ZA907346B - New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase - Google Patents

New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase

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Publication number
ZA907346B
ZA907346B ZA907346A ZA907346A ZA907346B ZA 907346 B ZA907346 B ZA 907346B ZA 907346 A ZA907346 A ZA 907346A ZA 907346 A ZA907346 A ZA 907346A ZA 907346 B ZA907346 B ZA 907346B
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South Africa
Prior art keywords
inhibitors
acyl
heteroarylamide
aryl
new
Prior art date
Application number
ZA907346A
Other languages
English (en)
Inventor
Peter A Mccarthy
A Mccarthy Peter
Ernest S Hamanaka
S Hamanaka Ernest
Thien Truong
Truong Thien
Frederick J Walker
J Walker Frederick
George Chang
Chang George
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA907346B publication Critical patent/ZA907346B/xx

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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ZA907346A 1989-09-15 1990-09-14 New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase ZA907346B (en)

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PCT/US1989/004033 WO1991004027A1 (en) 1989-09-15 1989-09-15 New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)

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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
EP0559898B1 (en) * 1990-11-26 1996-05-08 Taisho Pharmaceutical Co. Ltd Anilide derivative
HUT69721A (en) * 1991-01-31 1995-09-28 Pfizer Synthesis of intermediates in the preparation of acat inhibitors
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
EP0590094A1 (en) * 1991-04-26 1994-04-06 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatives
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
ATE175196T1 (de) * 1992-01-23 1999-01-15 Pfizer 4-phenyl-3-(heteroarylureido)-1,2-dihydro-2- oxochinolin derivate, als antihypercholesterolemische und antiatherosklerotische mittel
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
JPH05320143A (ja) * 1992-03-18 1993-12-03 Mochida Pharmaceut Co Ltd 新規ピリミジン誘導体
KR950701621A (ko) * 1992-05-28 1995-04-28 알렌 제이. 스피겔 아실 조효소a : 콜레스테롤 아실 전이효소(acat)의 억제제로서 신규한 n- 아릴 및 n- 헤테로아릴우레아 유도체(new n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a : cholesterol acyl transferase(acat)
US5462958A (en) * 1992-07-20 1995-10-31 Eisai Co., Ltd. Benzene derivatives and method of treating arteriosclerosis with benzene derivatives
US5239082A (en) * 1992-08-03 1993-08-24 Warner-Lambert Company Sulfonamide tetrazole ACAT inhibitors
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
EP0771319A1 (en) * 1994-07-15 1997-05-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
WO1996026925A1 (fr) * 1995-03-01 1996-09-06 Banyu Pharmaceutical Co., Ltd. Derives de l'arylthioacetamide
JP4191269B2 (ja) 1996-05-17 2008-12-03 興和株式会社 新規なアニリド化合物及びこれを含有する医薬
EP1473292A1 (en) * 1997-11-03 2004-11-03 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
WO1999023091A1 (en) 1997-11-03 1999-05-14 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
WO1999043659A1 (fr) * 1998-02-25 1999-09-02 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyridone et leur procede de fabrication
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
CA2360934A1 (en) 1999-02-22 2000-08-31 Lin-Hua Zhang Polycyclo heterocyclic derivatives as antiinflammatory agents
MXPA01009077A (es) 1999-03-12 2002-03-27 Boehringer Ingelheim Pharma Composiciones heterociclicos aromaticos como agentes anti-inflamatorios.
NZ514711A (en) 1999-03-12 2004-02-27 Boehringer Ingelheim Pharma Compounds useful as anti-inflammatory agents
ATE312823T1 (de) 1999-07-09 2005-12-15 Boehringer Ingelheim Pharma Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
DE60036726T2 (de) 1999-11-16 2008-02-07 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Harnstoff derivate als entzündungshemmende mittel
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
CA2398219A1 (en) 2000-02-02 2001-08-09 Warner-Lambert Company Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
DE10050663A1 (de) † 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
JP2004530690A (ja) 2001-05-16 2004-10-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 抗炎症性薬剤として有用なジアリールウレア誘導体
JP2004531571A (ja) 2001-05-25 2004-10-14 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド サイトカイン生産のインヒビターとしてのカルバメート及びオキサミド化合物
ES2319886T3 (es) * 2002-02-20 2009-05-14 Abbott Laboratories Compuestos azabiciclicos condensados que inhiben el sutipo 1 del receptor valinoide (vr1).
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
AU2003213806A1 (en) 2002-02-25 2003-09-09 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases
CA2744893A1 (en) 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as glucokinase activators
CL2003001415A1 (es) * 2002-07-12 2005-01-07 Janssen Pharmaceutica Nv Compuestos d derivados de naftil, quinolinil e isoquinolinil urea; composicion farmaceutica; y uso en el tratamiento y prevencion de condiciones de dolor y en el sibndrome del colon irritable y condiciones asociadas.
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
BRPI0417543A (pt) 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
BRPI0506662B8 (pt) 2004-01-06 2021-05-25 Novo Nordisk As compostos ativadores de glucoquinase
JP4205757B2 (ja) 2004-05-06 2009-01-07 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ４−フェニルアミノ−キナゾリン−６−イル−アミド
JPWO2006003974A1 (ja) 2004-06-30 2008-04-17 興和株式会社 環状ジアミン誘導体の製造法
KR20080024211A (ko) 2005-07-08 2008-03-17 노보 노르디스크 에이/에스 디시클로알킬 우레아 글루코키나제 활성제
ES2382815T3 (es) 2005-07-08 2012-06-13 Novo Nordisk A/S Dicicloalquilcarbamoil ureas como activadores de glucoquinasa
MX2008000255A (es) 2005-07-14 2008-04-02 Novo Nordisk As Activadores de urea glucocinasa.
ES2341489T3 (es) 2005-07-27 2010-06-21 F.Hoffmann-La Roche Ag Derivados de 4-ariloxi quinolina como moduladores de 5-ht6.
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010501592A (ja) 2006-08-25 2010-01-21 アボット・ラボラトリーズ Ｔｒｐｖ１を阻害するインダゾール誘導体およびその使用
CA2664310A1 (en) * 2006-09-25 2008-04-03 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2134678A2 (en) 2006-12-20 2009-12-23 Abbott Laboratories N-(5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
JP2010515701A (ja) 2007-01-09 2010-05-13 ノボ・ノルデイスク・エー／エス ウレアグルコキナーゼアクチベーター
US8318778B2 (en) 2007-01-11 2012-11-27 Novo Nordisk A/S Urea glucokinase activators
EP2489660A1 (en) 2008-03-20 2012-08-22 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists
ES2575215T3 (es) 2009-12-11 2016-06-27 Autifony Therapeutics Limited Derivados de imidazolidindiona
JP5913357B2 (ja) 2010-12-06 2016-04-27 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤として有用なヒダントイン誘導体
EP2718285B1 (en) 2011-06-07 2016-03-16 Autifony Therapeutics Limited Hydantoin derivatives as kv3 inhibitors
JP6240667B2 (ja) 2012-05-22 2017-11-29 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤としてのトリアゾール
JP2015517563A (ja) 2012-05-22 2015-06-22 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤としてのヒダントイン誘導体
KR20210020866A (ko) 2018-06-12 2021-02-24 브이티브이 테라퓨틱스 엘엘씨 인슐린 또는 인슐린 유사체와 조합된 글루코키나제 활성제의 치료적 용도
CN109553591B (zh) * 2019-01-15 2020-12-15 山东安信制药有限公司 一种富马酸喹硫平中间体的制备方法
GB201919213D0 (en) * 2019-12-23 2020-02-05 Ucb Biopharma Sprl Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125255C (no) * 1964-07-31
CH500980A (de) * 1966-01-28 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren
CH484906A (de) * 1966-01-28 1970-01-31 Geigy Ag J R Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren
US3555035A (en) * 1966-01-28 1971-01-12 Geigy Chem Corp N-(substituted pyridyl) linolamides and -linolenamides
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
US4716175A (en) * 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
US5238908A (en) * 1989-08-31 1993-08-24 Rohm And Haas Company Herbicidal glutaramic acids and derivatives
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).

