ZA955437B - Method and apparatus for the formation or particles - Google Patents

Method and apparatus for the formation or particles

Info

Publication number
ZA955437B
ZA955437B ZA955437A ZA955437A ZA955437B ZA 955437 B ZA955437 B ZA 955437B ZA 955437 A ZA955437 A ZA 955437A ZA 955437 A ZA955437 A ZA 955437A ZA 955437 B ZA955437 B ZA 955437B
Authority
ZA
South Africa
Prior art keywords
vehicle
supercritical fluid
suspension
solution
substance
Prior art date
Application number
ZA955437A
Other languages
English (en)
Inventor
Mazen Hanna
Peter York
Original Assignee
Univ Bradford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10757607&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA955437(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Bradford filed Critical Univ Bradford
Publication of ZA955437B publication Critical patent/ZA955437B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0403Solvent extraction of solutions which are liquid with a supercritical fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0403Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0403Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0488Flow sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008Processes carried out under supercritical conditions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/02Feed or outlet devices therefor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
ZA955437A 1994-06-30 1995-06-30 Method and apparatus for the formation or particles ZA955437B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413202A GB9413202D0 (en) 1994-06-30 1994-06-30 Method and apparatus for the formation of particles

Publications (1)

Publication Number Publication Date
ZA955437B true ZA955437B (en) 1996-02-16

Family

ID=10757607

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955437A ZA955437B (en) 1994-06-30 1995-06-30 Method and apparatus for the formation or particles

Country Status (15)

