ZA200500062B - Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulationof the cross-beta structure, its formation and it s associated toxicity. - Google Patents

Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulationof the cross-beta structure, its formation and it s associated toxicity. Download PDF

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Publication number
ZA200500062B
ZA200500062B ZA200500062A ZA200500062A ZA200500062B ZA 200500062 B ZA200500062 B ZA 200500062B ZA 200500062 A ZA200500062 A ZA 200500062A ZA 200500062 A ZA200500062 A ZA 200500062A ZA 200500062 B ZA200500062 B ZA 200500062B
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South Africa
Prior art keywords
cross
tpa
protein
compound
binding
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ZA200500062A
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English (en)
Inventor
Martijn Frans Ben Gerard Gebbink
Onno Wouter Kranenburg
Barend Bouma
Louise Maria Johanna Kroon
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Uni Medisch Ct Utrecht Univers
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Publication of ZA200500062B publication Critical patent/ZA200500062B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972Plasminogen activators
    • G01N2333/9726Tissue plasminogen activator
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
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    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Urology & Nephrology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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ZA200500062A 2002-07-09 2005-01-04 Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulationof the cross-beta structure, its formation and it s associated toxicity. ZA200500062B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02077797A EP1380290A1 (fr) 2002-07-09 2002-07-09 La voie de la structure cross-béta et sa pertinence thérapeutique

Publications (1)

Publication Number Publication Date
ZA200500062B true ZA200500062B (en) 2005-11-01

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ZA200500062A ZA200500062B (en) 2002-07-09 2005-01-04 Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulationof the cross-beta structure, its formation and it s associated toxicity.

Country Status (13)

Country Link
US (3) US20060045853A1 (fr)
EP (5) EP1380290A1 (fr)
JP (1) JP2005537254A (fr)
AT (1) ATE417605T1 (fr)
AU (2) AU2003251233B2 (fr)
CA (1) CA2492010A1 (fr)
DE (1) DE60325381D1 (fr)
DK (1) DK1536778T3 (fr)
ES (1) ES2319982T3 (fr)
NZ (2) NZ537495A (fr)
PT (1) PT1536778E (fr)
WO (1) WO2004004698A2 (fr)
ZA (1) ZA200500062B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1820806A1 (fr) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Zones d'affinité
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1380290A1 (fr) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht La voie de la structure cross-béta et sa pertinence thérapeutique
EP1704867A1 (fr) * 2005-03-18 2006-09-27 Crossbeta Biosciences B.V. Des Structures cross-Beta sur des microorganismes
US20090202980A1 (en) * 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
BRPI0613525A2 (pt) * 2005-07-13 2011-05-31 Crossbeta Biosciences Bv métodos para produzir uma composição imunogênica, para melhorar a imunogenicidade de uma composição, para intensificar a imunogenicidade de uma composição de vacina, e para determinar a quantidade de estruturas beta-cruzadas em uma composição de vacina, usos de estruturas beta-cruzadas, e de uma composição imunogênica, vacina de subunidade, e, composição imunogênica
US20070015133A1 (en) * 2005-07-13 2007-01-18 Umc Utrecht Holding B.V. Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
US8114832B2 (en) * 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
CA2615078A1 (fr) * 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Methodes de determination de l'effet d'un traitement sur la teneur d'une proteine a structure croisee-.beta. selection des traitements et leurs utilisations
ATE554394T1 (de) * 2005-07-13 2012-05-15 Crossbeta Biosciences Bv Cross-beta-struktur-bindende verbindungen
WO2007108675A1 (fr) * 2006-03-17 2007-09-27 Crossbeta Biosciences B.V. Procédés de liaison de structures bêta croisées avec des molécules chaperonnes
GB0710976D0 (en) 2007-06-07 2007-07-18 Bioalvo Am Screening method
EP2058000A1 (fr) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Compositions immunogènes capables d'activer des cellules T
EP2058001A1 (fr) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Amélioration de l'immunogénicité des antigènes
CN104777308B (zh) * 2008-10-31 2017-04-12 耶鲁大学 先兆子痫检测和治疗的方法和组合物
EP2361645B1 (fr) 2008-12-22 2014-10-29 Fujita Health University Utilisation d'un support pour l'elimination de proteine amyloïde-beta a partir de fluides extracorporels
EP2322163A1 (fr) * 2009-11-03 2011-05-18 Pharnext Nouvelles approches thérapeutiques pour traiter la maladie d'Alzheimer
JP5843345B2 (ja) 2010-07-08 2016-01-13 旭化成メディカル株式会社 β−アミロイド除去システム
DE102011003944A1 (de) 2011-02-10 2012-08-16 Oxprotect Gmbh Detektion und Entfernung von missgefalteten Proteinen/Peptiden
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
TW202019398A (zh) * 2018-06-28 2020-06-01 張翔毓 用於治療或預防構形疾病之方法及藥物篩選方法

