ZA9811060B - N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres. - Google Patents

N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres.

Info

Publication number
ZA9811060B
ZA9811060B ZA9811060A ZA9811060A ZA9811060B ZA 9811060 B ZA9811060 B ZA 9811060B ZA 9811060 A ZA9811060 A ZA 9811060A ZA 9811060 A ZA9811060 A ZA 9811060A ZA 9811060 B ZA9811060 B ZA 9811060B
Authority
ZA
South Africa
Prior art keywords
carboxylic acid
acid isosteres
heterocyclic
carboxylic acids
linked sulfonamides
Prior art date
Application number
ZA9811060A
Other languages
English (en)
Inventor
Gregory S Hamilton
Mark H Norman
Yong-Qian Wu
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of ZA9811060B publication Critical patent/ZA9811060B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
ZA9811060A 1998-06-03 1998-12-03 N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres. ZA9811060B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8784298P 1998-06-03 1998-06-03

Publications (1)

Publication Number Publication Date
ZA9811060B true ZA9811060B (en) 1999-12-03

Family

ID=22207576

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811060A ZA9811060B (en) 1998-06-03 1998-12-03 N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres.

Country Status (17)

Country Link
US (3) US7459473B2 (ru)
EP (1) EP1084106A1 (ru)
JP (1) JP2002516904A (ru)
KR (1) KR20010052503A (ru)
CN (1) CN1295561A (ru)
AU (1) AU1708099A (ru)
BG (1) BG105012A (ru)
BR (1) BR9815882A (ru)
CA (1) CA2334002A1 (ru)
EA (1) EA200001247A1 (ru)
HU (1) HUP0102935A3 (ru)
IL (1) IL140040A0 (ru)
NO (1) NO20006078L (ru)
PL (1) PL348661A1 (ru)
SK (1) SK18302000A3 (ru)
WO (1) WO1999062880A1 (ru)
ZA (1) ZA9811060B (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9804426D0 (en) * 1998-03-02 1998-04-29 Pfizer Ltd Heterocycles
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
AU6913700A (en) * 1999-08-18 2001-03-13 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
NZ526213A (en) * 2000-12-13 2005-05-27 Wyeth Corp Heterocyclic sulfonamide inhibitors of beta amyloid production
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
CN1173960C (zh) * 2001-12-06 2004-11-03 中国人民解放军军事医学科学院毒物药物研究所 取代六元氮杂环类化合物及其作为神经调节剂的用途
CA2364985A1 (en) * 2001-12-14 2003-06-14 John W. Gillard Imidazo(2,1-b)thiadiazole sulfonamides
GB0209995D0 (en) * 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401763D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
AU2006239929B2 (en) 2005-04-22 2011-11-03 Alantos Pharmaceuticals Holding, Inc. Dipeptidyl peptidase-IV inhibitors
DE102005050377A1 (de) * 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclische Verbindungen und ihre Verwendung
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
CA2736018C (en) * 2008-09-16 2015-11-03 Stephanie Merchant Compositions for treating or delaying the onset of hair loss
JP2012041325A (ja) * 2010-08-23 2012-03-01 Bayer Cropscience Ag オキサジアゾリノン誘導体およびその有害生物の防除用途
TWI534142B (zh) * 2011-03-15 2016-05-21 大正製藥股份有限公司 Azole derivatives
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
AU2013363398B2 (en) 2012-12-20 2017-06-01 Tempest Therapeutics, Inc. Triazolone compounds and uses thereof
EA201690230A1 (ru) 2013-09-06 2016-07-29 Инсепшн 2, Инк. Соединения триазолона и их применения
EP3096755A4 (en) * 2014-01-23 2017-12-27 Sova Pharmaceuticals, Inc. CYSTATHIONINE-(gamma)-LYASE (CSE) INHIBITORS FOR TREATING PAIN
JP6541118B1 (ja) * 2018-04-27 2019-07-10 株式会社成和化成 化粧品基材および該化粧品基材を含有する毛髪用化粧品、美白剤
CA3223875A1 (en) * 2021-06-25 2022-12-29 Shigeru Matsuoka Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277087A (en) 1964-08-21 1966-10-04 American Home Prod 4, 1, 2-benzoxathiazine dioxides and intermediates in their preparation
US3424749A (en) 1965-06-23 1969-01-28 Heinz A Pfenninger Certain n-(benzenesulfonyl) pipecolinic acids and lower alkyl esters thereof
US3501512A (en) 1966-01-21 1970-03-17 American Home Prod N-(4,4-diloweralkyloxy and thio butyl) benzene sulfonamides
US4377521A (en) 1972-12-26 1983-03-22 Pfizer Inc. Sulfamylbenzoic acids
US3890311A (en) 1974-03-18 1975-06-17 American Home Prod 7-(2-(1-(phenylsulfonyl)-2-pyrrolidinylthio)acetamino)cephalosporanic acids
DE2505114C3 (de) 1975-02-07 1979-06-13 Valentin Dr.Med. Koehler Kopfhautpflegemlttel
US4070361A (en) 1977-04-21 1978-01-24 E. R. Squibb & Sons, Inc. Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof
JPS5822111B2 (ja) 1977-10-29 1983-05-06 協和醗酵工業株式会社 柑橘類果実の改質剤
ZA794723B (en) 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS55153763A (en) * 1979-05-21 1980-11-29 Kyowa Hakko Kogyo Co Ltd Modifier for citrus fruits
US4734420A (en) 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
