ATE289500T1 - Ophtalmologische medikamentenzuführvorrichtung - Google Patents

Ophtalmologische medikamentenzuführvorrichtung

Info

Publication number
ATE289500T1
ATE289500T1 AT00972099T AT00972099T ATE289500T1 AT E289500 T1 ATE289500 T1 AT E289500T1 AT 00972099 T AT00972099 T AT 00972099T AT 00972099 T AT00972099 T AT 00972099T AT E289500 T1 ATE289500 T1 AT E289500T1
Authority
AT
Austria
Prior art keywords
delivery device
drug delivery
ophthalmological drug
ophthalmological
drug
Prior art date
Application number
AT00972099T
Other languages
English (en)
Inventor
Yoseph Yaacobi
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of ATE289500T1 publication Critical patent/ATE289500T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00885Methods or devices for eye surgery using laser for treating a particular disease
    • A61F2009/00891Glaucoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
AT00972099T 1999-10-21 2000-10-12 Ophtalmologische medikamentenzuführvorrichtung ATE289500T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16067399P 1999-10-21 1999-10-21
US09/664,790 US6416777B1 (en) 1999-10-21 2000-09-19 Ophthalmic drug delivery device
PCT/US2000/028187 WO2001028474A1 (en) 1999-10-21 2000-10-12 Ophthalmic drug delivery device

Publications (1)

Publication Number Publication Date
ATE289500T1 true ATE289500T1 (de) 2005-03-15

Family

ID=26857116

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00972099T ATE289500T1 (de) 1999-10-21 2000-10-12 Ophtalmologische medikamentenzuführvorrichtung

Country Status (19)

