CN108707174A - 制备烟酰胺核苷和其衍生物的方法 - Google Patents

制备烟酰胺核苷和其衍生物的方法 Download PDF

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Publication number
CN108707174A
CN108707174A CN201810413840.9A CN201810413840A CN108707174A CN 108707174 A CN108707174 A CN 108707174A CN 201810413840 A CN201810413840 A CN 201810413840A CN 108707174 A CN108707174 A CN 108707174A
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optionally
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English (en)
Chinese (zh)
Inventor
M·米高德
P·瑞德帕斯
K·克罗西
M·多尔蒂
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Queens University of Belfast
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Queens University of Belfast
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201810413840.9A 2013-07-29 2014-07-24 制备烟酰胺核苷和其衍生物的方法 Pending CN108707174A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
GB1313465.5 2013-07-29
CN201480043268.1A CN105636973B (zh) 2013-07-29 2014-07-24 制备烟酰胺核苷和其衍生物的方法

Related Parent Applications (1)

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CN201480043268.1A Division CN105636973B (zh) 2013-07-29 2014-07-24 制备烟酰胺核苷和其衍生物的方法

Publications (1)

Publication Number Publication Date
CN108707174A true CN108707174A (zh) 2018-10-26

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CN201810413840.9A Pending CN108707174A (zh) 2013-07-29 2014-07-24 制备烟酰胺核苷和其衍生物的方法
CN201480043268.1A Active CN105636973B (zh) 2013-07-29 2014-07-24 制备烟酰胺核苷和其衍生物的方法

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Country Status (14)

Country Link
US (7) US10000519B2 (enExample)
EP (2) EP3321274A1 (enExample)
JP (1) JP6208352B2 (enExample)
KR (2) KR102414886B1 (enExample)
CN (2) CN108707174A (enExample)
AU (4) AU2014298629B2 (enExample)
BR (1) BR112016001774B1 (enExample)
CA (2) CA3192957A1 (enExample)
ES (1) ES2652654T3 (enExample)
GB (1) GB201313465D0 (enExample)
HK (1) HK1255037A1 (enExample)
MX (1) MX349969B (enExample)
WO (1) WO2015014722A1 (enExample)
ZA (1) ZA201802315B (enExample)

Cited By (1)

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CN110642897A (zh) * 2019-09-27 2020-01-03 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法

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RU2016149767A (ru) 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
CN106715454B (zh) * 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
CA2978069C (en) 2015-03-09 2021-10-12 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
BR112017019696A2 (pt) * 2015-03-16 2018-09-04 ChromaDex Inc. composto e usos de um composto
US10392414B2 (en) 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
AU2016302005B2 (en) 2015-08-05 2021-03-04 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
WO2017079195A1 (en) * 2015-11-02 2017-05-11 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
WO2017145151A1 (en) 2016-02-23 2017-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (nr) and cosmetic composition comprising (nr and a phosphate-binding agent
US10000520B2 (en) 2016-03-16 2018-06-19 ChromaDex Inc. B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
MX393076B (es) 2016-04-20 2025-03-24 Chromadex Inc Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
EP3538099A4 (en) 2016-11-11 2020-06-17 The Queen's University of Belfast EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
EP3554285A4 (en) 2016-11-29 2021-01-20 University of Iowa Research Foundation USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring
EP3642214A2 (en) 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
JP2020526511A (ja) * 2017-06-30 2020-08-31 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドの合成方法
WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
US11414407B2 (en) 2017-12-22 2022-08-16 Elysium Health, Inc. Crystalline forms of nicotinamide riboside chloride
WO2019152416A1 (en) 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
CN113490675B (zh) * 2018-05-22 2026-01-09 江普斯塔特生育有限公司 作为抗衰老剂的烟酸核苷的氨基酸盐
US12403152B2 (en) 2018-06-21 2025-09-02 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
US11833167B2 (en) 2018-12-17 2023-12-05 Mitopower Llc Nicotinyl riboside compounds and their uses
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US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
CN119684381A (zh) 2019-07-19 2025-03-25 生物合成股份公司 烟酰胺呋喃核糖苷盐的结晶形式以及包含其的营养补充剂和药物组合物
CN114555619A (zh) * 2019-08-14 2022-05-27 麦德龙国际生物科技有限责任公司 用于烟酰胺腺嘌呤二核苷酸的差分调节的化合物和组合物
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
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CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
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Publication number Priority date Publication date Assignee Title
CN110642897A (zh) * 2019-09-27 2020-01-03 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法

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KR20160043974A (ko) 2016-04-22
CA3192957A1 (en) 2015-02-05
US20220259250A1 (en) 2022-08-18
MX349969B (es) 2017-08-23
AU2020201254B2 (en) 2022-05-26
ES2652654T3 (es) 2018-02-05
US20260062436A1 (en) 2026-03-05
AU2018211238A1 (en) 2018-08-16
KR102303966B1 (ko) 2021-09-24
US20240101588A1 (en) 2024-03-28
US20180186824A1 (en) 2018-07-05
CA2918955C (en) 2023-05-09
HK1255037A1 (en) 2019-08-02
AU2014298629A1 (en) 2016-02-11
US10000519B2 (en) 2018-06-19
KR20210038718A (ko) 2021-04-07
CN105636973A (zh) 2016-06-01
WO2015014722A1 (en) 2015-02-05
AU2022203196B2 (en) 2023-11-23
US11981698B2 (en) 2024-05-14
BR112016001774A2 (pt) 2017-08-01
EP3321274A1 (en) 2018-05-16
US20160168184A1 (en) 2016-06-16
JP6208352B2 (ja) 2017-10-04
US11584770B2 (en) 2023-02-21
JP2016530248A (ja) 2016-09-29
US20200291055A1 (en) 2020-09-17
US12252506B2 (en) 2025-03-18
AU2022203196A1 (en) 2022-06-02
EP3027635B1 (en) 2017-09-20
EP3027635A1 (en) 2016-06-08
AU2020201254A1 (en) 2020-03-12
BR112016001774B1 (pt) 2021-06-22
GB201313465D0 (en) 2013-09-11
HK1218918A1 (en) 2017-03-17
AU2014298629B2 (en) 2018-08-16
CN105636973B (zh) 2018-06-01
US20240239831A1 (en) 2024-07-18
US10815262B2 (en) 2020-10-27
KR102414886B1 (ko) 2022-07-01
NZ716277A (en) 2021-03-26
BR112016001774A8 (pt) 2020-01-21
ZA201802315B (en) 2023-02-22
MX2016001211A (es) 2016-10-28
CA2918955A1 (en) 2015-02-05

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