AR019634A1 - Inhibidores de transcriptasa inversa del vih - Google Patents

Inhibidores de transcriptasa inversa del vih

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Publication number
AR019634A1
AR019634A1 ARP990102711A ARP990102711A AR019634A1 AR 019634 A1 AR019634 A1 AR 019634A1 AR P990102711 A ARP990102711 A AR P990102711A AR P990102711 A ARP990102711 A AR P990102711A AR 019634 A1 AR019634 A1 AR 019634A1
Authority
AR
Argentina
Prior art keywords
reverse transcriptase
multiple ligand
hiv
ligand compounds
hiv reverse
Prior art date
Application number
ARP990102711A
Other languages
English (en)
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of AR019634A1 publication Critical patent/AR019634A1/es

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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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Abstract

La presenta está relacionada con compuestos de ligaciones multiples que inhiben la enzima transcriptasa inversa del virus de inmunodeficiencia humana(VIH), una enzima que cataliza la conversion del RNA viral a DNA de un solo filamento. Los compuestosde ligaciones multiples de esta contienen de 2 a 10ligandos unidos covalentemente a uno o más enlazadores. Cada compuesto de ligaciones multiples contiene por lo menos un inhibidor nucleosido de transcriptasainversa y por lo menos un inhibidor no-nuu cleosido de transcriptasa inversa. Los compuestos de ligaciones multiples de esta son utiles para inhibir latranscriptasa inversa del VIH in vivo y, por lo tanto, inhiben la reproduccion del VIH in vivo.
ARP990102711A 1998-06-08 1999-06-08 Inhibidores de transcriptasa inversa del vih AR019634A1 (es)

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US8844898P 1998-06-08 1998-06-08
US9307298P 1998-07-16 1998-07-16

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AR019634A1 true AR019634A1 (es) 2002-02-27

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ID=26778665

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ARP990102707A AR018631A1 (es) 1998-06-08 1999-06-08 Compuesto de multiple ligamento, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento, metodo para la identifidicho compuesto y una biblioteca de dicho compuesto
ARP990102712A AR019635A1 (es) 1998-06-08 1999-06-08 Novedosos agentes antibacterianos
ARP990102711A AR019634A1 (es) 1998-06-08 1999-06-08 Inhibidores de transcriptasa inversa del vih

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ARP990102707A AR018631A1 (es) 1998-06-08 1999-06-08 Compuesto de multiple ligamento, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento, metodo para la identifidicho compuesto y una biblioteca de dicho compuesto
ARP990102712A AR019635A1 (es) 1998-06-08 1999-06-08 Novedosos agentes antibacterianos

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EP0989857A4 (en) 2001-01-17
US6288234B1 (en) 2001-09-11
EP1003541A1 (en) 2000-05-31
EP1085861A1 (en) 2001-03-28
AU4551899A (en) 1999-12-30
US6566509B1 (en) 2003-05-20
WO1999064047A1 (en) 1999-12-16
AU4674599A (en) 1999-12-30
CA2321274A1 (en) 1999-12-16
EP1005356B1 (en) 2006-04-12
EP1143991A2 (en) 2001-10-17
CA2321190A1 (en) 1999-12-16
NZ505979A (en) 2003-09-26
EP1005356A4 (en) 2001-08-22
WO1999064048A9 (en) 2000-07-20
EP0989857A1 (en) 2000-04-05
WO1999063929A9 (en) 2000-03-16
WO1999063937A3 (en) 2000-03-02
WO1999063937A9 (en) 2001-06-28
AU4677399A (en) 1999-12-30
SG106036A1 (en) 2004-09-30
PT1005356E (pt) 2006-07-31
WO1999063937A2 (en) 1999-12-16
DK1005356T3 (da) 2006-08-14
WO1999064033A1 (en) 1999-12-16
EP1083919A1 (en) 2001-03-21
WO1999064037A1 (en) 1999-12-16
HK1028737A1 (en) 2001-03-02
JP2002517422A (ja) 2002-06-18
CA2319477A1 (en) 1999-12-16
WO1999064033A9 (en) 2000-07-27
CA2316999A1 (en) 1999-12-16
EP1085891A1 (en) 2001-03-28

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