ZA977482B - 7α(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents. - Google Patents

7α(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents.

Info

Publication number
ZA977482B
ZA977482B ZA9707482A ZA977482A ZA977482B ZA 977482 B ZA977482 B ZA 977482B ZA 9707482 A ZA9707482 A ZA 9707482A ZA 977482 A ZA977482 A ZA 977482A ZA 977482 B ZA977482 B ZA 977482B
Authority
ZA
South Africa
Prior art keywords
estratrienes
aminoalkyl
production
contain
well
Prior art date
Application number
ZA9707482A
Other languages
English (en)
Inventor
Rolf Bohlmann
Dieter Bittler
Josef Heindl
Nikolaus Heinrich
Helmut Hofmeister
Hermann Kuenzer
Gerhard Sauer
Christa Hegele-Hartung
Rosemarie Lichter
Yukishige Nishino
Karsten Parczyk
Martin Schneider
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA977482B publication Critical patent/ZA977482B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
ZA9707482A 1996-08-20 1997-08-20 7α(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents. ZA977482B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19635525A DE19635525A1 (de) 1996-08-20 1996-08-20 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

Publication Number Publication Date
ZA977482B true ZA977482B (en) 1998-02-23

Family

ID=7804367

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707482A ZA977482B (en) 1996-08-20 1997-08-20 7α(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents.

Country Status (29)

Country Link
EP (1) EP0920441B1 (is)
JP (1) JP2001503024A (is)
KR (1) KR20000068261A (is)
CN (1) CN1231670A (is)
AR (1) AR009278A1 (is)
AT (1) ATE231882T1 (is)
AU (1) AU728843B2 (is)
BG (1) BG62972B1 (is)
BR (1) BR9711328A (is)
CA (1) CA2263708A1 (is)
CZ (1) CZ57999A3 (is)
DE (2) DE19635525A1 (is)
DK (1) DK0920441T3 (is)
EA (1) EA001577B1 (is)
EE (1) EE04021B1 (is)
ES (1) ES2191857T3 (is)
HU (1) HUP9903106A3 (is)
IL (1) IL128601A (is)
IS (1) IS4976A (is)
NO (1) NO315655B1 (is)
NZ (1) NZ334277A (is)
PL (1) PL186309B1 (is)
PT (1) PT920441E (is)
SK (1) SK18899A3 (is)
TR (1) TR199900432T2 (is)
TW (1) TW552267B (is)
UA (1) UA50792C2 (is)
WO (1) WO1998007740A1 (is)
ZA (1) ZA977482B (is)

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DE10159217A1 (de) * 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
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US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
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JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
JP2009001551A (ja) 2007-05-18 2009-01-08 Sumitomo Chemical Co Ltd 有機硫黄化合物及びその有害節足動物防除用途
DE102007032800A1 (de) 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
NZ585389A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2070941A1 (en) 2007-12-14 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Stereoselective synthesis of selective estrogen receptor down-regulators
EP2070909A1 (de) 2007-12-15 2009-06-17 Bayer Schering Pharma AG Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102008057230A1 (de) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
JP5212350B2 (ja) 2008-12-24 2013-06-19 住友化学株式会社 含ハロゲン有機硫黄化合物およびその用途
EP2258375A1 (de) 2009-06-04 2010-12-08 Bayer Schering Pharma Aktiengesellschaft 17B-alkyl-17alpha-oxy-estratriene
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
WO2011092127A1 (en) 2010-01-26 2011-08-04 Bayer Schering Pharma Aktiengesellschaft 14,17-bridged estratriene derivatives comprising heterocyclic bioisosteres for the phenolic a-ring
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
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DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
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Also Published As

Publication number Publication date
EA001577B1 (ru) 2001-06-25
IL128601A0 (en) 2000-01-31
CA2263708A1 (en) 1998-02-26
IL128601A (en) 2003-07-31
WO1998007740A1 (de) 1998-02-26
ES2191857T3 (es) 2003-09-16
EP0920441A1 (de) 1999-06-09
HUP9903106A2 (hu) 2000-03-28
AR009278A1 (es) 2000-04-12
EE04021B1 (et) 2003-04-15
PT920441E (pt) 2003-06-30
DE59709239D1 (de) 2003-03-06
UA50792C2 (uk) 2002-11-15
BG103185A (en) 1999-11-30
BG62972B1 (bg) 2000-12-29
NZ334277A (en) 2000-10-27
BR9711328A (pt) 1999-08-17
TW552267B (en) 2003-09-11
EP0920441B1 (de) 2003-01-29
EA199900210A1 (ru) 1999-08-26
SK18899A3 (en) 1999-08-06
AU4552097A (en) 1998-03-06
IS4976A (is) 1999-02-11
CZ57999A3 (cs) 1999-08-11
TR199900432T2 (xx) 1999-04-21
PL331863A1 (en) 1999-08-16
NO315655B1 (no) 2003-10-06
KR20000068261A (ko) 2000-11-25
PL186309B1 (pl) 2003-12-31
DE19635525A1 (de) 1998-02-26
ATE231882T1 (de) 2003-02-15
NO990793D0 (no) 1999-02-19
CN1231670A (zh) 1999-10-13
EE9900075A (et) 1999-10-15
JP2001503024A (ja) 2001-03-06
HUP9903106A3 (en) 2000-05-29
AU728843B2 (en) 2001-01-18
DK0920441T3 (da) 2003-05-26
NO990793L (no) 1999-04-20

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