ZA200301319B - Hard capsule. - Google Patents
Hard capsule. Download PDFInfo
- Publication number
- ZA200301319B ZA200301319B ZA200301319A ZA200301319A ZA200301319B ZA 200301319 B ZA200301319 B ZA 200301319B ZA 200301319 A ZA200301319 A ZA 200301319A ZA 200301319 A ZA200301319 A ZA 200301319A ZA 200301319 B ZA200301319 B ZA 200301319B
- Authority
- ZA
- South Africa
- Prior art keywords
- hard capsule
- capsule
- capsule according
- hard
- polymerizable vinyl
- Prior art date
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- 239000007902 hard capsule Substances 0.000 title claims description 113
- 239000002775 capsule Substances 0.000 claims description 50
- -1 alkylamine salts Chemical class 0.000 claims description 35
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 33
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 33
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 33
- 239000000178 monomer Substances 0.000 claims description 26
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 26
- 229920002554 vinyl polymer Polymers 0.000 claims description 26
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 23
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 21
- 239000000194 fatty acid Substances 0.000 claims description 21
- 229930195729 fatty acid Natural products 0.000 claims description 21
- 229920000642 polymer Polymers 0.000 claims description 21
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 19
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 19
- 239000002202 Polyethylene glycol Substances 0.000 claims description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims description 17
- 238000006116 polymerization reaction Methods 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 8
- MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 8
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 230000000379 polymerizing effect Effects 0.000 claims description 7
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 6
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 6
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 3
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims description 3
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims description 3
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 claims description 3
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 3
- RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 claims description 3
- CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 claims description 3
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 3
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 150000003863 ammonium salts Chemical class 0.000 claims description 3
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 3
- OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 claims description 3
- KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 3
- 159000000001 potassium salts Chemical class 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 230000008859 change Effects 0.000 description 48
- 238000012360 testing method Methods 0.000 description 31
- 238000000034 method Methods 0.000 description 27
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 238000005452 bending Methods 0.000 description 17
- 125000000914 phenoxymethylpenicillanyl group Chemical group CC1(S[C@H]2N([C@H]1C(=O)*)C([C@H]2NC(COC2=CC=CC=C2)=O)=O)C 0.000 description 17
- 238000011156 evaluation Methods 0.000 description 16
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- 230000015572 biosynthetic process Effects 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 13
