ZA976705B - Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid. - Google Patents

Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid.

Info

Publication number
ZA976705B
ZA976705B ZA9706705A ZA976705A ZA976705B ZA 976705 B ZA976705 B ZA 976705B ZA 9706705 A ZA9706705 A ZA 9706705A ZA 976705 A ZA976705 A ZA 976705A ZA 976705 B ZA976705 B ZA 976705B
Authority
ZA
South Africa
Prior art keywords
pct
dihydroxybutric
synthesis
acid
protected esters
Prior art date
Application number
ZA9706705A
Other languages
English (en)
Inventor
Thomas Elliott Jacks
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA976705B publication Critical patent/ZA976705B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/03Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34Oxygen atoms
ZA9706705A 1996-07-29 1997-07-28 Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid. ZA976705B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2236996P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
ZA976705B true ZA976705B (en) 1998-02-10

Family

ID=21809241

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9706705A ZA976705B (en) 1996-07-29 1997-07-28 Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid.

Country Status (18)

Country Link
US (1) US5998633A (fr)
EP (1) EP0915866B1 (fr)
JP (1) JP2000515882A (fr)
KR (1) KR100447370B1 (fr)
CN (1) CN1093126C (fr)
AT (1) ATE215078T1 (fr)
AU (1) AU3515497A (fr)
CO (1) CO4950542A1 (fr)
DE (1) DE69711391T2 (fr)
DK (1) DK0915866T3 (fr)
ES (1) ES2176756T3 (fr)
HK (1) HK1020728A1 (fr)
HU (1) HU226465B1 (fr)
IL (1) IL127058A (fr)
PT (1) PT915866E (fr)
TR (1) TR199900191T2 (fr)
WO (1) WO1998004543A1 (fr)
ZA (1) ZA976705B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2176756T3 (es) * 1996-07-29 2002-12-01 Warner Lambert Co Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico.
KR100332703B1 (ko) * 1998-07-24 2002-08-27 삼성정밀화학 주식회사 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법
JP3614366B2 (ja) * 1998-07-24 2005-01-26 サムスン ファイン ケミカルズ カンパニー リミテッド 光学的に純粋な(s)−3,4−ジヒドロキシ酪酸誘導体の製造方法
US6713290B2 (en) 1998-07-24 2004-03-30 Samsung Fine Chemicals Co., Ltd. Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone
US6235930B1 (en) * 1999-03-31 2001-05-22 Board Of Trustees Operating Michigan State University Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
ES2252088T3 (es) 1999-12-17 2006-05-16 Pfizer Science And Technology Ireland Limited Procedimiento de produccion a escala industrial de la hemisal de calcio de la atorvastatina trihidrato cristalina.
MXPA02004082A (es) * 1999-12-17 2002-10-11 Warner Lambert Res & Dev Un proceso para producir calcio de atorvastatin cristalino.
JP4598917B2 (ja) * 2000-04-28 2010-12-15 ダイセル化学工業株式会社 ラクトンの製造方法
KR100645665B1 (ko) 2000-07-27 2006-11-13 에스케이 주식회사 (s)-베타-하이드록시-감마-부티로락톤의 연속 제조방법
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1734034A3 (fr) 2001-01-09 2007-01-03 Warner-Lambert Company LLC Acides carboxyliques des esters ou amides de beta-alanine
WO2002057229A1 (fr) * 2001-01-19 2002-07-25 Biocon India Limited FORME V CRISTALLINE DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE)
HUP0400381A2 (hu) 2001-06-29 2004-09-28 Warner-Lambert Company Llc [R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái
WO2003004456A1 (fr) * 2001-07-06 2003-01-16 Teva Pharmaceutical Industries Ltd. Procede de preparation de derives d'acide 7-amino syn 3,5-dihydroxy heptanoique via des derives d'acide 6-cyano syn 3,5-dihydroxy hexanoique
ATE444299T1 (de) * 2002-02-25 2009-10-15 Biocon Ltd Neue boronatester
GB0211716D0 (en) 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
