ZA817780B - Substituted pyrimidines - Google Patents
Substituted pyrimidinesInfo
- Publication number
- ZA817780B ZA817780B ZA817780A ZA817780A ZA817780B ZA 817780 B ZA817780 B ZA 817780B ZA 817780 A ZA817780 A ZA 817780A ZA 817780 A ZA817780 A ZA 817780A ZA 817780 B ZA817780 B ZA 817780B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted pyrimidines
- pyrimidines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8036135 | 1980-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA817780B true ZA817780B (en) | 1983-06-29 |
Family
ID=10517217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA817780A ZA817780B (en) | 1980-11-11 | 1981-11-10 | Substituted pyrimidines |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US4438267A (ko) |
| EP (1) | EP0051879B1 (ko) |
| JP (1) | JPS57114581A (ko) |
| KR (1) | KR880001736B1 (ko) |
| AR (1) | AR245447A1 (ko) |
| AU (1) | AU549449B2 (ko) |
| CA (1) | CA1186310A (ko) |
| CS (1) | CS273153B2 (ko) |
| CY (1) | CY1419A (ko) |
| DD (1) | DD201896A5 (ko) |
| DE (1) | DE3173752D1 (ko) |
| DK (1) | DK172884B1 (ko) |
| EG (1) | EG16107A (ko) |
| ES (5) | ES8307759A1 (ko) |
| FI (1) | FI76333C (ko) |
| GB (1) | GB2087881B (ko) |
| GR (1) | GR81317B (ko) |
| HK (1) | HK23388A (ko) |
| HU (1) | HU188762B (ko) |
| IE (1) | IE52128B1 (ko) |
| IL (1) | IL64256A (ko) |
| IT (1) | IT1210589B (ko) |
| MC (1) | MC1418A1 (ko) |
| MY (1) | MY8600678A (ko) |
| NO (2) | NO160137C (ko) |
| NZ (1) | NZ198932A (ko) |
| PH (2) | PH22654A (ko) |
| PL (4) | PL139828B1 (ko) |
| PT (1) | PT73960B (ko) |
| RU (1) | RU1819264C (ko) |
| SG (1) | SG62686G (ko) |
| SU (4) | SU1424732A3 (ko) |
| YU (5) | YU42444B (ko) |
| ZA (1) | ZA817780B (ko) |
| ZM (1) | ZM9481A1 (ko) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
| US4590271A (en) * | 1982-05-01 | 1986-05-20 | Burroughs Wellcome Co. | 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials |
| ZA833067B (en) * | 1982-05-01 | 1984-12-24 | Wellcome Found | Antibacterial compounds |
| DK190983A (da) * | 1982-05-01 | 1983-11-02 | Wellcome Found | 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor |
| US4587341A (en) * | 1982-05-07 | 1986-05-06 | Burroughs Wellcome Co. | 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials |
| CA1244028A (en) * | 1983-04-14 | 1988-11-01 | Hans Maag | Pyrimidine derivatives |
| GB8603964D0 (en) * | 1986-02-18 | 1986-03-26 | Cooper Animal Health Ltd | Compositions |
| GB8603962D0 (en) * | 1986-02-18 | 1986-03-26 | Wellcome Found | Chemical compositions |
| LU86703A1 (fr) * | 1986-12-08 | 1988-07-14 | Oreal | Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b |
| FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
| GB8903978D0 (en) * | 1989-02-22 | 1989-04-05 | Coopers Animal Health | Chemical compositions |
| GB9000241D0 (en) * | 1990-01-05 | 1990-03-07 | Coopers Animal Health | Pharmaceutical use |
| RU95113597A (ru) * | 1992-12-02 | 1997-06-10 | ФМК Корпорейшн (US) | Инсектицидная композиция, способы борьбы с насекомыми |
| US5707996A (en) * | 1995-11-06 | 1998-01-13 | Macleod Pharmaceuticals, Inc. | Pharmaceutical solution and methods for preparation thereof |
| JP3309340B2 (ja) * | 1995-12-04 | 2002-07-29 | アルピダ・アーゲー | ジアミノピリミジン、それらを含む医薬組成物及びそれらの抗菌剤としての用途 |
| WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
| CA2452368A1 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| CA2452169A1 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory diseases |
| EP1401416B1 (en) | 2001-06-29 | 2006-10-25 | AB Science | Use of c-kit inhibitors for treating inflammatory bowel diseases (ibd) |
| DE60216281T2 (de) * | 2001-06-29 | 2007-07-05 | Ab Science | Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen |
| ATE404202T1 (de) * | 2001-09-20 | 2008-08-15 | Ab Science | Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung |
| ATE401078T1 (de) * | 2001-09-20 | 2008-08-15 | Ab Science | Die verwendung von c-kithemmern zur förderung des haarwuchses |
| US20040241226A1 (en) * | 2001-09-20 | 2004-12-02 | Alain Moussy | Use of potent, selective and non-toxic c-kit inhibitors for treating bacterial infections |
| ATE469146T1 (de) * | 2003-07-11 | 2010-06-15 | Arpida Ag | Benzofuranderivate und deren verwendung bei der behandlung von mikrobiellen infektionen |
| RO122853B1 (ro) * | 2005-02-18 | 2010-03-30 | Arpida Ag | Procedeu de preparare a unui derivat de benzofuran |
| AU2006286576B2 (en) * | 2005-09-01 | 2012-06-14 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as P2X3 and P3X2/3 modulators |
| US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| US20120122819A1 (en) * | 2009-06-12 | 2012-05-17 | Socpra - Sciences Et Genie S.E.C. | Guanine riboswitch binding compounds and their use as antibiotics |
| CN102649786B (zh) * | 2011-02-28 | 2014-08-27 | 郑州福源动物药业有限公司 | 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法 |
| CN103755684B (zh) * | 2014-02-10 | 2015-09-09 | 青岛蔚蓝生物股份有限公司 | 一种巴喹普林的制备方法 |
| JP7538153B2 (ja) * | 2019-06-06 | 2024-08-21 | ベイジン タイド ファーマシューティカル カンパニー リミテッド | Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用 |
| CN110818694B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体及其应用 |
| EP4320104A1 (en) * | 2021-04-09 | 2024-02-14 | The Trustees of The University of Pennsylvania | Control of protein expression with tmp-protac compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3049544A (en) * | 1962-08-14 | Method for the preparation of | ||
| DE1303727B (de) | 1959-09-03 | 1976-02-05 | Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London | Alpha-Arylidensubstituierte Propioni-Irile |
| US3956327A (en) * | 1969-03-06 | 1976-05-11 | Burroughs Wellcome Co. | Method of preparing 2,4-diamino-5-benzyl pyrimidines |
| BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
| GB1468374A (en) | 1974-03-06 | 1977-03-23 | Wellcome Found | Process for preparing a pyrimidine derivative |
| US4039543A (en) | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| GB1582245A (en) * | 1976-06-09 | 1981-01-07 | Wellcome Found | Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives |
| DE2730467A1 (de) * | 1977-07-06 | 1979-01-18 | Basf Ag | Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4258045A (en) * | 1979-11-30 | 1981-03-24 | Merck & Co., Inc. | Inhibitor of dihydrofolate reductase |
| US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
-
1981
- 1981-11-09 US US06/319,644 patent/US4438267A/en not_active Expired - Lifetime
- 1981-11-10 GR GR66482A patent/GR81317B/el unknown
- 1981-11-10 IE IE2631/81A patent/IE52128B1/en not_active IP Right Cessation
- 1981-11-10 IT IT8149676A patent/IT1210589B/it active
- 1981-11-10 CS CS825781A patent/CS273153B2/cs unknown
- 1981-11-10 CA CA000389807A patent/CA1186310A/en not_active Expired
- 1981-11-10 DK DK198104966A patent/DK172884B1/da active Protection Beyond IP Right Term
- 1981-11-10 ES ES506969A patent/ES8307759A1/es not_active Expired
- 1981-11-10 PT PT73960A patent/PT73960B/pt unknown
- 1981-11-10 MC MC811560A patent/MC1418A1/xx unknown
- 1981-11-10 NZ NZ198932A patent/NZ198932A/en unknown
- 1981-11-10 EG EG653/81A patent/EG16107A/xx active
- 1981-11-10 NO NO813804A patent/NO160137C/no not_active IP Right Cessation
- 1981-11-10 SU SU813358051A patent/SU1424732A3/ru active
- 1981-11-10 JP JP56180271A patent/JPS57114581A/ja active Granted
- 1981-11-10 HU HU813359A patent/HU188762B/hu unknown
- 1981-11-10 IL IL64256A patent/IL64256A/xx not_active IP Right Cessation
- 1981-11-10 YU YU2663/81A patent/YU42444B/xx unknown
- 1981-11-10 DD DD81234745A patent/DD201896A5/de not_active IP Right Cessation
- 1981-11-10 ZA ZA817780A patent/ZA817780B/xx unknown
- 1981-11-10 KR KR1019810004348A patent/KR880001736B1/ko active
- 1981-11-10 PL PL1981239280A patent/PL139828B1/pl unknown
- 1981-11-10 AU AU77334/81A patent/AU549449B2/en not_active Expired
- 1981-11-10 FI FI813546A patent/FI76333C/fi not_active IP Right Cessation
- 1981-11-10 PL PL1981239279A patent/PL139427B1/pl unknown
- 1981-11-10 GB GB8133833A patent/GB2087881B/en not_active Expired
- 1981-11-10 PL PL1981239278A patent/PL139827B1/pl unknown
- 1981-11-10 PL PL1981233754A patent/PL139523B1/pl unknown
- 1981-11-11 CY CY141981A patent/CY1419A/xx unknown
- 1981-11-11 ZM ZM94/81A patent/ZM9481A1/xx unknown
- 1981-11-11 DE DE8181109631T patent/DE3173752D1/de not_active Expired
- 1981-11-11 EP EP81109631A patent/EP0051879B1/en not_active Expired
-
1983
- 1983-01-27 SU SU833543245A patent/SU1318148A3/ru active
- 1983-01-31 SU SU833547444A patent/SU1306473A3/ru active
- 1983-04-02 ES ES521203A patent/ES521203A0/es active Granted
- 1983-04-02 ES ES521204A patent/ES8405380A1/es not_active Expired
- 1983-04-02 ES ES521201A patent/ES521201A0/es active Granted
- 1983-04-02 ES ES521202A patent/ES8405378A1/es not_active Expired
- 1983-09-07 PH PH29502A patent/PH22654A/en unknown
- 1983-09-07 PH PH29503A patent/PH25053A/en unknown
- 1983-10-03 YU YU1983/83A patent/YU43551B/xx unknown
- 1983-10-03 YU YU01982/83A patent/YU198283A/xx unknown
- 1983-10-03 YU YU01981/83A patent/YU198183A/xx unknown
- 1983-10-31 US US06/546,850 patent/US4587342A/en not_active Expired - Lifetime
- 1983-12-30 US US06/567,248 patent/US4603136A/en not_active Expired - Lifetime
-
1986
- 1986-02-02 RU SU863552053A patent/RU1819264C/ru active
- 1986-03-12 US US06/839,463 patent/US4761475A/en not_active Expired - Lifetime
- 1986-07-17 SG SG626/86A patent/SG62686G/en unknown
- 1986-12-30 MY MY678/86A patent/MY8600678A/xx unknown
-
1987
- 1987-01-14 SU SU874028793A patent/SU1535379A3/ru active
-
1988
- 1988-03-30 HK HK233/88A patent/HK23388A/xx not_active IP Right Cessation
- 1988-06-17 AR AR88311165A patent/AR245447A1/es active
- 1988-07-26 YU YU144288A patent/YU46697B/sh unknown
-
1994
- 1994-12-29 NO NO1994029C patent/NO1994029I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT73960B (en) | Substituted pyrimidines | |
| MY8700562A (en) | Pyrimidones | |
| JPS5795965A (en) | Disubstituted pyrimidines | |
| PH17948A (en) | Pyrimidone derivatives | |
| CU35489A (en) | Pyrimidine derivatives | |
| EG15900A (en) | Pyrimidine derivatives | |
| GB2089792B (en) | Substituted benzopyranotriazoles | |
| JPS57123170A (en) | Novel pyrimidone compound | |
| GB2078222B (en) | 4-(3-iodopropargyloxy)pyrimidines | |
| GB2086386B (en) | Pyrimidine derivatives | |
| CS193681A1 (en) | Dalkove ovladany regulacni sroub barvicich zarizeni v zasobnicich barev tiskovych stroju | |
| GB2102800B (en) | Pyrimidines | |
| JPS56159443A (en) | Construction | |
| BG30674A1 (en) | Polysubstituated fluorcontaining pyrimidine | |
| ZW25081A1 (en) | Birckwork construction | |
| ZW9482A1 (en) | Substituted pyrimidines | |
| IL75635A0 (en) | Substituted pyrimidine derivatives | |
| IE800710L (en) | Pyrimidine derivatives | |
| CA47291S (en) | Footgauge | |
| IE801689L (en) | Substituted trichloropropylureas | |
| JPS56154482A (en) | Pyrimidone derivative | |
| JPS56140956A (en) | Novel ortho-alkoxy substituted 2-haloacetanilide | |
| CS434180A2 (en) | Svetelny ukazatel se zvysenym kontrastem | |
| JPS56147995A (en) | Construction member | |
| CS225080A1 (en) | Sposob vyroby ozubenia v zvarovanych vencov |