ZA879382B - Antiviral compounds - Google Patents
Antiviral compoundsInfo
- Publication number
- ZA879382B ZA879382B ZA879382A ZA879382A ZA879382B ZA 879382 B ZA879382 B ZA 879382B ZA 879382 A ZA879382 A ZA 879382A ZA 879382 A ZA879382 A ZA 879382A ZA 879382 B ZA879382 B ZA 879382B
- Authority
- ZA
- South Africa
- Prior art keywords
- antiviral compounds
- cytomegalovirus
- prophylaxis
- pharmaceutically acceptable
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Developing Agents For Electrophotography (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868629892A GB8629892D0 (en) | 1986-12-15 | 1986-12-15 | Antiviral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA879382B true ZA879382B (en) | 1989-08-30 |
Family
ID=10609013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA879382A ZA879382B (en) | 1986-12-15 | 1987-12-14 | Antiviral compounds |
Country Status (30)
Country | Link |
---|---|
US (1) | US5079235A (de) |
EP (3) | EP0417560A1 (de) |
JP (2) | JPS63165397A (de) |
KR (1) | KR880007521A (de) |
CN (2) | CN87108265A (de) |
AT (1) | ATE88713T1 (de) |
AU (2) | AU601529B2 (de) |
CA (1) | CA1319143C (de) |
CS (3) | CS342591A3 (de) |
DD (2) | DD264924A5 (de) |
DE (1) | DE3785651T2 (de) |
DK (2) | DK654287A (de) |
ES (1) | ES2054693T3 (de) |
FI (2) | FI875487A (de) |
GB (1) | GB8629892D0 (de) |
HU (4) | HU200932B (de) |
IE (2) | IE930470L (de) |
IL (3) | IL84810A (de) |
LT (1) | LT2064B (de) |
LV (1) | LV5273A3 (de) |
MC (1) | MC1882A1 (de) |
MX (1) | MX9203216A (de) |
NO (1) | NO167576C (de) |
NZ (1) | NZ222898A (de) |
PH (2) | PH24104A (de) |
PL (3) | PL160321B1 (de) |
PT (1) | PT86356B (de) |
RU (1) | RU2036199C1 (de) |
SU (1) | SU1731064A3 (de) |
ZA (1) | ZA879382B (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988010264A1 (en) * | 1987-06-24 | 1988-12-29 | Howard Florey Institute Of Experimental Physiology | Nucleoside derivatives |
US4954485A (en) * | 1987-10-20 | 1990-09-04 | Sanyo-Kokusaku Pulp Co., Ltd. | 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them |
EP0346108A3 (de) * | 1988-06-09 | 1991-04-24 | The Wellcome Foundation Limited | Anti-infektiöse Nukleoside |
US5157114A (en) * | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
GB8827339D0 (en) * | 1988-11-23 | 1988-12-29 | Wellcome Found | Antiviral compounds |
US5006646A (en) * | 1989-02-22 | 1991-04-09 | Yuki Gosei Kogyo Co., Ltd. | Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine |
NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
GB8919607D0 (en) * | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
US6337209B1 (en) | 1992-02-26 | 2002-01-08 | Glaxo Wellcome Inc. | Molecular constructs containing a carcinoembryonic antigen regulatory sequence |
GB9008696D0 (en) * | 1990-04-18 | 1990-06-13 | Wellcome Found | Anti-viral compounds |
GB9012899D0 (en) * | 1990-06-09 | 1990-08-01 | Wellcome Found | Anti-hbv pyrimidine nucleoside |
GB9014618D0 (en) * | 1990-06-30 | 1990-08-22 | Wellcome Found | Process for the preparation of pyrimidine nucleosides |
WO1992001452A1 (en) * | 1990-07-19 | 1992-02-06 | The Wellcome Foundation Limited | Enzyme inactivators |
US5643913A (en) * | 1990-07-19 | 1997-07-01 | Glaxo Wellcome Inc. | Pharmaceutical compositions of 5-substituted uracil compounds |
GB9020930D0 (en) | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
GB9104165D0 (en) * | 1991-02-27 | 1991-04-17 | Wellcome Found | Novel entities for hiv therapy |
GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
US5646123A (en) * | 1991-06-10 | 1997-07-08 | Alberta Research Council | Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen |
US5580858A (en) * | 1991-06-10 | 1996-12-03 | Alberta Research Council | Immunosuppressive and tolerogenic modified Lewisx compounds |