US4692458A (en) 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4578474A (en) 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4390695A (en) 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
DE3360065D1 (en) 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4596819A (en) 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
WO1985004577A1 (en) 1984-04-06 1985-10-24 Gail Sansone Bazzano Compositions used for hair growth
US4593102A (en) 1984-04-10 1986-06-03 A. H. Robins Company, Inc. N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position
US4642348A (en) 1984-04-10 1987-02-10 A. H. Robins Company, Incorporated N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-positions
US5714510A (en) 1985-07-18 1998-02-03 Proctor; Peter H. Topical proxyl composition and method
US5472687A (en) 1985-07-18 1995-12-05 Proctor; Peter H. Topical pyridine N-oxides
BR8603599A (pt) 1985-08-06 1987-03-10 Air Prod & Chem Polimeros de monomeros de inter-ligacao isentos de formaldeido auto-reagentes e reagentes ao diol
FR2597478B1 (fr) 1986-04-21 1988-12-16 Esteve Labor Dr Benzimidazoles et imidazopyridines sulfonamides, leur preparation et leur application en tant que medicaments.
WO1988000040A1 (en) 1986-07-02 1988-01-14 American Health Products Corporation Topical hair growing composition and kit
US5214034A (en) 1986-09-26 1993-05-25 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same
DE3636278A1 (de) 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
IT1206078B (it) 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
JPS6419063A (en) 1987-07-13 1989-01-23 Kirin Brewery Novel heterocyclic compound and use thereof
JPS6419063U (ru) 1987-07-24 1989-01-31
US5232923A (en) 1988-03-18 1993-08-03 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives and pharmaceutical preparations containing same
US5274097A (en) 1988-04-19 1993-12-28 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
KR0143565B1 (ko) 1988-06-13 1998-07-15 사노 가즈오 피발산의 p-치환된 페닐 에스테르 유도체, 그의 제조 방법 및 이를 포함하는 조성물.
US5002964A (en) 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof
US5166317A (en) 1988-10-31 1992-11-24 Houston Biotechnology Incorporated Neurotrophic factor
US5359138A (en) 1989-04-15 1994-10-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Poststatin and related compounds or salts thereof
GB8912303D0 (en) 1989-05-27 1989-07-12 Pfizer Ltd Therapeutic agents
US5128483A (en) 1989-07-19 1992-07-07 American Cyanamid Company Dibromovinyl and acetylene-1-pyrrolidinecarboxylic acid intermediates
US5215969A (en) 1989-08-11 1993-06-01 Hahnemann University Dopaminergic neurotrophic factor for treatment of Parkinson's disease
US5703088A (en) 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
NZ234883A (en) 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
JP2930337B2 (ja) 1989-12-12 1999-08-03 アサヒビール株式会社 ピロリジン誘導体およびそれを有効成分とする抗健忘症剤
ES2084801T3 (es) 1990-02-19 1996-05-16 Ciba Geigy Ag Acil compuestos.
US5504197A (en) 1990-06-20 1996-04-02 The Salk Institute For Biological Studies DNA encoding neurotrophic growth factors
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
ES2104597T3 (es) 1990-08-14 1997-10-16 Kenneth M Hallam Composicion para la promocion del crecimiento del cabello.
JPH04124198A (ja) 1990-09-12 1992-04-24 Sumitomo Pharmaceut Co Ltd 神経栄養ペプチド誘導体
DE69118826T2 (de) 1990-11-27 1996-11-14 Fuji Photo Film Co Ltd Propenamidderivate, deren Polymere, Copolymere und deren Verwendung
AU9049391A (en) 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
WO1992011850A2 (en) 1990-12-28 1992-07-23 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
FR2671082B1 (fr) 1990-12-28 1993-04-16 Oreal Agent a plusieurs composants ou kit de preparation de la forme sulfo-conjuguee de composes pyrimidino- ou triazino-n-oxyde et procede de mise en óoeuvre.
US5620971A (en) 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
MX9202466A (es) 1991-05-24 1994-06-30 Vertex Pharma Compuestos inmunosupresores novedosos.
FR2677884B1 (fr) 1991-06-20 1993-07-09 Oreal Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues.
JPH05194235A (ja) 1991-07-25 1993-08-03 Tanabe Seiyaku Co Ltd 中枢性カルシウム拮抗剤
US5604294A (en) 1991-09-05 1997-02-18 Luly; Jay R. Macrocyclic immunomodulators
ES2084176T3 (es) 1991-09-05 1996-05-01 Pharno Wedropharm Gmbh Derivados de sulfonamidas aromaticas, su uso como inhibidores de enzimas y composiciones farmaceuticas que los contienen.
DE4206041A1 (de) 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazolylpropensaeurederivate
US5342942A (en) 1992-06-09 1994-08-30 Warner-Lambert Company Pyrazoloquinazolone derivatives as neurotrophic agents
