RU2330038C2 - Конденсированные гетероциклические сукцинимидные соединения и их аналоги как модуляторы функций рецептора гормонов ядра - Google Patents

Конденсированные гетероциклические сукцинимидные соединения и их аналоги как модуляторы функций рецептора гормонов ядра Download PDF

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RU2330038C2
RU2330038C2 RU2004122403/04A RU2004122403A RU2330038C2 RU 2330038 C2 RU2330038 C2 RU 2330038C2 RU 2004122403/04 A RU2004122403/04 A RU 2004122403/04A RU 2004122403 A RU2004122403 A RU 2004122403A RU 2330038 C2 RU2330038 C2 RU 2330038C2
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bonds
modulators
nucleus
functions
hormones
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RU2004122403/04A
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RU2004122403A (ru
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Марк Е. СЭЛВЕТИ (US)
Марк Е. СЭЛВЕТИ
Джеймс Аарон БЭЛОГ (US)
Джеймс Аарон БЭЛОГ
Дарси А. ПИКЕРИНГ (US)
Дарсия А. ПИКЕРИНГ
Сорен ГИЗ (US)
Сорен ГИЗ
Аберра ФУРА (US)
Аберра ФУРА
Венйинг ЛИ (US)
Венйинг ЛИ
Рэмеш Н. ПЭТЕЛ (US)
Рэмеш Н. ПЭТЕЛ
Роналд Л. ХЭНСОН (US)
Роналд Л. ХЭНСОН
Тумас МИТТ (US)
Тумас МИТТ
Жак РОБЕРЖ (US)
Жак РОБЕРЖ
Джеймс Р. КОРТ (US)
Джеймс Р. КОРТ
Стивен Х. СПЕРГЕЛ (US)
Стивен Х. СПЕРГЕЛ
Ричард А. РЭМПУЛЛА (US)
Ричард А. РЭМПУЛЛА
Радж МИСРА (US)
Радж МИСРА
Хай-Юн КСИАО (US)
Хай-Юн КСИАО
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Бристол-Маерс Сквибб Компани
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Abstract

Изобретение относится к соединению формулы I, где R7 обозначает -NHSO2R1, причем R1 выбран из С1-С6алкила, С3-С8циклоалкила, арила или замещенного галогеном арила, или его фармацевтически приемлемой соли. Изобретение также относится к соединениям формулы (а) и (б). Технический результат - конденсированные гетероциклические сукцинимидные соединения, полезные в качестве модуляторов функции рецепторов стероидсвязанных гормонов ядра. 3 н. и 1 з.п. ф-лы, 19 табл.
Figure 00000001
Figure 00000002

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Claims (4)

1. Соединение формулы
Figure 00000587
где R7 обозначает -NHSO2R1, причем R1 выбран из С1-С6 алкила, С3-С8 циклоалкила, арила или замещенного галогеном арила, или его фармацевтически приемлемая соль.
2. Соединение представляющее собой
Figure 00000588
или его фармацевтически приемлемая соль.
3. Соединение по п.2, представляющее собой
Figure 00000589
или его фармацевтически приемлемая соль.
4. Соединение
Figure 00000590
или его фармацевтически приемлемая соль.
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