CA2247900A1 - Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents - Google Patents

Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents

Info

Publication number
CA2247900A1
CA2247900A1 CA002247900A CA2247900A CA2247900A1 CA 2247900 A1 CA2247900 A1 CA 2247900A1 CA 002247900 A CA002247900 A CA 002247900A CA 2247900 A CA2247900 A CA 2247900A CA 2247900 A1 CA2247900 A1 CA 2247900A1
Authority
CA
Canada
Prior art keywords
antisolvent
coating
dispersant
supercritical
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002247900A
Other languages
French (fr)
Other versions
CA2247900C (en
Inventor
Bala Subramaniam
Said Saim
Roger A. Rajewski
Valentino Stella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
The University Of Kansas
Bala Subramaniam
Said Saim
Roger A. Rajewski
Valentino Stella
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/723,463 external-priority patent/US5874029A/en
Priority claimed from US08/805,215 external-priority patent/US5833891A/en
Application filed by The University Of Kansas, Bala Subramaniam, Said Saim, Roger A. Rajewski, Valentino Stella filed Critical The University Of Kansas
Priority claimed from PCT/US1997/003207 external-priority patent/WO1997031691A1/en
Publication of CA2247900A1 publication Critical patent/CA2247900A1/en
Application granted granted Critical
Publication of CA2247900C publication Critical patent/CA2247900C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/025—Processes for applying liquids or other fluent materials performed by spraying using gas close to its critical state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
    • B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state

Abstract

Improved method and apparatus (110) for particle precipitation and coating using near- or supercritical fluid conditions. A fluid dispersion (128) having a continuous phase dispersant and at least one precipitable substance therein is contacted with a supercritical fluid (SCF) antisolvent (126) so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets. The enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 microns. In coating processes, a turbulent fluidized flow of core particles is created using SCF antisolvent in an enclosed zone.
The core particles are contacted therein at or near supercritical conditions by fluid dispersion containing a dispersant and together with a precipitable substance. The antisolvent depletes the dispersant and the substance is precipitated onto fluidized particles.
CA002247900A 1996-03-01 1997-02-28 Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents Expired - Lifetime CA2247900C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1259296P 1996-03-01 1996-03-01
US1259396P 1996-03-01 1996-03-01
US60/012,592 1996-03-01
US60/012,593 1996-03-01
US08/723,463 US5874029A (en) 1996-10-09 1996-10-09 Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
US08/723,463 1996-10-09
US08/805,215 US5833891A (en) 1996-10-09 1997-02-27 Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
US08/805,215 1997-02-27
PCT/US1997/003207 WO1997031691A1 (en) 1996-03-01 1997-02-28 Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents

Publications (2)

Publication Number Publication Date
CA2247900A1 true CA2247900A1 (en) 1997-09-04
CA2247900C CA2247900C (en) 2006-08-01

Family

ID=36764348

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247900A Expired - Lifetime CA2247900C (en) 1996-03-01 1997-02-28 Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents

Country Status (1)

Country Link
CA (1) CA2247900C (en)

Also Published As

Publication number Publication date
CA2247900C (en) 2006-08-01

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Effective date: 20170228