BR0313246A (pt) * 2002-08-06 2005-06-14 Warner Lambert Co Processo de preparação de fenilamida do ácido 5-(4-fluorfenil)-1-[2-((2r,4r)-4-hidróxi-6-oxo-tetrahidr o-piran-2-il)etil]-2-isopropil-4-fenil-1h-pirrol-3-carbo xìlico
CA2499655A1 (fr) * 2002-09-18 2004-04-01 Sk Corporation Procede continu pour la production de (s)-(.beta.)hydroxy-(.gamma.)butyrolactone de purete optique
EP1625223A4 (fr) * 2002-09-20 2009-11-11 Verenium Corp Procedes chimioenzymatiques de synthese de statines et d'intermediaires de statine
US6713639B1 (en) 2002-10-28 2004-03-30 Council Of Scientific And Industrial Research Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone
KR100780984B1 (ko) * 2003-04-14 2007-11-29 워너-램버트 캄파니 엘엘씨 5-(4-플루오로페닐)-1-[2-((2r,4r)-4-히드록시-6-옥소-테트라히드로-피란-2-일)에틸]-2-이소프로필-4-페닐-1h-피롤-3-카르복실산 페닐아미드의 제조 방법
US7232920B2 (en) * 2003-04-22 2007-06-19 Biocon Process for stereoselective reduction of β-ketoesters
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
RU2315755C2 (ru) * 2003-09-17 2008-01-27 Уорнер-Ламберт Компани Ллс Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты
WO2005068642A2 (fr) 2003-10-01 2005-07-28 Board Of Trustees Operating Michigan State University Synthese d'enantiomeres 1,2,4-butanetriol issue de glucides
CN1960972A (zh) * 2004-04-16 2007-05-09 辉瑞产品公司 用于形成无定形阿托伐它汀钙的方法
CA2649054A1 (fr) 2004-05-05 2005-11-10 Pfizer Products Inc. Formes salines d'acide [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique
CA2672554C (fr) 2004-07-20 2012-01-03 Warner-Lambert Company Llc Nouvelles formes de [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoatede calcium (2:1)
EP1807055A1 (fr) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Procede de formation d'atorvastatine amorphe
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
DE602006013815D1 (de) * 2005-05-31 2010-06-02 Kowa Co Verfahren zur herstellung von optisch aktiven ppar-aktivierenden verbindungen und zwischenprodukte für die herstellung
CA2547216A1 (fr) 2005-09-21 2007-03-21 Renuka D. Reddy Procede de recuit de l'atorvastatine amorphe
WO2007057755A1 (fr) 2005-11-21 2007-05-24 Warner-Lambert Company Llc Nouvelles formes d’acide [r-(r*,r*)]-2-(4-fluorophenyl)-b,b-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique magnesium
US20110165641A1 (en) * 2006-03-31 2011-07-07 The Board Of Trustees Of Michigan State University Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates
CN101512004A (zh) * 2006-07-19 2009-08-19 密歇根州州立大学托管委员会 D-1,2,4-丁三醇的微生物合成
KR100850558B1 (ko) 2008-01-02 2008-08-06 조동옥 아토르바스타틴의 효율적인 제조방법
JP2009256316A (ja) 2008-03-28 2009-11-05 Daicel Chem Ind Ltd β−ヒドロキシ−γ−ブチロラクトンの製造方法
CN101337906B (zh) * 2008-08-15 2012-06-27 河南豫辰精细化工有限公司 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
CN103702982A (zh) 2011-07-01 2014-04-02 中化帝斯曼制药有限公司荷兰公司 阿托伐他汀半钙的超细晶体
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN106588689A (zh) * 2016-12-15 2017-04-26 河南豫辰药业股份有限公司 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法
CN112939901B (zh) * 2021-02-09 2023-05-09 中国科学院福建物质结构研究所 一种α-羟基-γ-丁内酯的制备方法
CN114195670B (zh) * 2021-12-31 2024-03-15 河南豫辰药业股份有限公司 一种阿托伐他汀母核m4的精制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2710688B2 (ja) * 1990-10-09 1998-02-10 鐘淵化学工業株式会社 4―ブロモ―3―ヒドロキシ酪酸エステル誘導体の製造法
CA2049536C (fr) * 1991-05-13 1999-07-06 Rawle I. Hollingsworth Procede d'obtention d'acide 3,4-dihydroxybutanoique et de ses sels
JP3351563B2 (ja) * 1992-12-03 2002-11-25 鐘淵化学工業株式会社 3−ヒドロキシ酪酸誘導体の製造法
ES2176756T3 (es) * 1996-07-29 2002-12-01 Warner Lambert Co Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico.

