WO2003062241A8 - Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function - Google Patents

Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function

Info

Publication number
WO2003062241A8
WO2003062241A8 PCT/US2002/040598 US0240598W WO03062241A8 WO 2003062241 A8 WO2003062241 A8 WO 2003062241A8 US 0240598 W US0240598 W US 0240598W WO 03062241 A8 WO03062241 A8 WO 03062241A8
Authority
WO
WIPO (PCT)
Prior art keywords
hormone receptor
succinimidecompounds
modulators
analogs
nuclear hormone
Prior art date
Application number
PCT/US2002/040598
Other languages
French (fr)
Other versions
WO2003062241A1 (en
Inventor
Mark E Salvati
James Aaron Balog
Dacia A Pickering
Soren Giese
Aberra Fura
Wenying Li
Ramesh N Patel
Ronald L Hanson
Toomas Mitt
Jacques Roberge
James R Corte
Steven H Spergel
Richard A Rampulla
Raj Misra
Hai-Yun Xiao
Original Assignee
Bristol Myers Squibb Co
Mark E Salvati
James Aaron Balog
Dacia A Pickering
Soren Giese
Aberra Fura
Wenying Li
Ramesh N Patel
Ronald L Hanson
Toomas Mitt
Jacques Roberge
James R Corte
Steven H Spergel
Richard A Rampulla
Raj Misra
Hai-Yun Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60229435T priority Critical patent/DE60229435D1/en
Priority to IL16254702A priority patent/IL162547A0/en
Priority to BR0215281-9A priority patent/BR0215281A/en
Priority to DK02797421T priority patent/DK1458723T3/en
Priority to MXPA04005876A priority patent/MXPA04005876A/en
Priority to EP02797421A priority patent/EP1458723B1/en
Priority to JP2003562118A priority patent/JP2005523257A/en
Application filed by Bristol Myers Squibb Co, Mark E Salvati, James Aaron Balog, Dacia A Pickering, Soren Giese, Aberra Fura, Wenying Li, Ramesh N Patel, Ronald L Hanson, Toomas Mitt, Jacques Roberge, James R Corte, Steven H Spergel, Richard A Rampulla, Raj Misra, Hai-Yun Xiao filed Critical Bristol Myers Squibb Co
Priority to HU0402554A priority patent/HUP0402554A3/en
Priority to SI200230767T priority patent/SI1458723T1/en
Priority to KR10-2004-7009794A priority patent/KR20040086248A/en
Priority to CA002471342A priority patent/CA2471342A1/en
Priority to AU2002361785A priority patent/AU2002361785B2/en
Priority to UA20040705945A priority patent/UA78265C2/en
Priority to NZ533471A priority patent/NZ533471A/en
Publication of WO2003062241A1 publication Critical patent/WO2003062241A1/en
Priority to HR20040567A priority patent/HRP20040567A2/en
Priority to IS7324A priority patent/IS7324A/en
Priority to NO20043068A priority patent/NO20043068L/en
Publication of WO2003062241A8 publication Critical patent/WO2003062241A8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
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    • A61P5/26—Androgens
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
PCT/US2002/040598 2001-12-19 2002-12-18 Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function WO2003062241A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
UA20040705945A UA78265C2 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
BR0215281-9A BR0215281A (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and their analogues, modulators of nuclear hormone receptor function
DK02797421T DK1458723T3 (en) 2001-12-19 2002-12-18 Condensed heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
MXPA04005876A MXPA04005876A (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function.
EP02797421A EP1458723B1 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2003562118A JP2005523257A (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof that are modulators of nuclear hormone receptor function
KR10-2004-7009794A KR20040086248A (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HU0402554A HUP0402554A3 (en) 2001-12-19 2002-12-18 Condensated heterocyclic succinimide compounds, their use, process for the preparation of some of them and pharmaceutical compositions containing the compounds
SI200230767T SI1458723T1 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE60229435T DE60229435D1 (en) 2001-12-19 2002-12-18 CONDENSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND THEIR ANALOGUES, MODULATORS OF THE FUNCTION OF NUCLEAR HORMONE RECEPTORS
CA002471342A CA2471342A1 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002361785A AU2002361785B2 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function
IL16254702A IL162547A0 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide derivatives and pharmaceutical compositions containing the same
NZ533471A NZ533471A (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HR20040567A HRP20040567A2 (en) 2001-12-19 2004-06-17 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
IS7324A IS7324A (en) 2001-12-19 2004-06-18 Synchronous heterocyclic succinimide compounds and their analogues, configured for nuclear hormone receptor activity
NO20043068A NO20043068L (en) 2001-12-19 2004-07-16 Condensed heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2511601A 2001-12-19 2001-12-19
US10/025,116 2001-12-19

Publications (2)

Publication Number Publication Date
WO2003062241A1 WO2003062241A1 (en) 2003-07-31
WO2003062241A8 true WO2003062241A8 (en) 2004-10-21

Family

ID=27609007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040598 WO2003062241A1 (en) 2001-12-19 2002-12-18 Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function

Country Status (31)

Country Link
EP (1) EP1458723B1 (en)
JP (1) JP2005523257A (en)
KR (1) KR20040086248A (en)
CN (1) CN1589271A (en)
AR (1) AR037950A1 (en)
AT (1) ATE411319T1 (en)
AU (1) AU2002361785B2 (en)
BR (1) BR0215281A (en)
CA (1) CA2471342A1 (en)
CO (1) CO5640082A2 (en)
DE (1) DE60229435D1 (en)
DK (1) DK1458723T3 (en)
ES (1) ES2314127T3 (en)
GE (1) GEP20063817B (en)
HR (1) HRP20040567A2 (en)
HU (1) HUP0402554A3 (en)
IL (1) IL162547A0 (en)
IS (1) IS7324A (en)
MX (1) MXPA04005876A (en)
NO (1) NO20043068L (en)
NZ (1) NZ533471A (en)
PL (1) PL370904A1 (en)
PT (1) PT1458723E (en)
RU (1) RU2330038C2 (en)
SI (1) SI1458723T1 (en)
TW (1) TWI263640B (en)
UA (1) UA78265C2 (en)
UY (1) UY27595A1 (en)
WO (1) WO2003062241A1 (en)
YU (1) YU53604A (en)
ZA (1) ZA200404812B (en)

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