William R Freeman Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides)
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5710165A (en) * 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
AU708529B2 (en) 1994-11-10 1999-08-05 University Of Kentucky Research Foundation, The Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
AU5857396A (en) 1995-05-14 1996-11-29 Optonol Ltd. Intraocular implant, delivery device, and method of implanta tion
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5743274A (en) 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5904144A (en) * 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
JP3309175B2 (ja) 1996-03-25 2002-07-29 参天製薬株式会社 タンパク性薬物含有強膜プラグ
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6120460A (en) * 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
DE69816980T2 (de) 1997-03-31 2004-07-22 Alza Corp., Palo Alto Implantierbares diffusionabgabesystem
JPH1170138A (ja) * 1997-07-02 1999-03-16 Santen Pharmaceut Co Ltd ポリ乳酸強膜プラグ
WO1999007418A2 (en) 1997-08-11 1999-02-18 Allergan Sales, Inc. Sterile bioerodible implant device with improved biocompatability and method
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
WO1999045920A2 (en) 1998-03-13 1999-09-16 Johns Hopkins University School Of Medicine The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
MXPA02002338A (es) * 1999-10-21 2002-07-30 Alcon Universal Ltd Dispositivo para la entrega de drogas.
RU2149615C1 (ru) 1999-11-10 2000-05-27 Нестеров Аркадий Павлович Способ введения лекарственных препаратов при заболеваниях заднего отрезка глаза
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
CA2420038C (en) * 2000-08-30 2010-11-09 John Hopkins University Devices for intraocular drug delivery

Also Published As

Publication number Publication date
EP1221919B1 (en) 2005-02-23
US20030003129A1 (en) 2003-01-02
JP4685311B2 (ja) 2011-05-18
BR0014928A (pt) 2002-10-01
HK1048428B (zh) 2005-08-26
US6669950B2 (en) 2003-12-30
PL196539B1 (pl) 2008-01-31
US20040131655A1 (en) 2004-07-08
KR20020060206A (ko) 2002-07-16
DK1221919T3 (da) 2005-06-20
ES2237463T3 (es) 2005-08-01
US20040131654A1 (en) 2004-07-08
AU2003262099A1 (en) 2003-12-04
US6416777B1 (en) 2002-07-09
PL355970A1 (en) 2004-05-31
TR200201046T2 (tr) 2002-08-21
JP2003511205A (ja) 2003-03-25
CN100341470C (zh) 2007-10-10
KR100752821B1 (ko) 2007-08-29
TW539560B (en) 2003-07-01
CN1376042A (zh) 2002-10-23
PT1221919E (pt) 2005-06-30
DE60018298T2 (de) 2006-01-12
AU2003262099B2 (en) 2005-05-26
WO2001028474A1 (en) 2001-04-26
AU1081201A (en) 2001-04-30
AU764226B2 (en) 2003-08-14
AR039130A2 (es) 2005-02-09
CA2384255C (en) 2010-01-26
EP1221919A1 (en) 2002-07-17
CA2384255A1 (en) 2001-04-26
BR0014928B1 (pt) 2008-11-18
HK1048428A1 (en) 2003-04-04
DE60018298D1 (de) 2005-03-31
ATE289500T1 (de) 2005-03-15

Similar Documents

Publication Publication Date Title
AR026183A1 (es) Dispositivo y metodo de administracion de medicamentos oftalmicos
AR039132A2 (es) Metodo para administrar un agente farmaceuticamente activo al ojo teniendo dicho ojo una esclerotica, una capsula de tenon y una macula
AR045039A1 (es) Dispositivo de administracion de drogas oftalmicas
KR101371685B1 (ko) 치료용 콘택트렌즈
DK1385452T3 (da) Anordning til tilförsel af et ophthalmisk medikament
AR036066A2 (es) Metodo para suministrar una droga a un ojo humano
BRPI0406486A (pt) Dispositivo de administração para medicamento fluido
AR031880A1 (es) Dispositivo de liberacion sustentada implantable para administrar localmente un medicamento
TW200605915A (en) Drug delivery compositions
WO2007100745A3 (en) Apparatus and formulations for suprachoroidal drug delivery
ES2571598T3 (es) Dispositivo de iontoforesis ocular que disminuye las irritaciones
TW200744574A (en) Use of L-carnitine or of alkanoyl L-carnitines for the preparation of a physiological supplement of medicament for ophthalmic use in the form of eye-drops
RU2009109358A (ru) Лечение глазных болезней
KR101427392B1 (ko) 치료용 콘택트렌즈
Donnenfeld et al. Safety and efficacy of nepafenac punctal plug delivery system in controlling postoperative ocular pain and inflammation after cataract surgery
US20200383946A1 (en) Lipoic acid formulations
SE9301877D0 (sv) In situ gel for therapeutic use
HN2001000038A (es) Sistema de administracion oral controlada para la ingestion diaria de ciprofloxacina
ES2512717T3 (es) Compuestos cíclicos peptidomiméticos para el tratamiento de la retinitis pigmentosa
Bellucci et al. Comparative efficacy of topical tetracaine solution versus lidocaine gel in cataract surgery
AR104177A1 (es) Sistema para la administración de fármacos en la glándula lagrimal
BR112021025291A2 (pt) Dispositivos de contenção de medicamento e composições associadas
KR102622048B1 (ko) 안구 치료용 구조체
Sussman The role of antidepressants in sexual dysfunction.
UA144734U (uk) Спосіб лікування вірусних інфекційних захворювань

Legal Events

Date Code Title Description
FG Grant, registration