Also Published As

Publication number Publication date
WO1998004543A1 (fr) 1998-02-05
IL127058A (en) 2001-07-24
HUP9904348A3 (en) 2004-03-01
DE69711391D1 (de) 2002-05-02
US5998633A (en) 1999-12-07
ES2176756T3 (es) 2002-12-01
DK0915866T3 (da) 2002-06-10
IL127058A0 (en) 1999-09-22
PT915866E (pt) 2002-07-31
CO4950542A1 (es) 2000-09-01
KR100447370B1 (ko) 2004-09-08
EP0915866A1 (fr) 1999-05-19
TR199900191T2 (xx) 1999-04-21
EP0915866B1 (fr) 2002-03-27
DE69711391T2 (de) 2002-11-07
JP2000515882A (ja) 2000-11-28
KR20000029648A (ko) 2000-05-25
HUP9904348A2 (hu) 2000-04-28
HK1020728A1 (en) 2000-05-19
CN1223647A (zh) 1999-07-21
AU3515497A (en) 1998-02-20
CN1093126C (zh) 2002-10-23
HU226465B1 (en) 2008-12-29
ATE215078T1 (de) 2002-04-15

Similar Documents

Publication Publication Date Title
ZA976705B (en) Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid.
BG106340A (en) Substituted oxoazaheterocyclyl compounds
MY121760A (en) Benzothiazin and benzoxazin derivatives;their preparation and uses
IL142649A0 (en) Azole derivatives
HK1001963A1 (en) Use of compounds in the preparation of a medicament for the inhibition of a pathological condition
HK1019878A1 (en) Total synthesis of antitumor acylfulvenes.
GR3033661T3 (en) Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
UA41291C2 (uk) ФТОРОВАНІ ПОХІДНІ 17<font face="Symbol">b</font>-ЗАМІЩЕНОГО-4-AЗA-5<font face="Symbol">a-</font>АНДРОСТАН-3-ОНУ І ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ
MY116862A (en) New processes for preparing pesticidal intermediates
MY103214A (en) Antihypercholesterolemic tetrazole compounds
IL136100A0 (en) Biphenylamidine derivatives, prodrugs thereof and pharmaceutical compositions containing the same
AP1519A (en) Process for the preparation of thiazolidinedione derivatives.
UA66866C2 (uk) Синтез морфолінових похідних
SI1102765T1 (en) PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C)QUINOLIZIN-3-ONES DERIVATIVES
AU3285000A (en) 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
ES8607967A1 (es) Un procedimiento para la preparacion de nuevos derivados delacido tiazolilacetico
IL138638A0 (en) Processes for preparing intermediates
AU2971997A (en) Intermediates for oligonucleotide synthesis
GB9915069D0 (en) New indolocarbazole alkaloids from a marine actinomycete
YU71400A (sh) Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana
EP0971899A4 (fr) Composes d'hexahydroindenopyridine presentant une activite antispermatogene
AU2639999A (en) Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
MX9801926A (es) Procedimiento para la preparacion de derivados de arilalquinil-n-hidroxiurea que tienen actividad inhibidora de lipoxigenasa.
TW254937B (en) Benzocycloheptene derivative and process for preparation thereof
MX9605794A (es) Intermediario para preparar un compuesto farmaceuticamente activo.