EG19358A - Process for preparing of new n- aryl and n- heteroaryla-mide and urea derivatives as inhibitors of acyl coenzymes a: cholesterol acyl transferase ( A C A T ) - Google Patents

Process for preparing of new n- aryl and n- heteroaryla-mide and urea derivatives as inhibitors of acyl coenzymes a: cholesterol acyl transferase ( A C A T )

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Publication number
EG19358A
EG19358A EG54590A EG54590A EG19358A EG 19358 A EG19358 A EG 19358A EG 54590 A EG54590 A EG 54590A EG 54590 A EG54590 A EG 54590A EG 19358 A EG19358 A EG 19358A
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EG
Egypt
Prior art keywords
acyl
inhibitors
heteroaryla
mide
aryl
Prior art date
Application number
EG54590A
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English (en)
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Pfizer
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Publication date
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Publication of EG19358A publication Critical patent/EG19358A/xx

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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
EG54590A 1989-09-15 1990-09-13 Process for preparing of new n- aryl and n- heteroaryla-mide and urea derivatives as inhibitors of acyl coenzymes a: cholesterol acyl transferase ( A C A T ) EG19358A (en)

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PCT/US1989/004033 WO1991004027A1 (en) 1989-09-15 1989-09-15 New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)

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EP (2) EP0609960B1 (no)
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KR (1) KR930011303B1 (no)
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AT (2) ATE121730T1 (no)
AU (1) AU652345B2 (no)
CA (1) CA2025301C (no)
DD (1) DD298092A5 (no)
DE (2) DE69032981T2 (no)
DK (2) DK0609960T3 (no)
EG (1) EG19358A (no)
ES (2) ES2071033T3 (no)
FI (1) FI111362B (no)
GR (1) GR3029826T3 (no)
HU (1) HUT70027A (no)
IE (1) IE66324B1 (no)
IL (3) IL95610A (no)
MX (1) MX22406A (no)
NO (1) NO904022L (no)
NZ (1) NZ235323A (no)
PL (4) PL165357B1 (no)
PT (1) PT95310B (no)
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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
US5475130A (en) * 1990-11-26 1995-12-12 Taisho Pharmaceutical Co., Ltd. Anilide derivative
DE69111828T2 (de) * 1991-01-31 1995-12-14 Pfizer Synthese von Zwischenprodukten zur Herstellung von ACAT-Inhibitoren.
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
JPH0776215B2 (ja) * 1991-04-26 1995-08-16 フアイザー・インコーポレイテツド ４−アリール−３−（ヘテロアリールウレイド）キノリン誘導体
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
DK0623112T3 (da) * 1992-01-23 1999-08-30 Pfizer 4-phenyl-3-(heteroarylureido)-1,2-dihydro-2-oxoquinolinderivater som antihypercholesterolæmiske og antiatherosclerotiske mi
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
JPH05320143A (ja) * 1992-03-18 1993-12-03 Mochida Pharmaceut Co Ltd 新規ピリミジン誘導体
SK142694A3 (en) * 1992-05-28 1995-06-07 Pfizer N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use
EP0609457B1 (en) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Benzene derivative
US5239082A (en) * 1992-08-03 1993-08-24 Warner-Lambert Company Sulfonamide tetrazole ACAT inhibitors
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
AU2935895A (en) * 1994-07-15 1996-02-16 Takeda Chemical Industries Ltd. Tricyclic compounds, their production and use
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
WO1996026925A1 (fr) * 1995-03-01 1996-09-06 Banyu Pharmaceutical Co., Ltd. Derives de l'arylthioacetamide
JP4191269B2 (ja) 1996-05-17 2008-12-03 興和株式会社 新規なアニリド化合物及びこれを含有する医薬
EP1473292A1 (en) * 1997-11-03 2004-11-03 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
AU1367599A (en) 1997-11-03 1999-05-24 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6300500B1 (en) 1998-02-25 2001-10-09 Sumitomo Pharmaceuticals Company, Limited Preparation of pyridone derivatives using phthalimido containing starting material
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
JP2002537397A (ja) 1999-02-22 2002-11-05 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 抗炎症剤としての多環ヘテロ環式誘導体
EE04799B1 (et) 1999-03-12 2007-04-16 Boehringer Ingelheim Pharmaceuticals, Inc. Ühendid, mis on kasulikud põletikuvastaste vahenditena, nende ühendite valmistamise meetodid ja neid sisaldavad farmatseutilised kompositsioonid
WO2000055152A1 (en) 1999-03-12 2000-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
