ZA200604578B - Thiazoles and oxazoles.useful as modulators of ATP Binding cassette transporters - Google Patents
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52035503P | 2003-11-14 | 2003-11-14 |
Publications (1)
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|---|---|
| ZA200604578B true ZA200604578B (en) | 2008-05-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200604578A ZA200604578B (en) | 2003-11-14 | 2004-11-15 | Thiazoles and oxazoles.useful as modulators of ATP Binding cassette transporters |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7407976B2 (fr) |
| EP (2) | EP1682127B1 (fr) |
| JP (1) | JP4869072B2 (fr) |
| KR (1) | KR20060121185A (fr) |
| CN (2) | CN1925854A (fr) |
| AT (1) | ATE437640T1 (fr) |
| AU (1) | AU2004290581B2 (fr) |
| CA (1) | CA2545719A1 (fr) |
| DE (1) | DE602004022319D1 (fr) |
| ES (1) | ES2328824T3 (fr) |
| HK (1) | HK1092353A1 (fr) |
| MX (1) | MXPA06005343A (fr) |
| NO (1) | NO20062773L (fr) |
| NZ (1) | NZ547220A (fr) |
| RU (1) | RU2006120549A (fr) |
| WO (1) | WO2005049018A1 (fr) |
| ZA (1) | ZA200604578B (fr) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| PL379553A1 (pl) * | 2003-02-10 | 2006-10-16 | Amgen Inc. | Ligandy receptora waniloidowego oraz ich zastosowanie w leczeniu |
| JP2007504255A (ja) | 2003-09-06 | 2007-03-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターの調節因子 |
| WO2005049018A1 (fr) * | 2003-11-14 | 2005-06-02 | Vertex Pharmaceuticals Incorporated | Thiazoles et oxazoles utiles en tant que modulateurs de transporteurs de type cassette de liaison a l'atp |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| MX2007000095A (es) | 2004-06-24 | 2007-03-21 | Vertex Pharma | Moduladores de transportadores con casete de union con atp. |
| CA2618057A1 (fr) | 2005-08-11 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Modulateurs du regulateur de la conductance transmembranaire de la fibrose kystique |
| PL2774925T3 (pl) | 2005-11-08 | 2017-07-31 | Vertex Pharmaceuticals Incorporated | Heterocykliczne modulatory transporterów z kasetą wiążącą ATP |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| SI3219705T1 (sl) | 2005-12-28 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid |
| CN101395147B (zh) | 2005-12-28 | 2013-05-29 | 弗特克斯药品有限公司 | 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物 |
| US7645773B2 (en) * | 2006-01-18 | 2010-01-12 | Hoffmann-La Roche Inc. | Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase |
| CA2645487A1 (fr) | 2006-03-23 | 2007-10-04 | Amgen Inc. | Composes d'amide 1-phenylsulfonyl-diaza heterocyclique et leurs utilisations comme modulateurs d'hydroxysteroide deshydrogenases |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| DK3091011T3 (en) | 2006-04-07 | 2018-02-26 | Vertex Pharma | MODULATORS OF ATP BINDING CASSETTE TRANSPORT |
| EP2009005A4 (fr) | 2006-04-19 | 2010-06-02 | Astellas Pharma Inc | Dérivé d'azolecarboxamide |
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| WO2009038913A2 (fr) * | 2007-08-24 | 2009-03-26 | Vertex Pharmaceuticals Incorporated | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique |
| EP2201010B1 (fr) * | 2007-09-14 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose |
| NZ600865A (en) * | 2007-09-14 | 2014-01-31 | Vertex Pharma | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CN101952254B (zh) * | 2007-11-16 | 2012-09-05 | 沃泰克斯药物股份有限公司 | Atp结合盒转运蛋白的异喹啉调节剂 |
| ES2611077T3 (es) * | 2007-12-07 | 2017-05-04 | Vertex Pharmaceuticals Incorporated | Forma solida de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il) ciclopropanocarboxamida)-3-metilpiridin-2-il) benzoico |
| ES2625957T3 (es) * | 2007-12-07 | 2017-07-21 | Vertex Pharmaceuticals Incorporated | Procedimiento para producir ácidos cicloalquilcarboxiamido-piridinabenzoicos |
| EP2237768A2 (fr) * | 2007-12-07 | 2010-10-13 | Vertex Pharmaceuticals Incorporated | Formulations d'acide 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-méthylpyridin-2-yl)benzoïque |
