ZA200500973B - CCK-1 receptor modulators - Google Patents
CCK-1 receptor modulators Download PDFInfo
- Publication number
- ZA200500973B ZA200500973B ZA200500973A ZA200500973A ZA200500973B ZA 200500973 B ZA200500973 B ZA 200500973B ZA 200500973 A ZA200500973 A ZA 200500973A ZA 200500973 A ZA200500973 A ZA 200500973A ZA 200500973 B ZA200500973 B ZA 200500973B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- methyl
- methoxy
- chloro
- dichloro
- Prior art date
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- -1 -Ophenyl Chemical group 0.000 claims description 436
- 125000005605 benzo group Chemical group 0.000 claims description 114
- 229910052799 carbon Inorganic materials 0.000 claims description 98
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 98
- 150000001875 compounds Chemical class 0.000 claims description 67
- 229910052757 nitrogen Inorganic materials 0.000 claims description 64
- 150000001721 carbon Chemical group 0.000 claims description 60
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 48
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 41
- 125000004432 carbon atom Chemical group C* 0.000 claims description 36
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
- 125000002950 monocyclic group Chemical group 0.000 claims description 28
- 125000006413 ring segment Chemical group 0.000 claims description 28
- 125000001931 aliphatic group Chemical group 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 27
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 125000004076 pyridyl group Chemical group 0.000 claims description 24
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 23
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- 125000005843 halogen group Chemical group 0.000 claims description 20
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- SZPWXAOBLNYOHY-UHFFFAOYSA-N [C]1=CC=NC2=CC=CC=C12 Chemical group [C]1=CC=NC2=CC=CC=C12 SZPWXAOBLNYOHY-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 6
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- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 4
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- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 4
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- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000004532 benzofuran-3-yl group Chemical group O1C=C(C2=C1C=CC=C2)* 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
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- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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| UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
| RU2379292C2 (ru) | 2003-04-18 | 2010-01-20 | Мемори Фармасьютиклз Корпорейшн | Производные пиразола в качестве ингибиторов фосфодиэстеразы 4 |
| KR20060030506A (ko) * | 2003-07-02 | 2006-04-10 | 얀센 파마슈티카 엔.브이. | Ｃｃｋ-1 수용체 조절제 |
| US20050020565A1 (en) * | 2003-07-02 | 2005-01-27 | Jones Todd K. | CCK-1 receptor modulators |
| WO2005063716A1 (en) * | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
| NZ551563A (en) * | 2004-06-30 | 2009-06-26 | Janssen Pharmaceutica Nv | Alpha,beta-unsaturated esters and acids by stereoselective dehydration |
| CN101166733A (zh) | 2004-10-15 | 2008-04-23 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的吡唑衍生物 |
| US20060177438A1 (en) * | 2005-02-08 | 2006-08-10 | New England Medical Center | Methods of altering absorption of hydrophobic compounds |
| CA2649927A1 (en) | 2006-04-14 | 2007-10-25 | Merck & Co., Inc. | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators |
| EP2010179B1 (en) * | 2006-04-14 | 2010-07-07 | Merck Sharp & Dohme Corp. | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators |
| JP5986098B2 (ja) * | 2010-11-24 | 2016-09-06 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | インテグリン結合キナーゼ阻害剤 |
| DK3071206T3 (da) | 2013-11-22 | 2021-05-25 | CL BioSciences LLC | Gastrinantagonister (eg yf476, netazepid) til behandling og forebyggelse af osteoporose |
| CA2929785C (en) | 2013-12-13 | 2018-02-13 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| WO2015086642A1 (en) | 2013-12-13 | 2015-06-18 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
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| US4826868A (en) | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
| US5164381A (en) | 1986-05-29 | 1992-11-17 | Ortho Pharmaceutical Corporation | Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same |
| US5051518A (en) | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
| AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
| ZA915372B (en) * | 1990-07-17 | 1993-03-31 | Lilly Co Eli | Pyrazolidinone cck and gastrin antagonists and pharmaceutical formulations thereof |
