ZA909762B - Process for the production of biologically active protein - Google Patents
Process for the production of biologically active proteinInfo
- Publication number
- ZA909762B ZA909762B ZA909762A ZA909762A ZA909762B ZA 909762 B ZA909762 B ZA 909762B ZA 909762 A ZA909762 A ZA 909762A ZA 909762 A ZA909762 A ZA 909762A ZA 909762 B ZA909762 B ZA 909762B
- Authority
- ZA
- South Africa
- Prior art keywords
- production
- biologically active
- active protein
- beta
- tgf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898927546A GB8927546D0 (en) | 1989-12-06 | 1989-12-06 | Process for the production of biologically active tgf-beta |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA909762B true ZA909762B (en) | 1991-08-28 |
Family
ID=10667491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA909762A ZA909762B (en) | 1989-12-06 | 1990-12-05 | Process for the production of biologically active protein |
Country Status (23)
Country | Link |
---|---|
US (2) | US5650494A (fr) |
EP (2) | EP0433225B1 (fr) |
JP (1) | JP3048061B2 (fr) |
KR (1) | KR100203230B1 (fr) |
AT (1) | ATE178616T1 (fr) |
AU (1) | AU638075B2 (fr) |
CA (1) | CA2031430C (fr) |
DE (1) | DE69033040T2 (fr) |
DK (1) | DK0433225T3 (fr) |
ES (1) | ES2132066T3 (fr) |
FI (1) | FI103278B (fr) |
GB (1) | GB8927546D0 (fr) |
GR (1) | GR3030703T3 (fr) |
HU (1) | HU218144B (fr) |
IE (2) | IE990992A1 (fr) |
IL (1) | IL96549A (fr) |
MX (1) | MX172600B (fr) |
NO (1) | NO301768B1 (fr) |
NZ (1) | NZ236333A (fr) |
PH (1) | PH31649A (fr) |
PT (1) | PT96068B (fr) |
SG (1) | SG52690A1 (fr) |
ZA (1) | ZA909762B (fr) |
Families Citing this family (113)
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AU664021B2 (en) * | 1990-09-05 | 1995-11-02 | Natinco Nv | Solubilization of proteins in active forms |
GB9106678D0 (en) * | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
WO1993009229A1 (fr) | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
GB9206861D0 (en) * | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
US6884787B2 (en) * | 2001-07-14 | 2005-04-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of transforming growth factor-beta 3 expression |
DE4243729A1 (de) * | 1992-12-23 | 1994-06-30 | Behringwerke Ag | Verfahren zur Reaktivierung von gereinigten Membranproteinen |
KR960700271A (ko) * | 1993-01-08 | 1996-01-19 | 로렌스 티. 웰츠 | 인간 호흡계 합포체 바이러스 fg 당단백질의 정제 및 리폴딩 방법(process for the purification and refolding of human respiratory syncytial virus fg glycoprotein) |
DE69432375T2 (de) | 1993-04-30 | 2004-02-12 | Biognostik Gesellschaft für Biomolekulare Diagnostik mbH | Antisense Oligonukleotide zur Behandlung von immunsuppressiven Wirkungen von TGF-beta2 |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5411940A (en) * | 1993-09-29 | 1995-05-02 | Alcon Laboratories, Inc. | Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma |
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US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
EP0733109B9 (fr) * | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons |
US6027919A (en) | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
TW517059B (en) * | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
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US5714371A (en) * | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
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US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
CA2235223A1 (fr) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Lyases de polysaccharides designees rationnellement derivees de l'heparinase i |
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DE69737809T2 (de) * | 1996-01-22 | 2008-02-21 | Curis, Inc., Cambridge | Methoden zur herstellung von op-1 morphogen analoge |
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US7723473B2 (en) | 1997-06-19 | 2010-05-25 | St. Louis University | Peptide antagonists of TGF-beta family members and therapeutic uses thereof |
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TWI649095B (zh) * | 2012-02-10 | 2019-02-01 | 捷百克股份有限公司 | 以非人類幹細胞之培養上清液為起始材料之化妝品或皮膚再生促進劑、及蛋白質之離子導入法 |
WO2014025771A2 (fr) * | 2012-08-06 | 2014-02-13 | Biogen Idec Ma Inc. | Procédés et compositions pour l'inactivation de virus enveloppés |
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1989
- 1989-12-06 GB GB898927546A patent/GB8927546D0/en active Pending
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1990
- 1990-11-27 AU AU67018/90A patent/AU638075B2/en not_active Expired
- 1990-11-27 DK DK90810922T patent/DK0433225T3/da active
- 1990-11-27 EP EP90810922A patent/EP0433225B1/fr not_active Expired - Lifetime
- 1990-11-27 EP EP98113487A patent/EP0891985A1/fr not_active Withdrawn
- 1990-11-27 AT AT90810922T patent/ATE178616T1/de not_active IP Right Cessation
- 1990-11-27 ES ES90810922T patent/ES2132066T3/es not_active Expired - Lifetime
- 1990-11-27 DE DE69033040T patent/DE69033040T2/de not_active Expired - Lifetime
- 1990-11-27 SG SG1996007909A patent/SG52690A1/en unknown
- 1990-11-30 JP JP2330871A patent/JP3048061B2/ja not_active Expired - Lifetime
- 1990-12-03 FI FI905956A patent/FI103278B/fi active IP Right Grant
- 1990-12-04 MX MX023579A patent/MX172600B/es unknown
- 1990-12-04 PT PT96068A patent/PT96068B/pt not_active IP Right Cessation
- 1990-12-04 CA CA002031430A patent/CA2031430C/fr not_active Expired - Lifetime
- 1990-12-04 NZ NZ236333A patent/NZ236333A/en unknown
- 1990-12-05 ZA ZA909762A patent/ZA909762B/xx unknown
- 1990-12-05 IE IE19990992A patent/IE990992A1/en not_active IP Right Cessation
- 1990-12-05 HU HU084/90A patent/HU218144B/hu unknown
- 1990-12-05 IL IL9654990A patent/IL96549A/xx not_active IP Right Cessation
- 1990-12-05 IE IE438690A patent/IE904386A1/en not_active IP Right Cessation
- 1990-12-05 NO NO905264A patent/NO301768B1/no not_active IP Right Cessation
- 1990-12-05 KR KR1019900019881A patent/KR100203230B1/ko not_active IP Right Cessation
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1994
- 1994-03-25 PH PH8001A patent/PH31649A/en unknown
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1995
- 1995-06-07 US US08/486,057 patent/US5650494A/en not_active Expired - Lifetime
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1997
- 1997-01-24 US US08/789,588 patent/US5922846A/en not_active Expired - Fee Related
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1999
- 1999-07-07 GR GR990401786T patent/GR3030703T3/el unknown
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