Country Link
US (4) US6063138A (xx)
EP (1) EP0767702B1 (xx)
JP (1) JP3386470B2 (xx)
AT (1) ATE174531T1 (xx)
AU (1) AU688526B2 (xx)
CA (1) CA2192811C (xx)
DE (1) DE69506707T2 (xx)
DK (1) DK0767702T3 (xx)
ES (1) ES2128743T3 (xx)
GB (1) GB9413202D0 (xx)
GR (1) GR3029531T3 (xx)
IN (1) IN191374B (xx)
MX (1) MX9606730A (xx)
WO (1) WO1996000610A1 (xx)
ZA (1) ZA955437B (xx)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
FR2753639B1 (fr) 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
JP3333699B2 (ja) * 1996-11-22 2002-10-15 仲道 山崎 連続水熱反応における原料粒子噴霧方法および装置
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
GB9804379D0 (en) * 1998-03-02 1998-04-22 Bradford Particle Design Ltd Method of particle formation
US6866786B2 (en) * 1998-04-03 2005-03-15 Symyx Technologies, Inc. Rapid characterization of polymers
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6048369A (en) * 1998-06-03 2000-04-11 North Carolina State University Method of dyeing hydrophobic textile fibers with colorant materials in supercritical fluid carbon dioxide
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
SE9804003D0 (sv) 1998-11-23 1998-11-23 Astra Ab A method of producing drug particles
SE9804001D0 (sv) 1998-11-23 1998-11-23 Astra Ab New process
SE9804000D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New composition of matter
US6864301B2 (en) * 1998-11-30 2005-03-08 The Regents Of The University Of Colorado Preparation and use of photopolymerized microparticles
US6403672B1 (en) * 1998-11-30 2002-06-11 University Technology Corporation Preparation and use of photopolymerized microparticles
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
SE9901059L (sv) * 1999-03-22 2000-09-23 Johan Carlfors Metod för framställning av partiklar
US6855258B2 (en) * 1999-04-02 2005-02-15 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
SE9901667D0 (sv) 1999-05-07 1999-05-07 Astra Ab Method and device for forming particles
EP1185248B1 (en) * 1999-06-09 2012-05-02 Robert E. Sievers Supercritical fluid-assisted nebulization and bubble drying
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
JP2003507410A (ja) * 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ,インコーポレイテッド 乾燥粉末製剤からの放出調節
EP1090894A1 (de) * 1999-10-06 2001-04-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung feinpartikulärer Explosivstoffe
GB9927011D0 (en) 1999-11-16 2000-01-12 Advanced Phytonics Ltd Method for the production of particles
FR2803538B1 (fr) * 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
US6761909B1 (en) 1999-12-21 2004-07-13 Rxkinetix, Inc. Particulate insulin-containing products and method of manufacture
AU2729101A (en) 1999-12-21 2001-07-03 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
US6261326B1 (en) 2000-01-13 2001-07-17 North Carolina State University Method for introducing dyes and other chemicals into a textile treatment system
PL202704B1 (pl) * 2000-03-03 2009-07-31 Boehringer Ingelheim Pharma Sposób obróbki substancji rozpuszczanej, sposób jej krystalizacji z roztworu, sposób jej ekstrakcji z mieszaniny, sposób powlekania substancją substratu, sposób nasycania nośnika substancją, sposób usuwania zanieczyszczeń z wyrobu, oraz sposób przeprowadzania reakcji chemicznych w celu wytworzenia produktu reakcji
CH694686A5 (it) 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
US6971383B2 (en) * 2001-01-24 2005-12-06 University Of North Carolina At Chapel Hill Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
US7326691B2 (en) 2004-06-21 2008-02-05 Nektar Therapeutics Compositions comprising amphotericin B, methods, and systems
YU34501A (sh) 2000-05-26 2003-10-31 Pfizer Products Inc. Postupak reaktivne kristalizacije radi povećanja veličine čestica
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
ES2170008B1 (es) * 2000-08-25 2003-05-01 Soc Es Carburos Metalicos Sa Procedimiento para la precipitacion de particulas solidas finamente divididas.
US6676710B2 (en) 2000-10-18 2004-01-13 North Carolina State University Process for treating textile substrates
FR2815540B1 (fr) 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
ATE319432T1 (de) * 2000-12-22 2006-03-15 Baxter Int Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
WO2002053190A2 (en) 2000-12-29 2002-07-11 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
IL157346A0 (en) * 2001-02-26 2004-02-19 Dompe Spa Apparatus and method for micron and submicron particle formation
CA2447681A1 (en) * 2001-05-18 2002-11-28 Unisearch Limited Vanadium redox battery electrolyte
WO2003006223A1 (en) * 2001-07-10 2003-01-23 University Technology Corporation Devices and methods for the production of particles
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
KR100870328B1 (ko) * 2001-08-22 2008-11-25 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 β-말토오스 함수결정 함유 분말과 그 제조방법 및 용도
US6730228B2 (en) * 2001-08-28 2004-05-04 Symyx Technologies, Inc. Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
JP2005504090A (ja) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
EA006064B1 (ru) * 2001-10-10 2005-08-25 Бёрингер Ингельхайм Фармасьютиклз, Инк. Способ обработки порошков сжиженными газами
