AP2052A - Pseudopolymorphic forms of HIV protease inhibitor - Google Patents

Pseudopolymorphic forms of HIV protease inhibitor

Info

Publication number
AP2052A
AP2052A AP2004003191A AP2004003191A AP2052A AP 2052 A AP2052 A AP 2052A AP 2004003191 A AP2004003191 A AP 2004003191A AP 2004003191 A AP2004003191 A AP 2004003191A AP 2052 A AP2052 A AP 2052A
Authority
AP
ARIPO
Prior art keywords
protease inhibitor
hiv protease
pseudopolymorphic forms
pseudopolymorphic
forms
Prior art date
Application number
AP2004003191A
Other languages
English (en)
Other versions
AP2004003191A0 (en
Inventor
Hans Wim Pieter Vermeersch
Daniel Joseph Christiaan Thone
Luc Donne Marie-Louise Janssens
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29724454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2052(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AP2004003191A0 publication Critical patent/AP2004003191A0/xx
Application granted granted Critical
Publication of AP2052A publication Critical patent/AP2052A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AP2004003191A 2002-05-16 2003-05-16 Pseudopolymorphic forms of HIV protease inhibitor AP2052A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076929 2002-05-16
PCT/EP2003/050176 WO2003106461A2 (en) 2002-05-16 2003-05-16 Pseudopolymorphic forms of a hiv protease inhibitor

Publications (2)

Publication Number Publication Date
AP2004003191A0 AP2004003191A0 (en) 2004-12-31
AP2052A true AP2052A (en) 2009-10-05

Family

ID=29724454

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2004003191A AP2052A (en) 2002-05-16 2003-05-16 Pseudopolymorphic forms of HIV protease inhibitor

Country Status (26)

Country Link
US (8) US7700645B2 (de)
EP (4) EP1567529B2 (de)
JP (1) JP4864320B2 (de)
KR (2) KR20100119906A (de)
CN (1) CN100475819C (de)
AP (1) AP2052A (de)
AU (2) AU2003271740B2 (de)
BR (1) BRPI0311176B8 (de)
CA (1) CA2485834C (de)
CY (3) CY1115665T1 (de)
DK (3) DK1567529T4 (de)
EA (1) EA007120B8 (de)
ES (4) ES2638412T3 (de)
HK (1) HK1081969A1 (de)
HR (1) HRP20041061B1 (de)
HU (1) HUE034389T2 (de)
IL (1) IL165140A0 (de)
LT (1) LT2767539T (de)
MX (1) MXPA04011427A (de)
NO (1) NO331477B1 (de)
NZ (1) NZ536497A (de)
PL (1) PL215151B1 (de)
PT (3) PT2314591E (de)
SI (3) SI2314591T2 (de)
WO (1) WO2003106461A2 (de)
ZA (1) ZA200410154B (de)