| CA2167154A1 (en) * | 1993-08-10 | 1995-02-16 | Sarkis Barret Kalindjian | Gastrin and cck receptor ligands |
| US5756529A (en) | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| JPH09151183A (ja) * | 1995-12-01 | 1997-06-10 | Yoshitomi Pharmaceut Ind Ltd | チエニルアミド化合物 |
| DE19621687A1 (de) | 1996-05-30 | 1997-12-04 | Bayer Ag | Verfahren zur Herstellung von substituierten Arylpyrazolen |
| DE60103136T2 (de) | 2000-03-06 | 2004-10-28 | Smithkline Beecham Plc, Brentford | Imidazolderivate als Raf-Kinase Inhibitoren |
| GB0011092D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (III) |
| GB0011095D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | astrin and cholecystokinin receptor ligands (III) |
| GB0011089D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (11) |
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| ATE455785T1 (de) * | 2000-11-02 | 2010-02-15 | Ajinomoto Kk | Neue pyrazolderivate und diese enthaltende mittel gegen diabetes |
| US6784185B2 (en) * | 2001-03-16 | 2004-08-31 | Pfizer Inc. | Pharmaceutically active compounds |
| WO2002092576A1 (en) * | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| WO2003011854A1 (en) * | 2001-08-03 | 2003-02-13 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
| JP4357295B2 (ja) * | 2001-08-03 | 2009-11-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピラゾール誘導キナーゼインヒビターとその使用 |
| WO2003024958A2 (en) | 2001-09-18 | 2003-03-27 | Onconova Therapeutics, Inc. | Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles |
| EP1438293A2 (en) * | 2001-09-19 | 2004-07-21 | Pharmacia Corporation | Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation |
| WO2003037336A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
| EP1551794A4 (en) * | 2002-06-19 | 2006-05-17 | Bristol Myers Squibb Co | UREIDO-SUBSTITUTED ANILINE COMPOUNDS SUITABLE AS SERINPROTEASE INHIBITORS |
| UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
-
2003
- 2003-02-07 UA UAA200500955A patent/UA79804C2/uk unknown
- 2003-07-02 AU AU2003253776A patent/AU2003253776A1/en not_active Abandoned
- 2003-07-02 JP JP2004521518A patent/JP2006501194A/ja active Pending
- 2003-07-02 EA EA200401621A patent/EA009479B1/ru not_active IP Right Cessation
- 2003-07-02 BR BR0312378-2A patent/BR0312378A/pt not_active IP Right Cessation
- 2003-07-02 KR KR1020057000056A patent/KR20050042130A/ko not_active Application Discontinuation
- 2003-07-02 CN CNB038207613A patent/CN100522947C/zh not_active Expired - Fee Related
- 2003-07-02 US US10/612,150 patent/US7037931B2/en not_active Expired - Lifetime
- 2003-07-02 EP EP03764341A patent/EP1525190A1/en not_active Withdrawn
- 2003-07-02 PL PL03374757A patent/PL374757A1/xx not_active Application Discontinuation
- 2003-07-02 CA CA002491213A patent/CA2491213A1/en not_active Abandoned
- 2003-07-02 NZ NZ537899A patent/NZ537899A/en unknown
- 2003-07-02 MX MXPA05000204A patent/MXPA05000204A/es active IP Right Grant
- 2003-07-02 WO PCT/US2003/020787 patent/WO2004007463A1/en active Application Filing
- 2003-07-03 AR ARP030102418A patent/AR041183A1/es unknown
- 2003-07-03 CL CL200301360A patent/CL2003001360A1/es unknown
- 2003-07-03 CO CO03056084A patent/CO5400148A1/es not_active Application Discontinuation
- 2003-07-03 TW TW092118137A patent/TW200418469A/zh unknown
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2004
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- 2004-12-30 IL IL16606904A patent/IL166069A0/xx unknown
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2005
- 2005-01-28 NO NO20050498A patent/NO20050498L/no not_active Application Discontinuation
- 2005-02-02 ZA ZA200500973A patent/ZA200500973B/en unknown
- 2005-09-19 US US11/230,200 patent/US7465808B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL166069A0 (en) | 2006-01-15 |
| PL374757A1 (en) | 2005-10-31 |
| US20040067983A1 (en) | 2004-04-08 |
| CL2003001360A1 (es) | 2005-06-03 |
| EP1525190A1 (en) | 2005-04-27 |
| US7465808B2 (en) | 2008-12-16 |
| NO20050498L (no) | 2005-03-16 |
| UA79804C2 (en) | 2007-07-25 |
| NZ537899A (en) | 2007-04-27 |
| CO5400148A1 (es) | 2004-05-31 |
| EA009479B1 (ru) | 2008-02-28 |
| KR20050042130A (ko) | 2005-05-04 |
| CN1678587A (zh) | 2005-10-05 |
| US7037931B2 (en) | 2006-05-02 |
| AR041183A1 (es) | 2005-05-04 |
| EA200401621A1 (ru) | 2005-06-30 |
| JP2006501194A (ja) | 2006-01-12 |
| MXPA05000204A (es) | 2005-09-30 |
| WO2004007463A1 (en) | 2004-01-22 |
| AU2003253776A1 (en) | 2004-02-02 |
| TW200418469A (en) | 2004-10-01 |
| CA2491213A1 (en) | 2004-01-22 |
| BR0312378A (pt) | 2005-04-26 |
| US20060014817A1 (en) | 2006-01-19 |
| CN100522947C (zh) | 2009-08-05 |
| HRP20041224A2 (en) | 2007-03-31 |
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