CO5601013A2 - Compuestos que modulan la actividad de ppar - Google Patents
Compuestos que modulan la actividad de pparInfo
- Publication number
- CO5601013A2 CO5601013A2 CO04082303A CO04082303A CO5601013A2 CO 5601013 A2 CO5601013 A2 CO 5601013A2 CO 04082303 A CO04082303 A CO 04082303A CO 04082303 A CO04082303 A CO 04082303A CO 5601013 A2 CO5601013 A2 CO 5601013A2
- Authority
- CO
- Colombia
- Prior art keywords
- cr4r5
- alkyl
- alkynyl
- absent
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
1.- Un compuesto que tiene la fórmula I: o una de sus sales farmacéuticamente aceptables, en la que: T es una cadena de hidrocarburo saturada o insaturada, sustituida o no sustituida, o una cadena de hidrocarburo con heteroátomo que tiene de 3 a 6 átomos, en la que el átomo de carbono de la posición 2 está conectado al átomo de carbono de la posición 3 para formar un anillo de cinco a ocho miembros; W es O, S, CH2, CR4R5, NR3, cicloalquileno, o heterocicloalquileno; Y está ausente, O, CR4R5 en el que Y es CR4R5 o está ausente cuando W es O, S, o NR3, e Y es O o está ausente cuando W es CH2 o CR4R5; R1 y R2 son independientemente hidrógeno, alquilo inferior, alcoxi inferior, haloalquilo, -O-(CH2)pCF3, halógeno, nitro, ciano, -OH, -SH, -CF3, S(O)palquilo, S(O)parilo, -(CH2)mOR3, o -(CH2)mNR6R7, COR3, -CO2H, -CO2R3, o -NR6R7; R3 es hidrógeno, alquilo, alquenilo, alquinilo, o arilo; R4 y R5 son independientemente hidrógeno, alquilo, alquenilo, alquinilo, o arilo, o están unidos para formar un anillo de 4 a 7 miembros que tiene 0 a 3 heteroátomos; R6 y R7 son independientemente hidrógeno, alquilo, alquenilo, alquinilo, -COalquilo, -COarilo, cicloalquilo, CO2alquilo, -CO2arilo, -SO2alquilo, -SO2arilo, o están unidos para formar un anillo de 4 a 7 miembros que tiene 1 a 3 heteroátomos; X0 y X1 son independientemente O o S; Ar1 es arilo o heteroarilo sustituido o no sustituido; m es 0 a 5; n es 0 a 5; y p es 0 a 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36240002P | 2002-03-07 | 2002-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5601013A2 true CO5601013A2 (es) | 2006-01-31 |
Family
ID=27789156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04082303A CO5601013A2 (es) | 2002-03-07 | 2004-08-24 | Compuestos que modulan la actividad de ppar |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6833380B2 (es) |
| EP (1) | EP1485091A1 (es) |
| JP (1) | JP2005524665A (es) |
| KR (1) | KR20040091694A (es) |
| CN (1) | CN1638768A (es) |
| AP (1) | AP2004003123A0 (es) |
| AR (1) | AR038883A1 (es) |
| AU (1) | AU2003207891A1 (es) |
| BR (1) | BR0308221A (es) |
| CA (1) | CA2476580A1 (es) |
| CO (1) | CO5601013A2 (es) |
| EA (1) | EA200401160A1 (es) |
| EC (1) | ECSP045275A (es) |
| GT (1) | GT200300053A (es) |
| HR (1) | HRP20040810A2 (es) |
| IL (1) | IL163768A0 (es) |
| IS (1) | IS7399A (es) |
| MA (1) | MA27182A1 (es) |
| MX (1) | MXPA04008624A (es) |
| NO (1) | NO20044245L (es) |
| OA (1) | OA12781A (es) |
| PA (1) | PA8568701A1 (es) |
| PE (1) | PE20031010A1 (es) |
| PL (1) | PL372971A1 (es) |
| TN (1) | TNSN04167A1 (es) |
| TW (1) | TW200400027A (es) |
| UY (1) | UY27704A1 (es) |
| WO (1) | WO2003074052A1 (es) |
| ZA (1) | ZA200406491B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
| EP1745014B1 (en) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
| US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
| JP2008500358A (ja) * | 2004-05-25 | 2008-01-10 | メタボレックス インコーポレーティッド | Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法 |
| KR20070036076A (ko) * | 2004-05-25 | 2007-04-02 | 메타볼렉스, 인코포레이티드 | Ｐｐａｒ의 조절제로서의 치환된 트리아졸 및 이의제조방법 |
| ES2449618T3 (es) | 2005-06-30 | 2014-03-20 | High Point Pharmaceuticals, Llc | Ácidos fenoxiacéticos como activadores de PPAR-delta |
| CN1896069B (zh) * | 2005-07-15 | 2011-10-05 | 中国科学院上海药物研究所 | 一类取代噻唑-4酮化合物、制备方法和用途 |
| AU2006327003B2 (en) | 2005-12-22 | 2011-10-06 | Vtv Therapeutics Llc | Phenoxy acetic acids as PPAR delta activators |
| US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| ATE516272T1 (de) | 2007-09-14 | 2011-07-15 | Ortho Mcneil Janssen Pharm | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one |