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5571832A (en) 1992-11-13 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Nitrogen-containing cyclohetero alkylamino aryl derivatives for CNS disorders
CA2149892C (en) 1992-11-20 1998-12-08 Koji Kobayashi Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
DK0610744T3 (da) * 1993-02-09 1999-07-19 Bayer Ag Sulfonamidaminomethylenderivater som immunosuppressive stoffer
JP3599287B2 (ja) 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
US5846981A (en) 1993-05-28 1998-12-08 Gpi Nil Holdings Inc. Inhibitors of rotamase enzyme activity
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US5612350A (en) 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5898029A (en) 1994-04-12 1999-04-27 The John Hopkins University Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
IT1269511B (it) 1994-05-17 1997-04-01 Univ Degli Studi Milano Derivati di acidi ammino-solfonici , loro impiego nella sintesi di pseudopeptidi e procedimento per la loro preparazione
DE4425950A1 (de) 1994-07-21 1996-01-25 Bayer Ag Verwendung von Sulfonylbenzyl-substituierten Imidazolen, Imidazopyridinen und Benzimidazolen
WO1996006846A1 (es) 1994-09-01 1996-03-07 Universidad Complutense De Madrid Nuevos derivados de arilpiperazinas
GB9420503D0 (en) 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
US5543423A (en) 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US6017887A (en) 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5804560A (en) 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
ATE246678T1 (de) 1995-04-20 2003-08-15 Searle & Co Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren
AU5644396A (en) * 1995-05-05 1996-11-21 Novo Nordisk A/S Novel heterocyclic chemistry
US5696135A (en) 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5795890A (en) 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
JPH09169758A (ja) 1995-10-18 1997-06-30 Nippon Paper Ind Co Ltd 新規なプリンヌクレオシド誘導体、その製造方法、及びそれを用いた抗ウイルス剤
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
AU1463997A (en) 1995-12-22 1997-07-17 Acea Pharmaceuticals, Inc. Subtype-selective nmda receptor ligands and the use thereof
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
US5717092A (en) 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
US5905076A (en) 1996-04-10 1999-05-18 National Research Council Of Canada 6-substituted amino-4-oxa-1-azabicyclo 3,2,0! heptan-7-one derivatives as cysteine protease inhibitors
US5629325A (en) 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
GB9612884D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
EP0912550A1 (en) 1996-06-25 1999-05-06 Smithkline Beecham Plc Sulfonamide derivatives as 5ht7 receptor antagonists
EP0823419A3 (en) 1996-08-09 2000-08-16 Takeda Chemical Industries, Ltd. Dimethylpropanediol compounds
BR9712792A (pt) 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
AU734834B2 (en) 1996-08-28 2001-06-21 Procter & Gamble Company, The Heterocyclic metalloprotease inhibitors
CA2263932A1 (en) * 1996-08-28 1998-03-05 Yetunde Olabisi Taiwo 1,4-heterocyclic metalloprotease inhibitors
US5786378A (en) 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5780484A (en) 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
US5840736A (en) 1996-11-13 1998-11-24 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5874449A (en) * 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6268384B1 (en) 1997-08-29 2001-07-31 Vertex Pharmaceuticals Incorporated Compounds possessing neuronal activity
AU766579B2 (en) * 1997-08-29 2003-10-16 Vertex Pharmaceuticals Incorporated Compounds possessing neuronal activity
CA2304647A1 (en) * 1997-09-24 1999-04-01 Amgen Inc. Method for preventing and treating hearing loss using sensorineurotophic compounds
DE19742263A1 (de) 1997-09-25 1999-04-01 Asta Medica Ag Neue spezifische Immunophilin-Liganden als Antiasthmatika, Antiallergika, Antirheumatika, Immunsuppressiva, Antipsoriatika, Neuroprotektiva

Also Published As

Publication number Publication date
JP2002516904A (ja) 2002-06-11
KR20010052503A (ko) 2001-06-25
PL348661A1 (en) 2002-06-03
EA200001247A1 (ru) 2001-08-27
BG105012A (en) 2001-08-31
US20020052510A1 (en) 2002-05-02
HUP0102935A3 (en) 2002-01-28
US7078424B2 (en) 2006-07-18
WO1999062880A1 (en) 1999-12-09
AU1708099A (en) 1999-12-20
IL140040A0 (en) 2002-02-10
CN1295561A (zh) 2001-05-16
BR9815882A (pt) 2002-09-17
US20020052514A1 (en) 2002-05-02
SK18302000A3 (sk) 2001-06-11
HUP0102935A2 (en) 2001-12-28
NO20006078L (no) 2001-02-05
US7459473B2 (en) 2008-12-02
EP1084106A1 (en) 2001-03-21
CA2334002A1 (en) 1999-12-09
US20040082622A1 (en) 2004-04-29
NO20006078D0 (no) 2000-11-30

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