| US20100036130A1 (en) * | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| AU2008335031B2 (en) * | 2007-12-13 | 2013-11-28 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| ES2647531T3 (es) * | 2008-02-28 | 2017-12-22 | Vertex Pharmaceuticals Incorporated | Derivados de heteroarilo como moduladores de CFTR |
| CN103951614A (zh) * | 2008-03-31 | 2014-07-30 | 沃泰克斯药物股份有限公司 | 作为cftr调节剂的吡啶基衍生物 |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| CN102164587A (zh) * | 2008-09-29 | 2011-08-24 | 沃泰克斯药物股份有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的剂量单元 |
| PT2358680E (pt) * | 2008-10-23 | 2013-05-14 | Vertex Pharma | Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2- (trifluorometil)fenil)-4-oxo- 5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida |
| TWI465449B (zh) * | 2008-10-23 | 2014-12-21 | Vertex Pharma | 囊腫性纖維化跨膜傳導調節因子之調控因子 |
| JP5645834B2 (ja) * | 2008-10-23 | 2014-12-24 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス制御因子の修飾因子 |
| US8367660B2 (en) * | 2008-12-30 | 2013-02-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| LT2821400T (lt) * | 2009-03-20 | 2018-02-12 | Vertex Pharmaceuticals Incorporated | Cistinės fibrozės transmembraninio laidumo reguliatoriaus moduliatorių gamybos būdas |
| ES2540810T3 (es) * | 2009-09-17 | 2015-07-13 | Vertex Pharmaceuticals Incorporated | Proceso para preparar compuestos azabicíclicos |
| CA2777245A1 (fr) * | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorporated | Compositions destinees au traitement de la mucoviscidose et d'autres maladies chroniques |
-
2004
- 2004-11-15 WO PCT/US2004/038566 patent/WO2005049018A1/fr active Application Filing
- 2004-11-15 CN CNA2004800394953A patent/CN1925854A/zh active Pending
- 2004-11-15 AU AU2004290581A patent/AU2004290581B2/en not_active Ceased
- 2004-11-15 ES ES04811321T patent/ES2328824T3/es active Active
- 2004-11-15 DE DE602004022319T patent/DE602004022319D1/de active Active
- 2004-11-15 EP EP04811321A patent/EP1682127B1/fr not_active Not-in-force
- 2004-11-15 ZA ZA200604578A patent/ZA200604578B/en unknown
- 2004-11-15 US US10/989,218 patent/US7407976B2/en active Active
- 2004-11-15 NZ NZ547220A patent/NZ547220A/en not_active IP Right Cessation
- 2004-11-15 EP EP09164393A patent/EP2140865A1/fr not_active Withdrawn
- 2004-11-15 CA CA002545719A patent/CA2545719A1/fr not_active Abandoned
- 2004-11-15 RU RU2006120549/04A patent/RU2006120549A/ru not_active Application Discontinuation
- 2004-11-15 KR KR1020067011655A patent/KR20060121185A/ko not_active Application Discontinuation
- 2004-11-15 CN CN200910142522A patent/CN101675928A/zh active Pending
- 2004-11-15 AT AT04811321T patent/ATE437640T1/de not_active IP Right Cessation
- 2004-11-15 JP JP2006540025A patent/JP4869072B2/ja not_active Expired - Fee Related
- 2004-11-15 MX MXPA06005343A patent/MXPA06005343A/es unknown
-
2006
- 2006-06-13 NO NO20062773A patent/NO20062773L/no not_active Application Discontinuation
- 2006-08-24 HK HK06109405.4A patent/HK1092353A1/xx not_active IP Right Cessation
-
2008
- 2008-07-31 US US12/183,580 patent/US7846951B2/en active Active
-
2010
- 2010-10-27 US US12/913,089 patent/US8232302B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110144123A1 (en) | 2011-06-16 |
| ES2328824T3 (es) | 2009-11-18 |
| JP2007511538A (ja) | 2007-05-10 |
| US7407976B2 (en) | 2008-08-05 |
| EP1682127A1 (fr) | 2006-07-26 |
| US7846951B2 (en) | 2010-12-07 |
| CN101675928A (zh) | 2010-03-24 |
| NZ547220A (en) | 2009-12-24 |
| US20050130970A1 (en) | 2005-06-16 |
| NO20062773L (no) | 2006-08-08 |
| MXPA06005343A (es) | 2006-07-10 |
| WO2005049018A1 (fr) | 2005-06-02 |
| EP1682127B1 (fr) | 2009-07-29 |
| KR20060121185A (ko) | 2006-11-28 |
| RU2006120549A (ru) | 2007-12-27 |
| DE602004022319D1 (de) | 2009-09-10 |
| CN1925854A (zh) | 2007-03-07 |
| US8232302B2 (en) | 2012-07-31 |
| HK1092353A1 (en) | 2007-02-09 |
| JP4869072B2 (ja) | 2012-02-01 |
| EP2140865A1 (fr) | 2010-01-06 |
| CA2545719A1 (fr) | 2005-06-02 |
| ATE437640T1 (de) | 2009-08-15 |
| US20090018140A1 (en) | 2009-01-15 |
| AU2004290581A1 (en) | 2005-06-02 |
| AU2004290581B2 (en) | 2011-07-14 |
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