| JP5133416B2 (ja) | 2007-09-14 | 2013-01-30 | オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １’，３’−二置換−４−フェニル−３，４，５，６−テトラヒドロ−２ｈ，１’ｈ−［１，４’］ビピリジニル−２’−オン |
| EP2205565B1 (en) | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US8691849B2 (en) | 2008-09-02 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| CA2738849C (en) | 2008-10-16 | 2016-06-28 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| US9487493B2 (en) | 2013-09-09 | 2016-11-08 | Vtv Therapeutics Llc | Use of a PPAR-delta agonist for treating muscle atrophy |
| BR112016016390B1 (pt) | 2014-01-21 | 2023-04-11 | Janssen Pharmaceutica Nv | Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a |
| ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
| CN113045523B (zh) * | 2019-12-27 | 2022-09-23 | 上海泓博智源医药股份有限公司 | 一种咪唑啉吡啶化合物中间体的制备方法 |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028137A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Heterocyclic derivatives as antidiabetic and antiobesity agents |
| WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| KR20000068151A (ko) | 1996-08-19 | 2000-11-25 | 미즈노 마사루 | 프로피온산 유도체 및 그의 용도 |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| ES2204684T3 (es) | 1999-08-27 | 2004-05-01 | Eli Lilly And Company | Derivados de biaril-oxa(tia)zol y su uso como modulares de ppar. |
| BR0113409A (pt) | 2000-08-23 | 2003-07-01 | Lilly Co Eli | Agonistas de receptores ativados por proliferadores de peroxissomas |
| WO2002018355A1 (en) | 2000-08-23 | 2002-03-07 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
| GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| JP2004517100A (ja) | 2000-12-20 | 2004-06-10 | グラクソ グループ リミテッド | ｈＰＰＡＲアルファアゴニストとしての置換オキサゾールおよびチアゾール |
| GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| KR100874677B1 (ko) | 2001-05-29 | 2008-12-18 | 교토 야쿠힝 고교 가부시키가이샤 | 신규 복소환 유도체 및 그 의약 용도 |
| BR0210167A (pt) | 2001-06-07 | 2004-04-06 | Lilly Co Eli | Composto, composição farmacêutica, métodos para modular um receptor ativado com proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição e para abaixar a glicose no sangue, e, uso de um composto |
| JPWO2002102780A1 (ja) | 2001-06-18 | 2004-09-30 | 小野薬品工業株式会社 | テトラヒドロキノリン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| AR036237A1 (es) | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
| MXPA04002330A (es) | 2001-09-14 | 2005-04-08 | Japan Tobacco Inc | Compuestos biarilo ligados. |
| US20030207924A1 (en) | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
| US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
-
2002
- 2002-12-19 US US10/324,278 patent/US6833380B2/en not_active Expired - Fee Related
-
2003
- 2003-03-03 BR BR0308221-0A patent/BR0308221A/pt not_active IP Right Cessation
- 2003-03-03 OA OA1200400233A patent/OA12781A/en unknown
- 2003-03-03 IL IL16376803A patent/IL163768A0/xx unknown
- 2003-03-03 EP EP03704893A patent/EP1485091A1/en not_active Withdrawn
- 2003-03-03 WO PCT/IB2003/000817 patent/WO2003074052A1/en not_active Application Discontinuation
- 2003-03-03 CN CNA038054639A patent/CN1638768A/zh active Pending
- 2003-03-03 PL PL03372971A patent/PL372971A1/xx not_active Application Discontinuation
- 2003-03-03 MX MXPA04008624A patent/MXPA04008624A/es active IP Right Grant
- 2003-03-03 AU AU2003207891A patent/AU2003207891A1/en not_active Abandoned
- 2003-03-03 JP JP2003572569A patent/JP2005524665A/ja not_active Withdrawn
- 2003-03-03 KR KR10-2004-7013962A patent/KR20040091694A/ko not_active Application Discontinuation
- 2003-03-03 AP APAP/P/2004/003123A patent/AP2004003123A0/en unknown
- 2003-03-03 EA EA200401160A patent/EA200401160A1/ru unknown
- 2003-03-03 CA CA002476580A patent/CA2476580A1/en not_active Abandoned
- 2003-03-05 AR ARP030100739A patent/AR038883A1/es unknown
- 2003-03-05 PE PE2003000214A patent/PE20031010A1/es not_active Application Discontinuation
- 2003-03-06 TW TW092104847A patent/TW200400027A/zh unknown
- 2003-03-07 GT GT200300053A patent/GT200300053A/es unknown
- 2003-03-07 PA PA20038568701A patent/PA8568701A1/es unknown
