TR199900191T2 - (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. - Google Patents
(S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.Info
- Publication number
- TR199900191T2 TR199900191T2 TR1999/00191T TR9900191T TR199900191T2 TR 199900191 T2 TR199900191 T2 TR 199900191T2 TR 1999/00191 T TR1999/00191 T TR 1999/00191T TR 9900191 T TR9900191 T TR 9900191T TR 199900191 T2 TR199900191 T2 TR 199900191T2
- Authority
- TR
- Turkey
- Prior art keywords
- improved process
- synthesis
- dihydroxybutyric acid
- esters
- protected esters
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DZAIOXUZHHTJKN-VKHMYHEASA-N 3S,4-dihydroxy-butyric acid Chemical compound OC[C@@H](O)CC(O)=O DZAIOXUZHHTJKN-VKHMYHEASA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- FUDDLSHBRSNCBV-VKHMYHEASA-N (4s)-4-hydroxyoxolan-2-one Chemical compound O[C@@H]1COC(=O)C1 FUDDLSHBRSNCBV-VKHMYHEASA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2236996P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199900191T2 true TR199900191T2 (xx) | 1999-04-21 |
Family
ID=21809241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/00191T TR199900191T2 (xx) | 1996-07-29 | 1997-07-01 | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5998633A (fr) |
| EP (1) | EP0915866B1 (fr) |
| JP (1) | JP2000515882A (fr) |
| KR (1) | KR100447370B1 (fr) |
| CN (1) | CN1093126C (fr) |
| AT (1) | ATE215078T1 (fr) |
| AU (1) | AU3515497A (fr) |
| CO (1) | CO4950542A1 (fr) |
| DE (1) | DE69711391T2 (fr) |
| DK (1) | DK0915866T3 (fr) |
| ES (1) | ES2176756T3 (fr) |
| HK (1) | HK1020728A1 (fr) |
| HU (1) | HU226465B1 (fr) |
| IL (1) | IL127058A (fr) |
| PT (1) | PT915866E (fr) |
| TR (1) | TR199900191T2 (fr) |
| WO (1) | WO1998004543A1 (fr) |
| ZA (1) | ZA976705B (fr) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176756T3 (es) * | 1996-07-29 | 2002-12-01 | Warner Lambert Co | Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico. |
| KR100332703B1 (ko) * | 1998-07-24 | 2002-08-27 | 삼성정밀화학 주식회사 | 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법 |
| JP3614366B2 (ja) * | 1998-07-24 | 2005-01-26 | サムスン ファイン ケミカルズ カンパニー リミテッド | 光学的に純粋な（ｓ）−３，４−ジヒドロキシ酪酸誘導体の製造方法 |
| US6713290B2 (en) | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| US6235930B1 (en) * | 1999-03-31 | 2001-05-22 | Board Of Trustees Operating Michigan State University | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars |
| HU227840B1 (en) * | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| ES2252088T3 (es) | 1999-12-17 | 2006-05-16 | Pfizer Science And Technology Ireland Limited | Procedimiento de produccion a escala industrial de la hemisal de calcio de la atorvastatina trihidrato cristalina. |
| MXPA02004082A (es) * | 1999-12-17 | 2002-10-11 | Warner Lambert Res & Dev | Un proceso para producir calcio de atorvastatin cristalino. |
| JP4598917B2 (ja) * | 2000-04-28 | 2010-12-15 | ダイセル化学工業株式会社 | ラクトンの製造方法 |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (ｓ)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| EP1734034A3 (fr) | 2001-01-09 | 2007-01-03 | Warner-Lambert Company LLC | Acides carboxyliques des esters ou amides de beta-alanine |
| WO2002057229A1 (fr) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORME V CRISTALLINE DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE) |