Country Link
US (4) US6416777B1 (de)
EP (1) EP1221919B1 (de)
JP (1) JP4685311B2 (de)
KR (1) KR100752821B1 (de)
CN (1) CN100341470C (de)
AR (2) AR026183A1 (de)
AT (1) ATE289500T1 (de)
AU (2) AU764226B2 (de)
BR (1) BR0014928B1 (de)
CA (1) CA2384255C (de)
DE (1) DE60018298T2 (de)
DK (1) DK1221919T3 (de)
ES (1) ES2237463T3 (de)
HK (1) HK1048428B (de)
PL (1) PL196539B1 (de)
PT (1) PT1221919E (de)
TR (1) TR200201046T2 (de)
TW (1) TW539560B (de)
WO (1) WO2001028474A1 (de)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040837A3 (de) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Medikamente zur Behandlung von Erkrankungen der Aderhaut des Auges
WO2000064389A1 (en) 1999-04-26 2000-11-02 Lynch Mary G Trabeculotomy device and method for treating glaucoma
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
AR030346A1 (es) 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
AU2002247284A1 (en) * 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
JP4264704B2 (ja) 2001-04-07 2009-05-20 グローコス コーポレーション 緑内障ステントおよび緑内障治療方法
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
CA2450771C (en) 2001-06-12 2010-09-07 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
CN100349562C (zh) * 2001-07-23 2007-11-21 爱尔康公司 眼部药物输送装置
AU2002319596B2 (en) 2001-07-23 2006-04-27 Alcon, Inc. Ophthalmic drug delivery device
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7749528B2 (en) * 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
BR0205990A (pt) * 2001-08-29 2004-01-13 Ricardo Azevedo Ponte Carvalho Um sistema implantável de liberação unidirecional de agentes terapêuticos para tecidos
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
KR101127502B1 (ko) * 2002-03-11 2012-03-23 알콘, 인코퍼레이티드 이식 가능한 약물 전달 시스템
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
WO2003092669A2 (en) * 2002-05-03 2003-11-13 Alcon, Inc. Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac
WO2004012742A1 (en) * 2002-08-05 2004-02-12 Alcon, Inc. Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration
DE10238310A1 (de) * 2002-08-21 2004-03-04 Erich Jaeger Gmbh Elektrodenanordnung
CA2689424A1 (en) * 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US20030187072A1 (en) * 2003-02-14 2003-10-02 Kapin Michael A. Method of treating angiogenesis-related disorders
US20040167109A1 (en) * 2003-02-20 2004-08-26 Bingaman David P Formulations of glucocorticoids to treat pathologic ocular angiogenesis
CN1750828A (zh) * 2003-02-20 2006-03-22 爱尔康公司 类固醇治疗眼病患者的用途
US20040236343A1 (en) * 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
RU2006101150A (ru) * 2003-06-13 2006-06-10 Алькон, Инк. (Ch) Композиции нестероидных противовоспалительных средств для лечения патологического ангиогенеза глаз
US20040258769A1 (en) * 2003-06-20 2004-12-23 Barker Ronnie C. Use of ocular vitamins in conjunction with other treatment methods for AMD
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
KR20060082792A (ko) * 2003-07-10 2006-07-19 알콘, 인코퍼레이티드 안과용 약물 전달 장치
CA2536454C (en) * 2003-08-26 2013-03-26 Vista Scientific Ocular drug delivery device
US7585517B2 (en) 2003-09-18 2009-09-08 Macusight, Inc. Transscleral delivery
US20050158365A1 (en) * 2003-12-22 2005-07-21 David Watson Drug delivery device with mechanical locking mechanism
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US9549895B2 (en) * 2004-04-23 2017-01-24 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
WO2006014484A2 (en) 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
US7722669B2 (en) * 2004-08-13 2010-05-25 Richard Foulkes Method and insert for modifying eye color
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
CN100428958C (zh) * 2004-09-06 2008-10-29 段亚东 一种治疗眼病的植入剂
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
BRPI0607606B1 (pt) 2005-02-09 2021-06-22 Santen Pharmaceutical, Co., Ltd. Formulação líquida
BRPI0609432A2 (pt) * 2005-03-21 2010-04-06 Macusight Inc sistemas de distribuição de fármacos para tratamento de doenças ou condições
US8003124B2 (en) 2005-04-08 2011-08-23 Surmodics, Inc. Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
AU2006272497B2 (en) 2005-07-27 2012-07-19 University Of Florida Research Foundation, Inc. Small compounds that correct protein misfolding and uses thereof
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
WO2007047626A1 (en) * 2005-10-14 2007-04-26 Alcon, Inc. Combination treatment with anecortave acetate and bevacizumab or ranibizumab for pathologic ocular angiogenesis
SI1968594T1 (sl) 2005-11-29 2011-01-31 Glaxosmithkline Llc Tretma okularnih neovaskularnih motenj, kot makularne degeneracije, angiodnih prog. uveitisa in makularnega edema
EP2001438A2 (de) * 2006-02-09 2008-12-17 Macusight, Inc. Stabile formulierungen sowie verfahren zu ihrer herstellung und verwendung
WO2007106557A2 (en) 2006-03-14 2007-09-20 University Of Southern California Mems device for delivery of therapeutic agents
JP5506378B2 (ja) 2006-03-23 2014-05-28 参天製薬株式会社 血管透過性に関連する疾患または病気のための製剤および方法
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
EP2019646A4 (de) * 2006-05-04 2013-12-04 Herbert Kaufman Verfahren, vorrichtung und system zur freisetzung eines therapeutischen wirkstoffes im auge
US8506515B2 (en) 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
WO2008063639A2 (en) 2006-11-21 2008-05-29 Massachusetts Eye And Ear Infirmary Compositions and methods for preserving cells of the eye
MX2009006146A (es) * 2006-12-18 2009-06-19 Alcon Res Ltd Dispositivos y metodos para la administracion de farmacos oftalmicos.
DE102007024642A1 (de) 2007-05-24 2008-11-27 Eyesense Ag Hydrogel-Implantat für Sensorik von Metaboliten am Auge
JP5542691B2 (ja) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア 治療薬を送達するための装置および方法
EP2727616B1 (de) * 2008-01-03 2017-04-26 University Of Southern California Implantierbare Wirkstofffreisetzungsvorrichtungen sowie Geräte und Verfahren zum Auffüllen der Vorrichtungen
CN102202708B (zh) * 2008-05-08 2015-01-21 迷你泵有限责任公司 药物输送泵及其制造方法
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2320989B1 (de) * 2008-05-08 2015-03-11 MiniPumps, LLC Implantierbare pumpen und kanülen dafür
US8348897B2 (en) 2008-05-08 2013-01-08 Minipumps, Llc Implantable drug-delivery devices, and apparatus and methods for filling the devices
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
WO2009140246A2 (en) 2008-05-12 2009-11-19 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
WO2010056677A1 (en) 2008-11-12 2010-05-20 Duke University Methods of inhibiting cancer cell growth with hdac inhibitors and methods of screening for hdac10 inhibitors
CA3045436A1 (en) 2009-01-29 2010-08-05 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP5695035B2 (ja) 2009-06-03 2015-04-01 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 前眼部薬物供給
IN2012DN00352A (de) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
AU2010284216B2 (en) 2009-08-18 2015-10-15 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
WO2011039648A1 (en) 2009-09-30 2011-04-07 Glaxo Wellcome Manufacturing Pte Ltd. Methods of administration and treatment
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US20130137642A1 (en) 2010-04-23 2013-05-30 Demetrios Vavvas Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells
WO2011146483A1 (en) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
HRP20211909T1 (hr) 2010-08-05 2022-03-18 Forsight Vision4, Inc. Uređaj za liječenja oka
EP2600876B1 (de) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Verfahren und vorrichtung zur verabreichung kombinierter arzneimittel
PL2600930T3 (pl) 2010-08-05 2021-09-06 Forsight Vision4, Inc. Urządzenie wstrzykujące do dostarczania leku
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US20120109054A1 (en) * 2010-10-29 2012-05-03 Vista Scientific Llc Devices with an erodible surface for delivering at least one active agent to tissue over a prolonged period of time
US20140024598A1 (en) 2010-11-01 2014-01-23 Demetrios Vavvas Methods and compositions for preserving retinal ganglion cells
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2720539B1 (de) 2011-06-14 2018-10-24 Bikam Pharmaceuticals, Inc. Opsinbindende liganden, deren zusammensetzungen und anwendungsverfahren
US20150005254A1 (en) 2011-06-27 2015-01-01 Massachusetts Eye And Ear Infirmary Methods for treating ocular inflammatory disorders
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
US9724357B2 (en) 2011-08-15 2017-08-08 Massachusetts Eye & Ear Infirmary Methods for preserving photoreceptor cell viability following retinal detachment
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
EP4193907A1 (de) 2011-09-13 2023-06-14 Glaukos Corporation Intraokularer physiologischer sensor
CA2848397C (en) 2011-09-14 2022-04-26 Forsight Vision5, Inc. Ocular insert apparatus and methods
LT2755600T (lt) 2011-09-16 2021-04-26 Forsight Vision4, Inc. Skysčio pakeitimo aparatas
AU2012325341B2 (en) 2011-10-19 2017-01-05 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
US20140357570A1 (en) 2011-10-21 2014-12-04 Massachusetts Eye And Ear Infirmary Compositions comprising necrosis inhibitors, such as necrostatins, alone or in combination, for promoting axon regeneration and nerve function, thereby treating cns disorders
EP2944628B1 (de) 2011-11-30 2017-01-04 Bikam Pharmaceuticals, Inc. Opsinbindende liganden, zusammensetzungen und verfahren zur verwendung
EP2785178B1 (de) 2011-12-01 2019-05-01 Bikam Pharmaceuticals, Inc. Opsinbindende liganden, zusammensetzungen damit und anwendungsverfahren dafür
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
HUE046128T2 (hu) 2012-10-26 2020-02-28 Forsight Vision5 Inc Szemészeti rendszer gyógyszer szembe való késleltetett kibocsátására
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
AU2014241163B2 (en) 2013-03-28 2018-09-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US10098836B2 (en) * 2013-05-02 2018-10-16 Retina Foundation Of The Southwest Method for forming a molded two-layer ocular implant
KR102523466B1 (ko) 2013-11-07 2023-04-20 에디타스 메디신, 인코포레이티드 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
WO2015103480A1 (en) 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
WO2015134812A1 (en) 2014-03-05 2015-09-11 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11141493B2 (en) 2014-03-10 2021-10-12 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
US9938521B2 (en) 2014-03-10 2018-04-10 Editas Medicine, Inc. CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
MY182497A (en) 2014-07-15 2021-01-25 Forsight Vision4 Inc Ocular implant delivery device and method
CA2957548A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
WO2016077371A1 (en) 2014-11-10 2016-05-19 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
US10010502B2 (en) 2015-05-19 2018-07-03 Amorphex Therapeutics Llc Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017075475A1 (en) 2015-10-30 2017-05-04 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
BR112018010063A2 (pt) 2015-11-20 2018-11-13 Forsight Vision4 Inc estruturas porosas para dispositivos de administração de medicamento de liberação estendida
CN105997338B (zh) * 2016-03-09 2019-04-26 泰山医学院 经玻璃体纳米材料给药系统
WO2017176886A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
EP3442479A1 (de) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Vorrichtung zur verabreichung eines bioresorbierbaren okularen medikaments
AU2017305404B2 (en) 2016-08-02 2023-11-30 Editas Medicine, Inc. Compositions and methods for treating CEP290 associated disease
EP3484463B1 (de) 2016-08-19 2020-02-12 The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer Selektive östrogenrezeptormodulatoren (serm) zur verleihung von schutz gegen photorezeptordegeneration
WO2018081504A1 (en) 2016-10-28 2018-05-03 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
EP3618841B1 (de) 2017-05-05 2023-03-22 University of Pittsburgh - of The Commonwealth System of Higher Education Okulare anwendungen von matrixgebundenen vesikeln (mbvs)
PE20200743A1 (es) 2017-06-30 2020-07-24 Univ California Composiciones y metodos para modular el crecimiento del cabello
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
US20210009651A1 (en) 2018-03-02 2021-01-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Se Use of il-34 to treat retinal inflammation and neurodegeneration
CN111989030B (zh) * 2018-04-18 2024-03-01 株式会社尼康 图像处理方法、程序及图像处理装置
US20220079899A1 (en) * 2019-01-14 2022-03-17 The Regents Of The University Of California Compositions and methods for treating ocular conditions
KR20210133993A (ko) 2019-02-25 2021-11-08 에디타스 메디신, 인코포레이티드 Rho-연관 상염색체-우성 망막색소변성증(adrp)을 치료하기 위한 crispr/rna-가이드 뉴클레아제-관련 방법 및 조성물
CA3165922A1 (en) 2020-01-17 2021-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene therapy for treatment of crx-autosomal dominant retinopathies
JP2023532134A (ja) 2020-07-02 2023-07-26 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 網膜変性の処置において使用するための環式化合物
WO2022221741A1 (en) 2021-04-16 2022-10-20 Editas Medicine, Inc. Crispr/rna-guided nuclease-related methods and compositions for treating rho-associated autosomal-dominant retinitis pigmentosa (adrp)

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3756478A (en) * 1971-02-03 1973-09-04 D Podell Eye drop dispenser with liquid metering device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
DE3905050A1 (de) 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii)
US4946450A (en) 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
ES2115594T3 (es) * 1989-08-14 1998-07-01 Photogenesis Inc Instrumentos quirurgicos y aislamiento de celulas.
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE4022553A1 (de) 1990-07-16 1992-01-23 Hund Helmut Gmbh Vorrichtung zur hochreproduzierbaren applikation definierter volumina von loesungen und suspensionen diagnostisch oder therapeutisch wirksamer substanzen auf der cornea-oberflaeche
US5290892A (en) 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5770592A (en) 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
US5679666A (en) * 1991-11-22 1997-10-21 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids
WO1993020785A1 (en) * 1992-04-20 1993-10-28 Basilice Vincent P Improvements in dispensing eye drops
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
FR2690846B1 (fr) 1992-05-05 1995-07-07 Aiache Jean Marc Forme galenique pour administration oculaire et procede de preparation.
US5387202A (en) * 1992-07-20 1995-02-07 Aaron Medical Industries Eye drop dispensing device
WO1994005257A1 (en) 1992-09-08 1994-03-17 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
AU685063B2 (en) * 1993-03-16 1998-01-15 Photogenesis, Incorporated Method for preparation and transplantation of volute grafts and surgical instrument therefor
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
EP0754046A1 (de) 1994-04-04 1997-01-22 FREEMAN, William R. Verwendung der phosphonylmethoxyalkyl-nukleoside zur behandlung des erhöhten innenaugendrucks
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5710165A (en) * 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
DK0788351T3 (da) 1994-11-10 2003-05-26 Univ Kentucky Res Found Implanterbar, genopfyldelig anordning til hastighedsreguleret lægemiddeladministration direkte til en indre del af kroppen
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
DE69633074T2 (de) 1995-05-14 2004-12-30 Optonol Ltd. Intraokulares implantat, einführgerät sowie implantierungsverfahren
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US5743274A (en) 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5904144A (en) * 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
JP3309175B2 (ja) 1996-03-25 2002-07-29 参天製薬株式会社 タンパク性薬物含有強膜プラグ
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6120460A (en) * 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
PT973499E (pt) 1997-03-31 2003-12-31 Alza Corp Sistema de administracao difusor implantavel
JPH1170138A (ja) * 1997-07-02 1999-03-16 Santen Pharmaceut Co Ltd ポリ乳酸強膜プラグ
CA2300154C (en) 1997-08-11 2008-07-08 Allergan Sales, Inc. Sterile bioerodible implant device with improved biocompatability and method
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
AU756515B2 (en) 1998-03-13 2003-01-16 Johns Hopkins University School Of Medicine, The The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
PT1473003E (pt) * 1999-10-21 2008-12-26 Alcon Inc Dispositivo para administração de fármacos
RU2149615C1 (ru) 1999-11-10 2000-05-27 Нестеров Аркадий Павлович Способ введения лекарственных препаратов при заболеваниях заднего отрезка глаза
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
DK1313415T3 (da) * 2000-08-30 2008-10-13 Univ Johns Hopkins Indretninger til intraokulær lægemiddeladministration

