ZA200208504B - Muscarinic agonists. - Google Patents
Muscarinic agonists. Download PDFInfo
- Publication number
- ZA200208504B ZA200208504B ZA200208504A ZA200208504A ZA200208504B ZA 200208504 B ZA200208504 B ZA 200208504B ZA 200208504 A ZA200208504 A ZA 200208504A ZA 200208504 A ZA200208504 A ZA 200208504A ZA 200208504 B ZA200208504 B ZA 200208504B
- Authority
- ZA
- South Africa
- Prior art keywords
- propyl
- butylpiperidine
- compound
- alkyl
- butyl
- Prior art date
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- 239000000472 muscarinic agonist Substances 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 151
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 139
- 238000000034 method Methods 0.000 claims description 93
- 125000000217 alkyl group Chemical group 0.000 claims description 74
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims description 58
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims description 58
- 102000009660 Cholinergic Receptors Human genes 0.000 claims description 45
- 108010009685 Cholinergic Receptors Proteins 0.000 claims description 45
- 125000001475 halogen functional group Chemical group 0.000 claims description 39
- 125000003118 aryl group Chemical group 0.000 claims description 36
- 230000000694 effects Effects 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 26
- 125000003342 alkenyl group Chemical group 0.000 claims description 24
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 24
- 125000000304 alkynyl group Chemical group 0.000 claims description 23
- 125000001188 haloalkyl group Chemical group 0.000 claims description 21
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- -1 amino, hydroxyl Chemical group 0.000 claims description 19
- 229910052760 oxygen Inorganic materials 0.000 claims description 17
- 229910052717 sulfur Inorganic materials 0.000 claims description 17
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 16
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 14
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- 125000001118 alkylidene group Chemical group 0.000 claims description 12
- UNKALQOWCZDDGF-UHFFFAOYSA-N methyl 4-(4-butylpiperidin-1-yl)butanoate Chemical compound CCCCC1CCN(CCCC(=O)OC)CC1 UNKALQOWCZDDGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000000651 prodrug Substances 0.000 claims description 12
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims description 11
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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US20079100P | 2000-04-28 | 2000-04-28 |
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ZA200208504A ZA200208504B (en) | 2000-04-28 | 2002-10-21 | Muscarinic agonists. |
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US (3) | US6627645B2 (ko) |
EP (1) | EP1278741B1 (ko) |
JP (2) | JP4119126B2 (ko) |
KR (2) | KR100901221B1 (ko) |
CN (3) | CN101016296A (ko) |
AR (1) | AR028385A1 (ko) |
AT (1) | ATE290000T1 (ko) |
AU (2) | AU2001259190B2 (ko) |
BR (1) | BR0110420A (ko) |
CA (1) | CA2407594A1 (ko) |
DE (1) | DE60109148T2 (ko) |
ES (1) | ES2238437T3 (ko) |
HK (1) | HK1058196A1 (ko) |
MX (1) | MXPA02010550A (ko) |
NO (1) | NO326106B1 (ko) |
NZ (1) | NZ521978A (ko) |
RU (1) | RU2269523C2 (ko) |
TW (3) | TW200505900A (ko) |
WO (1) | WO2001083472A1 (ko) |
ZA (1) | ZA200208504B (ko) |
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US3412097A (en) | 1964-09-07 | 1968-11-19 | Koninklijke Pharma Fab Nv | Indole derivatives |
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FR2735129B1 (fr) * | 1995-06-07 | 1997-07-11 | Adir | Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2751647B1 (fr) | 1996-07-25 | 1998-09-11 | Synthelabo | Derives de benzimidazole, leurs preparations et leurs applications en therapeutique |
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DE19725664A1 (de) | 1997-06-18 | 1998-12-24 | Merck Patent Gmbh | 3-Benzylpiperidine |
FR2803298A1 (fr) | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2804429B1 (fr) | 2000-01-31 | 2003-05-09 | Adir | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
TW200505900A (en) * | 2000-04-28 | 2005-02-16 | Acadia Pharm Inc | Muscarinic agonists |
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2001
- 2001-04-27 TW TW093131300A patent/TW200505900A/zh unknown
- 2001-04-27 CN CNA2006101006886A patent/CN101016296A/zh active Pending
- 2001-04-27 MX MXPA02010550A patent/MXPA02010550A/es active IP Right Grant
- 2001-04-27 AR ARP010102000A patent/AR028385A1/es unknown
- 2001-04-27 CA CA002407594A patent/CA2407594A1/en not_active Abandoned
- 2001-04-27 NZ NZ521978A patent/NZ521978A/en unknown
- 2001-04-27 WO PCT/US2001/013561 patent/WO2001083472A1/en active IP Right Grant
- 2001-04-27 CN CNA2006100037035A patent/CN1814596A/zh active Pending
- 2001-04-27 US US09/844,685 patent/US6627645B2/en not_active Expired - Fee Related
- 2001-04-27 TW TW090110141A patent/TWI306859B/zh active
- 2001-04-27 RU RU2002131937/04A patent/RU2269523C2/ru active
- 2001-04-27 CN CNB01811718XA patent/CN1249051C/zh not_active Expired - Fee Related
- 2001-04-27 EP EP01932682A patent/EP1278741B1/en not_active Expired - Lifetime
- 2001-04-27 BR BR0110420-9A patent/BR0110420A/pt not_active IP Right Cessation
- 2001-04-27 AT AT01932682T patent/ATE290000T1/de not_active IP Right Cessation
- 2001-04-27 ES ES01932682T patent/ES2238437T3/es not_active Expired - Lifetime
- 2001-04-27 KR KR1020077014206A patent/KR100901221B1/ko not_active IP Right Cessation
- 2001-04-27 JP JP2001580900A patent/JP4119126B2/ja not_active Expired - Fee Related
- 2001-04-27 AU AU2001259190A patent/AU2001259190B2/en not_active Ceased
- 2001-04-27 AU AU5919001A patent/AU5919001A/xx active Pending
- 2001-04-27 DE DE60109148T patent/DE60109148T2/de not_active Expired - Fee Related
- 2001-04-27 KR KR1020027014436A patent/KR20030005306A/ko not_active IP Right Cessation
- 2001-04-27 TW TW093131368A patent/TWI310035B/zh not_active IP Right Cessation
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2002
- 2002-10-21 ZA ZA200208504A patent/ZA200208504B/en unknown
- 2002-10-24 NO NO20025115A patent/NO326106B1/no unknown
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2003
- 2003-07-17 US US10/623,119 patent/US7238713B2/en not_active Expired - Fee Related
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- 2004-02-12 HK HK04100926A patent/HK1058196A1/xx not_active IP Right Cessation
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2007
- 2007-02-16 US US11/676,178 patent/US20070155795A1/en not_active Abandoned
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2008
- 2008-02-07 JP JP2008028114A patent/JP2008133297A/ja not_active Withdrawn
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