PL2477992T3 - Proces przygotowania Darunawiru i jego amorficznych postaci - Google Patents
Proces przygotowania Darunawiru i jego amorficznych postaciInfo
- Publication number
- PL2477992T3 PL2477992T3 PL10795061T PL10795061T PL2477992T3 PL 2477992 T3 PL2477992 T3 PL 2477992T3 PL 10795061 T PL10795061 T PL 10795061T PL 10795061 T PL10795061 T PL 10795061T PL 2477992 T3 PL2477992 T3 PL 2477992T3
- Authority
- PL
- Poland
- Prior art keywords
- darunavir
- processes
- preparation
- amorphous form
- amorphous
- Prior art date
Links
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 title 1
- 229960005107 darunavir Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2257CH2009 | 2009-09-17 | ||
| IN54CH2010 | 2010-01-08 | ||
| IN939CH2010 | 2010-04-05 | ||
| EP10795061.0A EP2477992B1 (en) | 2009-09-17 | 2010-09-16 | Processes for the preparation of darunavir and the amorphous form thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2477992T3 true PL2477992T3 (pl) | 2017-07-31 |
Family
ID=43501151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10795061T PL2477992T3 (pl) | 2009-09-17 | 2010-09-16 | Proces przygotowania Darunawiru i jego amorficznych postaci |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8703980B2 (pl) |
| EP (1) | EP2477992B1 (pl) |
| CA (1) | CA2776807C (pl) |
| DK (1) | DK2477992T3 (pl) |
| ES (1) | ES2619562T3 (pl) |
| HR (1) | HRP20170392T1 (pl) |
| PL (1) | PL2477992T3 (pl) |
| PT (1) | PT2477992T (pl) |
| SI (1) | SI2477992T1 (pl) |
| WO (1) | WO2011048604A2 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2381786B1 (en) * | 2009-01-29 | 2014-12-24 | Mapi Pharma Limited | Dimethylsulfoxide solvate of darunavir |
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| WO2011051978A2 (en) * | 2009-10-30 | 2011-05-05 | Lupin Limited | A novel process for preparation of darunavir and darunavir ethanolate of fine particle size |
| CA2785998A1 (en) * | 2010-01-05 | 2011-07-14 | Cipla Limited | Darunavir polymorph and process for preparation thereof |
| BR112012018862A2 (pt) | 2010-01-28 | 2015-10-13 | Mapi Pharma Ltd | processo para a preparação de darunavir e intermediários de darunavir |
| WO2012107889A1 (en) * | 2011-02-10 | 2012-08-16 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous darunavir |
| PL2729128T3 (pl) * | 2011-07-07 | 2017-05-31 | Janssen Sciences Ireland Uc | Preparat darunawiru |
| PT2729130T (pt) * | 2011-07-07 | 2017-12-13 | Gilead Sciences Inc | Formulações de combinação de darunavir |
| WO2013011485A1 (en) | 2011-07-20 | 2013-01-24 | Ranbaxy Laboratories Limited | Process for the preparation of sulfonamides useful as retroviral protease inhibitors |
| WO2013114382A1 (en) * | 2011-12-05 | 2013-08-08 | Mylan Laboratories Ltd | Crystalline darunavir |
| WO2013189049A1 (zh) * | 2012-06-20 | 2013-12-27 | 上海迪赛诺药业有限公司 | 制备达芦那韦无定形物的方法 |
| CN103509031B (zh) * | 2012-06-20 | 2016-04-27 | 上海迪赛诺药业有限公司 | 制备达芦那韦无定形物的方法 |
| WO2014016660A2 (en) | 2012-07-24 | 2014-01-30 | Laurus Labs Private Limited | A process for preparation of darunavir |