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KR910006233A (ko) 1991-04-27
MX22406A (es) 1994-01-31
EP0418071A3 (en) 1992-03-25
EP0609960A1 (en) 1994-08-10
JPH03120243A (ja) 1991-05-22
JPH0825974B2 (ja) 1996-03-13
ATE121730T1 (de) 1995-05-15
AU6255390A (en) 1991-04-18
IE66324B1 (en) 1995-12-27
DK0418071T3 (da) 1995-09-04
IL110324A0 (en) 1994-10-21
NO904022D0 (no) 1990-09-14
NO904022L (no) 1991-03-18
PL291471A1 (en) 1992-06-26
CN1050183A (zh) 1991-03-27
IL95610A0 (en) 1991-06-30
HUT70027A (en) 1995-09-28
EP0418071B1 (en) 1995-04-26
AU652345B2 (en) 1994-08-25
DE69018908T2 (de) 1995-08-24
FI111362B (fi) 2003-07-15
EP0418071A2 (en) 1991-03-20
ES2127878T3 (es) 1999-05-01
PT95310A (pt) 1991-05-22
DE69032981D1 (de) 1999-04-08
EG19358A (en) 1994-12-30
WO1991004027A1 (en) 1991-04-04
PT95310B (pt) 1997-06-30
PL165370B1 (pl) 1994-12-30
PL291470A1 (en) 1992-07-13
KR930011303B1 (ko) 1993-11-29
CA2025301A1 (en) 1991-03-16
IE903336A1 (en) 1991-04-10
DE69018908D1 (de) 1995-06-01
IL95610A (en) 1994-12-29
DK0609960T3 (da) 1999-09-27
NZ235323A (en) 1993-02-25
DE69032981T2 (de) 1999-07-08
GR3029826T3 (en) 1999-06-30
ES2071033T3 (es) 1995-06-16
IL110321A0 (en) 1994-10-21
FI904537A0 (fi) 1990-09-14
HU9302945D0 (en) 1993-12-28
PL165357B1 (pl) 1994-12-30
EP0609960B1 (en) 1999-03-03
DD298092A5 (de) 1992-02-06
CA2025301C (en) 2001-10-16
ATE177082T1 (de) 1999-03-15
PL291472A1 (en) 1992-07-13

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