ZA200710644B - Amylases for pharmaceutical use - Google Patents

Amylases for pharmaceutical use

Info

Publication number
ZA200710644B
ZA200710644B ZA200710644A ZA200710644A ZA200710644B ZA 200710644 B ZA200710644 B ZA 200710644B ZA 200710644 A ZA200710644 A ZA 200710644A ZA 200710644 A ZA200710644 A ZA 200710644A ZA 200710644 B ZA200710644 B ZA 200710644B
Authority
ZA
South Africa
Prior art keywords
amylases
pharmaceutical use
pharmaceutical
Prior art date
Application number
ZA200710644A
Other languages
English (en)
Inventor
Svendsen Allan
Gregory Peter Colin
Original Assignee
Novozymes As
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As, Solvay Pharm Gmbh filed Critical Novozymes As
Publication of ZA200710644B publication Critical patent/ZA200710644B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2414Alpha-amylase (3.2.1.1.)
    • C12N9/2417Alpha-amylase (3.2.1.1.) from microbiological source
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200710644A 2005-06-24 2007-12-06 Amylases for pharmaceutical use ZA200710644B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200500931 2005-06-24

Publications (1)

Publication Number Publication Date
ZA200710644B true ZA200710644B (en) 2008-11-26

Family

ID=34956782

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710644A ZA200710644B (en) 2005-06-24 2007-12-06 Amylases for pharmaceutical use

Country Status (15)

