AP662A - Anhydrous crystalline valaciclovir hydrochloride. - Google Patents

Anhydrous crystalline valaciclovir hydrochloride. Download PDF

Info

Publication number
AP662A
AP662A APAP/P/1997/001058A AP9701058A AP662A AP 662 A AP662 A AP 662A AP 9701058 A AP9701058 A AP 9701058A AP 662 A AP662 A AP 662A
Authority
AP
ARIPO
Prior art keywords
valaciclovir
hydrochloride
valaciclovir hydrochloride
crystalline
anhydrous crystalline
Prior art date
Application number
APAP/P/1997/001058A
Other languages
English (en)
Other versions
AP9701058A0 (en
Inventor
Carter Barry Howard
Partin Jane Muse
Varlashkin Peter Gregory
Winnike Richard Augustus
Grubb William Bayne
Conway Gregory Alan
Lake Philip George
Skinner David Michael
Whatrup David James
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP662(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Publication of AP9701058A0 publication Critical patent/AP9701058A0/xx
Application granted granted Critical
Publication of AP662A publication Critical patent/AP662A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
APAP/P/1997/001058A 1995-01-20 1996-01-19 Anhydrous crystalline valaciclovir hydrochloride. AP662A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501178.9A GB9501178D0 (en) 1995-01-20 1995-01-20 Guanine derivative
PCT/GB1996/000117 WO1996022291A1 (en) 1995-01-20 1996-01-19 Guanine derivative

Publications (2)

Publication Number Publication Date
AP9701058A0 AP9701058A0 (en) 1997-10-31
AP662A true AP662A (en) 1998-08-19

Family

ID=10768347

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/001058A AP662A (en) 1995-01-20 1996-01-19 Anhydrous crystalline valaciclovir hydrochloride.

Country Status (40)

Country Link
US (1) US6107302A (cs)
EP (1) EP0804436B1 (cs)
JP (1) JP3176633B2 (cs)
KR (1) KR100376074B1 (cs)
CN (1) CN1049893C (cs)
AP (1) AP662A (cs)
AR (1) AR002270A1 (cs)
AT (1) ATE302777T1 (cs)
AU (1) AU702794B2 (cs)
BG (1) BG63393B1 (cs)
BR (1) BR9606768A (cs)
CA (1) CA2210799C (cs)
CY (1) CY2531B1 (cs)
CZ (1) CZ297065B6 (cs)
DE (1) DE69635106T2 (cs)
DK (1) DK0804436T3 (cs)
EA (1) EA000364B1 (cs)
EE (1) EE03528B1 (cs)
ES (1) ES2248806T3 (cs)
FI (1) FI973063A7 (cs)
GB (1) GB9501178D0 (cs)
GE (1) GEP20001940B (cs)
HR (1) HRP960024B1 (cs)
HU (1) HU222993B1 (cs)
IL (1) IL116831A (cs)
IN (1) IN182468B (cs)
IS (1) IS2268B (cs)
NO (1) NO315558B1 (cs)
NZ (1) NZ298851A (cs)
OA (1) OA10499A (cs)
PL (1) PL182175B1 (cs)
RO (1) RO118693B1 (cs)
RS (1) RS49518B (cs)
SI (1) SI0804436T1 (cs)
SK (1) SK285329B6 (cs)
TR (1) TR199700656T1 (cs)
UA (1) UA46001C2 (cs)
UY (1) UY25779A1 (cs)
WO (1) WO1996022291A1 (cs)
ZA (1) ZA96449B (cs)

Families Citing this family (61)