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* Cited by examiner, † Cited by third party
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PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
SI2314591T2 (sl) * 2002-05-16 2021-08-31 Janssen Sciences Ireland Unlimited Company Psevdopolimorfne oblike zaviralca HIV proteaze
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
PT1856125E (pt) 2005-02-25 2009-11-06 Tibotec Pharm Ltd Síntese de precursor de inibidor de proteases
DE602007012365D1 (de) * 2006-11-09 2011-03-17 Little Island Co Cork Verfahren zur herstellung von hexahydrofuroä2,3-büfuran-3-ol
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
AU2009339140A1 (en) * 2009-01-29 2011-08-11 Mapi Pharma Limited Polymorphs of darunavir
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2477992T3 (pl) 2009-09-17 2017-07-31 Mylan Laboratories Limited Proces przygotowania Darunawiru i jego amorficznych postaci
US9062065B2 (en) 2009-10-30 2015-06-23 Lupin Limited Process for preparation of darunavir and darunavir ethanolate of fine particle size
ES2546866T3 (es) 2009-12-16 2015-09-29 Hetero Research Foundation Polimorfos de darunavir
WO2011083287A2 (en) * 2010-01-05 2011-07-14 Cipla Limited Darunavir polymorph and process for preparation thereof
US8829208B2 (en) 2010-01-28 2014-09-09 Mapi Pharma Ltd. Process for the preparation of darunavir and darunavir intermediates
US8853430B2 (en) * 2010-05-20 2014-10-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir
WO2012107889A1 (en) 2011-02-10 2012-08-16 Ranbaxy Laboratories Limited Process for the preparation of amorphous darunavir
PL2729130T3 (pl) 2011-07-07 2018-02-28 Janssen Sciences Ireland Uc Preparaty kombinowane darunawiru
US9216990B2 (en) 2011-12-05 2015-12-22 Mylan Labs Limited Crystalline Darunavir
EP2804869B1 (de) * 2012-01-18 2019-06-12 Aurobindo Pharma Limited Neuartige solvate von darunavir
CN103509031B (zh) * 2012-06-20 2016-04-27 上海迪赛诺药业有限公司 制备达芦那韦无定形物的方法
WO2014016660A2 (en) * 2012-07-24 2014-01-30 Laurus Labs Private Limited A process for preparation of darunavir
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
US9346820B2 (en) * 2013-09-11 2016-05-24 Purdue Research Foundation HIV-1 protease inhibitors having gem-di-fluoro bicyclic P2-ligands
WO2016092525A1 (en) 2014-12-12 2016-06-16 Lupin Limited Darunavir n-propanol solvate and process for preparation thereof
WO2016092527A1 (en) * 2014-12-12 2016-06-16 Sun Pharmaceutical Industries Limited A process for the preparation of dolutegravir
LT3271347T (lt) 2015-03-19 2022-10-10 Mycovia Pharmaceuticals, Inc. Priešgrybeliniai junginiai ir jų gamybos būdai
US11045423B2 (en) 2016-08-08 2021-06-29 Hetero Labs Limited Anti-retroviral compositions
US20190175511A1 (en) 2016-08-08 2019-06-13 Hetero Labs Limited A Multi-Class Anti-Retroviral Composition
WO2018081292A1 (en) 2016-10-27 2018-05-03 Gilead Sciences, Inc. Crystalline forms of darunavir free base, hydrate, solvates and salts
CN108727401A (zh) * 2017-04-20 2018-11-02 盐城迪赛诺制药有限公司 达鲁那韦新晶型及其制备方法和应用
CN109053753A (zh) * 2018-08-05 2018-12-21 浙江大学 一种制备达卢那韦二水合物晶型的方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1999067417A2 (en) * 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods

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US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
JPH05230044A (ja) 1992-02-21 1993-09-07 Hoechst Japan Ltd ピレタニドの新規な結晶多形
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6096779A (en) * 1995-02-22 2000-08-01 Hoechst Pharmaceuticals & Chemicals K.K. Amorphous piretanide, piretanide polymorphs, process for their preparation and their use
ZA984514B (en) * 1997-05-29 1998-11-30 Merck & Co Inc Hiv protease inhibitor
GB9712253D0 (en) 1997-06-13 1997-08-13 Glaxo Group Ltd Antiviral compound
US6287693B1 (en) * 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
GB9805898D0 (en) * 1998-03-20 1998-05-13 Glaxo Group Ltd Process for the sythesis of hiv protease inhibitors
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
BR9916750A (pt) 1998-11-19 2001-11-06 Du Pont Pharm Co Compostos inibidores de transcriptase reversa, composições farmacêuticas, métodos de tratamento de infecções por vìrus da imunodeficiência humana, processos de preparação do composto e forma cristalina do mesmo
ATE311391T1 (de) 1999-02-12 2005-12-15 Vertex Pharma Aspartyl-protease-inhibitoren
SI2314591T2 (sl) 2002-05-16 2021-08-31 Janssen Sciences Ireland Unlimited Company Psevdopolimorfne oblike zaviralca HIV proteaze
WO2011083287A2 (en) * 2010-01-05 2011-07-14 Cipla Limited Darunavir polymorph and process for preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1999067417A2 (en) * 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Borka L et al *
Ghosh A K et al *
Giron et al *
Grunenberg A et al *

