ZW4785A1 - 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents - Google Patents
3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agentsInfo
- Publication number
- ZW4785A1 ZW4785A1 ZW47/85A ZW4785A ZW4785A1 ZW 4785 A1 ZW4785 A1 ZW 4785A1 ZW 47/85 A ZW47/85 A ZW 47/85A ZW 4785 A ZW4785 A ZW 4785A ZW 4785 A1 ZW4785 A1 ZW 4785A1
- Authority
- ZW
- Zimbabwe
- Prior art keywords
- alkyl
- optionally substituted
- oxindole
- carboxamides
- analgesic
- Prior art date
Links
- UYINJAQCJCYCGO-UHFFFAOYSA-N 2-oxo-3h-indole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)C(=O)CC2=C1 UYINJAQCJCYCGO-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- WVKPYYLOFMTDHB-UHFFFAOYSA-N 2-norbornyl radical Chemical group C1CC2[CH]CC1C2 WVKPYYLOFMTDHB-UHFFFAOYSA-N 0.000 abstract 1
- -1 bicyclo [2.2.1]hept-5-en-2-yl Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59065984A | 1984-03-19 | 1984-03-19 | |
| US06/684,634 US4556672A (en) | 1984-03-19 | 1984-12-21 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZW4785A1 true ZW4785A1 (en) | 1985-06-19 |
Family
ID=27080909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZW47/85A ZW4785A1 (en) | 1984-03-19 | 1985-03-18 | 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US4556672A (cs) |
| EP (1) | EP0156603B1 (cs) |
| JP (1) | JPH04235165A (cs) |
| KR (1) | KR860001873B1 (cs) |
| AT (1) | ATE45731T1 (cs) |
| AU (1) | AU549927B2 (cs) |
| BG (1) | BG60347B2 (cs) |
| CA (2) | CA1251441A (cs) |
| CS (1) | CS249539B2 (cs) |
| CY (1) | CY1668A (cs) |
| DE (1) | DE3572481D1 (cs) |
| DK (1) | DK162090C (cs) |
| EG (1) | EG17795A (cs) |
| ES (1) | ES8603408A1 (cs) |
| FI (2) | FI82042C (cs) |
| GR (1) | GR850668B (cs) |
| HK (1) | HK78392A (cs) |
| HU (1) | HU196178B (cs) |
| IE (1) | IE57743B1 (cs) |
| IL (3) | IL74631A (cs) |
| LV (1) | LV5618A3 (cs) |
| MA (1) | MA20380A1 (cs) |
| MY (1) | MY101987A (cs) |
| NL (1) | NL940025I2 (cs) |
| NO (1) | NO165799C (cs) |
| NZ (2) | NZ224134A (cs) |
| OA (1) | OA07966A (cs) |
| PH (2) | PH21323A (cs) |
| PL (1) | PL145951B1 (cs) |
| PT (1) | PT80117B (cs) |
| RO (1) | RO90952B (cs) |
| SI (1) | SI8510440A8 (cs) |
| SU (1) | SU1445556A3 (cs) |
| UA (1) | UA6343A1 (cs) |
| YU (1) | YU43870B (cs) |
| ZW (1) | ZW4785A1 (cs) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE41420T1 (de) * | 1984-02-07 | 1989-04-15 | Pfizer | 1,3-disubstituierte 2-oxindole und deren anwendung als analgetische und antiinflammatorische mittel. |
| US4686224A (en) * | 1984-10-31 | 1987-08-11 | Pfizer Inc. | Oxindole antiinflammatory agents |
| US4678802A (en) * | 1985-07-09 | 1987-07-07 | Pfizer Inc. | 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents |
| EP0208510B1 (en) * | 1985-07-09 | 1991-09-11 | Pfizer Inc. | 1-substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents |
| GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
| RO105052B1 (en) * | 1987-02-02 | 1994-12-01 | Pfizer | Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide |
| US4885370A (en) * | 1987-03-11 | 1989-12-05 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
| US4761485A (en) * | 1987-03-11 | 1988-08-02 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| DE3803775A1 (de) * | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
| US4853409A (en) * | 1988-04-13 | 1989-08-01 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function |
| DE68923673T2 (de) * | 1988-10-18 | 1996-01-18 | Pfizer | Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden. |
| HU208421B (en) * | 1988-10-18 | 1993-10-28 | Pfizer | Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity |
| WO1990008145A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles |
| US5300655A (en) * | 1989-04-18 | 1994-04-05 | Pfizer Inc. | 2-carboxy-thiophene derivatives |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| IL95880A (en) * | 1989-10-13 | 1995-12-31 | Pfizer | Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis |
| WO1991009598A1 (en) * | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
