ZA977475B - N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action. - Google Patents

N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.

Info

Publication number
ZA977475B
ZA977475B ZA9707475A ZA977475A ZA977475B ZA 977475 B ZA977475 B ZA 977475B ZA 9707475 A ZA9707475 A ZA 9707475A ZA 977475 A ZA977475 A ZA 977475A ZA 977475 B ZA977475 B ZA 977475B
Authority
ZA
South Africa
Prior art keywords
glyoxylamides
asthmatic
antiallergic
immunosuppressant
immuno
Prior art date
Application number
ZA9707475A
Other languages
English (en)
Inventor
Guillaume Lebaut
Cecilia Menciu
Bernhard Kutscher
Peter Emig
Stefan Szelenyi
Kay Brune
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA977475B publication Critical patent/ZA977475B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ZA9707475A 1996-09-06 1997-08-20 N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action. ZA977475B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19636150A DE19636150A1 (de) 1996-09-06 1996-09-06 N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung

Publications (1)

Publication Number Publication Date
ZA977475B true ZA977475B (en) 1998-02-19

Family

ID=7804772

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707475A ZA977475B (en) 1996-09-06 1997-08-20 N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.

Country Status (27)

Country Link
US (4) US6008231A (ru)
EP (1) EP0931063B3 (ru)
JP (1) JP3296437B2 (ru)
KR (1) KR100516321B1 (ru)
CN (3) CN100488948C (ru)
AR (1) AR008630A1 (ru)
AT (1) ATE342889T1 (ru)
AU (1) AU726521B2 (ru)
BR (1) BR9712808B1 (ru)
CA (1) CA2215013C (ru)
CZ (1) CZ302301B6 (ru)
DE (2) DE19636150A1 (ru)
DK (1) DK0931063T5 (ru)
ES (1) ES2276433T7 (ru)
HK (3) HK1021641A1 (ru)
HU (1) HU227797B1 (ru)
IL (1) IL127798A (ru)
NO (2) NO314725B3 (ru)
NZ (1) NZ334476A (ru)
PT (1) PT931063E (ru)
RU (1) RU2237661C2 (ru)
SK (1) SK285618B6 (ru)
TR (1) TR199900469T2 (ru)
TW (1) TW550256B (ru)
UA (1) UA60312C2 (ru)
WO (1) WO1998009946A1 (ru)
ZA (1) ZA977475B (ru)

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DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
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DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
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DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
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US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
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Also Published As

Publication number Publication date
NO314725B1 (no) 2003-05-12
EP0931063B1 (de) 2006-10-18
NO20030481D0 (no) 2003-01-30
CN1496980A (zh) 2004-05-19
RU2237661C2 (ru) 2004-10-10
EP0931063A1 (de) 1999-07-28
KR100516321B1 (ko) 2005-09-23
SK285618B6 (sk) 2007-05-03
DE19636150A1 (de) 1998-03-12
JP3296437B2 (ja) 2002-07-02
AU726521C (en) 1998-03-26
CZ302301B6 (cs) 2011-02-09
DE59712752D1 (de) 2006-11-30
US6008231A (en) 1999-12-28
CN1227542A (zh) 1999-09-01
CZ61699A3 (cs) 1999-06-16
DK0931063T5 (da) 2010-01-11
SK27199A3 (en) 1999-08-06
IL127798A (en) 2003-07-31
EP0931063B3 (de) 2009-04-08
IL127798A0 (en) 1999-10-28
UA60312C2 (ru) 2003-10-15
CN100376554C (zh) 2008-03-26
TR199900469T2 (xx) 1999-05-21
NO20030481L (no) 1999-03-04
ATE342889T1 (de) 2006-11-15
HUP9903741A3 (en) 2001-01-29
CN101219985B (zh) 2011-04-27
NO991071L (no) 1999-03-04
HK1123280A1 (en) 2009-06-12
AR008630A1 (es) 2000-02-09
HK1021641A1 (en) 2000-06-23
AU4015897A (en) 1998-03-26
WO1998009946A1 (de) 1998-03-12
US20030207892A1 (en) 2003-11-06
CA2215013A1 (en) 1998-03-06
BR9712808B1 (pt) 2009-05-05
ES2276433T3 (es) 2007-06-16
BR9712808A (pt) 1999-11-23
NO314725B3 (no) 2009-03-09
NO991071D0 (no) 1999-03-04
ES2276433T7 (es) 2009-11-05
CA2215013C (en) 2002-03-05
HU227797B1 (en) 2012-03-28
US6919344B2 (en) 2005-07-19
NZ334476A (en) 2000-05-26
DK0931063T3 (da) 2007-02-19
PT931063E (pt) 2007-02-28
KR20000068495A (ko) 2000-11-25
HUP9903741A2 (hu) 2000-04-28
JP2000505098A (ja) 2000-04-25
CN101219985A (zh) 2008-07-16
HK1064379A1 (en) 2005-01-28
TW550256B (en) 2003-09-01
CN100488948C (zh) 2009-05-20
US6344467B1 (en) 2002-02-05
AU726521B2 (en) 2000-11-09
US20020161025A1 (en) 2002-10-31

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