- 239000002904 solvent Substances 0.000 description 12
- 239000007903 gelatin capsule Substances 0.000 description 11
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 11
- 230000001225 therapeutic effect Effects 0.000 description 11
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- 239000004615 ingredient Substances 0.000 description 9
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
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- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229940063557 methacrylate Drugs 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000012966 redox initiator Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000259830 | 2000-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301319B true ZA200301319B (en) | 2004-02-10 |
Family
ID=18747950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301319A ZA200301319B (en) | 2000-08-29 | 2003-02-18 | Hard capsule. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6967026B2 (hu) |
| EP (1) | EP1323404B1 (hu) |
| JP (1) | JP4596732B2 (hu) |
| KR (1) | KR100829474B1 (hu) |
| CN (1) | CN1209091C (hu) |
| AU (2) | AU8013801A (hu) |
| BR (1) | BR0113570A (hu) |
| CA (1) | CA2419825C (hu) |
| ES (1) | ES2437791T3 (hu) |
| HU (1) | HUP0300853A3 (hu) |
| MX (1) | MXPA03001854A (hu) |
| RU (1) | RU2003108732A (hu) |
| TW (1) | TWI249411B (hu) |
| WO (1) | WO2002017848A1 (hu) |
| ZA (1) | ZA200301319B (hu) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0005016D0 (en) * | 2000-03-01 | 2000-04-26 | Jumik Technologies Limited | PVA-Containing compositions |
| EP2112920B1 (en) | 2003-06-26 | 2018-07-25 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US20060153909A1 (en) * | 2003-06-27 | 2006-07-13 | Soko Motoune | Hard capsule |
| US8277844B2 (en) | 2003-08-20 | 2012-10-02 | Shionogi & Co., Ltd. | Coating composition |
| DE10358799A1 (de) * | 2003-12-12 | 2005-07-14 | Basf Ag | Verwendung von wasserdispergierbaren Copolymerisaten von Hydroxyalkyl(meth)acrylaten zur Herstellung von Hartkapseln |
| JPWO2005113010A1 (ja) * | 2004-05-24 | 2008-07-31 | クオリカプス株式会社 | 表面改質および溶解性が改善された硬カプセル |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US20080008750A1 (en) * | 2004-12-28 | 2008-01-10 | Shinji Tochio | Band-Seals For Hard Capsules |
| WO2006106799A1 (ja) * | 2005-03-31 | 2006-10-12 | Shionogi & Co., Ltd. | ポリビニルアルコール共重合体を用いたマイクロカプセル |
| JP2007091670A (ja) * | 2005-09-29 | 2007-04-12 | Shionogi & Co Ltd | 退色が抑制された着色カプセル |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| ES2904546T3 (es) | 2006-02-03 | 2022-04-05 | Opko Renal Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| JP2007230948A (ja) * | 2006-03-02 | 2007-09-13 | Univ Meijo | 腸溶性化硬カプセル |
| CA2648280C (en) | 2006-04-03 | 2014-03-11 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
| KR100721431B1 (ko) * | 2006-04-19 | 2007-05-25 | 학교법인 포항공과대학교 | 고분자 캡슐 및 그 제조방법 |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| EP2057985B1 (en) * | 2006-06-13 | 2013-10-16 | Nippon Shinyaku Co., Ltd. | Tablet coated with a polyvinyl alcohol copolymer |
| PL2679228T3 (pl) | 2006-06-21 | 2018-07-31 | Opko Ireland Global Holdings, Ltd. | Terapia z użyciem środka do uzupełniania witaminy D i środka do zastępowania hormonami witaminy D |
| WO2008018825A1 (en) * | 2006-08-10 | 2008-02-14 | Astrazeneca Ab | Oral polyvinyl alcohol capsules comprising proton pump inhibitors |
| ES2602571T3 (es) | 2007-02-15 | 2017-02-21 | Qualicaps Co., Ltd. | Elemento de sellado en banda para cápsulas duras que presentan PEG encapsulado en las mismas |
| JP5140804B2 (ja) * | 2007-02-27 | 2013-02-13 | 国立大学法人広島大学 | 生体再生カプセル |