Country Link
US (1) US8017351B2 (ja)
EP (1) EP1896057A2 (ja)
JP (1) JP2008546396A (ja)
KR (1) KR20080031868A (ja)
CN (1) CN101242853A (ja)
AU (1) AU2006261444A1 (ja)
BR (1) BRPI0611932A2 (ja)
CA (1) CA2612811A1 (ja)
IL (1) IL187635A0 (ja)
MX (1) MX2007015471A (ja)
NO (1) NO20080439L (ja)
NZ (1) NZ563737A (ja)
RU (1) RU2008102650A (ja)
WO (1) WO2006136161A2 (ja)
ZA (1) ZA200710644B (ja)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008012638A (es) 2006-04-04 2008-10-13 Novozymes As Proceso de mezclado.
US8273348B2 (en) 2006-12-21 2012-09-25 Novozymes A/S Lipase variants for pharmaceutical use
AU2008333313A1 (en) 2007-12-04 2009-06-11 Novozymes A/S Protease variants for pharmaceutical use
GB2468629B (en) * 2008-06-08 2011-10-26 Tarig Sayed Mustafa Arbab Method, composition, device for the treatment of amylase malfunctions/inactivity in association with saccharides (mainly polysaccharides) based diseases
US9023408B2 (en) * 2009-03-04 2015-05-05 Meyer Nutriceuticals Llc Composition and method for control of diabetes
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
CN102918150A (zh) 2010-01-04 2013-02-06 诺维信公司 α-淀粉酶
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
WO2013155476A1 (en) * 2012-04-12 2013-10-17 Integrative Enzymatics, Inc. Composition and method for modulating inflammatory molecules with amylase
US20160108388A1 (en) 2013-05-29 2016-04-21 Danisco Us Inc. Novel metalloproteases
EP3004342B1 (en) 2013-05-29 2023-01-11 Danisco US Inc. Novel metalloproteases
US20160122738A1 (en) 2013-05-29 2016-05-05 Danisco Us Inc. Novel metalloproteases
US20160160202A1 (en) 2013-05-29 2016-06-09 Danisco Us Inc. Novel metalloproteases
WO2015089441A1 (en) 2013-12-13 2015-06-18 Danisco Us Inc. Serine proteases of bacillus species
EP3080263B1 (en) 2013-12-13 2019-07-03 Danisco US Inc. Serine proteases of the bacillus gibsonii-clade
JP6598778B2 (ja) 2013-12-16 2019-10-30 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー ポリα−1,3−グルカンエーテル化合物を含む洗濯洗剤又は衣類柔軟剤
KR102410391B1 (ko) 2013-12-18 2022-06-16 뉴트리션 앤드 바이오사이언시스 유에스에이 4, 인크. 양이온성 폴리 알파-1,3-글루칸 에테르
WO2015123323A1 (en) 2014-02-14 2015-08-20 E. I. Du Pont De Nemours And Company Poly-alpha-1,3-1,6-glucans for viscosity modification
CN103789285B (zh) * 2014-02-19 2016-01-20 江南大学 一种热稳定性提高的淀粉酶突变体及其构建方法和应用
EP3116914B8 (en) 2014-03-11 2021-04-21 E. I. du Pont de Nemours and Company Oxidized poly alpha-1,3-glucan as detergent builder
EP3587569B1 (en) 2014-03-21 2022-08-03 Danisco US Inc. Serine proteases of bacillus species
KR20160147879A (ko) * 2014-04-25 2016-12-23 바스프 에스이 아밀라제 변이체
US9771548B2 (en) 2014-06-19 2017-09-26 E I Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
US9714403B2 (en) 2014-06-19 2017-07-25 E I Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
CN104212780A (zh) * 2014-09-02 2014-12-17 华东理工大学 一种α-淀粉酶及其编码基因与应用
WO2016036834A1 (en) * 2014-09-02 2016-03-10 Danisco Us Inc. Dp5-enriched syrups
US20170233710A1 (en) 2014-10-17 2017-08-17 Danisco Us Inc. Serine proteases of bacillus species
WO2016069557A1 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases of bacillus species
EP3212783A1 (en) 2014-10-27 2017-09-06 Danisco US Inc. Serine proteases
EP3957729A1 (en) 2014-10-27 2022-02-23 Danisco US Inc. Serine proteases
WO2016069548A2 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases
WO2016069552A1 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases
JP6770519B2 (ja) 2014-12-23 2020-10-14 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 酵素により製造されるセルロース
WO2016183509A1 (en) 2015-05-13 2016-11-17 Danisco Us Inc. AprL-CLADE PROTEASE VARIANTS AND USES THEREOF
WO2016201044A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc Osmotic burst encapsulates
WO2016201069A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc Low-density enzyme-containing particles
WO2016201040A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc. Water-triggered enzyme suspension
JP7015695B2 (ja) 2015-06-17 2022-02-03 ダニスコ・ユーエス・インク バチルス・ギブソニイ(Bacillus gibsonii)クレードセリンプロテアーゼ
WO2017052455A1 (en) 2015-09-23 2017-03-30 Anara Ab Amylase fragments for blood glucose control
US20180320158A1 (en) 2015-11-05 2018-11-08 Danisco Us Inc. Paenibacillus and bacillus spp. mannanases
JP7364331B2 (ja) 2015-11-05 2023-10-18 ダニスコ・ユーエス・インク パエニバチルス(Paenibacillus)属種マンナナーゼ
WO2017083229A1 (en) 2015-11-13 2017-05-18 E. I. Du Pont De Nemours And Company Glucan fiber compositions for use in laundry care and fabric care
JP7045313B2 (ja) 2015-11-13 2022-03-31 ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー,インコーポレイテッド 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物
WO2017083226A1 (en) 2015-11-13 2017-05-18 E. I. Du Pont De Nemours And Company Glucan fiber compositions for use in laundry care and fabric care
BR112018011755A2 (pt) 2015-12-09 2018-12-04 Danisco Us Inc variantes combinatórias de alfa-amilase
CN108699543B (zh) 2015-12-18 2023-07-14 丹尼斯科美国公司 具有内切葡聚糖酶活性的多肽及其用途
WO2017191160A1 (en) * 2016-05-03 2017-11-09 Novozymes A/S Alpha-amylase variants and polynucleotides encoding the same