HU207524B (en) * | 1991-11-22 | 1993-04-28 | Mta Koezponti Kemiai Kutato In | Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis |
TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
US5484908A (en) * | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
WO1993010820A1 (en) * | 1991-11-26 | 1993-06-10 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
EP0643718A4 (de) * | 1992-05-26 | 1998-08-05 | Alberta Res Council | IMMUNOSUPPRESIVE UND TOLEROGENE MODIFIZIERTE LEWIS C UND LacNac VERBINDUNGEN. |
CA2119315A1 (en) * | 1993-03-18 | 1994-09-19 | Tsujiaki Hata | Nucleoside derivatives and anti-herpes composition |
US6432924B1 (en) | 1993-12-26 | 2002-08-13 | East Carolina University | Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase |
JPH11513992A (ja) * | 1995-12-22 | 1999-11-30 | イースト・カロライナ・ユニバーシティ | シチジンデアミナーゼまたはデオキシシチジンデアミナーゼの過剰発現を伴う疾患を治療するための薬剤および方法 |
EP0878193A1 (de) * | 1996-02-02 | 1998-11-18 | Showa Shell Sekiyu K.K. | Heilmittel für herpesvirusinfektionen, die durch den herpesvirus verursacht werden, sowie mittel zur vorbeugung der wiederkehr der infektion, die beide triterpenderivate als wirkstoff enthalten |
US6653318B1 (en) * | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
US7019129B1 (en) | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
CA2470938A1 (en) * | 2001-12-20 | 2003-07-03 | Raymond F. Schinazi | Treatment of ebv and khsv infection and associated abnormal cellular proliferation |
MX2007006646A (es) | 2004-12-03 | 2007-11-16 | Adherex Technologies Inc | Metodos para administrar inhibidores de dihidropirimidina deshidrogenasa en combinacion con 5-fluorouracilo y profarmacos de 5-fluorouracilo. |
PL2757091T3 (pl) | 2008-04-01 | 2017-10-31 | Biosearch Tech Inc | Stabilizowane ciemne wygaszające sondy fluoroforowe kwasu nukleinowego |
CN101768197A (zh) * | 2008-12-29 | 2010-07-07 | 北京德众万全药物技术开发有限公司 | 一种奈拉滨的制备方法 |
EA201270551A1 (ru) | 2009-10-14 | 2012-12-28 | Эдхиэрекс Текнолоджиз, Инк. | Лечение нейротоксичности, ассоциированной с комбинациями 5-fu или его пролекарств с ингибиторами dpd |
ES2764226T3 (es) * | 2014-03-30 | 2020-06-02 | Cepheid | Oligómeros polinucleotídicos de citosina modificados y métodos |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1601020A (en) | 1978-04-24 | 1981-10-21 | Stichting Grega Vzw | 2'-deoxy-5 (2-halogenovinyl)-uridines |
US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
US4247544A (en) * | 1979-07-02 | 1981-01-27 | The Regents Of The University Of California | C-5 Substituted uracil nucleosides |
US4267171A (en) * | 1979-07-02 | 1981-05-12 | The Regents Of The University Of California | C-5 Substituted cytosine nucleosides |
US4274544A (en) * | 1980-03-11 | 1981-06-23 | The Continental Group, Inc. | Single-piece plastic closure having integral seal forming means |
EP0082667A1 (de) * | 1981-12-18 | 1983-06-29 | Beecham Group Plc | Pharmazeutische Zusammensetzungen |
EP0082668A1 (de) * | 1981-12-18 | 1983-06-29 | Beecham Group Plc | 5-(2-Halogenvinyl)-2'-Deoxyuridinderivate, Verfahren zu ihrer Herstellung, die sie enthaltende pharmazeutische Präparate und ihre Verwendung bei der Bekämpfung von viralen Infektionen |
EP0095294A1 (de) * | 1982-05-22 | 1983-11-30 | Beecham Group Plc | Deoxyuridin-Derivate, ihre Herstellungsverfahren und ihre medizinische Anwendung |
EP0097039A1 (de) * | 1982-06-16 | 1983-12-28 | Beecham Group Plc | 5-(E-2-Halovinyl)-2'-deoxyuridin-Derivate, Verfahren zur Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und ihre Anwendung bei der Behandlung von viralen Infektionen |
GB8517402D0 (en) * | 1985-07-10 | 1985-08-14 | Wellcome Found | Treatment of viral infections |
