ES2035598T3 - Nuevos derivados heteroarotinoides, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados heteroarotinoides, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2035598T3 ES2035598T3 ES198989401016T ES89401016T ES2035598T3 ES 2035598 T3 ES2035598 T3 ES 2035598T3 ES 198989401016 T ES198989401016 T ES 198989401016T ES 89401016 T ES89401016 T ES 89401016T ES 2035598 T3 ES2035598 T3 ES 2035598T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- aminocarbonyl
- lower alkyl
- heteroarotinoid
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA GENERAL (I): EN LA QUE R REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, O UN AGRUPAMIENTO HIDROXI, ALCOILO INFERIOR, ALCOILOXI INFERIOR, CARBOXILO, ALCOILOXI INFERIOR CARBONIL, ARILALCOILOXI INFERIOR CARBONILO, AMINOCARBONILO, MONO O DIALCOILO INFERIOR AMINO CARBONILO, ARIL ALCOILO INFERIOR AMINO CARBONILO, N HETEROCICILAMINOCARBONIL, TIO, ALCOILO, INFERIOR TIO, SULFONILO, ALCOILO INFERIOR SULFONIL, R1, R2, R3, R4 IGUALES O DIFERENTES REPRESENTAN UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN AGRUPAMIENTO ALCOILO INFERIOR, ALQUENIL INFERIOR, ALCOILOXI INFERIOR O ALQUENILOXI INFERIOR, EVENTUALMENTE SUSTITUIDOS POR UNO O VARIOS ATOMOS DE HALOGENO, SUS ISOMEROS, ENANCIOMEROS, DIASTEREO ISOMEROS ASI COMO CUANDO R REPRESENTA UN CARBOXILO, SUS SALES DE ADICION A UNA BASE FARMACEUTICAMENTE ACEPTABLE, Y CUANDO R CONTIENE UN AGRUPAMIENTO BASICO, SUS SALES DE ADICION A UN ACIDO FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8804870A FR2630110B1 (fr) | 1988-04-13 | 1988-04-13 | Nouveaux derives heteroarotinoides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2035598T3 true ES2035598T3 (es) | 1993-04-16 |
Family
ID=9365267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198989401016T Expired - Lifetime ES2035598T3 (es) | 1988-04-13 | 1989-04-13 | Nuevos derivados heteroarotinoides, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4975455A (es) |
EP (1) | EP0338895B1 (es) |
JP (1) | JPH01305078A (es) |
AT (1) | ATE80881T1 (es) |
AU (1) | AU610379B2 (es) |
CA (1) | CA1326674C (es) |
DE (1) | DE68902946T2 (es) |
DK (1) | DK179289A (es) |
ES (1) | ES2035598T3 (es) |
FR (1) | FR2630110B1 (es) |
GR (1) | GR3006480T3 (es) |
IE (1) | IE64357B1 (es) |
NZ (1) | NZ228716A (es) |
OA (1) | OA09114A (es) |
PT (1) | PT90261B (es) |
ZA (1) | ZA892716B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2630111B1 (fr) * | 1988-04-13 | 1990-07-27 | Adir | Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5686465A (en) * | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
US5183827A (en) * | 1989-09-19 | 1993-02-02 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5250547A (en) * | 1991-08-29 | 1993-10-05 | Syntex (U.S.A.) Inc. | Benzopyran derivatives |
US6060503A (en) * | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
JPH0852659A (ja) * | 1994-08-08 | 1996-02-27 | Tousetsu Denki Kk | バイス |
US6586460B1 (en) | 2001-04-02 | 2003-07-01 | The Board Of Regents For Oklahoma State University | Heteroarotinoids containing urea or thiourea linker |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH651034A5 (de) * | 1982-05-12 | 1985-08-30 | Hoffmann La Roche | Chroman-, thiochroman- oder 1,2,3,4-tetrahydrochinolinderivate und ihre verwendung als arzneimittel-wirkstoffe. |
US4808597A (en) * | 1983-07-05 | 1989-02-28 | Pfizer Inc. | Method for inhibiting the degradation of cartilage |
JPS60178815A (ja) * | 1984-02-24 | 1985-09-12 | Rikagaku Kenkyusho | 制癌剤 |
US4826984A (en) * | 1984-04-09 | 1989-05-02 | The Board Of Regents For The Oklahoma Agricultural And Mechanical College Acting For And On Behalf Of Oklahoma State University | Heteroarotinoid compounds as anticancer agents |
FR2630111B1 (fr) * | 1988-04-13 | 1990-07-27 | Adir | Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2642065B1 (fr) * | 1989-01-24 | 1991-05-24 | Lipha | Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant |
-
1988
- 1988-04-13 FR FR8804870A patent/FR2630110B1/fr not_active Expired - Lifetime
-
1989
- 1989-04-10 CA CA000596390A patent/CA1326674C/fr not_active Expired - Fee Related
- 1989-04-11 US US07/336,224 patent/US4975455A/en not_active Expired - Fee Related
- 1989-04-12 IE IE116189A patent/IE64357B1/en not_active IP Right Cessation
- 1989-04-12 PT PT90261A patent/PT90261B/pt not_active IP Right Cessation
- 1989-04-12 AU AU32659/89A patent/AU610379B2/en not_active Ceased
- 1989-04-12 NZ NZ228716A patent/NZ228716A/en unknown
- 1989-04-13 OA OA59560A patent/OA09114A/xx unknown
- 1989-04-13 DE DE8989401016T patent/DE68902946T2/de not_active Expired - Fee Related
- 1989-04-13 EP EP89401016A patent/EP0338895B1/fr not_active Expired - Lifetime
- 1989-04-13 ES ES198989401016T patent/ES2035598T3/es not_active Expired - Lifetime
- 1989-04-13 AT AT89401016T patent/ATE80881T1/de not_active IP Right Cessation
- 1989-04-13 ZA ZA892716A patent/ZA892716B/xx unknown
- 1989-04-13 DK DK179289A patent/DK179289A/da not_active Application Discontinuation
- 1989-04-13 JP JP1094306A patent/JPH01305078A/ja active Granted
-
1992
- 1992-12-09 GR GR920402836T patent/GR3006480T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1326674C (fr) | 1994-02-01 |
GR3006480T3 (es) | 1993-06-21 |
ZA892716B (en) | 1989-12-27 |
IE64357B1 (en) | 1995-07-26 |
FR2630110A1 (fr) | 1989-10-20 |
JPH01305078A (ja) | 1989-12-08 |
DK179289A (da) | 1989-10-14 |
EP0338895A1 (fr) | 1989-10-25 |
NZ228716A (en) | 1990-11-27 |
DE68902946D1 (de) | 1992-10-29 |
PT90261B (pt) | 1994-07-29 |
JPH0585550B2 (es) | 1993-12-07 |
OA09114A (fr) | 1991-10-31 |
FR2630110B1 (fr) | 1990-07-27 |
DK179289D0 (da) | 1989-04-13 |
DE68902946T2 (de) | 1993-04-29 |
IE891161L (en) | 1989-10-13 |
ATE80881T1 (de) | 1992-10-15 |
EP0338895B1 (fr) | 1992-09-23 |
AU610379B2 (en) | 1991-05-16 |
PT90261A (pt) | 1989-11-10 |
US4975455A (en) | 1990-12-04 |
AU3265989A (en) | 1989-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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