US20190194636A1 (en) 2016-05-03 2019-06-27 Danisco Us Inc Protease variants and uses thereof
CN109072213A (zh) 2016-05-05 2018-12-21 丹尼斯科美国公司 蛋白酶变体及其用途
CA3026064A1 (en) 2016-05-31 2017-12-07 Danisco Us Inc. Protease variants and uses thereof
EP3251687A1 (en) 2016-06-01 2017-12-06 Centrum Innowacji Edoradca Sp. z o.o. Spolka Komandytowa Bioactive peptides for blood glucose control
BR112018075933A2 (pt) 2016-06-17 2019-10-01 Danisco Us Inc variantes de protease e usos das mesmas
GB201614415D0 (en) 2016-08-24 2016-10-05 Pepsis Ltd Enzymes for the treatment of human enterometabolic dysfunction
WO2018085524A2 (en) 2016-11-07 2018-05-11 Danisco Us Inc Laundry detergent composition
CN110312794B (zh) 2016-12-21 2024-04-12 丹尼斯科美国公司 吉氏芽孢杆菌进化枝丝氨酸蛋白酶
US20200392477A1 (en) 2016-12-21 2020-12-17 Danisco Us Inc. Protease variants and uses thereof
EP3583210B1 (en) 2017-03-15 2021-07-07 Danisco US Inc. Trypsin-like serine proteases and uses thereof
WO2018183662A1 (en) 2017-03-31 2018-10-04 Danisco Us Inc Delayed release enzyme formulations for bleach-containing detergents
BR112019027976A2 (pt) 2017-06-30 2020-07-07 Danisco Us Inc. partículas de baixa aglomeração, contendo enzimas
EP3717643A1 (en) 2017-11-29 2020-10-07 Danisco US Inc. Subtilisin variants having improved stability
CN111742041B (zh) 2017-12-21 2023-06-06 丹尼斯科美国公司 包含耐热干燥剂的含酶的热熔细粒
BR112020016068A2 (pt) 2018-02-08 2020-12-08 Danisco Us Inc. Partículas cera termicamente resistente matriz para encapsulamento de enzima
WO2019204486A1 (en) * 2018-04-18 2019-10-24 Baylor College Of Medicine Development of amyloglucosidase as a medicinal food or dietary supplement
WO2019245705A1 (en) 2018-06-19 2019-12-26 Danisco Us Inc Subtilisin variants
US20210214703A1 (en) 2018-06-19 2021-07-15 Danisco Us Inc Subtilisin variants
US20210189295A1 (en) 2018-08-30 2021-06-24 Danisco Us Inc Enzyme-containing granules
JP2022503923A (ja) 2018-09-27 2022-01-12 ダニスコ・ユーエス・インク 医療用器具を洗浄するための組成物
EP3887515A1 (en) 2018-11-28 2021-10-06 Danisco US Inc. Subtilisin variants having improved stability
US20220220419A1 (en) 2019-05-24 2022-07-14 Danisco Us Inc Subtilisin variants and methods of use
WO2020247582A1 (en) 2019-06-06 2020-12-10 Danisco Us Inc Methods and compositions for cleaning
WO2022047149A1 (en) 2020-08-27 2022-03-03 Danisco Us Inc Enzymes and enzyme compositions for cleaning
US20240117275A1 (en) 2021-01-29 2024-04-11 Danisco Us Inc. Compositions for cleaning and methods related thereto
WO2023278297A1 (en) 2021-06-30 2023-01-05 Danisco Us Inc Variant lipases and uses thereof
CN117916354A (zh) 2021-09-03 2024-04-19 丹尼斯科美国公司 用于清洁的衣物洗涤组合物
WO2023039270A2 (en) 2021-09-13 2023-03-16 Danisco Us Inc. Bioactive-containing granules
WO2023114939A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114936A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114932A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023168234A1 (en) 2022-03-01 2023-09-07 Danisco Us Inc. Enzymes and enzyme compositions for cleaning
WO2023250301A1 (en) 2022-06-21 2023-12-28 Danisco Us Inc. Methods and compositions for cleaning comprising a polypeptide having thermolysin activity
WO2024050343A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Subtilisin variants and methods related thereto
WO2024050339A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Mannanase variants and methods of use
WO2024050346A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Detergent compositions and methods related thereto
WO2024102698A1 (en) 2022-11-09 2024-05-16 Danisco Us Inc. Subtilisin variants and methods of use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173590D0 (da) 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5281526A (en) * 1992-10-20 1994-01-25 Solvay Enzymes, Inc. Method of purification of amylase by precipitation with a metal halide and 4-hydroxybenzic acid or a derivative thereof
CA2222682A1 (en) * 1995-05-31 1996-12-05 Medzyme N.V. Composition to improve digestibility and utilisation of nutrients
BR9708887B1 (pt) * 1996-04-30 2014-10-29 Novozymes As "variante de uma alfa-amilase, uso da mesma, construção de dna, vetor de expressão recombinante, célula de bactéria ou fungo, aditivo e composição detergente".
CA2745783C (en) 1997-10-13 2016-05-24 Novozymes A/S .alpha.-amylase mutants
CN1221284C (zh) * 1999-03-17 2005-10-05 索尔瓦药物有限公司 治疗糖尿病的药物
US6410295B1 (en) * 1999-03-30 2002-06-25 Novozymes A/S Alpha-amylase variants
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
RU2201763C1 (ru) 2001-12-29 2003-04-10 Закрытое акционерное общество "Брынцалов-А" Полиферментное средство ферестал
DE10260903A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Neue Perhydrolasen
EP1597363B1 (en) * 2003-02-26 2015-07-15 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
CN101208429A (zh) * 2005-06-24 2008-06-25 诺维信公司 用于药物用途的脂肪酶
BRPI0611936A2 (pt) * 2005-06-24 2011-02-22 Solvay Pharm Gmbh protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de doença