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GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
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CN1250449A (zh) * 1997-01-17 2000-04-12 味之素株式会社 新型z－伐昔洛韦结晶
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SK1592004A3 (sk) * 2001-09-07 2005-03-04 Teva Pharmaceutical Industries Ltd. Kryštalické formy valaciklovírus hydrochlóridu
AU2002348022B2 (en) * 2001-11-05 2006-06-15 Glaxo Group Limited Anhydrous crystal form of valaciclovir hydrochloride
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WO2004000265A2 (en) * 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
DE60307494D1 (de) * 2002-10-16 2006-09-21 Teva Pharma Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid
WO2004052892A1 (en) * 2002-12-09 2004-06-24 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
WO2004106338A1 (en) * 2003-05-30 2004-12-09 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Novel crystalline forms of valacyclovir hydrochloride
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EP1706406A1 (en) * 2004-01-21 2006-10-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valacyclovir hydrochloride
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EP1761535A1 (en) * 2004-06-30 2007-03-14 Teva Pharmaceutical Industries Ltd Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
EP1891071B1 (en) * 2005-05-25 2012-02-22 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
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DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN103951667A (zh) * 2006-05-04 2014-07-30 勃林格殷格翰国际有限公司 多晶型
CN1903854B (zh) * 2006-08-09 2012-05-23 丽珠医药集团股份有限公司 一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) * 2007-05-30 2007-07-11 Univ Birmingham Use of antivirals in the treatment of medical disorders
BRPI0815405A2 (pt) * 2007-08-17 2015-02-03 Boehringer Ingelheim Int Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
JPWO2009031576A1 (ja) * 2007-09-03 2010-12-16 味の素株式会社 バラシクロビル塩酸塩結晶の製造方法
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
PE20140960A1 (es) * 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
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CA2736421A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CA2745037C (en) 2008-12-23 2020-06-23 Boehringer Ingelheim International Gmbh Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
CN102946875A (zh) 2010-05-05 2013-02-27 贝林格尔.英格海姆国际有限公司 组合疗法
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
ES2802243T3 (es) 2010-06-24 2021-01-18 Boehringer Ingelheim Int Terapia para la diabetes
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
MX366629B (es) 2011-07-15 2019-07-17 Boehringer Ingelheim Int Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.
US20140296520A1 (en) * 2011-11-25 2014-10-02 Piramal Enterprises Limited Process for the preparation of valacyclovir hydrochloride
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
EP3110449B1 (en) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Medical use of a dpp-4 inhibitor
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994029311A1 (en) * 1993-06-10 1994-12-22 Farmhispania Sa Amino acid ester of nucleoside analogues
EP0308065B1 (en) * 1987-08-15 1995-01-04 The Wellcome Foundation Limited Therapeutic nucleosides
WO1996022291A1 (en) * 1995-01-20 1996-07-25 The Wellcome Foundation Limited Guanine derivative

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0308065B1 (en) * 1987-08-15 1995-01-04 The Wellcome Foundation Limited Therapeutic nucleosides
EP0596542B1 (en) * 1987-08-15 1996-05-29 The Wellcome Foundation Limited Therapeutic nucleosides
WO1994029311A1 (en) * 1993-06-10 1994-12-22 Farmhispania Sa Amino acid ester of nucleoside analogues
WO1996022291A1 (en) * 1995-01-20 1996-07-25 The Wellcome Foundation Limited Guanine derivative

Also Published As

Publication number Publication date
CA2210799A1 (en) 1996-07-25
ES2248806T3 (es) 2006-03-16
NZ298851A (en) 1999-01-28
EP0804436A1 (en) 1997-11-05
EE9700175A (et) 1998-02-16
ATE302777T1 (de) 2005-09-15
SK285329B6 (sk) 2006-11-03
KR100376074B1 (ko) 2003-06-02
EE03528B1 (et) 2001-10-15
ZA96449B (en) 1996-08-07
FI973063L (fi) 1997-09-18
EA199700124A1 (ru) 1997-12-30
NO973326L (no) 1997-09-16
DK0804436T3 (da) 2005-12-27
HUP9801836A2 (hu) 1999-05-28
HU222993B1 (hu) 2004-01-28
BR9606768A (pt) 1997-12-30
GB9501178D0 (en) 1995-03-08
SI0804436T1 (sl) 2006-02-28
BG101833A (bg) 1998-04-30
JP3176633B2 (ja) 2001-06-18
HUP9801836A3 (en) 1999-06-28
SK96597A3 (en) 1998-02-04
PL321326A1 (en) 1997-12-08
DE69635106D1 (de) 2005-09-29
EP0804436B1 (en) 2005-08-24
NO315558B1 (no) 2003-09-22
CY2531B1 (en) 2006-04-12
HRP960024A2 (en) 1997-10-31
UA46001C2 (uk) 2002-05-15
WO1996022291A1 (en) 1996-07-25
IL116831A (en) 1998-10-30
CA2210799C (en) 2008-06-10
RS49518B (sr) 2006-10-27
KR19980701525A (ko) 1998-05-15
NO973326D0 (no) 1997-07-18
IN182468B (cs) 1999-04-17
IS4527A (is) 1997-07-15
AU702794B2 (en) 1999-03-04
HRP960024B1 (en) 2005-08-31
CZ297065B6 (cs) 2006-08-16
AU4453996A (en) 1996-08-07
AP9701058A0 (en) 1997-10-31
GEP20001940B (en) 2000-02-05
CN1179159A (zh) 1998-04-15
IL116831A0 (en) 1996-05-14
YU3396A (sh) 1998-12-23
CZ229497A3 (en) 1997-12-17
MX9705462A (es) 1997-10-31
RO118693B1 (ro) 2003-09-30
DE69635106T2 (de) 2006-06-08
FI973063A7 (fi) 1997-09-18
FI973063A0 (fi) 1997-07-18
AR002270A1 (es) 1998-03-11
EA000364B1 (ru) 1999-06-24
PL182175B1 (pl) 2001-11-30
BG63393B1 (bg) 2001-12-29
CN1049893C (zh) 2000-03-01
UY25779A1 (es) 2000-08-21
US6107302A (en) 2000-08-22
TR199700656T1 (xx) 1998-03-21
JPH11503718A (ja) 1999-03-30
OA10499A (en) 2002-04-10
IS2268B (is) 2007-07-15

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