ZA201802315B - Methods of preparing nicotinamide riboside and derivatives thereof - Google Patents
Methods of preparing nicotinamide riboside and derivatives thereofInfo
- Publication number
- ZA201802315B ZA201802315B ZA2018/02315A ZA201802315A ZA201802315B ZA 201802315 B ZA201802315 B ZA 201802315B ZA 2018/02315 A ZA2018/02315 A ZA 2018/02315A ZA 201802315 A ZA201802315 A ZA 201802315A ZA 201802315 B ZA201802315 B ZA 201802315B
- Authority
- ZA
- South Africa
- Prior art keywords
- derivatives
- methods
- nicotinamide riboside
- preparing nicotinamide
- preparing
- Prior art date
Links
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title 1
- 235000020956 nicotinamide riboside Nutrition 0.000 title 1
- 239000011618 nicotinamide riboside Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1313465.5A GB201313465D0 (en) | 2013-07-29 | 2013-07-29 | Methods of preparing nicotinamide riboside and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201802315B true ZA201802315B (en) | 2023-02-22 |
Family
ID=49167061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2018/02315A ZA201802315B (en) | 2013-07-29 | 2018-04-09 | Methods of preparing nicotinamide riboside and derivatives thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US10000519B2 (enExample) |
| EP (2) | EP3027635B1 (enExample) |
| JP (1) | JP6208352B2 (enExample) |
| KR (2) | KR102303966B1 (enExample) |
| CN (2) | CN105636973B (enExample) |
| AU (4) | AU2014298629B2 (enExample) |
| BR (1) | BR112016001774B1 (enExample) |
| CA (2) | CA3192957A1 (enExample) |
| ES (1) | ES2652654T3 (enExample) |
| GB (1) | GB201313465D0 (enExample) |
| HK (1) | HK1255037A1 (enExample) |
| MX (1) | MX349969B (enExample) |
| WO (1) | WO2015014722A1 (enExample) |
| ZA (1) | ZA201802315B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| RU2016149764A (ru) * | 2014-06-02 | 2018-07-17 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Получение и применение кристаллического бета-d-никотинамида рибозида |
| EP3152220A1 (en) * | 2014-06-06 | 2017-04-12 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| ES2908332T3 (es) * | 2014-07-24 | 2022-04-28 | Grace W R & Co | Forma cristalina de cloruro de ribosilnicotinamida |
| ES2963057T3 (es) * | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
| KR102426320B1 (ko) * | 2015-03-16 | 2022-07-29 | 크로마덱스 아이엔씨. | 니코틴산 리보사이드 또는 니코틴아미드 리보사이드 조성물, 이의 환원 유도체, 및 이의 용도 |
| WO2017011788A1 (en) | 2015-07-15 | 2017-01-19 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| KR102354784B1 (ko) | 2015-08-05 | 2022-01-25 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| WO2017079195A1 (en) * | 2015-11-02 | 2017-05-11 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
| US11248018B2 (en) | 2016-02-23 | 2022-02-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent |
| CA3017254C (en) * | 2016-03-16 | 2023-08-22 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| KR20190008246A (ko) | 2016-04-20 | 2019-01-23 | 크로마덱스 아이엔씨. | Nad+ 증가용 전구체로서 니코틴산 리보사이드 또는 니코틴아미드 리보사이트 유도체 및 이의 환원된 유도체의 용도 |
| WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
| GB2553001A (en) * | 2016-08-19 | 2018-02-21 | The Queen's Univ Of Belfast | Lactone intermediates of nicotinamide riboside and nicotinate riboside |
| CN120383644A (zh) | 2016-11-11 | 2025-07-29 | 英国贝尔法斯特女王大学 | 烟酰基核苷和还原的烟酰基核苷、其改性衍生物、磷酸化的类似物、腺苷二核苷酸共轭物、以及新颖结晶形式的有效且可规模化的合成 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および／または子の健康を向上させるためのｎａｄ前駆体の使用 |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| US11629163B2 (en) * | 2017-06-30 | 2023-04-18 | Elysium Health, Inc. | Methods of synthesizing nicotinamide riboside |
| JP2021506898A (ja) | 2017-12-22 | 2021-02-22 | エリシウム ヘルス，インコーポレーテッド | ニコチンアミドリボシドクロリドの結晶形態 |
| WO2019122084A1 (en) | 2017-12-22 | 2019-06-27 | Stemtek Therapeutics, S.L. | Process for the preparation of nicotinamide riboside chloride derivatives |
| WO2019152416A1 (en) | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN110283221A (zh) * | 2018-03-19 | 2019-09-27 | 药源药物化学（上海）有限公司 | 杂环化合物的制备和纯化方法 |
| CN110452277A (zh) * | 2018-05-07 | 2019-11-15 | 明特奇点医疗科技(成都)有限公司 | 一种烟酰胺核糖的制备方法 |
| JP2021525279A (ja) * | 2018-05-22 | 2021-09-24 | ジャンプスタート ファーティリティ ピーティーワイ リミテッド | 抗加齢剤としてのニコチン酸リボシドのアミノ酸塩 |