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60103964A (ja) * 1983-11-10 1985-06-08 ユニチカ株式会社 抗血栓性材料
US5700447A (en) * 1992-05-21 1997-12-23 The Picowder Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5869534A (en) * 1992-05-21 1999-02-09 The Picower Institute For Medical Research Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
US5733524A (en) * 1984-03-19 1998-03-31 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5801200A (en) * 1984-03-19 1998-09-01 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5733933A (en) * 1984-03-19 1998-03-31 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
DE3682891D1 (de) * 1986-02-17 1992-01-23 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
EP0319144A1 (fr) * 1987-11-06 1989-06-07 Asahi Kasei Kogyo Kabushiki Kaisha Absorbant de bêta-2-microglobuline
JPH01171638A (ja) * 1987-12-25 1989-07-06 Kanegafuchi Chem Ind Co Ltd 血清アミロイドa蛋白用吸着体
US5216127A (en) * 1987-11-20 1993-06-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Adsorbent for serum amyloid protein
DE3880647T2 (de) * 1987-11-20 1993-11-18 Kanegafuchi Chemical Ind Sorbentmittel für Serum-Amyloid-Proteine.
US5151082A (en) * 1988-08-05 1992-09-29 Heathdyne, Inc. Apparatus and method for kidney dialysis using plasma in lieu of blood
US5679320A (en) * 1988-12-29 1997-10-21 Bio-Technology General Corp. Fibrin binding domain polypeptides and uses and methods of producing same
CA1335361C (fr) * 1989-05-24 1995-04-25 Andrei Z. Budzynski Complexes diriges contre les thrombus et formes d'activateurs du plasminogene et de fragments de fibrine
US5180615A (en) * 1989-12-13 1993-01-19 W.R. Grace & Co.-Conn. Metallized bag for static protection of electronic components
US5591431A (en) * 1990-03-09 1997-01-07 G.D. Searle & Co. Enhancement of clot lysis
US5753624A (en) * 1990-04-27 1998-05-19 Milkhaus Laboratory, Inc. Materials and methods for treatment of plaquing disease
SE502414C2 (sv) * 1990-05-28 1995-10-16 Ljungqvist Olle Medical Ab Användning av glukos för framställning av lösning för preoperativ administrering samt infusionslösning därför
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US5650418A (en) * 1990-06-04 1997-07-22 Therapy 2000 Therapeutic lysine salt composition and method of use
US5230996A (en) * 1990-06-04 1993-07-27 Therapy 2000 Use of ascorbate and tranexamic acid solution for organ and blood vessel treatment prior to transplantation
EP0532706B1 (fr) * 1990-06-04 1995-05-10 Health Now REDUCTION D'OCCLUSIONS DE VAISSEAUX CARDIOVASCULAIRES A L'AIDE D'ASCORBATE ET D'INHIBITEURS DE LIAISON DE LA LIPOPROTEINE (a)
US5780587A (en) * 1990-08-24 1998-07-14 President And Fellows Of Harvard College Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
SE468881B (sv) * 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
US5221628A (en) * 1991-03-19 1993-06-22 Northwestern University Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component
US5276059A (en) * 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
US5491129A (en) * 1992-07-30 1996-02-13 Yeda Research And Development Co. Ltd. Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
DE4242736A1 (de) * 1992-12-17 1994-06-23 Behringwerke Ag Synthetische Peptide, Antikörper dagegen und ihre Verwendung
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
EP0683234B2 (fr) * 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Anticorps dirige contre le beta-amyloide ou un derive de ce dernier et son utilisation
US5449663A (en) * 1993-06-11 1995-09-12 Bicher; Haim I. Antineoplastic compositions
JP3680114B2 (ja) * 1993-09-17 2005-08-10 敏一 中村 脳神経障害治療剤
CA2156255C (fr) * 1993-12-17 2008-02-05 Yasuyuki Kunihiro Dispositif a semi-conducteur
US6410598B1 (en) * 1994-02-03 2002-06-25 Michael P. Vitek Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
US5935927A (en) * 1994-02-03 1999-08-10 The Picower Institute For Medical Research Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts
KR0163563B1 (ko) * 1994-03-23 1998-12-01 김종인 피부질환 치료용 의약조성물
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5589154A (en) * 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
US6136548A (en) * 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US5888774A (en) * 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
DE69621607T2 (de) * 1995-03-14 2003-01-02 Praecis Pharm Inc VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN
US5817626A (en) * 1995-03-14 1998-10-06 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation
US5854215A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US6436969B1 (en) * 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
AU7253596A (en) * 1995-10-02 1997-04-28 Mohammad W. Katoot Biologically-active polymers
US5985242A (en) * 1995-10-27 1999-11-16 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
US6310046B1 (en) * 1995-11-17 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Sequestrin of Plasmodium falciparum
WO1997026919A2 (fr) * 1996-01-24 1997-07-31 Warner-Lambert Company Methode d'imagerie de depots amyloides
US5785187A (en) * 1996-04-29 1998-07-28 Lipman; Daniel Mechandising display assembly
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
AU734183C (en) * 1996-08-09 2001-11-22 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6929807B1 (en) * 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6689275B1 (en) * 1996-12-31 2004-02-10 Ajay Gupta Method and pharmaceutical composition for replacing iron losses in dialysis patients
US6372473B1 (en) * 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
JP2001509369A (ja) * 1997-07-08 2001-07-24 ノボファーム バイオテック インコーポレイテッド ガン細胞を特異的に検出する4b5と命名される抗原結合フラグメント、フラグメントをコードするヌクレオチド、ならびにガンの予防および検出のためのそれらの使用
US20020122807A1 (en) * 1998-07-07 2002-09-05 Dan Michael D. Antigen binding fragments, designated 4B5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
DE19735902A1 (de) * 1997-08-19 1999-02-25 Imtec Immundiagnostika Gmbh Selektives Adsorbens für biologische Materialien
WO1999009999A1 (fr) * 1997-08-28 1999-03-04 University Of Washington Compositions de saccharide et methodes de traitement specifiques de la maladie d'alzheimer et d'autres amyloidoses
ATE555780T1 (de) * 1997-10-24 2012-05-15 John P Blass Nahrungsergänzungsmittel für metabolische hirnleistungsstörungen
WO1999047072A1 (fr) * 1998-03-18 1999-09-23 Tyndale Plains-Hunter, Ltd. Polyurethanes de polyether hydrophile contenant de l'acide carboxylique
JP4037525B2 (ja) 1998-03-25 2008-01-23 生化学工業株式会社 新規抗菌性ペプチド
US7041287B2 (en) * 1998-05-21 2006-05-09 Trustees Of The University Of Pennsylvania Compositions and methods for selective dissolution of nascent intravascular blood clots
WO2000009562A1 (fr) 1998-08-12 2000-02-24 The New York Blood Center, Inc. Nouveaux fragments scindes du fibrinogene
JP2002525323A (ja) * 1998-09-25 2002-08-13 スノル・モレキュラー・コーポレーション 医薬活性化合物及びその使用方法
IN190822B (fr) * 1998-12-24 2003-08-23 Council Scient Ind Res
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6161547A (en) * 1999-01-15 2000-12-19 Coaxia, Inc. Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use