| EP2140883B1 (en) | 2007-04-20 | 2012-10-31 | Daido Chemical Corporation | Novel base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| US20100144684A1 (en) | 2007-04-25 | 2010-06-10 | Proventiv Therapeutics, Inc. | Method of Safely and Effectively Treating and Preventing Secondary Hyperparathyroidism in Chronic Kidney Disease |
| DK2481400T3 (da) | 2007-04-25 | 2014-09-29 | Opko Ip Holdings Ii Inc | Orale præparater med kontrolleret frigivelse omfattende en vitamin D-forbindelse og en voksagtig bærer |
| ES2954932T3 (es) | 2008-04-02 | 2023-11-27 | Eirgen Pharma Ltd | Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados |
| JP5328768B2 (ja) * | 2008-04-10 | 2013-10-30 | クオリカプス株式会社 | 硬質カプセル剤 |
| WO2009125483A1 (ja) * | 2008-04-10 | 2009-10-15 | クオリカプス株式会社 | 硬質カプセル剤 |
| CN102006863A (zh) | 2008-04-15 | 2011-04-06 | 盐野义制药株式会社 | 膜组合物 |
| JP5498387B2 (ja) | 2008-09-12 | 2014-05-21 | 第一三共ヘルスケア株式会社 | 変色が抑制された安定な医薬製剤 |
| IT1393524B1 (it) * | 2009-01-30 | 2012-04-27 | Altergon Sa | Contenitore per uso farmaceutico atto al rilascio quantitativo di una monodose per somministrazione orale di ormoni tiroidei t3 e t4 in soluzione |
| CA2751703A1 (en) * | 2009-02-13 | 2010-08-19 | Nisshin Kasei Co., Ltd. | Hard capsule |
| US20120022169A1 (en) * | 2009-04-03 | 2012-01-26 | Nisshin Kasei Co., Ltd. | Hard capsule |
| CN102470177A (zh) | 2009-08-31 | 2012-05-23 | 日新化成株式会社 | 包衣用组合物 |
| EP2540286A4 (en) * | 2010-02-26 | 2015-05-27 | Nisshin Kasei Co Ltd | HARD CAPSULE AND METHOD OF PRODUCING THE SAME |
| LT2552484T (lt) | 2010-03-29 | 2020-04-27 | Opko Ireland Global Holdings, Ltd. | Būdai ir kompozicijos, skirti paratiroidų lygiams sumažinti |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| DK2946774T3 (da) * | 2014-05-19 | 2020-05-25 | Tillotts Pharma Ag | Coatede kapsler med modificeret frigivelse |
| CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
| EP3193925A2 (en) | 2014-08-07 | 2017-07-26 | OPKO Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin d |
| CN104530320B (zh) * | 2014-12-26 | 2017-06-23 | 中科院广州化学有限公司 | 一种丙烯酸接枝聚乙烯醇增强剂及其制备方法和应用 |
| JP6646469B2 (ja) * | 2015-02-23 | 2020-02-14 | 株式会社Ｎｂｃメッシュテック | 抗ウイルス性を有する吸水性高分子 |
| CN108883120A (zh) | 2016-03-28 | 2018-11-23 | 欧普科爱尔兰环球控股有限公司 | 维生素d治疗方法 |
| CA3029979A1 (en) | 2016-07-06 | 2018-01-11 | Qualicaps Co., Ltd. | Hard capsule having improved hardness, and method for manufacturing same |
| EP3636253B1 (en) * | 2017-06-09 | 2023-09-13 | Fuji Capsule Co., Ltd. | Seamless capsule shell composition and seamless capsule |
| WO2020071395A1 (ja) | 2018-10-02 | 2020-04-09 | クオリカプス株式会社 | 強度が改善された硬質カプセル、及びその製造方法 |
| US20210369627A1 (en) | 2018-10-02 | 2021-12-02 | Qualicaps Co., Ltd. | Improved-strength hard capsule and production method for same |
| CN109060540A (zh) * | 2018-10-11 | 2018-12-21 | 湖北中烟工业有限责任公司 | 一种烟用爆珠表面压陷值的检测装置 |
| CN113447356B (zh) * | 2021-07-12 | 2022-02-18 | 广州白云山星群(药业)股份有限公司 | 一种软胶囊囊皮机械性能测试方法及设备 |
| CN113999668B (zh) * | 2021-08-18 | 2023-12-19 | 江苏集萃先进高分子材料研究所有限公司 | 一种不可逆变色微胶囊及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300546A (en) * | 1965-10-05 | 1967-01-24 | American Cyanamid Co | Water soluble envelope prepared from a graft polymer of alkyl acrylate on a polyvinyl alcohol/polyvinyl acetate co-polymer |
| US3630955A (en) * | 1968-01-29 | 1971-12-28 | Ncr Co | Graft polymerization as a capsule wall treating process |
| DE2363853A1 (de) * | 1973-12-21 | 1975-07-03 | Hoechst Ag | Selbsttragende packungen oder kapseln zum umhuellen von medikamenten |
| JPS5586463A (en) * | 1978-12-22 | 1980-06-30 | Shinetsu Chemical Co | Enteric coating hard capsule |
| JPS6176413A (ja) | 1984-09-21 | 1986-04-18 | Junzo Sunamoto | 吸水性高分子によりカプセル化されたリポソ−ムの製造法 |