| US20160075643A1 (en) * | 2014-09-16 | 2016-03-17 | Zcl Chemicals Limited | Novel process to prepare intermediates of hiv-protease inhibitors thereof |
| CN106854212A (zh) * | 2015-12-08 | 2017-06-16 | 浙江九洲药业股份有限公司 | 一种达芦那韦无定型的制备方法 |
| CN107021919A (zh) * | 2016-01-29 | 2017-08-08 | 上海医药工业研究院 | 一种阿扎那韦原料药杂质或其盐、其制备方法和应用 |
| CN107235987A (zh) * | 2016-03-28 | 2017-10-10 | 浙江九洲药业股份有限公司 | 一种地瑞那韦甲醇溶剂化物及其制备方法和用途 |
| WO2018015929A1 (en) * | 2016-07-22 | 2018-01-25 | Granules India Limited | A novel process for the preparation of hiv protease inhibitor and intermediates thereof |
| US10407438B2 (en) | 2016-10-27 | 2019-09-10 | Gilead Sciences, Inc. | Crystalline forms of darunavir |
| CN108794498A (zh) * | 2017-05-03 | 2018-11-13 | 江苏瑞科医药科技有限公司 | 一种达芦那韦无定型的制备方法 |
| CN108822123A (zh) * | 2018-09-06 | 2018-11-16 | 南通雅本化学有限公司 | 一种地瑞那韦的制备方法 |
| CN111039951A (zh) * | 2019-12-16 | 2020-04-21 | 上海雅本化学有限公司 | 一种地瑞那韦的制备方法 |
| CN114685322B (zh) * | 2020-12-30 | 2023-08-25 | 上海飞腾医药科技有限公司 | 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| SI1567529T2 (sl) * | 2002-05-16 | 2021-08-31 | Janssen Sciences Ireland Unlimited Company | Psevdopolimorfne oblike zaviralca HIV proteaze |
| BRPI0417272B8 (pt) | 2003-12-23 | 2021-05-25 | Janssen R&D Ireland | processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato |
| US20080014280A1 (en) * | 2006-07-17 | 2008-01-17 | Glenmark Pharmaceuticals Limited | Amorphous pregabalin and process for the preparation thereof |
| US20080014263A1 (en) * | 2006-07-17 | 2008-01-17 | Glenmark Pharmaceuticals Limited | Amorphous eprosartan mesylate and process for the preparation thereof |
| EP2381786B1 (en) | 2009-01-29 | 2014-12-24 | Mapi Pharma Limited | Dimethylsulfoxide solvate of darunavir |
| WO2011017395A1 (en) * | 2009-08-04 | 2011-02-10 | Glaxosmithkline Llc | Chemical compounds |
-
2010
- 2010-09-16 DK DK10795061.0T patent/DK2477992T3/en active
- 2010-09-16 ES ES10795061.0T patent/ES2619562T3/es active Active
- 2010-09-16 CA CA2776807A patent/CA2776807C/en not_active Expired - Fee Related
- 2010-09-16 US US13/496,642 patent/US8703980B2/en active Active
- 2010-09-16 EP EP10795061.0A patent/EP2477992B1/en not_active Not-in-force
- 2010-09-16 SI SI201031422A patent/SI2477992T1/sl unknown
- 2010-09-16 PL PL10795061T patent/PL2477992T3/pl unknown
- 2010-09-16 WO PCT/IN2010/000625 patent/WO2011048604A2/en not_active Ceased
- 2010-09-16 HR HRP20170392TT patent/HRP20170392T1/hr unknown
- 2010-09-16 PT PT107950610T patent/PT2477992T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2477992T (pt) | 2017-03-20 |
| WO2011048604A2 (en) | 2011-04-28 |
| EP2477992B1 (en) | 2016-12-14 |
| SI2477992T1 (sl) | 2017-05-31 |
| CA2776807C (en) | 2018-10-16 |
| DK2477992T3 (en) | 2017-03-27 |
| ES2619562T3 (es) | 2017-06-26 |
| CA2776807A1 (en) | 2011-04-28 |
| US8703980B2 (en) | 2014-04-22 |
| US20120251826A1 (en) | 2012-10-04 |
| EP2477992A2 (en) | 2012-07-25 |
| WO2011048604A3 (en) | 2011-09-09 |
| HRP20170392T1 (hr) | 2017-06-02 |
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