US20050123509A1 (en) * 2001-10-19 2005-06-09 Lehrman S. R. Modulating charge density to produce improvements in the characteristics of spray-dried proteins
US20050013867A1 (en) * 2001-10-19 2005-01-20 Lehrman S. Russ Use of proton sequestering agents in drug formulations
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
JP4374249B2 (ja) 2001-10-22 2009-12-02 ドンペ ピーエイチエー.アール.エムエー エス.ピー.エー. 超臨界的流体による処理方法:タンパク質微粒子の調製およびそれらの安定化
ES2415654T3 (es) * 2001-11-20 2013-07-26 Civitas Therapeutics, Inc. Composiciones particuladas mejoradas para suministro pulmonar
AU2003218308B2 (en) * 2002-03-20 2006-07-20 Advanced Inhalation Research, Inc. hGH (human growth hormone) formulations for pulmonary administration
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050163725A1 (en) * 2002-03-20 2005-07-28 Blizzard Charles D. Method for administration of growth hormone via pulmonary delivery
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
WO2003090717A1 (en) * 2002-04-23 2003-11-06 Nanotherapeutics, Inc Process of forming and modifying particles and compositions produced thereby
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
KR20110017465A (ko) * 2002-04-25 2011-02-21 더 스크립스 리서치 인스티튜트 폐질환 증상의 치료 및 예방
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
JP2006512264A (ja) * 2002-06-25 2006-04-13 オルボア・ウニヴェルシテート 一次粒子径がサブミクロンの生成物の製造方法、該方法によって製造された生成物、及び該方法に用いる装置
EP1534366B1 (en) * 2002-06-27 2014-01-08 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
GB0221150D0 (en) * 2002-09-12 2002-10-23 Matthews Siobhan O Incorporation of functional materials into bulk materials
WO2004056341A1 (en) * 2002-12-19 2004-07-08 Baxter International, Inc. Process for preparing pharmaceutical formulations using supercritical fluids
US20040152720A1 (en) * 2002-12-20 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powdered medicaments containing a tiotropium salt and salmeterol xinafoate
JP4808970B2 (ja) * 2002-12-30 2011-11-02 ネクター セラピューティクス 噴霧乾燥システム
US6931888B2 (en) * 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US7041144B2 (en) * 2003-03-04 2006-05-09 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization process
MXPA05009413A (es) * 2003-03-04 2005-11-04 Five Star Technologies Inc Dispositivo y procedimiento para cristalizacion por cavitacion hidrodinamica.
US20080194868A1 (en) * 2003-03-04 2008-08-14 Kozyuk Oleg V Hydrodynamic cavitation crystallization device and process
MXPA05011343A (es) * 2003-05-08 2005-12-12 Nektar Therapeutics Uk Ltd Materiales particulados.
WO2004108265A2 (en) 2003-06-03 2004-12-16 Ferro Corporation Nanoparticles from supercritical fluid antisolvent process using particle growth and agglomeration retardants
US20060275219A1 (en) * 2003-06-10 2006-12-07 Taisho Pharmaceutical Co., Ltd. Radial spherical crystallization product, process for producing the same, and dry powder preparation containing the crystallization product
CA2538237A1 (en) * 2003-09-10 2005-03-24 Map Pharmaceuticals, Inc. Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
GB0324086D0 (en) * 2003-10-14 2003-11-19 Glaxo Group Ltd Process for preparing a co-precipitate of a non-crystalline solid drug substance
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
JP4131225B2 (ja) * 2003-10-29 2008-08-13 富士フイルム株式会社 金属微粒子の連続製造方法及び装置
EP1694314A4 (en) * 2003-12-04 2009-07-01 Scripps Research Inst TREATMENT AND PREVENTION OF ASTHMA
WO2005061410A1 (en) * 2003-12-23 2005-07-07 Aalborg Universitet Method and apparatus for production of a compound having submicron particle size and a compound produced by the method
EP1701714A2 (en) * 2004-01-07 2006-09-20 Nektar Therapeutics Improved sustained release compositions for pulmonary administration of insulin
DE102004002318A1 (de) * 2004-01-16 2005-08-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung feindisperser kristallinger Treib-, Explosivstoffe und Oxidatoren
EP1711163A2 (en) * 2004-02-05 2006-10-18 Baxter International Inc. Dispersions prepared by use of self-stabilizing agents
CA2555294A1 (en) 2004-02-11 2005-08-25 Marina Yu Etinger Candesartan cilexetil polymorphs
US7223445B2 (en) 2004-03-31 2007-05-29 Eastman Kodak Company Process for the deposition of uniform layer of particulate material
US7220456B2 (en) 2004-03-31 2007-05-22 Eastman Kodak Company Process for the selective deposition of particulate material
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
US7901606B2 (en) * 2004-07-12 2011-03-08 Ferro Corporation Production of porous materials by supercritical fluid processing
DE102004059069A1 (de) * 2004-12-07 2006-06-08 Bühler AG Vertropfungsanlage
WO2006076097A2 (en) * 2004-12-07 2006-07-20 Nektar Therapeutics Stable non-crystalline formulation comprising losartan
JP4635154B2 (ja) * 2005-02-22 2011-02-16 日本工機株式会社 微粒子化合火薬類の微粒子生成装置、微粒子化合火薬類の製造装置および微粒子化合火薬類の製造方法
EP1866407A4 (en) * 2005-03-22 2010-07-14 Regeron Inc DEVICE AND METHOD FOR SUBMICRONIZING PROTEINS USING SUPERCRITICAL LIQUIDS
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
AU2006259594A1 (en) * 2005-06-14 2006-12-28 Baxter Healthcare S.A. Pharmaceutical formulations for minimizing drug-drug interactions