| HUP0400381A2 (hu) | 2001-06-29 | 2004-09-28 | Warner-Lambert Company Llc | [R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái |
| WO2003004456A1 (fr) * | 2001-07-06 | 2003-01-16 | Teva Pharmaceutical Industries Ltd. | Procede de preparation de derives d'acide 7-amino syn 3,5-dihydroxy heptanoique via des derives d'acide 6-cyano syn 3,5-dihydroxy hexanoique |
| ATE444299T1 (de) * | 2002-02-25 | 2009-10-15 | Biocon Ltd | Neue boronatester |
| GB0211716D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| BR0313246A (pt) * | 2002-08-06 | 2005-06-14 | Warner Lambert Co | Processo de preparação de fenilamida do ácido 5-(4-fluorfenil)-1-[2-((2r,4r)-4-hidróxi-6-oxo-tetrahidr o-piran-2-il)etil]-2-isopropil-4-fenil-1h-pirrol-3-carbo xìlico |
| CA2499655A1 (fr) * | 2002-09-18 | 2004-04-01 | Sk Corporation | Procede continu pour la production de (s)-(.beta.)hydroxy-(.gamma.)butyrolactone de purete optique |
| EP1625223A4 (fr) * | 2002-09-20 | 2009-11-11 | Verenium Corp | Procedes chimioenzymatiques de synthese de statines et d'intermediaires de statine |
| US6713639B1 (en) | 2002-10-28 | 2004-03-30 | Council Of Scientific And Industrial Research | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone |
| KR100780984B1 (ko) * | 2003-04-14 | 2007-11-29 | 워너-램버트 캄파니 엘엘씨 | 5-(4-플루오로페닐)-1-[2-((2ｒ,4ｒ)-4-히드록시-6-옥소-테트라히드로-피란-2-일)에틸]-2-이소프로필-4-페닐-1ｈ-피롤-3-카르복실산 페닐아미드의 제조 방법 |
| US7232920B2 (en) * | 2003-04-22 | 2007-06-19 | Biocon | Process for stereoselective reduction of β-ketoesters |
| US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| RU2315755C2 (ru) * | 2003-09-17 | 2008-01-27 | Уорнер-Ламберт Компани Ллс | Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты |
| WO2005068642A2 (fr) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Synthese d'enantiomeres 1,2,4-butanetriol issue de glucides |
| CN1960972A (zh) * | 2004-04-16 | 2007-05-09 | 辉瑞产品公司 | 用于形成无定形阿托伐它汀钙的方法 |
| CA2649054A1 (fr) | 2004-05-05 | 2005-11-10 | Pfizer Products Inc. | Formes salines d'acide [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique |
| CA2672554C (fr) | 2004-07-20 | 2012-01-03 | Warner-Lambert Company Llc | Nouvelles formes de [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoatede calcium (2:1) |
| EP1807055A1 (fr) * | 2004-10-28 | 2007-07-18 | Warner-Lambert Company LLC | Procede de formation d'atorvastatine amorphe |
| JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
| DE602006013815D1 (de) * | 2005-05-31 | 2010-06-02 | Kowa Co | Verfahren zur herstellung von optisch aktiven ppar-aktivierenden verbindungen und zwischenprodukte für die herstellung |
| CA2547216A1 (fr) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Procede de recuit de l'atorvastatine amorphe |
| WO2007057755A1 (fr) | 2005-11-21 | 2007-05-24 | Warner-Lambert Company Llc | Nouvelles formes d’acide [r-(r*,r*)]-2-(4-fluorophenyl)-b,b-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique magnesium |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| CN101512004A (zh) * | 2006-07-19 | 2009-08-19 | 密歇根州州立大学托管委员会 | D-1,2,4-丁三醇的微生物合成 |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| JP2009256316A (ja) | 2008-03-28 | 2009-11-05 | Daicel Chem Ind Ltd | β−ヒドロキシ−γ−ブチロラクトンの製造方法 |
| CN101337906B (zh) * | 2008-08-15 | 2012-06-27 | 河南豫辰精细化工有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法 |