| GB2214918B (en) * | 1988-02-03 | 1992-10-07 | Warner Lambert Co | Polymeric materials made from starch and at least one synthetic thermoplastic polymeric material |
| US5095054A (en) * | 1988-02-03 | 1992-03-10 | Warner-Lambert Company | Polymer compositions containing destructurized starch |
| US5281356A (en) * | 1993-03-25 | 1994-01-25 | Lever Brothers Company | Heavy duty liquid detergent compositions containing non-proteolytic enzymes comprising capsules comprising proteolytic enzyme and composite polymer |
| US5424265A (en) * | 1993-06-15 | 1995-06-13 | Safetec Of America | Capsule for absorbing liquid waste in a suction canister |
| JPH09216818A (ja) * | 1995-12-04 | 1997-08-19 | Kyowa Hakko Kogyo Co Ltd | 硬カプセル剤 |
| CA2318782A1 (en) | 1998-03-11 | 1999-09-16 | Xiongwei He | Polyvinyl alcohol compositions |
| ES2212633T3 (es) * | 1998-09-30 | 2004-07-16 | Basf Aktiengesellschaft | Empleo de polimeros hidrosolubles o dispersables en agua, que contienen polieter como agente de recubrimiento, aglutinante y/o producto auxiliar formador de pelicula en formas de presentacion farmaceuticas. |
| DE19932144A1 (de) * | 1999-07-09 | 2001-01-11 | Basf Ag | Mikrokapselzubereitungen und Mikrokapseln enthaltende Wasch- und Reinigungsmittel |
| JP2001170137A (ja) * | 1999-12-16 | 2001-06-26 | Shionogi Qualicaps Kk | 硬質カプセル及びその製造方法 |
-
2001
- 2001-08-24 AU AU8013801A patent/AU8013801A/xx active Pending
- 2001-08-24 RU RU2003108732/15A patent/RU2003108732A/ru not_active Application Discontinuation
- 2001-08-24 CA CA2419825A patent/CA2419825C/en not_active Expired - Fee Related
- 2001-08-24 WO PCT/JP2001/007244 patent/WO2002017848A1/ja active IP Right Grant
- 2001-08-24 HU HU0300853A patent/HUP0300853A3/hu unknown
- 2001-08-24 JP JP2002522823A patent/JP4596732B2/ja not_active Expired - Fee Related
- 2001-08-24 BR BR0113570-8A patent/BR0113570A/pt not_active Application Discontinuation
- 2001-08-24 CN CNB018147372A patent/CN1209091C/zh not_active Expired - Fee Related
- 2001-08-24 ES ES01958454.9T patent/ES2437791T3/es not_active Expired - Lifetime
- 2001-08-24 KR KR1020037002968A patent/KR100829474B1/ko not_active IP Right Cessation
- 2001-08-24 US US10/362,114 patent/US6967026B2/en not_active Expired - Fee Related
- 2001-08-24 MX MXPA03001854A patent/MXPA03001854A/es unknown
- 2001-08-24 EP EP01958454.9A patent/EP1323404B1/en not_active Expired - Lifetime
- 2001-08-24 AU AU2001280138A patent/AU2001280138B2/en not_active Ceased
- 2001-08-28 TW TW090121157A patent/TWI249411B/zh not_active IP Right Cessation
-
2003
- 2003-02-18 ZA ZA200301319A patent/ZA200301319B/en unknown
-
2005
- 2005-04-20 US US11/110,428 patent/US20050186268A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4596732B2 (ja) | 2010-12-15 |
| KR20030026358A (ko) | 2003-03-31 |
| ES2437791T3 (es) | 2014-01-14 |
| WO2002017848A1 (en) | 2002-03-07 |
| CA2419825C (en) | 2010-05-25 |
| TWI249411B (en) | 2006-02-21 |
| CN1209091C (zh) | 2005-07-06 |
| CA2419825A1 (en) | 2003-02-18 |
| KR100829474B1 (ko) | 2008-05-16 |
| EP1323404A1 (en) | 2003-07-02 |
| HUP0300853A2 (hu) | 2003-10-28 |
| EP1323404A4 (en) | 2005-06-22 |
| MXPA03001854A (es) | 2004-12-03 |
| BR0113570A (pt) | 2004-07-06 |
| EP1323404A8 (en) | 2004-02-25 |
| EP1323404B1 (en) | 2013-10-16 |
| US20050186268A1 (en) | 2005-08-25 |
| US6967026B2 (en) | 2005-11-22 |
| US20030166763A1 (en) | 2003-09-04 |
| CN1449272A (zh) | 2003-10-15 |
| RU2003108732A (ru) | 2004-07-27 |
| AU8013801A (en) | 2002-03-13 |
| HUP0300853A3 (en) | 2006-07-28 |
| AU2001280138B2 (en) | 2006-03-16 |
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