EP1904219A4 (en) * 2005-07-15 2011-07-27 Map Pharmaceuticals Inc METHOD FOR FORMING PARTICLES
CA2615378C (en) * 2005-07-15 2015-02-17 Map Pharmaceuticals, Inc. Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof
US20070134341A1 (en) * 2005-11-15 2007-06-14 Kipp James E Compositions of lipoxygenase inhibitors
US8293869B2 (en) * 2005-12-16 2012-10-23 Nektar Therapeutics Polymer conjugates of GLP-1
EP1963000B1 (en) * 2005-12-22 2010-09-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for preparing particles from an emulsion in supercritical or liquid co2
NL1031224C2 (nl) * 2006-02-23 2007-09-03 Friesland Brands Bv Het bereiden van gedroogde deeltjes met behulp van een superkritisch medium.
FR2898516B1 (fr) * 2006-03-17 2008-05-30 Innov Ia Sa Procede de preparation d'une composition pulverulente et produit tel qu'obtenu
EP2476412B1 (en) * 2006-10-11 2014-03-19 Crititech, Inc. Apparatus for precipitation of small medicament particles into use containers
US20090152176A1 (en) * 2006-12-23 2009-06-18 Baxter International Inc. Magnetic separation of fine particles from compositions
GB0702402D0 (en) 2007-02-08 2007-03-21 Thar Pharmaceuticals Inc Method of creating crystalline substances
AU2008214205B2 (en) * 2007-02-11 2014-04-24 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
AU2008331967B2 (en) * 2007-12-07 2012-10-25 Xspray Microparticles Ab Method and arrangement for the production of particles
CN102083418A (zh) * 2008-04-24 2011-06-01 伊万斯彻有限公司 口服避孕药剂及其制备方法
BRPI0913021A2 (pt) 2008-05-15 2015-10-13 Novartis Ag distribuição pulmonar de uma fluoroquinolona
CN101444709B (zh) * 2008-12-05 2010-06-02 厦门大学 一种以超临界二氧化碳从水溶液中获取固体颗粒的方法
EP2380006A4 (en) * 2009-01-21 2012-05-16 Biocon Ltd PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM
US20100291221A1 (en) * 2009-05-15 2010-11-18 Robert Owen Cook Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
PL3106149T3 (pl) 2009-05-29 2020-06-01 Pearl Therapeutics, Inc. Kompozycje do płucnego dostarczania długo-działających antagonistów muskarynowych i długo-działających agonistów receptora beta-2 adrenergicznego oraz powiązane sposoby i układy
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
ES2675120T3 (es) * 2010-04-01 2018-07-06 The Governors Of The University Of Alberta Tratamiento de biopolímeros de alto peso molecular con fluidos supercríticos
EP2604335A4 (en) * 2010-08-11 2017-05-17 LG Chem, Ltd. Production device for inorganic compounds and a production method for inorganic compounds using the same
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
US9925512B2 (en) 2013-03-14 2018-03-27 Crititech, Inc. Equipment assembly for and method of processing particles
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
JP6454323B2 (ja) 2013-03-15 2019-01-16 パール セラピューティクス,インコーポレイテッド 粒子状結晶性材料のコンディショニングのための方法及びシステム
EP2999460A1 (en) 2013-05-22 2016-03-30 Pearl Therapeutics, Inc. Compositions, methods&systems for respiratory delivery of three or more active agents
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
WO2016153922A1 (en) * 2015-03-20 2016-09-29 Sabic Global Technologies B.V. Improved drying systems
RU2590561C1 (ru) * 2015-03-26 2016-07-10 Сергей Александрович Сошин Установка для получения мелкодисперсных порошков и способ получения мелкодисперсных порошков
SG10201913947RA (en) 2015-06-04 2020-03-30 Crititech Inc Taxane particles and their use
DE102015007604A1 (de) * 2015-06-12 2016-12-29 Messer France S.A.S Vorrichtung und Verfahren zum Kühlen und Zerstäuben flüssiger oder pastöser Stoffe
WO2018001486A1 (en) * 2016-06-30 2018-01-04 Sabic Global Technologies B.V. Process for the preparation of polyolefin particles
US11136438B2 (en) 2015-07-13 2021-10-05 Sabic Global Technologies B.V. Process for the preparation of polyolefin particles
EP3325456A4 (en) 2015-07-22 2019-01-23 Anavex Life Sciences Corp. CRYSTAL FORMS OF TETRA-HYDRO-N, N-DIMETHYL-2,2-DIPHENYL-3-FURANOMETHANAMINE HYDROCHLORIDE, METHOD FOR THE PREPARATION OF SUCH FORMS, AND THEIR PHARMACEUTICAL COMPOSITIONS
KR102125156B1 (ko) * 2015-09-25 2020-06-22 사피 네덜란드 서비시즈 비.브이. 초임계 c02 셀룰로즈 분무건조 방법
KR102317108B1 (ko) 2016-04-04 2021-10-25 크리티테크, 인크. 고형 종양의 치료 방법
WO2018121980A1 (en) 2017-01-02 2018-07-05 Sabic Global Technologies B.V. Process for recycling polyolefin
SG10201913649TA (en) 2017-06-09 2020-03-30 Crititech Inc Treatment of epithelial cysts by intracystic injection of antineoplastic particles
AU2018284247B2 (en) 2017-06-14 2020-04-30 Crititech Inc. Methods for treating lung disorders
CA3076919A1 (en) 2017-10-03 2019-04-11 Crititech, Inc. Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
KR20220140095A (ko) 2021-04-08 2022-10-18 삼성디스플레이 주식회사 페로브스카이트 박막 형성 방법 및 이로부터 제조된 층을 포함하는 발광 소자
CA3226557A1 (en) 2021-07-09 2023-01-12 Astrazeneca Pharmaceuticals Lp Compositions, methods and systems for aerosol drug delivery
WO2023119093A1 (en) 2021-12-20 2023-06-29 Astrazeneca Ab Compositions, methods and systems for aerosol drug delivery
WO2023212191A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab Combination of albuterol and budesonide for the treatment of asthma

