SI2477992T1 - Postopki za pripravo darunavirja in njega amorfne oblike - Google Patents

Postopki za pripravo darunavirja in njega amorfne oblike

Info

Publication number
SI2477992T1
SI2477992T1 SI201031422A SI201031422A SI2477992T1 SI 2477992 T1 SI2477992 T1 SI 2477992T1 SI 201031422 A SI201031422 A SI 201031422A SI 201031422 A SI201031422 A SI 201031422A SI 2477992 T1 SI2477992 T1 SI 2477992T1
Authority
SI
Slovenia
Prior art keywords
darunavir
processes
preparation
amorphous form
amorphous
Prior art date
Application number
SI201031422A
Other languages
English (en)
Inventor
Siva Rama Prasad Vellanki
Arabinda Sahu
Aravind Kumar Katukuri
Vikram Vanama
Satishbabu Kothari
Venkata Suryanarayana Ponnekanti
Debashish Datta
Original Assignee
Mylan Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Limited filed Critical Mylan Laboratories Limited
Publication of SI2477992T1 publication Critical patent/SI2477992T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201031422A 2009-09-17 2010-09-16 Postopki za pripravo darunavirja in njega amorfne oblike SI2477992T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2257CH2009 2009-09-17
IN54CH2010 2010-01-08
IN939CH2010 2010-04-05
PCT/IN2010/000625 WO2011048604A2 (en) 2009-09-17 2010-09-16 An improved process for the preparation of darunavir
EP10795061.0A EP2477992B1 (en) 2009-09-17 2010-09-16 Processes for the preparation of darunavir and the amorphous form thereof

Publications (1)

Publication Number Publication Date
SI2477992T1 true SI2477992T1 (sl) 2017-05-31

Family

ID=43501151

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031422A SI2477992T1 (sl) 2009-09-17 2010-09-16 Postopki za pripravo darunavirja in njega amorfne oblike

Country Status (10)

Country Link
US (1) US8703980B2 (sl)
EP (1) EP2477992B1 (sl)
CA (1) CA2776807C (sl)
DK (1) DK2477992T3 (sl)
ES (1) ES2619562T3 (sl)
HR (1) HRP20170392T1 (sl)
PL (1) PL2477992T3 (sl)
PT (1) PT2477992T (sl)
SI (1) SI2477992T1 (sl)
WO (1) WO2011048604A2 (sl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2381786T3 (pl) * 2009-01-29 2015-06-30 Mapi Pharma Ltd Dimetylosulfotlenkowy solwat darunawiru
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
BR112012009956A2 (pt) 2009-10-30 2015-09-29 Lupin Ltd um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
WO2011083287A2 (en) * 2010-01-05 2011-07-14 Cipla Limited Darunavir polymorph and process for preparation thereof
WO2011092687A1 (en) 2010-01-28 2011-08-04 Mapi Pharma Hk Limited Process for the preparation of darunavir and darunavir intermediates
WO2012107889A1 (en) * 2011-02-10 2012-08-16 Ranbaxy Laboratories Limited Process for the preparation of amorphous darunavir
WO2013004816A1 (en) 2011-07-07 2013-01-10 Janssen R&D Ireland Darunavir formulations
DK2729130T3 (en) * 2011-07-07 2017-12-11 Janssen Sciences Ireland Uc Darunavir-COMBINATION FORMULATIONS
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
WO2013114382A1 (en) * 2011-12-05 2013-08-08 Mylan Laboratories Ltd Crystalline darunavir
CN103509031B (zh) * 2012-06-20 2016-04-27 上海迪赛诺药业有限公司 制备达芦那韦无定形物的方法
WO2013189049A1 (zh) * 2012-06-20 2013-12-27 上海迪赛诺药业有限公司 制备达芦那韦无定形物的方法
ES2969589T3 (es) * 2012-07-24 2024-05-21 Laurus Labs Ltd Solvato de Propionato de Darunavir
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
CN106854212A (zh) * 2015-12-08 2017-06-16 浙江九洲药业股份有限公司 一种达芦那韦无定型的制备方法
CN107021919A (zh) * 2016-01-29 2017-08-08 上海医药工业研究院 一种阿扎那韦原料药杂质或其盐、其制备方法和应用
CN107235987A (zh) * 2016-03-28 2017-10-10 浙江九洲药业股份有限公司 一种地瑞那韦甲醇溶剂化物及其制备方法和用途
WO2018015929A1 (en) * 2016-07-22 2018-01-25 Granules India Limited A novel process for the preparation of hiv protease inhibitor and intermediates thereof
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
CN108794498A (zh) * 2017-05-03 2018-11-13 江苏瑞科医药科技有限公司 一种达芦那韦无定型的制备方法
CN108822123A (zh) * 2018-09-06 2018-11-16 南通雅本化学有限公司 一种地瑞那韦的制备方法
CN111039951A (zh) * 2019-12-16 2020-04-21 上海雅本化学有限公司 一种地瑞那韦的制备方法
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
AU2003271740B2 (en) 2002-05-16 2010-05-13 Janssen R&D Ireland Pseudopolymorphic forms of a HIV protease inhibitor
CA2549460C (en) 2003-12-23 2014-08-05 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
US20080014280A1 (en) * 2006-07-17 2008-01-17 Glenmark Pharmaceuticals Limited Amorphous pregabalin and process for the preparation thereof
US20080014263A1 (en) * 2006-07-17 2008-01-17 Glenmark Pharmaceuticals Limited Amorphous eprosartan mesylate and process for the preparation thereof
PL2381786T3 (pl) 2009-01-29 2015-06-30 Mapi Pharma Ltd Dimetylosulfotlenkowy solwat darunawiru
WO2011017395A1 (en) * 2009-08-04 2011-02-10 Glaxosmithkline Llc Chemical compounds

Also Published As

Publication number Publication date
WO2011048604A3 (en) 2011-09-09
PT2477992T (pt) 2017-03-20
DK2477992T3 (en) 2017-03-27
EP2477992B1 (en) 2016-12-14
EP2477992A2 (en) 2012-07-25
PL2477992T3 (pl) 2017-07-31
CA2776807A1 (en) 2011-04-28
ES2619562T3 (es) 2017-06-26
US20120251826A1 (en) 2012-10-04
US8703980B2 (en) 2014-04-22
HRP20170392T1 (hr) 2017-06-02
CA2776807C (en) 2018-10-16
WO2011048604A2 (en) 2011-04-28

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