WO2000059493A2 (fr) * 1999-04-06 2000-10-12 Kansas University Medical Center Solutions de dialyse et methodes de dialyse ameliorees
EP1179588B9 (fr) * 1999-04-30 2006-07-19 Akira Matsumoto Carboxypeptidase b du cerveau humain
WO2000068263A2 (fr) * 1999-05-05 2000-11-16 Neurochem, Inc. Peptides stereoselectifs antifibrillogenese et peptidomimetiques correspondants
AT500670A1 (de) * 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
CA2376693C (fr) * 1999-06-16 2013-09-10 Boston Biomedical Research Institute Temoin immunologique de niveaux de .beta.-amyloide in vivo
GB9917725D0 (en) * 1999-07-28 1999-09-29 Medical Res Council Peptides
AU6766800A (en) * 1999-08-13 2001-03-13 Trustees Of Columbia University In The City Of New York, The Methods of inhibiting binding of beta-sheet fibril to rage and consequences thereof
US20040013647A1 (en) * 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
WO2001019836A1 (fr) * 1999-09-14 2001-03-22 Meiji Seika Kaisha, Ltd. Derives d'acides phosphoniques presentant une activite inhibitrice de carboxypeptidase b
US6399314B1 (en) * 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
DE60116733T2 (de) 2000-01-20 2006-11-02 Regents Of The University Of Minnesota, Minneapolis Peptide mit antibakterieller wirkung
AU3173301A (en) * 2000-02-11 2001-08-20 European Molecular Biology Laboratory Methods and compositions for treatment of alzheimer's disease by enhancing plasmin or plasmin-like activity
JP5025871B2 (ja) * 2000-02-21 2012-09-12 エイチ.リュンドベック エイ/エス アミロイドの新規なダウン−レギュレート方法
CA2400838C (fr) * 2000-02-21 2013-04-23 Pharmexa A/S Nouvelle methode de regulation negative d'amyloide
EP1130031A1 (fr) * 2000-02-25 2001-09-05 Universitair Medisch Centrum Utrecht Procédé pour inhiber l'angiogenèse à l'aide des molécules qui augmentent la formation de la plasmine ou qui prolongent son activité
WO2001070762A2 (fr) * 2000-03-21 2001-09-27 Research Foundation Of State University Of New York Adsorption de polyampholytes a des surfaces chargees et analyses associees
DE10017690A1 (de) * 2000-04-08 2001-10-25 Simmoteit Robert Vorrichtung zum Stoffaustausch und Kultivierung von Zellen
EP2264018B1 (fr) * 2000-08-24 2015-02-11 University of Pittsburgh - Of the Commonwealth System of Higher Education Dérivés de thioflavine pour le diagnostic de la maladie d'Alzheimer
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
EP1186299A1 (fr) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnostic, prévention et/ou traitement d' athérosclérose, infections et perturbations du système immunitaire
WO2002028441A2 (fr) * 2000-10-04 2002-04-11 California Institute Of Technology Agents d'imagerie par resonance magnetique pour la detection et l'etiquetage in vivo de depots amyloides
EP1219300B1 (fr) * 2000-12-28 2006-12-06 BIOMAY Produktions- und Handels- Aktiengesellschaft Traitement des allergies
US6808927B2 (en) * 2001-04-04 2004-10-26 American Diagnostica, Inc. Method of preparation of stabilized thrombin-activatable fibrinolysis inhibitor (TAFI) and methods of use thereof
JP4235544B2 (ja) 2001-05-31 2009-03-11 アドライフ インコーポレーティッド 欠陥折畳み蛋白質センサー方法
US6960465B1 (en) * 2001-06-27 2005-11-01 Northwestern University Increased cell resistance to toxic organic substances
US6737401B2 (en) 2001-06-28 2004-05-18 Metronic Minimed, Inc. Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
WO2003006893A2 (fr) * 2001-07-09 2003-01-23 Elan Pharmaceuticals, Inc. Procedes inhibant la toxicite amyloide
JP2003024080A (ja) * 2001-07-19 2003-01-28 Univ Tokyo p53依存性アポトーシス誘導タンパク質、およびアポトーシス調節剤のスクリーニング方法
GB0202275D0 (en) 2002-01-31 2002-03-20 Hansa Medica Ab Peptide
EP1820806A1 (fr) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Zones d'affinité
CA2477569C (fr) 2002-02-28 2013-09-24 Microsens Biophage Limited Liaison selective de formes pathologiques de proteines de prion au moyen de polymeres polyioniques
EP1507543A4 (fr) * 2002-05-09 2006-07-26 Cambridgemed Inc Composition pharmaceutique destinee au traitement de plaies et contenant du plasma ou du serum sanguins
EP1380290A1 (fr) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht La voie de la structure cross-béta et sa pertinence thérapeutique
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
US20050142611A1 (en) * 2002-09-30 2005-06-30 Auburn University Method of isolation and self-assembly of small protein particles from blood and other biological materials
US7470667B2 (en) * 2002-12-05 2008-12-30 Medgenn (Hong Kong) Ltd Methods of treating cancer using a modified endostatin protein
EP1449536A1 (fr) 2003-02-14 2004-08-25 Prionics AG Protéines prions comme agents thérapeutiques pour le traitement de maladies associées à AP-1
US7172875B2 (en) * 2003-02-18 2007-02-06 The Ohio State University Research Foundation Identifying inhibitors of intracellular protein fibrillization
ES2622522T3 (es) 2003-08-26 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas
AU2004285928B2 (en) 2003-10-24 2012-02-02 Amgen, Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
US20090156471A1 (en) 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
JP2008531553A (ja) * 2005-02-25 2008-08-14 メディジーンズ カンパニー リミテッド 血漿または血清を含むアベリノ角膜ジストロフィー治療用の医薬組成物
EP1704867A1 (fr) * 2005-03-18 2006-09-27 Crossbeta Biosciences B.V. Des Structures cross-Beta sur des microorganismes
US20090202980A1 (en) * 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
ATE554394T1 (de) * 2005-07-13 2012-05-15 Crossbeta Biosciences Bv Cross-beta-struktur-bindende verbindungen
US20070015133A1 (en) * 2005-07-13 2007-01-18 Umc Utrecht Holding B.V. Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
CA2615078A1 (fr) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Methodes de determination de l'effet d'un traitement sur la teneur d'une proteine a structure croisee-.beta. selection des traitements et leurs utilisations
BRPI0613525A2 (pt) * 2005-07-13 2011-05-31 Crossbeta Biosciences Bv métodos para produzir uma composição imunogênica, para melhorar a imunogenicidade de uma composição, para intensificar a imunogenicidade de uma composição de vacina, e para determinar a quantidade de estruturas beta-cruzadas em uma composição de vacina, usos de estruturas beta-cruzadas, e de uma composição imunogênica, vacina de subunidade, e, composição imunogênica
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
US20090136587A1 (en) 2005-08-11 2009-05-28 Medigenes Co., Ltd Pharmaceutical composition for the treatment of nerve damage comprising blood plasma or serum
US8543424B2 (en) * 2005-12-30 2013-09-24 Darryl Mark Hunsaker Vehicle insurance status display system
WO2007108675A1 (fr) 2006-03-17 2007-09-27 Crossbeta Biosciences B.V. Procédés de liaison de structures bêta croisées avec des molécules chaperonnes
PL2029173T3 (pl) * 2006-06-26 2017-04-28 Macrogenics, Inc. Przeciwciała swoiste dla FC RIIB i sposoby ich zastosowania
EP2058000A1 (fr) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Compositions immunogènes capables d'activer des cellules T
EP2058001A1 (fr) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Amélioration de l'immunogénicité des antigènes

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