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361281A (en) * 1980-07-07 1982-11-30 General Electric Company Exhaust nozzle
US4328107A (en) * 1980-11-28 1982-05-04 Synergo, Inc. Process and apparatus for forming dispersions
US4582731A (en) * 1983-09-01 1986-04-15 Battelle Memorial Institute Supercritical fluid molecular spray film deposition and powder formation
US4514574A (en) * 1984-01-09 1985-04-30 The Dow Chemical Company Process for separating isomeric mixtures
US4702799A (en) * 1985-09-03 1987-10-27 Nestec S.A. Dryer and drying method
US4737384A (en) * 1985-11-01 1988-04-12 Allied Corporation Deposition of thin films using supercritical fluids
DE3787533T2 (de) * 1987-12-21 1994-01-20 Union Carbide Corp Verwendung von superkritischen Flüssigkeiten als Verdünner beim Aufsprühen von Überzügen.
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US4919853A (en) * 1988-01-21 1990-04-24 The United States Of America As Represented By The United States Department Of Energy Apparatus and method for spraying liquid materials
US4977785A (en) * 1988-02-19 1990-12-18 Extrel Corporation Method and apparatus for introduction of fluid streams into mass spectrometers and other gas phase detectors
US5066522A (en) * 1988-07-14 1991-11-19 Union Carbide Chemicals And Plastics Technology Corporation Supercritical fluids as diluents in liquid spray applications of adhesives
JP2843857B2 (ja) * 1988-10-05 1999-01-06 ファルマシア・アンド・アップジョン・カンパニー 反溶剤への沈澱を介する微細分化固体結晶性粉末
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5009367A (en) * 1989-03-22 1991-04-23 Union Carbide Chemicals And Plastics Technology Corporation Methods and apparatus for obtaining wider sprays when spraying liquids by airless techniques
US5106659A (en) * 1989-10-04 1992-04-21 Nordson Corporation Method and apparatus for spraying a liquid coating containing supercritical fluid or liquified gas
US4970093A (en) * 1990-04-12 1990-11-13 University Of Colorado Foundation Chemical deposition methods using supercritical fluid solutions
DE4118230A1 (de) * 1990-12-20 1992-06-25 Bayer Ag Verfahren zur isolierung von polymeren aus ihren loesungsmitteln mit kohlendioxid-haltigen fluessigkeiten
DE4117751A1 (de) * 1991-05-30 1992-12-03 Bayer Ag Verfahren zur isolierung von polycarbonaten
JPH0557166A (ja) * 1991-08-31 1993-03-09 Kobe Steel Ltd 被覆微粒子の製造方法
US6063910A (en) * 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
US5196575A (en) * 1992-02-19 1993-03-23 Hoechst Celanese Corp. Supercritical separation of isomers of functional organic compounds at moderate conditions
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
WO1994009913A1 (en) * 1992-11-02 1994-05-11 Ferro Corporation Method of preparing coating materials
DE59308043D1 (de) * 1993-02-24 1998-02-26 Sulzer Chemtech Ag Reinigung von salzbeladenem Abwasser durch Nassoxidation bei superkritischen Bedingungen
US5336837A (en) * 1993-03-25 1994-08-09 Taiwan Styrene Monomer Corporation Separation of diethylbenzene isomers on silicalite in the presence of high pressure carbon dioxide and propane
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
PL314294A1 (en) * 1993-11-08 1996-09-02 Gillette Co Method of producing particles using a hypercritical fluid, aerogel particles obtained thereby and antiperspirants containing such particles
US5716558A (en) * 1994-11-14 1998-02-10 Union Carbide Chemicals & Plastics Technology Corporation Method for producing coating powders catalysts and drier water-borne coatings by spraying compositions with compressed fluids
MX9504934A (es) * 1994-12-12 1997-01-31 Morton Int Inc Revestimientos en polvo de pelicula delgada lisa.

