SG52690A1 - Process for the production of biologically active protein (e.g. tgf) - Google Patents
Process for the production of biologically active protein (e.g. tgf)Info
- Publication number
- SG52690A1 SG52690A1 SG1996007909A SG1996007909A SG52690A1 SG 52690 A1 SG52690 A1 SG 52690A1 SG 1996007909 A SG1996007909 A SG 1996007909A SG 1996007909 A SG1996007909 A SG 1996007909A SG 52690 A1 SG52690 A1 SG 52690A1
- Authority
- SG
- Singapore
- Prior art keywords
- tgf
- production
- biologically active
- active protein
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898927546A GB8927546D0 (en) | 1989-12-06 | 1989-12-06 | Process for the production of biologically active tgf-beta |
Publications (1)
Publication Number | Publication Date |
---|---|
SG52690A1 true SG52690A1 (en) | 1998-09-28 |
Family
ID=10667491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996007909A SG52690A1 (en) | 1989-12-06 | 1990-11-27 | Process for the production of biologically active protein (e.g. tgf) |
Country Status (23)
Country | Link |
---|---|
US (2) | US5650494A (fr) |
EP (2) | EP0433225B1 (fr) |
JP (1) | JP3048061B2 (fr) |
KR (1) | KR100203230B1 (fr) |
AT (1) | ATE178616T1 (fr) |
AU (1) | AU638075B2 (fr) |
CA (1) | CA2031430C (fr) |
DE (1) | DE69033040T2 (fr) |
DK (1) | DK0433225T3 (fr) |
ES (1) | ES2132066T3 (fr) |
FI (1) | FI103278B (fr) |
GB (1) | GB8927546D0 (fr) |
GR (1) | GR3030703T3 (fr) |
HU (1) | HU218144B (fr) |
IE (2) | IE904386A1 (fr) |
IL (1) | IL96549A (fr) |
MX (1) | MX172600B (fr) |
NO (1) | NO301768B1 (fr) |
NZ (1) | NZ236333A (fr) |
PH (1) | PH31649A (fr) |
PT (1) | PT96068B (fr) |
SG (1) | SG52690A1 (fr) |
ZA (1) | ZA909762B (fr) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
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GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
EP0547102B1 (fr) * | 1990-09-05 | 1998-07-08 | Southern Cross Biotech Pty.Ltd. | Solubilisation de proteines sous des formes actives |
GB9106678D0 (en) * | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
EP0612348B1 (fr) | 1991-11-04 | 2003-04-23 | Genetics Institute, LLC | Proteines heterodimeres morphogenetiques d'os de recombinaison, compositions et procedes d'utilisation |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
GB9206861D0 (en) | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
US6884787B2 (en) * | 2001-07-14 | 2005-04-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of transforming growth factor-beta 3 expression |
DE4243729A1 (de) * | 1992-12-23 | 1994-06-30 | Behringwerke Ag | Verfahren zur Reaktivierung von gereinigten Membranproteinen |
EP0678102A1 (fr) * | 1993-01-08 | 1995-10-25 | The Upjohn Company | Procede de purification et de repliement de la glycoproteine fg du virus syncytial respiratoire humain |
AU6794594A (en) | 1993-04-30 | 1994-11-21 | Biognostik Gesellschaft Fur Biomolekulare Diagnostik Mbh | Antisense-oligonucleotides for the treatment of immunosuppressive effects of transforming growth factor-beta (tgf-beta ) |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5411940A (en) * | 1993-09-29 | 1995-05-02 | Alcon Laboratories, Inc. | Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma |
AU7846894A (en) * | 1993-09-29 | 1995-04-18 | Alcon Laboratories, Inc. | Compositions containing growth factors and antiplastic agents |
US6027919A (en) | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
CA2176942C (fr) * | 1993-12-07 | 2011-11-01 | Anthony J. Celeste | Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons |
TW440566B (en) * | 1994-07-25 | 2001-06-16 | Novartis Ag | Novel process for the production of biologically active dimeric protein |
EP0804461A1 (fr) * | 1994-07-25 | 1997-11-05 | Novartis AG | Procede de repliement de proteines telles que l'hirudine ou le facteur de croissance epidermique de recombinaison |
TW517059B (en) | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
ATE325131T1 (de) | 1995-04-19 | 2006-06-15 | Bioph Biotech Entw Pharm Gmbh | Neues protein und verfahren zu dessen herstellung |
US5714371A (en) * | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
US6040431A (en) | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
US6217863B1 (en) | 1995-10-30 | 2001-04-17 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase I |
JP4019432B2 (ja) * | 1995-12-21 | 2007-12-12 | 味の素株式会社 | ヒトアクチビンaのリフォールディング方法 |
US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
CA2244228A1 (fr) * | 1996-01-22 | 1997-07-24 | Creative Biomolecules, Inc. | Procedes et composition de production d'analogues morphogenes |
US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
US7811793B2 (en) | 1996-12-25 | 2010-10-12 | Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Process for preparing purified active monomer of bone-derived factor |
US6500920B1 (en) * | 1997-06-19 | 2002-12-31 | St. Louis University | Inhibitor of transforming growth factor β and A method of inhibiting the biological effects of transforming growth factor |
US7723473B2 (en) | 1997-06-19 | 2010-05-25 | St. Louis University | Peptide antagonists of TGF-beta family members and therapeutic uses thereof |
EP0896825B1 (fr) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition et dispositif pour la réparation de cartilage in vivo comprenant des nanocapsules avec des facteurs ostéoinductifs et/ou chondroinductifs |
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EP1659178B1 (fr) * | 1998-02-05 | 2010-03-31 | GlaxoSmithKline Biologicals SA | Procédé de purification ou de préparation de la proteine MAGE |
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US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
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CA2643162C (fr) | 1999-04-23 | 2018-01-02 | Massachusetts Institute Of Technology | Systeme et procede d'identification et de sequencage de polymeres, et d'analyse de leur composition par comparaison des proprietes |
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CA2402160C (fr) | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii et ses utilisations |
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WO2012029148A1 (fr) | 2010-09-01 | 2012-03-08 | 株式会社オステオファーマ | Préparation cryodesséchée de protéine morphogénétique osseuse humaine recombinante 2 |
CN107049910A (zh) * | 2012-02-10 | 2017-08-18 | 株式会社加帕尼克 | 干细胞培养上清的生发育发用途、化妆品或皮肤形成促进剂以及蛋白质的离子导入方法 |
DK2879691T3 (da) | 2012-08-06 | 2019-06-11 | Biogen Ma Inc | Fremgangsmåder og sammensætninger til inaktivering af kappebærende vira |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US9758786B2 (en) | 2016-02-09 | 2017-09-12 | Autotelic, Llc | Compositions and methods for treating pancreatic cancer |
CA3048735A1 (fr) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Polypeptides recombinants, compositions et procedes associes |
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AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
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1989
- 1989-12-06 GB GB898927546A patent/GB8927546D0/en active Pending
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1990
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- 1990-11-27 ES ES90810922T patent/ES2132066T3/es not_active Expired - Lifetime
- 1990-11-27 EP EP98113487A patent/EP0891985A1/fr not_active Withdrawn
- 1990-11-30 JP JP2330871A patent/JP3048061B2/ja not_active Expired - Lifetime
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- 1990-12-05 IE IE438690A patent/IE904386A1/en not_active IP Right Cessation
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- 1990-12-05 KR KR1019900019881A patent/KR100203230B1/ko not_active IP Right Cessation
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1994
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1995
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1997
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1999
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