WO2001004115A2 (en) 1999-07-09 2001-01-18 Boehringer Ingelheim Pharmaceuticals, Inc. Novel process for synthesis of heteroaryl-substituted urea compounds
US6492393B1 (en) 1999-11-16 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
EA004255B1 (ru) 2000-02-02 2004-02-26 Уорнер-Ламберт Компани Применение 2,6-диизопропилфенилового эфира [(2,4,6-триизопропилфенил)ацетил]сульфаминовой кислоты в качестве ингибитора секреции сальных желез, в частности, для лечения акне и композиции и способы на основе данного соединения
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
DE10050663A1 (de) † 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
CA2445003A1 (en) 2001-05-16 2002-11-21 Boehringer Ingelheim Pharmaceuticals, Inc. Diarylurea derivatives useful as anti-inflammatory agents
EP1395561A1 (en) 2001-05-25 2004-03-10 Boehringer Ingelheim Pharmaceuticals Inc. Carbamate and oxamide compounds as inhibitors of cytokine production
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2003070247A1 (en) * 2002-02-20 2003-08-28 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
WO2003072569A1 (en) 2002-02-25 2003-09-04 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases
EP2471533A1 (en) 2002-06-27 2012-07-04 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
CL2003001415A1 (es) * 2002-07-12 2005-01-07 Janssen Pharmaceutica Nv Compuestos d derivados de naftil, quinolinil e isoquinolinil urea; composicion farmaceutica; y uso en el tratamiento y prevencion de condiciones de dolor y en el sibndrome del colon irritable y condiciones asociadas.
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
KR20070001922A (ko) 2003-12-12 2007-01-04 와이어쓰 심장혈관질환 치료에 유용한 퀴놀린
CA2551324C (en) 2004-01-06 2012-11-27 Novo Nordisk A/S Heteroaryl-ureas and their use as glucokinase activators
CA2565812C (en) 2004-05-06 2012-03-13 Warner-Lambert Company Llc 4-phenylamino-quinazolin-6-yl-amides
US7576203B2 (en) 2004-06-30 2009-08-18 Kowa Co., Ltd. Method for producing cyclic diamine derivative
ATE547396T1 (de) 2005-07-08 2012-03-15 Novo Nordisk As Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren
JP2009500377A (ja) 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス ジシクロアルキルウレア型グルコキナーゼ活性化剤
US7884210B2 (en) 2005-07-14 2011-02-08 Novo Nordisk A/S Ureido-thiazole glucokinase activators
JP2009502853A (ja) 2005-07-27 2009-01-29 エフ．ホフマン−ラ ロシュ アーゲー アリールオキシキノリン類及び５−ｈｔ６モジュレーターとしてのその使用
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
MX2009002018A (es) 2006-08-25 2009-03-05 Abbott Lab Derivados de indazol que inhiben vanilloide-1 potencial de receptor pasajero (trpv1) y usos de los mismos.
EP2074084B1 (en) * 2006-09-25 2013-08-28 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
EP2450346A1 (en) 2006-12-20 2012-05-09 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
EP2118083A1 (en) 2007-01-09 2009-11-18 Novo Nordisk A/S Urea glucokinase activators
AU2008204530B2 (en) 2007-01-11 2013-08-01 Vtv Therapeutics Llc Urea glucokinase activators
EP2489660A1 (en) 2008-03-20 2012-08-22 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists
BR112012015868A2 (pt) 2009-12-11 2017-06-20 Autifony Therapeutics Ltd derivados de imidazolidinadiona
CA2817205C (en) 2010-12-06 2020-04-07 Autifony Therapeutics Limited Hydantoin derivatives useful as kv3 inhibitors
BR112013031402A2 (pt) 2011-06-07 2017-06-27 Autifony Therapeutics Ltd derivados de hidantoína como inibidores de kv3
WO2013175215A1 (en) 2012-05-22 2013-11-28 Autifony Therapeutics Limited Triazoles as kv3 inhibitors
US9669030B2 (en) 2012-05-22 2017-06-06 Autifony Therapeutics Limited Hydantoin derivatives as Kv3 inhibitors
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
CN109553591B (zh) * 2019-01-15 2020-12-15 山东安信制药有限公司 一种富马酸喹硫平中间体的制备方法
GB201919213D0 (en) * 2019-12-23 2020-02-05 Ucb Biopharma Sprl Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125255C (no) * 1964-07-31
CH500980A (de) * 1966-01-28 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren
CH491112A (de) * 1966-01-28 1970-05-31 Geigy Ag J R Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren
US3555035A (en) * 1966-01-28 1971-01-12 Geigy Chem Corp N-(substituted pyridyl) linolamides and -linolenamides
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
US4716175A (en) * 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
US5238908A (en) * 1989-08-31 1993-08-24 Rohm And Haas Company Herbicidal glutaramic acids and derivatives
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).