Also Published As

Publication number Publication date
BRPI0611932A2 (pt) 2011-01-04
MX2007015471A (es) 2008-04-04
US8017351B2 (en) 2011-09-13
EP1896057A2 (en) 2008-03-12
KR20080031868A (ko) 2008-04-11
CA2612811A1 (en) 2006-12-28
WO2006136161A2 (en) 2006-12-28
NO20080439L (no) 2008-03-04
AU2006261444A1 (en) 2006-12-28
WO2006136161A3 (en) 2007-07-05
JP2008546396A (ja) 2008-12-25
CN101242853A (zh) 2008-08-13
US20090035293A1 (en) 2009-02-05
NZ563737A (en) 2010-08-27
IL187635A0 (en) 2008-03-20
RU2008102650A (ru) 2009-07-27

Similar Documents

Publication Publication Date Title
ZA200710644B (en) Amylases for pharmaceutical use
ZA200710643B (en) Lipases for pharmaceutical use
GB0501999D0 (en) Pharmaceutical compounds
GB0520657D0 (en) Pharmaceutical compounds
GB0520656D0 (en) Pharmaceutical compounds
AP2008004533A0 (en) Pharmaceutical combination
IL187510A0 (en) Proteases for pharmaceutical use
ZA200708705B (en) Pharmaceutical composition
ZA200800368B (en) New pharmaceutical compounds
EP1937255A4 (en) PHARMACEUTICAL COMPOSITION
EP1852117A4 (en) PHARMACEUTICAL AGENT COMPRISING SOLIFENACIN
EP1862184A4 (en) PHARMACEUTICAL COMPOSITION
GB0512643D0 (en) Pharmaceutical compounds
ZA200804666B (en) Pharmaceutical combination
ZA200710642B (en) Proteases for pharmaceutical use
GB0512246D0 (en) Novel pharmaceutical
ZA200705612B (en) Pharmaceutical compounds
GB0501475D0 (en) Pharmaceutical compounds
GB0500826D0 (en) Pharmaceutical use
GB0515315D0 (en) Pharmaceutical agents
GB0514530D0 (en) Pharmaceutical agent
GB0512654D0 (en) Pharmaceutical compounds
GB0516167D0 (en) Pharmaceutical compounds
GB0507474D0 (en) Pharmaceutical compounds
GB0501998D0 (en) Pharmaceutical compounds