JP6208352B2 - ニコチンアミドリボシドおよびその誘導体を調製する方法 - Google Patents

ニコチンアミドリボシドおよびその誘導体を調製する方法 Download PDF

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JP6208352B2
JP6208352B2 JP2016530446A JP2016530446A JP6208352B2 JP 6208352 B2 JP6208352 B2 JP 6208352B2 JP 2016530446 A JP2016530446 A JP 2016530446A JP 2016530446 A JP2016530446 A JP 2016530446A JP 6208352 B2 JP6208352 B2 JP 6208352B2
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compound
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JP2016530248A5 (enExample
JP2016530248A (ja
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ミゴード，マリー
レッドパス，フィリップ
クロッシー，ケリー
ドハーティ，マーク
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Queens University of Belfast
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016530446A 2013-07-29 2014-07-24 ニコチンアミドリボシドおよびその誘導体を調製する方法 Active JP6208352B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
GB1313465.5 2013-07-29
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

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JP2016530248A JP2016530248A (ja) 2016-09-29
JP2016530248A5 JP2016530248A5 (enExample) 2017-09-07
JP6208352B2 true JP6208352B2 (ja) 2017-10-04

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US (7) US10000519B2 (enExample)
EP (2) EP3321274A1 (enExample)
JP (1) JP6208352B2 (enExample)
KR (2) KR102414886B1 (enExample)
CN (2) CN108707174A (enExample)
AU (4) AU2014298629B2 (enExample)
BR (1) BR112016001774B1 (enExample)
CA (2) CA3192957A1 (enExample)
ES (1) ES2652654T3 (enExample)
GB (1) GB201313465D0 (enExample)
HK (1) HK1255037A1 (enExample)
MX (1) MX349969B (enExample)
WO (1) WO2015014722A1 (enExample)
ZA (1) ZA201802315B (enExample)

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CN106715454B (zh) * 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
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US10392414B2 (en) 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
AU2016302005B2 (en) 2015-08-05 2021-03-04 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
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WO2017145151A1 (en) 2016-02-23 2017-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (nr) and cosmetic composition comprising (nr and a phosphate-binding agent
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CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
CN113490675B (zh) * 2018-05-22 2026-01-09 江普斯塔特生育有限公司 作为抗衰老剂的烟酸核苷的氨基酸盐
US12403152B2 (en) 2018-06-21 2025-09-02 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
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CN114555619A (zh) * 2019-08-14 2022-05-27 麦德龙国际生物科技有限责任公司 用于烟酰胺腺嘌呤二核苷酸的差分调节的化合物和组合物
CN110642897B (zh) * 2019-09-27 2021-04-06 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
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KR20160043974A (ko) 2016-04-22
CA3192957A1 (en) 2015-02-05
US20220259250A1 (en) 2022-08-18
MX349969B (es) 2017-08-23
AU2020201254B2 (en) 2022-05-26
ES2652654T3 (es) 2018-02-05
US20260062436A1 (en) 2026-03-05
AU2018211238A1 (en) 2018-08-16
KR102303966B1 (ko) 2021-09-24
US20240101588A1 (en) 2024-03-28
US20180186824A1 (en) 2018-07-05
CA2918955C (en) 2023-05-09
HK1255037A1 (en) 2019-08-02
AU2014298629A1 (en) 2016-02-11
US10000519B2 (en) 2018-06-19
KR20210038718A (ko) 2021-04-07
CN105636973A (zh) 2016-06-01
WO2015014722A1 (en) 2015-02-05
AU2022203196B2 (en) 2023-11-23
US11981698B2 (en) 2024-05-14
BR112016001774A2 (pt) 2017-08-01
EP3321274A1 (en) 2018-05-16
US20160168184A1 (en) 2016-06-16
US11584770B2 (en) 2023-02-21
JP2016530248A (ja) 2016-09-29
US20200291055A1 (en) 2020-09-17
US12252506B2 (en) 2025-03-18
AU2022203196A1 (en) 2022-06-02
EP3027635B1 (en) 2017-09-20
EP3027635A1 (en) 2016-06-08
AU2020201254A1 (en) 2020-03-12
BR112016001774B1 (pt) 2021-06-22
GB201313465D0 (en) 2013-09-11
HK1218918A1 (en) 2017-03-17
CN108707174A (zh) 2018-10-26
AU2014298629B2 (en) 2018-08-16
CN105636973B (zh) 2018-06-01
US20240239831A1 (en) 2024-07-18
US10815262B2 (en) 2020-10-27
KR102414886B1 (ko) 2022-07-01
NZ716277A (en) 2021-03-26
BR112016001774A8 (pt) 2020-01-21
ZA201802315B (en) 2023-02-22
MX2016001211A (es) 2016-10-28
CA2918955A1 (en) 2015-02-05

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