AP1997A - 3-(3,5-dioxo-4,5-dihydro-3H-(1,2,4)triazin-2-YL)-benzamide derivatives as P2X7-inhibitors for the treatment of inflammatory diseases - Google Patents

3-(3,5-dioxo-4,5-dihydro-3H-(1,2,4)triazin-2-YL)-benzamide derivatives as P2X7-inhibitors for the treatment of inflammatory diseases

Info

Publication number
AP1997A
AP1997A AP2005003350A AP2005003350A AP1997A AP 1997 A AP1997 A AP 1997A AP 2005003350 A AP2005003350 A AP 2005003350A AP 2005003350 A AP2005003350 A AP 2005003350A AP 1997 A AP1997 A AP 1997A
Authority
AP
ARIPO
Prior art keywords
triazin
dioxo
dihydro
inhibitors
treatment
Prior art date
Application number
AP2005003350A
Other languages
English (en)
Other versions
AP2005003350A0 (en
Inventor
Mark Anthony Dombroski
Allen Jacob Duplantier
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2005003350A0 publication Critical patent/AP2005003350A0/xx
Application granted granted Critical
Publication of AP1997A publication Critical patent/AP1997A/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
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AP2005003350A 2002-12-31 2003-12-19 3-(3,5-dioxo-4,5-dihydro-3H-(1,2,4)triazin-2-YL)-benzamide derivatives as P2X7-inhibitors for the treatment of inflammatory diseases AP1997A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43750502P 2002-12-31 2002-12-31

Publications (2)

Publication Number Publication Date
AP2005003350A0 AP2005003350A0 (en) 2005-09-30
AP1997A true AP1997A (en) 2009-04-22

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Family Applications (1)

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AP2005003350A AP1997A (en) 2002-12-31 2003-12-19 3-(3,5-dioxo-4,5-dihydro-3H-(1,2,4)triazin-2-YL)-benzamide derivatives as P2X7-inhibitors for the treatment of inflammatory diseases

Country Status (40)

Country Link
US (4) US6974812B2 (no)
EP (1) EP1581232B1 (no)
JP (1) JP4560411B2 (no)
KR (1) KR100689138B1 (no)
CN (1) CN1732006A (no)
AP (1) AP1997A (no)
AR (1) AR042673A1 (no)
AU (1) AU2003285716B2 (no)
BR (1) BR0317803A (no)
CA (1) CA2512193C (no)
CL (1) CL2003002765A1 (no)
CO (1) CO5580749A2 (no)
CR (1) CR7884A (no)
DO (1) DOP2003000790A (no)
EA (1) EA008591B1 (no)
EC (1) ECSP055884A (no)
ES (1) ES2464350T3 (no)
GE (1) GEP20084304B (no)
GT (1) GT200300297A (no)
HR (1) HRP20050609A2 (no)
IL (2) IL168513A (no)
IS (1) IS7840A (no)
MA (1) MA27575A1 (no)
MX (1) MXPA05006749A (no)
MY (1) MY141984A (no)
NI (1) NI200500118A (no)
NL (1) NL1025148C2 (no)
NO (1) NO20053587L (no)
NZ (1) NZ539913A (no)
OA (1) OA12978A (no)
PA (1) PA8591801A1 (no)
PE (1) PE20040802A1 (no)
PL (1) PL378251A1 (no)
RS (1) RS20050490A (no)
TN (1) TNSN05174A1 (no)
TW (1) TWI288133B (no)
UA (1) UA82346C2 (no)
UY (1) UY28153A1 (no)
WO (1) WO2004058270A1 (no)
ZA (1) ZA200503912B (no)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
BRPI0410349A (pt) * 2003-05-12 2006-05-30 Pfizer Prod Inc inibidores de benzamida do receptor p2x7
EP1837330B1 (en) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
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