Also Published As

Publication number Publication date
JPH10502016A (ja) 1998-02-24
DK0767702T3 (da) 1999-08-23
US6063138A (en) 2000-05-16
CA2192811A1 (en) 1996-01-11
EP0767702B1 (en) 1998-12-16
MX9606730A (es) 1997-04-30
ES2128743T3 (es) 1999-05-16
WO1996000610A1 (en) 1996-01-11
US20060073087A1 (en) 2006-04-06
US20020010982A1 (en) 2002-01-31
US20020073511A1 (en) 2002-06-20
DE69506707D1 (de) 1999-01-28
GB9413202D0 (en) 1994-08-24
AU2800395A (en) 1996-01-25
EP0767702A1 (en) 1997-04-16
GR3029531T3 (en) 1999-06-30
DE69506707T2 (de) 1999-07-01
JP3386470B2 (ja) 2003-03-17
CA2192811C (en) 2004-11-16
IN191374B (xx) 2003-11-29
ATE174531T1 (de) 1999-01-15
AU688526B2 (en) 1998-03-12

Similar Documents

Publication Publication Date Title
ZA955437B (en) Method and apparatus for the formation or particles
CA2166301A1 (en) Method and apparatus for the formation of particles
GB9810559D0 (en) Method and apparatus for particle formation
GB2322326B (en) Method & apparatus for the formation of particles
GB2354968B (en) Method of particle formation
WO2001024935A3 (en) High pressure mill and method of creating ultra-fine particles of materials using the same
AU1876100A (en) Process and apparatus for producing particles using a supercritical fluid
DE69523781D1 (de) Koninuierliches verfahren zur feinstzerkleinerung von arzneimitteln
CA1115551A (en) Process for packing chromatographic columns
CA2321741A1 (en) Method of particle formation
CA2172055A1 (en) Process (ii) for the preparation of powdered medicament
AU4792300A (en) Method and device for forming particles
PT1572315E (pt) Aparelho e método para o isolamento de partículas produzidas como uma suspensão num fluido não-supercrítico
CA2056188A1 (en) Polymerization of monovinylaromatic compounds
SE9901059L (sv) Metod för framställning av partiklar
CA2247900A1 (en) Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents