ZA200406491B - Thiazole and oxazole derivativec that modulate ppar activity - Google Patents
Thiazole and oxazole derivativec that modulate ppar activity Download PDFInfo
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- ZA200406491B ZA200406491B ZA200406491A ZA200406491A ZA200406491B ZA 200406491 B ZA200406491 B ZA 200406491B ZA 200406491 A ZA200406491 A ZA 200406491A ZA 200406491 A ZA200406491 A ZA 200406491A ZA 200406491 B ZA200406491 B ZA 200406491B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- alkyl
- thiazol
- trifluoromethyl
- phenyl
- Prior art date
Links
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- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title description 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- 101150014691 PPARA gene Proteins 0.000 title 1
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- -1 1,3-thiazol-5- yl Chemical group 0.000 claims description 30
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- 238000000034 method Methods 0.000 claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
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US36240002P | 2002-03-07 | 2002-03-07 |
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ZA200406491B true ZA200406491B (en) | 2006-05-31 |
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ZA200406491A ZA200406491B (en) | 2002-03-07 | 2004-08-16 | Thiazole and oxazole derivativec that modulate ppar activity |
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US (1) | US6833380B2 (zh) |
EP (1) | EP1485091A1 (zh) |
JP (1) | JP2005524665A (zh) |
KR (1) | KR20040091694A (zh) |
CN (1) | CN1638768A (zh) |
AP (1) | AP2004003123A0 (zh) |
AR (1) | AR038883A1 (zh) |
AU (1) | AU2003207891A1 (zh) |
BR (1) | BR0308221A (zh) |
CA (1) | CA2476580A1 (zh) |
CO (1) | CO5601013A2 (zh) |
EA (1) | EA200401160A1 (zh) |
EC (1) | ECSP045275A (zh) |
GT (1) | GT200300053A (zh) |
HR (1) | HRP20040810A2 (zh) |
IL (1) | IL163768A0 (zh) |
IS (1) | IS7399A (zh) |
MA (1) | MA27182A1 (zh) |
MX (1) | MXPA04008624A (zh) |
NO (1) | NO20044245L (zh) |
OA (1) | OA12781A (zh) |
PA (1) | PA8568701A1 (zh) |
PE (1) | PE20031010A1 (zh) |
PL (1) | PL372971A1 (zh) |
TN (1) | TNSN04167A1 (zh) |
TW (1) | TW200400027A (zh) |
UY (1) | UY27704A1 (zh) |
WO (1) | WO2003074052A1 (zh) |
ZA (1) | ZA200406491B (zh) |
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US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
US20050203151A1 (en) * | 2003-12-19 | 2005-09-15 | Kalypsys, Inc. | Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions |
ATE486055T1 (de) | 2004-05-05 | 2010-11-15 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
ATE515494T1 (de) | 2004-05-05 | 2011-07-15 | High Point Pharmaceuticals Llc | Neue verbindungen, deren herstellung und verwendung |
EP1749000A4 (en) * | 2004-05-25 | 2009-12-30 | Metabolex Inc | BICYCLIC SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND METHOD FOR THE PRODUCTION THEREOF |
RU2006145872A (ru) * | 2004-05-25 | 2008-06-27 | Метаболекс, Инк. (Us) | Замещенные триазолы в качестве модуляторов ppar и способы их получения |
AU2006265172B2 (en) | 2005-06-30 | 2011-09-15 | Vtv Therapeutics Llc | Phenoxy acetic acids as PPAR delta activators |
CN1896069B (zh) * | 2005-07-15 | 2011-10-05 | 中国科学院上海药物研究所 | 一类取代噻唑-4酮化合物、制备方法和用途 |
EP2386540A1 (en) | 2005-12-22 | 2011-11-16 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200927731A (en) | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온 |
ES2637794T3 (es) | 2007-11-14 | 2017-10-17 | Janssen Pharmaceuticals, Inc. | Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2 |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
BRPI0920354A2 (pt) | 2008-10-16 | 2017-06-27 | Addex Pharmaceuticals Sa | derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
RS53075B (en) | 2009-05-12 | 2014-04-30 | Janssen Pharmaceuticals Inc. | 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
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AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
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MXPA03001558A (es) | 2000-08-23 | 2003-06-06 | Lilly Co Eli | Agonistas del receptor activado del proliferador de peroxisoma. |
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WO2002050047A1 (en) | 2000-12-20 | 2002-06-27 | Glaxo Group Limited | Substitued oxazoles and thiazoles as hppar alpha agonists |
GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
PL367676A1 (en) | 2001-05-29 | 2005-03-07 | Kyoto Pharmaceutical Industries, Ltd. | Novel heterocyclic derivatives and medicinal use thereof |
HUP0400268A2 (hu) | 2001-06-07 | 2004-07-28 | Eli Lilly And Co. | Peroxiszóma proliferátorral aktivált receptorokat (PPAR) módosító hatóanyagok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
JPWO2002102780A1 (ja) | 2001-06-18 | 2004-09-30 | 小野薬品工業株式会社 | テトラヒドロキノリン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
AR036237A1 (es) | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
MXPA04002330A (es) | 2001-09-14 | 2005-04-08 | Japan Tobacco Inc | Compuestos biarilo ligados. |
US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
US20030207924A1 (en) | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
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- 2004-08-12 IS IS7399A patent/IS7399A/is unknown
- 2004-08-16 ZA ZA200406491A patent/ZA200406491B/en unknown
- 2004-08-24 CO CO04082303A patent/CO5601013A2/es not_active Application Discontinuation
- 2004-08-30 MA MA27840A patent/MA27182A1/fr unknown
- 2004-09-03 TN TNP2004000167A patent/TNSN04167A1/fr unknown
- 2004-09-07 HR HRP20040810 patent/HRP20040810A2/hr not_active Application Discontinuation
- 2004-09-24 EC EC2004005275A patent/ECSP045275A/es unknown
- 2004-10-06 NO NO20044245A patent/NO20044245L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005524665A (ja) | 2005-08-18 |
CA2476580A1 (en) | 2003-09-12 |
UY27704A1 (es) | 2003-10-31 |
AP2004003123A0 (en) | 2004-09-30 |
MA27182A1 (fr) | 2005-01-03 |
PE20031010A1 (es) | 2003-12-12 |
OA12781A (en) | 2006-07-07 |
EP1485091A1 (en) | 2004-12-15 |
HRP20040810A2 (en) | 2004-12-31 |
MXPA04008624A (es) | 2004-12-06 |
AR038883A1 (es) | 2005-02-02 |
AU2003207891A1 (en) | 2003-09-16 |
CO5601013A2 (es) | 2006-01-31 |
BR0308221A (pt) | 2005-01-04 |
PL372971A1 (en) | 2005-08-08 |
PA8568701A1 (es) | 2003-11-12 |
US6833380B2 (en) | 2004-12-21 |
ECSP045275A (es) | 2004-10-26 |
NO20044245L (no) | 2004-10-06 |
CN1638768A (zh) | 2005-07-13 |
EA200401160A1 (ru) | 2005-02-24 |
TW200400027A (en) | 2004-01-01 |
IL163768A0 (en) | 2005-12-18 |
GT200300053A (es) | 2003-10-10 |
IS7399A (is) | 2004-08-12 |
KR20040091694A (ko) | 2004-10-28 |
US20030207916A1 (en) | 2003-11-06 |
WO2003074052A1 (en) | 2003-09-12 |
TNSN04167A1 (fr) | 2007-03-12 |
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