| US5006547A (en) * | 1990-03-19 | 1991-04-09 | Pfizer Inc. | Tenidap as an inhibitor of the release of elastase by neutrophils |
| US5008283A (en) * | 1990-03-19 | 1991-04-16 | Pfizer Inc. | Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase |
| US5064851A (en) * | 1990-07-24 | 1991-11-12 | Pfizer Inc. | 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5122534A (en) * | 1991-02-08 | 1992-06-16 | Pfizer Inc. | Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides |
| DE4111306C2 (de) * | 1991-04-08 | 1994-06-01 | Mack Chem Pharm | Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind |
| DE4111305C2 (de) * | 1991-04-08 | 1994-12-01 | Mack Chem Pharm | Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält |
| US5166401A (en) * | 1991-06-25 | 1992-11-24 | Pfizer Inc | Intermediates for 5-fluoro-6-chlorooxindole |
| US5210212A (en) * | 1991-06-25 | 1993-05-11 | Pfizer Inc | Process for 5-fluoro-6-chlorooxindole |
| TW438798B (en) * | 1992-10-07 | 2001-06-07 | Pfizer | 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions |
| US5288743A (en) * | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| AU671533B2 (en) * | 1993-01-22 | 1996-08-29 | Pfizer Inc. | Lysine salt of 6-chloro-5-fluoro-3-(2 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide |
| US5298522A (en) * | 1993-01-22 | 1994-03-29 | Pfizer Inc. | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio |
| US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| JP2709530B2 (ja) * | 1993-02-09 | 1998-02-04 | ファイザー・インク． | 抗炎症薬としてのオキシンドール１−［ｎ−（アルコキシカルボニル）］カルボキサミド類および１−（ｎ−カルボキサミド）カルボキサミド類 |
| ES2076106B1 (es) * | 1993-08-26 | 1996-06-16 | Pfizer | Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas |
| US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
| EP0679396A1 (en) * | 1994-03-02 | 1995-11-02 | Pfizer Inc. | Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury |
| US6469181B1 (en) | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
| US5545656A (en) * | 1995-04-05 | 1996-08-13 | Pfizer Inc. | 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6051588A (en) * | 1995-04-19 | 2000-04-18 | Nitromed Inc | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| WO1997022605A1 (en) * | 1995-12-19 | 1997-06-26 | Pfizer Inc. | Stable, long acting salts of indole derivatives for the treatment of joint diseases |
| HUP9600855A3 (en) * | 1996-04-03 | 1998-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tenidap |
| EP0826685A1 (en) * | 1996-08-21 | 1998-03-04 | Pfizer Inc. | Stable, long acting salts of carboxamides for the treatment of joint disease |
| CA2348741C (en) | 1998-10-30 | 2010-04-20 | Nitromed Inc. | Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use |
| CN1136217C (zh) | 1998-12-17 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | 作为jnk蛋白质激酶抑制剂的4-芳基羟吲哚 |
| BR9916327A (pt) | 1998-12-17 | 2001-09-18 | Hoffmann La Roche | Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2 |
| US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| CN1158283C (zh) | 1998-12-17 | 2004-07-21 | 霍夫曼-拉罗奇有限公司 | 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 |
| IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| JP2003512396A (ja) * | 1999-10-26 | 2003-04-02 | ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター | インドリン化合物を投与することを含む脱毛症の処置方法 |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
| IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
| WO2003009815A2 (en) | 2001-07-25 | 2003-02-06 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| PT3395372T (pt) | 2009-02-20 | 2022-05-05 | Enhanx Biopharm Inc | Sistema de entrega de medicamentos à base de glutationa |
| MY163048A (en) | 2009-05-06 | 2017-08-15 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN102911105B (zh) * | 2012-11-12 | 2013-12-04 | 辽宁科技大学 | 一种3-芳酰基吲哚化合物的合成方法 |
| WO2016161063A1 (en) * | 2015-03-31 | 2016-10-06 | Monsanto Technology Llc | Processes for the preparation of 2-thiophenecarbonyl chloride |
| WO2016179157A1 (en) | 2015-05-05 | 2016-11-10 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
| US10745376B2 (en) | 2016-03-24 | 2020-08-18 | Monsanto Technology Llc | Processes for the preparation of heteroaryl carboxylic acids |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125443C (cs) * | 1963-06-06 | |||
| US3462450A (en) * | 1966-06-29 | 1969-08-19 | Merck & Co Inc | Chemical compounds |
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| US3519592A (en) * | 1967-04-18 | 1970-07-07 | Smithkline Corp | Indole compounds |
| US3631177A (en) * | 1967-04-18 | 1971-12-28 | Smith Kline French Lab | 3-phenacyl-2-oxoindolines |
| BE714717A (cs) * | 1967-05-12 | 1968-09-30 | ||
| FR7337M (cs) * | 1968-01-11 | 1969-10-13 | ||
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| DE2306374A1 (de) * | 1973-02-09 | 1974-08-15 | Bayer Ag | Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeureamide |
| US4012394A (en) * | 1973-02-16 | 1977-03-15 | Labaz | Indole derivatives |
| DE2314242A1 (de) * | 1973-03-22 | 1974-09-26 | Bayer Ag | Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeurehydrazide |
| US3975531A (en) * | 1973-10-02 | 1976-08-17 | A. H. Robins Company, Incorporated | 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof |
-
1984
- 1984-12-21 US US06/684,634 patent/US4556672A/en not_active Expired - Lifetime
-
1985
- 1985-03-15 IE IE684/85A patent/IE57743B1/en not_active IP Right Cessation
- 1985-03-15 AT AT85301808T patent/ATE45731T1/de not_active IP Right Cessation
- 1985-03-15 CA CA000476605A patent/CA1251441A/en not_active Expired
- 1985-03-15 GR GR850668A patent/GR850668B/el unknown
- 1985-03-15 PT PT80117A patent/PT80117B/pt unknown
- 1985-03-15 EP EP85301808A patent/EP0156603B1/en not_active Expired
- 1985-03-15 DE DE8585301808T patent/DE3572481D1/de not_active Expired
- 1985-03-17 EG EG174/85A patent/EG17795A/xx active
- 1985-03-18 HU HU85992A patent/HU196178B/hu unknown
- 1985-03-18 SU SU853869754A patent/SU1445556A3/ru active
- 1985-03-18 IL IL74631A patent/IL74631A/xx not_active IP Right Cessation
- 1985-03-18 PL PL1985252434A patent/PL145951B1/pl unknown
- 1985-03-18 IL IL85130A patent/IL85130A/xx not_active IP Right Cessation
- 1985-03-18 ES ES541372A patent/ES8603408A1/es not_active Expired
- 1985-03-18 NZ NZ224134A patent/NZ224134A/xx unknown
- 1985-03-18 KR KR1019850001746A patent/KR860001873B1/ko not_active Expired
- 1985-03-18 UA UA3869754A patent/UA6343A1/uk unknown
- 1985-03-18 PH PH32001A patent/PH21323A/en unknown
- 1985-03-18 BG BG069278A patent/BG60347B2/bg unknown
- 1985-03-18 NO NO851054A patent/NO165799C/no not_active IP Right Cessation
- 1985-03-18 DK DK121385A patent/DK162090C/da not_active IP Right Cessation
- 1985-03-18 FI FI851069A patent/FI82042C/fi not_active IP Right Cessation
- 1985-03-18 NZ NZ211486A patent/NZ211486A/xx unknown
- 1985-03-18 MA MA20604A patent/MA20380A1/fr unknown
- 1985-03-18 ZW ZW47/85A patent/ZW4785A1/xx unknown
- 1985-03-18 AU AU40059/85A patent/AU549927B2/en not_active Expired
- 1985-03-19 OA OA58541A patent/OA07966A/xx unknown
- 1985-03-19 YU YU440/85A patent/YU43870B/xx unknown
- 1985-03-19 CS CS851920A patent/CS249539B2/cs unknown
- 1985-03-19 RO RO118055A patent/RO90952B/ro unknown
- 1985-03-19 SI SI8510440A patent/SI8510440A8/sl unknown
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1986
- 1986-02-21 PH PH33439A patent/PH21470A/en unknown
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1987
- 1987-08-17 MY MYPI87001358A patent/MY101987A/en unknown
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1988
- 1988-01-19 IL IL85130A patent/IL85130A0/xx unknown
- 1988-07-07 CA CA000571475A patent/CA1288422C/en not_active Expired - Lifetime
-
1989
- 1989-09-26 FI FI894540A patent/FI82449C/fi not_active IP Right Cessation
-
1991
- 1991-06-04 JP JP3132826A patent/JPH04235165A/ja active Granted
-
1992
- 1992-10-15 HK HK783/92A patent/HK78392A/en not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1668A patent/CY1668A/xx unknown
- 1993-11-11 LV LV931200A patent/LV5618A3/xx unknown
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1994
- 1994-12-15 NL NL940025C patent/NL940025I2/nl unknown
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