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DE69032981D1 (de) 1999-04-08
IL95610A (en) 1994-12-29
JPH03120243A (ja) 1991-05-22
HUT70027A (en) 1995-09-28
CA2025301C (en) 2001-10-16
IL110321A0 (en) 1994-10-21
IE66324B1 (en) 1995-12-27
NO904022D0 (no) 1990-09-14
EP0609960B1 (en) 1999-03-03
CN1050183A (zh) 1991-03-27
MX22406A (es) 1994-01-31
EP0418071A3 (en) 1992-03-25
IL95610A0 (en) 1991-06-30
PL165370B1 (pl) 1994-12-30
DE69018908D1 (de) 1995-06-01
HU9302945D0 (en) 1993-12-28
IE903336A1 (en) 1991-04-10
ATE121730T1 (de) 1995-05-15
PL291471A1 (en) 1992-06-26
FI111362B (fi) 2003-07-15
ES2071033T3 (es) 1995-06-16
KR930011303B1 (ko) 1993-11-29
DK0418071T3 (da) 1995-09-04
EP0418071B1 (en) 1995-04-26
DE69032981T2 (de) 1999-07-08
EP0418071A2 (en) 1991-03-20
NO904022L (no) 1991-03-18
PL291470A1 (en) 1992-07-13
ES2127878T3 (es) 1999-05-01
PT95310B (pt) 1997-06-30
NZ235323A (en) 1993-02-25
DE69018908T2 (de) 1995-08-24
GR3029826T3 (en) 1999-06-30
AU652345B2 (en) 1994-08-25
PT95310A (pt) 1991-05-22
PL165357B1 (pl) 1994-12-30
WO1991004027A1 (en) 1991-04-04
DK0609960T3 (da) 1999-09-27
FI904537A0 (fi) 1990-09-14
PL291472A1 (en) 1992-07-13
ZA907346B (en) 1992-05-27
CA2025301A1 (en) 1991-03-16
EP0609960A1 (en) 1994-08-10
KR910006233A (ko) 1991-04-27
IL110324A0 (en) 1994-10-21
ATE177082T1 (de) 1999-03-15
DD298092A5 (de) 1992-02-06
JPH0825974B2 (ja) 1996-03-13
AU6255390A (en) 1991-04-18

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