| EP2327682A1 (fr) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines. |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| CN103702982A (zh) | 2011-07-01 | 2014-04-02 | 中化帝斯曼制药有限公司荷兰公司 | 阿托伐他汀半钙的超细晶体 |
| CN106397241A (zh) * | 2016-08-23 | 2017-02-15 | 杨锋 | 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法 |
| CN106588689A (zh) * | 2016-12-15 | 2017-04-26 | 河南豫辰药业股份有限公司 | 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法 |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| CN114195670B (zh) * | 2021-12-31 | 2024-03-15 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀母核m4的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2710688B2 (ja) * | 1990-10-09 | 1998-02-10 | 鐘淵化学工業株式会社 | ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法 |
| CA2049536C (fr) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Procede d'obtention d'acide 3,4-dihydroxybutanoique et de ses sels |
| JP3351563B2 (ja) * | 1992-12-03 | 2002-11-25 | 鐘淵化学工業株式会社 | ３−ヒドロキシ酪酸誘導体の製造法 |
| ES2176756T3 (es) * | 1996-07-29 | 2002-12-01 | Warner Lambert Co | Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico. |
-
1997
- 1997-07-01 ES ES97931557T patent/ES2176756T3/es not_active Expired - Lifetime
- 1997-07-01 EP EP97931557A patent/EP0915866B1/fr not_active Expired - Lifetime
- 1997-07-01 US US09/230,397 patent/US5998633A/en not_active Expired - Fee Related
- 1997-07-01 JP JP10508813A patent/JP2000515882A/ja not_active Ceased
- 1997-07-01 AT AT97931557T patent/ATE215078T1/de not_active IP Right Cessation
- 1997-07-01 HU HU9904348A patent/HU226465B1/hu not_active IP Right Cessation
- 1997-07-01 TR TR1999/00191T patent/TR199900191T2/xx unknown
- 1997-07-01 DE DE69711391T patent/DE69711391T2/de not_active Expired - Fee Related
- 1997-07-01 AU AU35154/97A patent/AU3515497A/en not_active Abandoned
- 1997-07-01 IL IL12705897A patent/IL127058A/en not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/011654 patent/WO1998004543A1/fr active IP Right Grant
- 1997-07-01 DK DK97931557T patent/DK0915866T3/da active
- 1997-07-01 KR KR10-1999-7000721A patent/KR100447370B1/ko not_active IP Right Cessation
- 1997-07-01 PT PT97931557T patent/PT915866E/pt unknown
- 1997-07-01 CN CN97195996A patent/CN1093126C/zh not_active Expired - Fee Related
- 1997-07-28 ZA ZA9706705A patent/ZA976705B/xx unknown
- 1997-07-28 CO CO97042973A patent/CO4950542A1/es unknown
-
1999
- 1999-12-09 HK HK99105756A patent/HK1020728A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998004543A1 (fr) | 1998-02-05 |
| IL127058A (en) | 2001-07-24 |
| HUP9904348A3 (en) | 2004-03-01 |
| DE69711391D1 (de) | 2002-05-02 |
| US5998633A (en) | 1999-12-07 |
| ES2176756T3 (es) | 2002-12-01 |
| DK0915866T3 (da) | 2002-06-10 |
| IL127058A0 (en) | 1999-09-22 |
| ZA976705B (en) | 1998-02-10 |
| PT915866E (pt) | 2002-07-31 |
| CO4950542A1 (es) | 2000-09-01 |
| KR100447370B1 (ko) | 2004-09-08 |
| EP0915866A1 (fr) | 1999-05-19 |
| EP0915866B1 (fr) | 2002-03-27 |
| DE69711391T2 (de) | 2002-11-07 |
| JP2000515882A (ja) | 2000-11-28 |
| KR20000029648A (ko) | 2000-05-25 |
| HUP9904348A2 (hu) | 2000-04-28 |
| HK1020728A1 (en) | 2000-05-19 |
| CN1223647A (zh) | 1999-07-21 |
| AU3515497A (en) | 1998-02-20 |
| CN1093126C (zh) | 2002-10-23 |
| HU226465B1 (en) | 2008-12-29 |
| ATE215078T1 (de) | 2002-04-15 |
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