Also Published As

Publication number Publication date
HK1048428A1 (en) 2003-04-04
PL196539B1 (pl) 2008-01-31
DE60018298T2 (de) 2006-01-12
TW539560B (en) 2003-07-01
AR026183A1 (es) 2003-01-29
CN100341470C (zh) 2007-10-10
EP1221919B1 (de) 2005-02-23
US20040131654A1 (en) 2004-07-08
CA2384255A1 (en) 2001-04-26
AU2003262099B2 (en) 2005-05-26
US20040131655A1 (en) 2004-07-08
AU764226B2 (en) 2003-08-14
HK1048428B (zh) 2005-08-26
JP2003511205A (ja) 2003-03-25
US6669950B2 (en) 2003-12-30
BR0014928A (pt) 2002-10-01
AU1081201A (en) 2001-04-30
AU2003262099A1 (en) 2003-12-04
US6416777B1 (en) 2002-07-09
WO2001028474A1 (en) 2001-04-26
TR200201046T2 (tr) 2002-08-21
US20030003129A1 (en) 2003-01-02
KR100752821B1 (ko) 2007-08-29
AR039130A2 (es) 2005-02-09
PT1221919E (pt) 2005-06-30
DK1221919T3 (da) 2005-06-20
JP4685311B2 (ja) 2011-05-18
CN1376042A (zh) 2002-10-23
KR20020060206A (ko) 2002-07-16
PL355970A1 (en) 2004-05-31
ES2237463T3 (es) 2005-08-01
BR0014928B1 (pt) 2008-11-18
CA2384255C (en) 2010-01-26
DE60018298D1 (de) 2005-03-31
EP1221919A1 (de) 2002-07-17

Similar Documents

Publication Publication Date Title
ATE289500T1 (de) Ophtalmologische medikamentenzuführvorrichtung
DK1473003T3 (da) Lægemiddeladministrationsanordning
DK1409065T3 (da) Oftalmisk medikamentafgivelsesanordning
EE200200361A (et) Hüdrogeeli-juhitav ravimi doseerimise vahend
NO20004196D0 (no) Innretninger for legemiddelavlevering
DE60033176D1 (de) Medikamentspender
NO20020235D0 (no) Medisinsk anordning
NO20053224D0 (no) Patient controlled drug administration device.
AU2123200A (en) Drug delivery device
NO20041315L (no) Medikamentavleveringssystem
DE69923076D1 (de) Transthorakale arzneimittelabgabevorrichtung
AU4985600A (en) Drug delivery device
AU4947100A (en) Drug delivery device
NO20020531D0 (no) Beta-carbolin medikament produkter
EE05415B1 (et) Ravimi manustamise vahend, eriti androgeenide manustamiseks
FR2796287B1 (fr) Dispositif d'administration de medicament
DE10192797D2 (de) Drug-Delivery-Systeme
FR2820311B3 (fr) Distributeur de medicament portatif
DE60016530D1 (de) Verabreichungsvorrichtung für Medikamentenlösungen
NO20022013D0 (no) Transdermisk medikamentleveringsanordning
DK1183061T3 (da) Lægemiddelafgivelsessystem
DK1221917T3 (da) Anordning til lægemiddelafgivelse
SE0004677D0 (sv) Intraaxonal läkemedelsadministration
DE29901254U1 (de) Medizinisch therapeutisches Gerät
ITTO990393A0 (it) Apparecchio per infusione prolungata di farmaci

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1221919

Country of ref document: EP