ATE190064T1 (de) * | 1985-09-17 | 2000-03-15 | Wellcome Found | Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten. |
SE8701605D0 (sv) * | 1987-04-16 | 1987-04-16 | Astra Ab | Novel medicinal compounds |
-
1986
- 1986-12-15 GB GB868629892A patent/GB8629892D0/en active Pending
-
1987
- 1987-12-14 AU AU82521/87A patent/AU601529B2/en not_active Ceased
- 1987-12-14 ES ES87310951T patent/ES2054693T3/es not_active Expired - Lifetime
- 1987-12-14 CN CN198787108265A patent/CN87108265A/zh active Pending
- 1987-12-14 PL PL1987277926A patent/PL160321B1/pl unknown
- 1987-12-14 DK DK654287A patent/DK654287A/da not_active Application Discontinuation
- 1987-12-14 IE IE930470A patent/IE930470L/xx unknown
- 1987-12-14 PT PT86356A patent/PT86356B/pt not_active IP Right Cessation
- 1987-12-14 PL PL1987277927A patent/PL160322B1/pl unknown
- 1987-12-14 NO NO875209A patent/NO167576C/no unknown
- 1987-12-14 DE DE87310951T patent/DE3785651T2/de not_active Expired - Fee Related
- 1987-12-14 DD DD87310427A patent/DD264924A5/de not_active IP Right Cessation
- 1987-12-14 IL IL84810A patent/IL84810A/xx not_active IP Right Cessation
- 1987-12-14 JP JP62315960A patent/JPS63165397A/ja active Granted
- 1987-12-14 MC MC871936A patent/MC1882A1/xx unknown
- 1987-12-14 IL IL95141A patent/IL95141A/xx unknown
- 1987-12-14 PL PL1987269462A patent/PL158050B1/pl unknown
- 1987-12-14 EP EP90116634A patent/EP0417560A1/de not_active Withdrawn
- 1987-12-14 PH PH36211A patent/PH24104A/en unknown
- 1987-12-14 KR KR870014274A patent/KR880007521A/ko not_active Application Discontinuation
- 1987-12-14 CS CS913425A patent/CS342591A3/cs unknown
- 1987-12-14 HU HU893368A patent/HU200932B/hu not_active IP Right Cessation
- 1987-12-14 ZA ZA879382A patent/ZA879382B/xx unknown
- 1987-12-14 NZ NZ222898A patent/NZ222898A/en unknown
- 1987-12-14 CS CS877675A patent/CS275402B6/cs unknown
- 1987-12-14 EP EP87310951A patent/EP0272065B1/de not_active Expired - Lifetime
- 1987-12-14 HU HU893367A patent/HU202112B/hu not_active IP Right Cessation
- 1987-12-14 DD DD87320503A patent/DD274766A5/de not_active IP Right Cessation
- 1987-12-14 FI FI875487A patent/FI875487A/fi not_active Application Discontinuation
- 1987-12-14 IE IE930471A patent/IE930471L/xx unknown
- 1987-12-14 HU HU875642A patent/HU199867B/hu not_active IP Right Cessation
- 1987-12-14 CS CS879161A patent/CS275398B2/cs unknown
- 1987-12-14 HU HU903829A patent/HU207735B/hu not_active IP Right Cessation
- 1987-12-14 EP EP19920103712 patent/EP0486477A3/en not_active Withdrawn
- 1987-12-14 SU SU874355176A patent/SU1731064A3/ru active
- 1987-12-14 CA CA000554258A patent/CA1319143C/en not_active Expired - Fee Related
- 1987-12-14 AT AT87310951T patent/ATE88713T1/de not_active IP Right Cessation
-
1988
- 1988-07-05 PH PH37174A patent/PH24870A/en unknown
-
1989
- 1989-05-26 RU SU894614158A patent/RU2036199C1/ru active
-
1990
- 1990-01-16 US US07/465,552 patent/US5079235A/en not_active Expired - Lifetime
- 1990-07-20 IL IL95141A patent/IL95141A0/xx unknown
- 1990-07-26 AU AU59890/90A patent/AU626041B2/en not_active Ceased
- 1990-10-08 JP JP2270325A patent/JPH03141292A/ja active Pending
-
1991
- 1991-10-04 DK DK169991A patent/DK168323B1/da not_active IP Right Cessation
-
1992
- 1992-06-24 MX MX9203216A patent/MX9203216A/es unknown
- 1992-12-18 LV LV920338A patent/LV5273A3/xx unknown
- 1992-12-30 LT LTRP271A patent/LT2064B/xx unknown
-
1993
- 1993-02-27 CN CN93102155A patent/CN1080292A/zh active Pending
-
1994
- 1994-03-31 FI FI941523A patent/FI941523A0/fi not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0272065A3 (en) | Antiviral compounds | |
ATE63747T1 (de) | Antivirale verbindungen. |