ZA200602755B - Modulators of ATP-binding cassette transporters - Google Patents
Modulators of ATP-binding cassette transporters Download PDFInfo
- Publication number
- ZA200602755B ZA200602755B ZA200602755A ZA200602755A ZA200602755B ZA 200602755 B ZA200602755 B ZA 200602755B ZA 200602755 A ZA200602755 A ZA 200602755A ZA 200602755 A ZA200602755 A ZA 200602755A ZA 200602755 B ZA200602755 B ZA 200602755B
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- ZA
- South Africa
- Prior art keywords
- aliphatic
- optionally substituted
- ors
- phenyl
- ring
- Prior art date
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| NZ602838A (en) | 2010-04-07 | 2015-06-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
| KR20130056244A (ko) | 2010-04-22 | 2013-05-29 | 버텍스 파마슈티칼스 인코포레이티드 | 시클로알킬카르복스아미도-인돌 화합물의 제조 방법 |
| CA2796642A1 (en) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| AU2011242454A1 (en) | 2010-04-22 | 2012-11-08 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| EP2560651A1 (en) | 2010-04-22 | 2013-02-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| TW201202250A (en) | 2010-05-20 | 2012-01-16 | Vertex Pharma | Processes for producing modulators of cystic fibrosis transmembrane conductance regulator |
| NZ603386A (en) | 2010-05-20 | 2015-02-27 | Vertex Pharma | Pharmaceutical compositions and administrations thereof |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| CA2808501A1 (en) | 2010-08-23 | 2012-03-01 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof |
| RU2013113627A (ru) | 2010-08-27 | 2014-10-10 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтическая композиция и ее введения |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| KR101985044B1 (ko) | 2011-11-08 | 2019-05-31 | 버텍스 파마슈티칼스 인코포레이티드 | Atp-결합 카세트 수송체의 조절제 |
| PT2806859T (pt) | 2012-01-25 | 2019-09-04 | Vertex Pharma | Formulações de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico |
| MX389751B (es) | 2012-02-27 | 2025-03-20 | Vertex Pharma | Composición farmacéutica y administraciones de la misma. |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CA2874851A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cftr-mediated disorders |
| AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| EP4556008A3 (en) | 2012-11-02 | 2025-08-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cftr mediated diseases |
| US20140221424A1 (en) | 2013-01-30 | 2014-08-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for use in the treatment of cystic fibrosis |
-
2004
- 2004-09-07 US US10/936,448 patent/US7973169B2/en active Active
- 2004-09-07 CN CNA200480031503XA patent/CN1898221A/zh active Pending
- 2004-09-07 KR KR1020067004627A patent/KR20060088537A/ko not_active Withdrawn
- 2004-09-07 ZA ZA200602755A patent/ZA200602755B/en unknown
- 2004-09-07 CA CA002537841A patent/CA2537841A1/en not_active Abandoned
- 2004-09-07 JP JP2006525534A patent/JP2007504255A/ja active Pending
- 2004-09-07 RU RU2006111093/04A patent/RU2006111093A/ru not_active Application Discontinuation
- 2004-09-07 WO PCT/US2004/029206 patent/WO2005026137A2/en not_active Ceased
- 2004-09-07 EP EP04783449A patent/EP1664006A2/en not_active Withdrawn
- 2004-09-07 AU AU2004272599A patent/AU2004272599A1/en not_active Abandoned
- 2004-09-07 MX MXPA06002567A patent/MXPA06002567A/es unknown
-
2006
- 2006-03-06 IL IL174128A patent/IL174128A0/en unknown
- 2006-04-05 NO NO20061543A patent/NO20061543L/no not_active Application Discontinuation
-
2011
- 2011-07-01 US US13/174,844 patent/US8431605B2/en not_active Expired - Fee Related
-
2013
- 2013-03-22 US US13/848,970 patent/US8741939B2/en not_active Expired - Lifetime
- 2013-11-14 US US14/079,664 patent/US8853415B2/en not_active Expired - Fee Related
-
2014
- 2014-10-06 US US14/506,856 patent/US9249131B2/en not_active Expired - Lifetime
-
2016
- 2016-01-29 US US15/010,542 patent/US20160228414A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL174128A0 (en) | 2006-08-01 |
| US7973169B2 (en) | 2011-07-05 |
| CA2537841A1 (en) | 2005-03-24 |
| NO20061543L (no) | 2006-06-06 |
| US20130252333A1 (en) | 2013-09-26 |
| WO2005026137A2 (en) | 2005-03-24 |
| KR20060088537A (ko) | 2006-08-04 |
| US8431605B2 (en) | 2013-04-30 |
| US8853415B2 (en) | 2014-10-07 |
| WO2005026137A3 (en) | 2005-07-21 |
| CN1898221A (zh) | 2007-01-17 |
| US8741939B2 (en) | 2014-06-03 |
| US20150025076A1 (en) | 2015-01-22 |
| US9249131B2 (en) | 2016-02-02 |
| JP2007504255A (ja) | 2007-03-01 |
| MXPA06002567A (es) | 2006-09-04 |
| US20160228414A1 (en) | 2016-08-11 |
| US20140072995A1 (en) | 2014-03-13 |
| AU2004272599A1 (en) | 2005-03-24 |
| EP1664006A2 (en) | 2006-06-07 |
| US20120004216A1 (en) | 2012-01-05 |
| US20050176789A1 (en) | 2005-08-11 |
| RU2006111093A (ru) | 2007-10-27 |
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