| BR112020022985A2 (pt) * | 2018-06-21 | 2021-02-02 | Société des Produits Nestlé S.A. | composições e métodos que usam um precursor de nicotinamida adenina dinucleotídeo (nad+) e pelo menos uma cetona ou um precursor de cetona |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| KR102060374B1 (ko) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| CN119684381A (zh) | 2019-07-19 | 2025-03-25 | 生物合成股份公司 | 烟酰胺呋喃核糖苷盐的结晶形式以及包含其的营养补充剂和药物组合物 |
| EP4013766B1 (en) * | 2019-08-14 | 2025-01-22 | Metro International Biotech, LLC | Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide |
| CN110642897B (zh) * | 2019-09-27 | 2021-04-06 | 武汉一若生物材料有限公司 | 一种β-烟酰胺核糖氯化物的制备方法 |
| CN110658224B (zh) * | 2019-10-15 | 2022-11-22 | 中国中医科学院中药研究所 | 一种氢核磁定量分析技术测定nmn绝对含量的方法 |
| CN111153953A (zh) * | 2020-01-07 | 2020-05-15 | 杭州洁汉化工有限公司 | 一种烟酰胺核糖氯化物的高效合成方法 |
| CN111454311B (zh) * | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| CN111647032B (zh) * | 2020-06-29 | 2023-02-24 | 上海舒泽生物科技研究所 | 一种β-烟酰胺单核苷酸的合成方法 |
| CN111848710A (zh) * | 2020-08-20 | 2020-10-30 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖及其还原态、盐的制备方法 |
| ES3001124T3 (es) * | 2020-09-15 | 2025-03-04 | Nestle Sa | Métodos para producir ribósido dihidronicotinamida a partir de cloruro de ribósido de nicotinamida |
| CN112851730B (zh) * | 2021-01-08 | 2023-02-21 | 厦门瑞林药业有限公司 | 一种nmn中间体nr氯化物合成方法 |
| JP2024517260A (ja) | 2021-05-04 | 2024-04-19 | ボーハン アンド カンパニー エーエス | ニコチンアミドリボシドクロリド（ｎｒｃｌ）の合成プロセス |
| KR20240020716A (ko) | 2021-05-27 | 2024-02-15 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴산 모노뉴클레오타이드 및 이의 에스터의 결정질 고체 및 제조 및 사용 방법 |
| KR20240156408A (ko) | 2022-03-04 | 2024-10-29 | 보한 앤드 컴퍼니 에이에스. | 니코틴아미드-베타-리보사이드 트리아세테이트 클로라이드(NRA-Cl)로부터 1,4-디히드로니코틴아미드 리보사이드(NRH)의 합성 방법 |
| CN116462727A (zh) * | 2023-04-23 | 2023-07-21 | 安徽瑞邦生物科技有限公司 | 一种β-烟酰胺核糖氯化物的制备方法 |
| WO2024259359A2 (en) * | 2023-06-14 | 2024-12-19 | ChromaDex Inc. | Nicotinamide riboside and derivatives thereof in intravenous formulations and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU681337B2 (en) | 1991-10-23 | 1997-08-28 | Cancer Research Campaign Technology Limited | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form |
| US6689760B1 (en) | 2000-07-10 | 2004-02-10 | Enzrel Inc. | Anti-mycobacterial compositions |
| WO2007061798A2 (en) * | 2005-11-18 | 2007-05-31 | Cornell Research Foundation, Inc. | Nicotinoyl riboside compositions and methods of use |
| WO2011081942A1 (en) * | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt5 |
| JP2013522171A (ja) * | 2010-03-01 | 2013-06-13 | ミレクシス， インコーポレイテッド | 化合物およびその治療用途 |
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| EP3152220A1 (en) * | 2014-06-06 | 2017-04-12 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
-
2013
- 2013-07-29 GB GBGB1313465.5A patent/GB201313465D0/en not_active Ceased
-
2014
- 2014-07-24 JP JP2016530446A patent/JP6208352B2/ja active Active
- 2014-07-24 AU AU2014298629A patent/AU2014298629B2/en active Active
- 2014-07-24 EP EP14744082.0A patent/EP3027635B1/en active Active
- 2014-07-24 CA CA3192957A patent/CA3192957A1/en active Pending
- 2014-07-24 KR KR1020167005556A patent/KR102303966B1/ko active Active
- 2014-07-24 US US14/908,831 patent/US10000519B2/en active Active
- 2014-07-24 BR BR112016001774-9A patent/BR112016001774B1/pt active IP Right Grant
- 2014-07-24 WO PCT/EP2014/065971 patent/WO2015014722A1/en not_active Ceased
- 2014-07-24 ES ES14744082.0T patent/ES2652654T3/es active Active
- 2014-07-24 MX MX2016001211A patent/MX349969B/es active IP Right Grant
- 2014-07-24 EP EP17191481.5A patent/EP3321274A1/en active Pending
- 2014-07-24 KR KR1020217009552A patent/KR102414886B1/ko active Active
- 2014-07-24 CN CN201480043268.1A patent/CN105636973B/zh active Active
- 2014-07-24 CA CA2918955A patent/CA2918955C/en active Active
- 2014-07-24 CN CN201810413840.9A patent/CN108707174A/zh active Pending
-
2018
- 2018-02-27 US US15/905,922 patent/US10815262B2/en active Active
- 2018-04-09 ZA ZA2018/02315A patent/ZA201802315B/en unknown
- 2018-08-01 AU AU2018211238A patent/AU2018211238A1/en not_active Abandoned
- 2018-11-06 HK HK18114160.5A patent/HK1255037A1/en unknown
-
2020
- 2020-02-21 AU AU2020201254A patent/AU2020201254B2/en active Active
- 2020-05-29 US US16/886,985 patent/US11584770B2/en active Active
-
2022
- 2022-05-04 US US17/736,834 patent/US11981698B2/en active Active
- 2022-05-12 AU AU2022203196A patent/AU2022203196B2/en active Active
-
2023
- 2023-04-26 US US18/307,733 patent/US12252506B2/en active Active
-
2024
- 2024-03-07 US US18/598,617 patent/US20240239831A1/en active Pending
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