Also Published As

Publication number Publication date
AU2012205289A1 (en) 2012-08-09
US10000504B2 (en) 2018-06-19
ES2503551T3 (es) 2014-10-07
HRP20041061B1 (hr) 2015-02-27
EP2314591B1 (de) 2014-06-18
EA200401503A1 (ru) 2005-06-30
HRP20041061A2 (en) 2006-07-31
NO331477B1 (no) 2012-01-16
US20170260196A1 (en) 2017-09-14
SI2314591T2 (sl) 2021-08-31
AU2003271740B2 (en) 2010-05-13
JP2005533068A (ja) 2005-11-04
EP2314591A1 (de) 2011-04-27
CA2485834A1 (en) 2003-12-24
CY1119311T1 (el) 2018-02-14
ES2503551T5 (es) 2021-10-28
PL215151B1 (pl) 2013-10-31
US7700645B2 (en) 2010-04-20
PT2314591E (pt) 2014-09-19
EP1567529A2 (de) 2005-08-31
EA007120B1 (ru) 2006-06-30
BRPI0311176B1 (pt) 2019-08-20
EP2314591B2 (de) 2021-02-24
ES2728735T3 (es) 2019-10-28
WO2003106461A2 (en) 2003-12-24
DK2314591T3 (da) 2014-09-22
SI1567529T1 (sl) 2014-11-28
IL165140A0 (en) 2005-12-18
EP3045460A1 (de) 2016-07-20
KR20050008715A (ko) 2005-01-21
CY1115665T1 (el) 2017-01-25
EA007120B8 (ru) 2012-03-30
AU2003271740A1 (en) 2003-12-31
MXPA04011427A (es) 2005-02-17
JP4864320B2 (ja) 2012-02-01
BR0311176A (pt) 2005-03-15
SI1567529T2 (sl) 2021-08-31
DK2767539T3 (en) 2017-09-11
CN1668623A (zh) 2005-09-14
US20140171499A1 (en) 2014-06-19
EP1567529B2 (de) 2021-02-24
AP2004003191A0 (en) 2004-12-31
US8518987B2 (en) 2013-08-27
CN100475819C (zh) 2009-04-08
DK1567529T3 (da) 2014-09-15
WO2003106461A3 (en) 2004-05-13
ES2638412T3 (es) 2017-10-20
KR20100119906A (ko) 2010-11-11
EP3045460B1 (de) 2019-04-17
EP1567529B1 (de) 2014-06-18
ES2498370T5 (es) 2021-11-24
US20180312517A1 (en) 2018-11-01
ZA200410154B (en) 2005-12-28
CY1117928T1 (el) 2017-05-17
NZ536497A (en) 2006-08-31
US20050250845A1 (en) 2005-11-10
HUE034389T2 (en) 2018-02-28
KR101128370B1 (ko) 2012-04-23
US20210179631A1 (en) 2021-06-17
DK2314591T4 (da) 2021-05-10
US20150336980A1 (en) 2015-11-26
NO20045409L (no) 2004-12-10
CA2485834C (en) 2007-07-17
LT2767539T (lt) 2017-09-25
ES2498370T3 (es) 2014-09-24
US20100204316A1 (en) 2010-08-12
SI2314591T1 (sl) 2014-11-28
DK1567529T4 (da) 2021-05-10
US10858369B2 (en) 2020-12-08
SI2767539T1 (sl) 2017-10-30
BRPI0311176B8 (pt) 2021-05-25
EP2767539B1 (de) 2017-07-12
PT1567529E (pt) 2014-09-09
HK1081969A1 (en) 2006-05-26
PL374321A1 (en) 2005-10-17
PT2767539T (pt) 2017-08-28
US20130303790A1 (en) 2013-11-14
EP2767539A1 (de) 2014-08-20

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