AR020861A2 - Derivados de acido arilsulfonil hidroxamico y composicion que contiene los mismos - Google Patents

Derivados de acido arilsulfonil hidroxamico y composicion que contiene los mismos

Info

Publication number
AR020861A2
AR020861A2 ARP000102693A ARP000102693A AR020861A2 AR 020861 A2 AR020861 A2 AR 020861A2 AR P000102693 A ARP000102693 A AR P000102693A AR P000102693 A ARP000102693 A AR P000102693A AR 020861 A2 AR020861 A2 AR 020861A2
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
heteroaryl
piperazino
piperidyl
Prior art date
Application number
ARP000102693A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR020861A2 publication Critical patent/AR020861A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Un derivado del ácido arilsulfonil hidroxámico caracterizado por la formula (1) o las sales farmacéuticamente aceptables del mismo, en la que la líneadiscontinua representa un doble enlace opcional; X es carbono, oxígeno o azufre; Y es carbono, oxígeno, azufre, sulfoxido, sulfona o nitrogeno; R1, R2, R3, R4,R5, R6, R7, R8 y R9 se seleccionan entre el grupo formado por hidrogeno, alquilo de C1-6 opcionalmente sustituido por alquilamino de C1-6, tioalquilo de C1-6,alcoxi de C1-6, trifluorometilo,arilo de C6-10, heteroarilo de C5-9, arilamino de C6-10, tioarilo de C6-10, ariloxi de C6-10, heteroarilamino de C5-9,tioheteroarilo de C5-9, heteroariloxi de C5-9, (arilo de C6-10)-(arilo de C6-10), cicloalquilo de C3-6, hidroxialquilo de C1-6, (alquilo de C1-6)-(hidroximetileno), piperacinilo, (arilo de C6-10)-(alcoxi de C1-6), (heteroarilo de C5-9)-(alcoxi de C1-6), acilamino de C1-6, tioacilo de C1-6, aciloxi deC1-6, alquilsulfinilo de C1-6, arilsulfinilo de C6-10, alquilsulfonilo de C1-6, arilsulfonilo de C6-10, amino, alquilamino de C1-6 o (alquilamino de C1-6)2;alquenilo de C2-6 (arilo de C6-10)-(alquenilo de C2-6), (heteroarilo de C5-9)-(alquenilo de C2-6), alquinilo de C2-6, (arilo de C6-10)-(alquinilo de C2-6),(heteroarilo de C5-9)-(alquinilo de C2-6), alquilamino de C1-6, tioalquilo de C1-6, alcoxi de C1-6, trifluorometilo, (alquilo de C1-6)-(difluorometileno),(alquilo de C1-3)-(difluorometileno)-(alquilo de C1-3), arilo de C6-10, heteroarilo de C5-9, arilamino de C6-10, tioarilo de C6-10, ariloxi de C6-10,heteroarilamino de C5-9, tioheteroarilo de C5-9, heteroariloxi de C5-9, cicloalquilo de C3-6, (alquilo de C1-6)-(hidroximetileno), piperidilo, (alquilo deC1-6)piperidilo, acilamino de C1-6, tioacilo de C1-6, aciloxi de C1-6, R13(alquilo de C1-6), en el que R13 es (acilo de C1-6)piperacino, (arilo de C6-10)piperacino, (heteroarilo de C5-9)piperacino, (alquilo de C1-6)piperacino, (arilo de C6-10)-(alquilo de C1-6)piperacino, (heteroarilo de C5-9)-(alquilo de C1-6)piperacino, morfolino, tiomorfolino, piperidino, pirrolidino, piperidilo, (alquilo de C1-6)piperidilo, (arilo de C6-10)piperidilo, (heteroarilo de C5-9)
ARP000102693A 1995-04-20 2000-05-31 Derivados de acido arilsulfonil hidroxamico y composicion que contiene los mismos AR020861A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB1995/000279 WO1996033172A1 (en) 1995-04-20 1995-04-20 Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors
CA002218503A CA2218503C (en) 1995-04-20 1995-04-20 Arylsulfonyl hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
AR020861A2 true AR020861A2 (es) 2002-05-29

Family

ID=25679732

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102693A AR020861A2 (es) 1995-04-20 2000-05-31 Derivados de acido arilsulfonil hidroxamico y composicion que contiene los mismos

Country Status (28)

Country Link
US (1) US5861510A (es)
EP (1) EP0821671B1 (es)
JP (1) JP3053222B2 (es)
KR (1) KR100219976B1 (es)
CN (2) CN1123566C (es)
AR (1) AR020861A2 (es)
AT (1) ATE198326T1 (es)
AU (1) AU694635B2 (es)
BR (1) BR9602001A (es)
CA (1) CA2218503C (es)
CZ (1) CZ287551B6 (es)
DE (1) DE69519751T2 (es)
DK (1) DK0821671T3 (es)
ES (1) ES2153031T4 (es)
FI (1) FI973974A0 (es)
GR (1) GR3035347T3 (es)
IL (1) IL117868A (es)
MX (1) MX9708026A (es)
NO (1) NO306253B1 (es)
NZ (1) NZ286417A (es)
PL (1) PL184847B1 (es)
PT (1) PT821671E (es)
RU (1) RU2146671C1 (es)
SG (1) SG43350A1 (es)
TR (1) TR199600322A2 (es)
TW (1) TW418197B (es)
WO (1) WO1996033172A1 (es)
ZA (1) ZA963130B (es)

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