ZA200404812B - Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function. - Google Patents
Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function. Download PDFInfo
- Publication number
- ZA200404812B ZA200404812B ZA200404812A ZA200404812A ZA200404812B ZA 200404812 B ZA200404812 B ZA 200404812B ZA 200404812 A ZA200404812 A ZA 200404812A ZA 200404812 A ZA200404812 A ZA 200404812A ZA 200404812 B ZA200404812 B ZA 200404812B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted
- heterocyclo
- cycloalkenyl
- cycloalkyl
- aryl
- Prior art date
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- 102000007399 Nuclear hormone receptor Human genes 0.000 title claims description 80
- 108020005497 Nuclear hormone receptor Proteins 0.000 title claims description 80
- -1 heterocyclic succinimide compounds Chemical class 0.000 title claims description 14
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 224
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 188
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 183
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 134
- 125000003118 aryl group Chemical group 0.000 claims description 116
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 112
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 111
- 125000003107 substituted aryl group Chemical group 0.000 claims description 107
- 125000003342 alkenyl group Chemical group 0.000 claims description 103
- 125000000304 alkynyl group Chemical group 0.000 claims description 96
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 95
- 125000000217 alkyl group Chemical group 0.000 claims description 94
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 94
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 92
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 46
- 229910052760 oxygen Inorganic materials 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 37
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 26
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
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- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| FR2860793A1 (fr) * | 2003-10-14 | 2005-04-15 | Entomed | Composes derives de norcantharidine, leurs procedes de preparation, les compositions les contenant et leurs utilisations |
| EP1692139B1 (en) * | 2003-11-13 | 2013-02-13 | Isis Pharmaceuticals, Inc. | 5,6 -dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis |
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| JP2009507843A (ja) * | 2005-09-09 | 2009-02-26 | シェーリング コーポレイション | アザ縮合サイクリン依存性キナーゼ阻害剤 |
| JP5275236B2 (ja) | 2006-09-29 | 2013-08-28 | スミスクライン ビーチャム コーポレーション | 置換されたインドール化合物 |
| WO2008157291A2 (en) * | 2007-06-15 | 2008-12-24 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (3Aα, 4β, 5α, 7β, 7Aα)-4-(OCTAHYDRO-5-ETHYLSULFONAMIDO-4,7-DIMETHYL-1,3-DIOXO-4,7-EPOXY-2H-ISOINDOL-2-YL)-2-(TRIFLUOROMETHYL)BENZONITRILE AND METHOD OF PREPARATION |
| AU2010242307A1 (en) * | 2009-04-30 | 2011-11-24 | Sumitomo Chemical Company, Limited | Thiophene derivative |
| WO2011007819A1 (ja) | 2009-07-17 | 2011-01-20 | 塩野義製薬株式会社 | ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬 |
| EP2475366A1 (en) | 2009-09-11 | 2012-07-18 | Bayer Pharma Aktiengesellschaft | Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs |
| ME03371B (me) | 2010-01-14 | 2020-01-20 | Novartis Ag | Upotreba agensa za modifikovanje hormona adrenalina |
| WO2014111871A1 (en) | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
| WO2014179564A1 (en) * | 2013-05-01 | 2014-11-06 | Vitae Pharmaceuticals, Inc. | Thiazalopyrrolidine inhibitors of ror-gamma |
| JP6156074B2 (ja) * | 2013-11-08 | 2017-07-05 | 住友化学株式会社 | スクシンイミド化合物及びその用途 |
| EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| DK3372585T3 (da) * | 2014-12-19 | 2022-05-30 | Aragon Pharmaceuticals Inc | Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse |
| JP6817962B2 (ja) * | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| KR20190098204A (ko) | 2016-12-29 | 2019-08-21 | 엔요 파마 | 항바이러스제로서의 티오펜 유도체 |
| AU2018307919B2 (en) | 2017-07-24 | 2022-12-01 | Vitae Pharmaceuticals, Llc | Inhibitors of RORϒ |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| JP2023518299A (ja) * | 2020-03-20 | 2023-04-28 | ユニバーシティー オブ サウザン カリフォルニア | 小分子エナンチオマーによるアンドロゲン受容体調節 |
| BR112022022669A2 (pt) | 2020-05-08 | 2023-01-17 | Halia Therapeutics Inc | Inibidores de nek7 quinase |
| CN114848795B (zh) * | 2021-02-03 | 2023-04-14 | 四川大学 | RORa蛋白及其激动剂在制备抗衰老药物中的应用 |
| WO2023154939A2 (en) * | 2022-02-14 | 2023-08-17 | The Johns Hopkins University | Gcpii inhibition for the treatment of sarcopenia and aging |
| WO2024059200A1 (en) | 2022-09-14 | 2024-03-21 | Halia Therapeutics, Inc. | Nek7 inhibitors |
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| US3320270A (en) * | 1963-10-08 | 1967-05-16 | Tri Kem Corp | Certain 2-acylimidothiazole compounds |
| US3215597A (en) * | 1963-10-30 | 1965-11-02 | Dow Chemical Co | Methods and compositions for use in animal husbandry |
| US3261845A (en) * | 1964-07-14 | 1966-07-19 | Dow Chemical Co | N-phenyl derivatives of 3,6-epoxyhexahydrophthalimide |
| US4892943A (en) * | 1985-10-16 | 1990-01-09 | American Home Products Corporation | Fused bicyclic imides with psychotropic activity |
| JPS63170383A (ja) * | 1987-02-26 | 1988-07-14 | Nippon Zeon Co Ltd | 脂環式ジカルボン酸イミド化合物 |
| ZA908641B (en) * | 1989-10-27 | 1992-06-24 | Du Pont | (n-phthalimidoalkyl)piperidines |
| CN1103769C (zh) * | 1996-10-25 | 2003-03-26 | 第一制药株式会社 | 三环胺衍生物 |
| FR2764890B1 (fr) * | 1997-06-24 | 1999-08-27 | Adir | Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU1928800A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Substituted tricyclics |
| US6960474B2 (en) * | 2000-06-28 | 2005-11-01 | Bristol-Myers Squibb Company | Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator |
| CZ2003780A3 (cs) * | 2000-09-19 | 2004-01-14 | Bristol-Myers Squibb Company | Kondenzované heterocyklické sukcinimidové sloučeniny a jejich analogy, modulátory funkce receptorů hormonů jádra |
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