- 2003-03-07 UY UY27704A patent/UY27704A1/es not_active Application Discontinuation
-
2004
- 2004-08-12 IS IS7399A patent/IS7399A/is unknown
- 2004-08-16 ZA ZA200406491A patent/ZA200406491B/en unknown
- 2004-08-24 CO CO04082303A patent/CO5601013A2/es not_active Application Discontinuation
- 2004-08-30 MA MA27840A patent/MA27182A1/fr unknown
- 2004-09-03 TN TNP2004000167A patent/TNSN04167A1/fr unknown
- 2004-09-07 HR HRP20040810 patent/HRP20040810A2/hr not_active Application Discontinuation
- 2004-09-24 EC EC2004005275A patent/ECSP045275A/es unknown
- 2004-10-06 NO NO20044245A patent/NO20044245L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL163768A0 (en) | 2005-12-18 |
| IS7399A (is) | 2004-08-12 |
| WO2003074052A1 (en) | 2003-09-12 |
| OA12781A (en) | 2006-07-07 |
| CN1638768A (zh) | 2005-07-13 |
| AR038883A1 (es) | 2005-02-02 |
| EA200401160A1 (ru) | 2005-02-24 |
| HRP20040810A2 (en) | 2004-12-31 |
| EP1485091A1 (en) | 2004-12-15 |
| ECSP045275A (es) | 2004-10-26 |
| UY27704A1 (es) | 2003-10-31 |
| JP2005524665A (ja) | 2005-08-18 |
| PL372971A1 (en) | 2005-08-08 |
| GT200300053A (es) | 2003-10-10 |
| BR0308221A (pt) | 2005-01-04 |
| AU2003207891A1 (en) | 2003-09-16 |
| US6833380B2 (en) | 2004-12-21 |
| TNSN04167A1 (fr) | 2007-03-12 |
| ZA200406491B (en) | 2006-05-31 |
| MXPA04008624A (es) | 2004-12-06 |
| MA27182A1 (fr) | 2005-01-03 |
| TW200400027A (en) | 2004-01-01 |
| AP2004003123A0 (en) | 2004-09-30 |
| PA8568701A1 (es) | 2003-11-12 |
| NO20044245L (no) | 2004-10-06 |
| CA2476580A1 (en) | 2003-09-12 |
| US20030207916A1 (en) | 2003-11-06 |
| PE20031010A1 (es) | 2003-12-12 |
| KR20040091694A (ko) | 2004-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5601013A2 (es) | Compuestos que modulan la actividad de ppar | |
| CO5640080A2 (es) | Compuestos que modulan la actividad ppar y procedimiento para su preparacion | |
| CO5601012A2 (es) | Compuestos que modulan la actividad de ppar | |
| AR038882A1 (es) | Compuestos que modulan la actividad de ppar y composicion farmaceutica que los contiene | |
| CO5580788A2 (es) | Compuestos de bencimidazol sustituidos utiles como inhibidores de proteina cinasas | |
| CO5160347A1 (es) | Derivados de acido carbamico | |
| AR046789A1 (es) | Inhibidores de fosfodiesterasa 4, que incluyen analogos de diarilamina n-sustituidos | |
| EA200300763A1 (ru) | Пиридиновые ингибиторы матриксных металлопротеиназ | |
| EA200601639A1 (ru) | Изоксазолинзамещённое производное бензамида и пестицид | |
| CO5261616A1 (es) | Inhibidores no peptidicos de la union celular dependientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias | |
| PE20020504A1 (es) | N-acilsulfonamidas promotoras de apoptosis | |
| PE20020354A1 (es) | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) | |
| EA200401172A1 (ru) | Производные n-[фенил(пиперидин-2-ил)метил]бензамида, способ их получения и их применение в терапии | |
| AR039933A1 (es) | Indoles sustituidos para tratamiento de desordenes respiratorios | |
| CO5011090A1 (es) | Derivados de acil-piperazinil-pirimidinas, procedimiento para su preparacion y composiciones farmaceuticas de los mismos | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| EA200700758A1 (ru) | Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ | |
| CO4650117A1 (es) | Derivados de bencilsulfuro y proceso para su produccion . | |
| PE20040907A1 (es) | Derivados de anilinopirazol | |
| ES2038678T3 (es) | Procedimiento para la preparacion de n-(2-alquil-3-mercapto-glutaril)-alfamino-acidos. | |
| CO4950553A1 (es) | Compuestos de 7-tetrahidroisoquinolinas y procedimiento para su preparacion | |
| PE20020253A1 (es) | Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos | |
| CO5180631A1 (es) | Derivados de bencimidazol sustituidos con aminocarbonilo, procedimientos para su preparacion y su utilizacion como medicamentos | |
| CO5630027A2 (es) | Agentes terapeuticos derivados de acido 3-fenilpropionico sustituido | |
| PE20051138A1 (es) | BLOQUEADORES DE Kv1.5 REFERIDOS AL AUMENTO SELECTIVO DE LA CONTRACTILIDAD |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |